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6BQR
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BU of 6bqr by Molmil
Human TRPM4 ion channel in lipid nanodiscs in a calcium-free state
Descriptor: CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 4
Authors:Autzen, H.E, Myasnikov, A.G, Campbell, M.G, Asarnow, D, Julius, D, Cheng, Y.
Deposit date:2017-11-28
Release date:2017-12-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the human TRPM4 ion channel in a lipid nanodisc.
Science, 359, 2018
6BQV
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BU of 6bqv by Molmil
Human TRPM4 ion channel in lipid nanodiscs in a calcium-bound state
Descriptor: CALCIUM ION, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 4
Authors:Autzen, H.E, Myasnikov, A.G, Campbell, M.G, Asarnow, D, Julius, D, Cheng, Y.
Deposit date:2017-11-28
Release date:2017-12-20
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure of the human TRPM4 ion channel in a lipid nanodisc.
Science, 359, 2018
6O77
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BU of 6o77 by Molmil
Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, calcium-bound state
Descriptor: CALCIUM ION, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8
Authors:Diver, M.M, Cheng, Y, Julius, D.
Deposit date:2019-03-07
Release date:2019-09-18
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural insights into TRPM8 inhibition and desensitization.
Science, 365, 2019
6OFA
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BU of 6ofa by Molmil
Wasabi Receptor Toxin
Descriptor: Wasabi Receptor Toxin
Authors:Lin King, J.V, Kelly, M.J.S, Julius, D.
Deposit date:2019-03-28
Release date:2019-08-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain.
Cell, 178, 2019
5IS0
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BU of 5is0 by Molmil
Structure of TRPV1 in complex with capsazepine, determined in lipid nanodisc
Descriptor: Transient receptor potential cation channel subfamily V member 1, capsazepine
Authors:Gao, Y, Cao, E, Julius, D, Cheng, Y.
Deposit date:2016-03-15
Release date:2016-05-25
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
5IRX
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BU of 5irx by Molmil
Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc
Descriptor: (2S)-2-(acetyloxy)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}propyl pentanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ...
Authors:Gao, Y, Cao, E, Julius, D, Cheng, Y.
Deposit date:2016-03-14
Release date:2016-05-25
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
5IRZ
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BU of 5irz by Molmil
Structure of TRPV1 determined in lipid nanodisc
Descriptor: (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4S,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(pentanoyloxy)propan-2-yl decanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ...
Authors:Gao, Y, Cao, E, Julius, D, Cheng, Y.
Deposit date:2016-03-15
Release date:2016-05-25
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
6O20
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BU of 6o20 by Molmil
Cryo-EM structure of TRPV5 with calmodulin bound
Descriptor: CALCIUM ION, Calmodulin, Transient receptor potential cation channel subfamily V member 5
Authors:Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J.
Deposit date:2019-02-22
Release date:2019-04-24
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural insight into TRPV5 channel function and modulation.
Proc.Natl.Acad.Sci.USA, 116, 2019
6O1N
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BU of 6o1n by Molmil
Cryo-EM structure of TRPV5 (1-660) in nanodisc
Descriptor: Transient receptor potential cation channel subfamily V member 5
Authors:Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J.
Deposit date:2019-02-21
Release date:2019-04-24
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural insight into TRPV5 channel function and modulation.
Proc.Natl.Acad.Sci.USA, 116, 2019
6O1U
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BU of 6o1u by Molmil
Cryo-EM structure of TRPV5 W583A in nanodisc
Descriptor: Transient receptor potential cation channel subfamily V member 5
Authors:Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J.
Deposit date:2019-02-21
Release date:2019-04-24
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural insight into TRPV5 channel function and modulation.
Proc.Natl.Acad.Sci.USA, 116, 2019
6O1P
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BU of 6o1p by Molmil
Cryo-EM structure of full length TRPV5 in nanodisc
Descriptor: Transient receptor potential cation channel subfamily V member 5
Authors:Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J.
Deposit date:2019-02-21
Release date:2019-04-24
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insight into TRPV5 channel function and modulation.
Proc.Natl.Acad.Sci.USA, 116, 2019
6V9Y
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BU of 6v9y by Molmil
Structure of TRPA1 bound with A-967079, PMAL-C8
Descriptor: Transient receptor potential cation channel subfamily A member 1
Authors:Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D.
Deposit date:2019-12-16
Release date:2020-05-06
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
Nature, 585, 2020
6V9X
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BU of 6v9x by Molmil
Structure of TRPA1 modified by iodoacetamide, PMAL-C8
Descriptor: Transient receptor potential cation channel subfamily A member 1
Authors:Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D.
Deposit date:2019-12-16
Release date:2020-05-06
Last modified:2020-09-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
Nature, 585, 2020
6V9V
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BU of 6v9v by Molmil
Structure of TRPA1 modified by Bodipy-iodoacetamide with bound calcium, LMNG
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily A member 1, ~{N}-[[2,2-bis(fluoranyl)-10,12-dimethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-4-yl]methyl]ethanamide
Authors:Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D.
Deposit date:2019-12-16
Release date:2020-05-06
Last modified:2020-09-16
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
Nature, 585, 2020
6V9W
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BU of 6v9w by Molmil
Structure of TRPA1 (ligand-free) with bound calcium, LMNG
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily A member 1
Authors:Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D.
Deposit date:2019-12-16
Release date:2020-05-06
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
Nature, 585, 2020
3J5Q
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BU of 3j5q by Molmil
Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron cryo-microscopy
Descriptor: Kappa-theraphotoxin-Cg1a 1, Transient receptor potential cation channel subfamily V member 1
Authors:Liao, M, Cao, E, Julius, D, Cheng, Y.
Deposit date:2013-10-28
Release date:2013-12-04
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:TRPV1 structures in distinct conformations reveal activation mechanisms.
Nature, 504, 2013
3J5P
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BU of 3j5p by Molmil
Structure of TRPV1 ion channel determined by single particle electron cryo-microscopy
Descriptor: Transient receptor potential cation channel subfamily V member 1
Authors:Liao, M, Cao, E, Julius, D, Cheng, Y.
Deposit date:2013-10-28
Release date:2013-12-04
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.275 Å)
Cite:Structure of the TRPV1 ion channel determined by electron cryo-microscopy.
Nature, 504, 2013
3J5R
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BU of 3j5r by Molmil
Reconstruction of TRPV1 ion channel in complex with capsaicin by single particle cryo-microscopy
Descriptor: Transient receptor potential cation channel subfamily V member 1
Authors:Liao, M, Cao, E, Julius, D, Cheng, Y.
Deposit date:2013-10-28
Release date:2013-12-04
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:TRPV1 structures in distinct conformations reveal activation mechanisms.
Nature, 504, 2013
3J9P
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BU of 3j9p by Molmil
Structure of the TRPA1 ion channel determined by electron cryo-microscopy
Descriptor: Maltose-binding periplasmic protein, Transient receptor potential cation channel subfamily A member 1 chimera
Authors:Paulsen, C.E, Armache, J.-P, Gao, Y, Cheng, Y, Julius, D.
Deposit date:2015-02-14
Release date:2015-04-08
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (4.24 Å)
Cite:Structure of the TRPA1 ion channel suggests regulatory mechanisms.
Nature, 520, 2015
6O6R
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BU of 6o6r by Molmil
Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, AMTB-bound state
Descriptor: (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate, CHOLESTEROL HEMISUCCINATE, N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-[(thiophen-2-yl)methyl]benzamide, ...
Authors:Diver, M.M, Cheng, Y, Julius, D.
Deposit date:2019-03-07
Release date:2019-09-18
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural insights into TRPM8 inhibition and desensitization.
Science, 365, 2019
6O6A
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BU of 6o6a by Molmil
Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, ligand-free state
Descriptor: CHOLESTEROL HEMISUCCINATE, SODIUM ION, Transient receptor potential cation channel subfamily M member 8
Authors:Diver, M.M, Cheng, Y, Julius, D.
Deposit date:2019-03-05
Release date:2019-09-18
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural insights into TRPM8 inhibition and desensitization.
Science, 365, 2019
6O72
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BU of 6o72 by Molmil
Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, TC-I 2014-bound state
Descriptor: (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate, 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, ...
Authors:Diver, M.M, Cheng, Y, Julius, D.
Deposit date:2019-03-07
Release date:2019-09-18
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into TRPM8 inhibition and desensitization.
Science, 365, 2019
4NTW
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BU of 4ntw by Molmil
Structure of acid-sensing ion channel in complex with snake toxin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, Basic phospholipase A2 homolog Tx-beta, ...
Authors:Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E.
Deposit date:2013-12-02
Release date:2014-02-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
4NTY
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BU of 4nty by Molmil
Cesium sites in the crystal structure of acid-sensing ion channel in complex with snake toxin
Descriptor: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Acid-sensing ion channel 1, Basic phospholipase A2 homolog Tx-beta, ...
Authors:Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E.
Deposit date:2013-12-02
Release date:2014-02-19
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
4NTX
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BU of 4ntx by Molmil
Structure of acid-sensing ion channel in complex with snake toxin and amiloride
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-DIAMINO-N-(AMINOIMINOMETHYL)-6-CHLOROPYRAZINECARBOXAMIDE, Acid-sensing ion channel 1, ...
Authors:Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E.
Deposit date:2013-12-02
Release date:2014-02-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014

 

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