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6FF7
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BU of 6ff7 by Molmil
human Bact spliceosome core structure
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, BUD13 homolog, ...
Authors:Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H.
Deposit date:2018-01-03
Release date:2019-03-13
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
Cell, 172, 2018
6FF4
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BU of 6ff4 by Molmil
human Bact spliceosome core structure
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ...
Authors:Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H.
Deposit date:2018-01-03
Release date:2018-08-29
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
Cell, 172, 2018
5M32
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BU of 5m32 by Molmil
Human 26S proteasome in complex with Oprozomib
Descriptor: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ...
Authors:Haselbach, D, Schrader, J, Lambrecht, F, Henneberg, F, Chari, A, Stark, H.
Deposit date:2016-10-14
Release date:2017-07-05
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs.
Nat Commun, 8, 2017
6H60
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BU of 6h60 by Molmil
pseudo-atomic structural model of the E3BP component of the human pyruvate dehydrogenase multienzyme complex
Descriptor: Pyruvate dehydrogenase protein X component, mitochondrial
Authors:Haselbach, D, Prajapati, S, Tittmann, K, Stark, H.
Deposit date:2018-07-25
Release date:2019-06-05
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (6 Å)
Cite:Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.
Structure, 27, 2019
6H55
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BU of 6h55 by Molmil
core of the human pyruvate dehydrogenase (E2)
Descriptor: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Authors:Haselbach, D, Prajapati, S, Tittmann, K, Stark, H.
Deposit date:2018-07-23
Release date:2019-06-05
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (6 Å)
Cite:Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.
Structure, 27, 2019
7QVE
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BU of 7qve by Molmil
Spinach 20S proteasome
Descriptor: Proteasome subunit alpha type, Proteasome subunit alpha type-3, Proteasome subunit beta, ...
Authors:Kandolf, S, Grishkovskaya, I, Meinhart, A, Haselbach, D.
Deposit date:2022-01-21
Release date:2022-05-25
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of the plant 26S proteasome.
Plant Commun., 3, 2022
8TAR
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BU of 8tar by Molmil
APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G.
Deposit date:2023-06-27
Release date:2023-09-27
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat.Struct.Mol.Biol., 30, 2023
8TAU
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BU of 8tau by Molmil
APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G.
Deposit date:2023-06-27
Release date:2023-09-27
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat.Struct.Mol.Biol., 30, 2023
8AMZ
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BU of 8amz by Molmil
Spinach 19S proteasome
Descriptor: 26S proteasome non-ATPase regulatory subunit 1 homolog, 26S proteasome non-ATPase regulatory subunit 2 homolog, 26S proteasome regulatory subunit 7, ...
Authors:Kandolf, S, Grishkovskaya, I, Meinhart, A, Haselbach, D.
Deposit date:2022-08-04
Release date:2022-08-24
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of the plant 26S proteasome
Plant Communications, 3, 2022
7Z11
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BU of 7z11 by Molmil
Structure of substrate bound DRG1 (AFG2)
Descriptor: ATPase family gene 2 protein, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, peptide substrate
Authors:Prattes, M, Grishkovskaya, I, Bergler, H, Haselbach, D.
Deposit date:2022-02-24
Release date:2022-09-21
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1.
Nat.Struct.Mol.Biol., 29, 2022
7Z34
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BU of 7z34 by Molmil
Structure of pre-60S particle bound to DRG1(AFG2).
Descriptor: 35S pre-ribosomal RNA, 5.8S rRNA, 5S rRNA, ...
Authors:Prattes, M, Grishkovskaya, I, Bergler, H, Haselbach, D.
Deposit date:2022-03-01
Release date:2022-09-21
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1.
Nat.Struct.Mol.Biol., 29, 2022
8BJA
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BU of 8bja by Molmil
Structure of the human UBR5 Dimer.
Descriptor: E3 ubiquitin-protein ligase UBR5, ZINC ION
Authors:Hodakova, Z, Grishkovskaya, I, Haselbach, D.
Deposit date:2022-11-03
Release date:2023-07-12
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5.
Embo J., 42, 2023
6TAY
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BU of 6tay by Molmil
Mouse RNF213 mutant R4753K modeling the Moyamoya-disease-related Human variant R4810K
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNF213,E3 ubiquitin-protein ligase RNF213,E3 ubiquitin-protein ligase RNF213, ...
Authors:Ahel, J, Meinhart, A, Haselbach, D, Clausen, T.
Deposit date:2019-10-31
Release date:2020-07-01
Last modified:2021-01-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism.
Elife, 9, 2020
6TAX
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BU of 6tax by Molmil
Mouse RNF213 wild type protein
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNF213,E3 ubiquitin-protein ligase RNF213,E3 ubiquitin-protein ligase RNF213, ...
Authors:Ahel, J, Meinhart, A, Haselbach, D, Clausen, T.
Deposit date:2019-10-31
Release date:2020-07-01
Last modified:2021-01-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism.
Elife, 9, 2020
7NKU
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BU of 7nku by Molmil
diazaborine bound Drg1(AFG2)
Descriptor: 6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL, ATPase family gene 2 protein, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Prattes, M, Bergler, H, Haselbach, D.
Deposit date:2021-02-19
Release date:2021-06-23
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine.
Nat Commun, 12, 2021
7NHT
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BU of 7nht by Molmil
Akirin2 bound human proteasome
Descriptor: Akirin-2, POTASSIUM ION, Proteasome subunit alpha type-1, ...
Authors:Singh, K, Brunner, H, Grishkovskaya, I, de Almeida, M, Hinterndorfer, M, Zuber, J, Haselbach, D.
Deposit date:2021-02-11
Release date:2021-09-01
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:AKIRIN2 controls the nuclear import of proteasomes in vertebrates.
Nature, 599, 2021
7ABR
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BU of 7abr by Molmil
Cryo-EM structure of B. subtilis ClpC (DWB mutant) hexamer bound to a substrate polypeptide
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Negative regulator of genetic competence ClpC/MecB, ...
Authors:Morreale, F.E, Meinhart, A, Haselbach, D, Clausen, T.
Deposit date:2020-09-08
Release date:2021-10-06
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:BacPROTACs mediate targeted protein degradation in bacteria.
Cell, 185, 2022
7AWT
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BU of 7awt by Molmil
E. coli NADH quinone oxidoreductase hydrophilic arm
Descriptor: FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, IRON/SULFUR CLUSTER, ...
Authors:Schimpf, J, Grishkovskaya, I, Haselbach, D, Friedrich, T.
Deposit date:2020-11-09
Release date:2021-09-15
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (2.73 Å)
Cite:Structure of the peripheral arm of a minimalistic respiratory complex I.
Structure, 30, 2022
7NH3
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BU of 7nh3 by Molmil
Nematocida Huwe1 in open conformation.
Descriptor: E3 ubiquitin-protein ligase HUWE1
Authors:Petrova, O, Grishkovskaya, I, Grabarczyk, D.B, Kessler, D, Haselbach, D, Clausen, T.
Deposit date:2021-02-09
Release date:2022-03-02
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (6.37 Å)
Cite:Crystal structure of HUWE1: One ring to ubiquitinate them all
To Be Published
5L9U
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BU of 5l9u by Molmil
Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A.
Deposit date:2016-06-11
Release date:2016-09-14
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
5L9T
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BU of 5l9t by Molmil
Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A.
Deposit date:2016-06-11
Release date:2016-10-26
Last modified:2016-11-02
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
5KHR
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BU of 5khr by Molmil
Model of human Anaphase-promoting complex/Cyclosome complex (APC15 deletion mutant) in complex with the E2 UBE2C/UBCH10 poised for ubiquitin ligation to substrate (APC/C-CDC20-substrate-UBE2C)
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:VanderLinden, R, Yamaguchi, M, Dube, P, Haselbach, D, Stark, H, Schulman, B.A.
Deposit date:2016-06-15
Release date:2016-08-24
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.
Mol.Cell, 63, 2016
7OYC
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BU of 7oyc by Molmil
Cryo-EM structure of the Xenopus egg 80S ribosome
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
Authors:Leesch, F, Lorenzo-Orts, L, Grishkovskaya, I, Kandolf, S, Belacic, K, Meinhart, A, Haselbach, D, Pauli, A.
Deposit date:2021-06-24
Release date:2022-07-20
Last modified:2023-02-08
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:A molecular network of conserved factors keeps ribosomes dormant in the egg.
Nature, 613, 2023
7OYD
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BU of 7oyd by Molmil
Cryo-EM structure of a rabbit 80S ribosome with zebrafish Dap1b
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ...
Authors:Leesch, F, Lorenzo-Orts, L, Grishkovskaya, I, Kandolf, S, Belacic, K, Meinhart, A, Haselbach, D, Pauli, A.
Deposit date:2021-06-24
Release date:2022-07-20
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:A molecular network of conserved factors keeps ribosomes dormant in the egg.
Nature, 613, 2023
7OYB
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BU of 7oyb by Molmil
Cryo-EM structure of the 6 hpf zebrafish embryo 80S ribosome
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ...
Authors:Leesch, F, Lorenzo-Orts, L, Grishkovskaya, I, Kandolf, S, Belacic, K, Meinhart, A, Haselbach, D, Pauli, A.
Deposit date:2021-06-24
Release date:2022-07-13
Last modified:2023-02-08
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:A molecular network of conserved factors keeps ribosomes dormant in the egg.
Nature, 613, 2023

 

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