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5KO9
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BU of 5ko9 by Molmil
Crystal Structure of the SRAP Domain of Human HMCES Protein
Descriptor: Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, UNKNOWN ATOM OR ION
Authors:Halabelian, L, Li, Y, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2016-06-29
Release date:2016-08-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.
Nat.Struct.Mol.Biol., 26, 2019
5J3E
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BU of 5j3e by Molmil
Crystal Structure of Human THYN1 protein in complex with 5-methylcytosine containing DNA
Descriptor: 5-methylcytosine containing DNA, Thymocyte nuclear protein 1, UNKNOWN ATOM OR ION
Authors:Halabelian, L, Tempel, W, Li, Y, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2016-03-30
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Human THYN1 protein in complex with 5-methylcytosine containing DNA
To be published
4L3C
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BU of 4l3c by Molmil
Structure of HLA-A2 in complex with D76N b2m mutant and NY-ESO1 double mutant
Descriptor: Beta-2-microglobulin, CHLORIDE ION, GLYCEROL, ...
Authors:Halabelian, L, Giorgetti, S, Bellotti, V, Bolognesi, M, Ricagno, S.
Deposit date:2013-06-05
Release date:2013-12-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin.
J.Biol.Chem., 289, 2014
4L29
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BU of 4l29 by Molmil
Structure of wtMHC class I with NY-ESO1 double mutant
Descriptor: Beta-2-microglobulin, CHLORIDE ION, GLYCEROL, ...
Authors:Halabelian, L, Giorgetti, S, Bellotti, V, Bolognesi, M, Ricagno, S.
Deposit date:2013-06-04
Release date:2013-12-25
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin.
J.Biol.Chem., 289, 2014
6VAH
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BU of 6vah by Molmil
Crystal structure of human TEAD2 transcription factor in complex with Flufenamic acid derivative
Descriptor: 2-fluoro-6-[(3-hexylphenyl)amino]benzoic acid, Transcriptional enhancer factor TEF-4, UNKNOWN ATOM OR ION
Authors:Halabelian, L, Zeng, H, Dong, A, Li, Y, Melin, L, Gagnon, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Santhakumar, V, Structural Genomics Consortium (SGC)
Deposit date:2019-12-17
Release date:2020-04-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Crystal structure of human TEAD2 transcription factor in complex with Flufenamic acid derivative
to be published
4RA3
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BU of 4ra3 by Molmil
Crystal structure of dimeric S33C beta-2 microglobulin mutant in complex with Thioflavin (ThT) at 2.8 Angstrom resolution
Descriptor: 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium, Beta-2-microglobulin
Authors:Halabelian, L, Bolognesi, M, Ricagno, S.
Deposit date:2014-09-09
Release date:2015-09-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A covalent homodimer probing early oligomers along amyloid aggregation.
Sci Rep, 5, 2015
4R9H
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BU of 4r9h by Molmil
Crystal structure of dimeric S33C beta-2 microglobulin mutant at 1.9 Angstrom resolution
Descriptor: Beta-2-microglobulin
Authors:Halabelian, L, Bolognesi, M, Ricagno, S.
Deposit date:2014-09-05
Release date:2015-09-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A covalent homodimer probing early oligomers along amyloid aggregation.
Sci Rep, 5, 2015
4RAH
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BU of 4rah by Molmil
Crystal structure of dimeric S33C beta-2 microglobulin mutant at 1.4 Angstrom resolution
Descriptor: Beta-2-microglobulin
Authors:Halabelian, L, Bolognesi, M, Ricagno, S.
Deposit date:2014-09-10
Release date:2015-09-16
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A covalent homodimer probing early oligomers along amyloid aggregation.
Sci Rep, 5, 2015
6VYC
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BU of 6vyc by Molmil
Crystal structure of WD-repeat domain of human WDR91
Descriptor: UNKNOWN ATOM OR ION, WD repeat-containing protein 91
Authors:Halabelian, L, Hutchinson, A, Li, Y, Seitova, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2020-02-26
Release date:2020-03-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of WD-repeat domain of human WDR91
To be Published
6WAJ
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BU of 6waj by Molmil
Crystal structure of the UBL domain of human NLE1
Descriptor: NLE1, UNKNOWN ATOM OR ION
Authors:Halabelian, L, Zeng, H, Li, Y, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2020-03-25
Release date:2020-04-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the UBL domain of human NLE1
To be Published
6WAD
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BU of 6wad by Molmil
Crystal Structure of Human Protein arginine N-methyltransferase 6 (PRMT6) in complex with MT2739 inhibitor
Descriptor: 5-bromo-N-(diphenylmethyl)-N-methylthiophene-2-carboxamide, Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Halabelian, L, Zeng, H, Dong, A, Schapira, M, De Freitas, R.F, Hutchinson, A, Seitova, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2020-03-25
Release date:2020-09-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure of Human Protein arginine N-methyltransferase 6 (PRMT6) in complex with MT2739 inhibitor
to be published
6VO5
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BU of 6vo5 by Molmil
Crystal structure of Human histone acetytransferas 1 (HAT1) in complex with isobutryl-COA and K12A mutant variant of histone H4
Descriptor: ACETATE ION, GLYCEROL, Histone H4, ...
Authors:Halabelian, L, Zeng, H, Dong, A, Loppnau, P, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2020-01-30
Release date:2020-03-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of Human histone acetytransferas 1 (HAT1) in complex with isobutryl-COA and K12A mutant variant of histone H4
to be published
6OEB
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BU of 6oeb by Molmil
Crystal structure of HMCES SRAP domain in complex with 3' overhang DNA
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*CP*AP*GP*AP*CP*GP*TP*T)-3'), DNA (5'-D(*GP*TP*CP*TP*GP*G)-3'), ...
Authors:Halabelian, L, Ravichandran, M, Li, Y, Zeng, H, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2019-03-27
Release date:2019-04-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.
Nat.Struct.Mol.Biol., 26, 2019
5WBV
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BU of 5wbv by Molmil
Crystal Structure of the SET Domain of Human SUV420H1 In Complex With Inhibitor
Descriptor: 2-chloro-5-(4-methyl-6-oxo-3-phenylpyrano[2,3-c]pyrazol-1(6H)-yl)benzoic acid, Histone-lysine N-methyltransferase KMT5B, S-ADENOSYLMETHIONINE, ...
Authors:Halabelian, L, Tempel, W, Brown, P.J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2017-06-29
Release date:2017-07-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the SET Domain of Human SUV420H1 In Complex With Inhibitor
To be published
6OE7
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BU of 6oe7 by Molmil
Crystal structure of HMCES cross-linked to DNA abasic site
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*CP*AP*GP*AP*CP*GP*TP*(DRZ)P*GP*TP*T)-3'), DNA (5'-D(*GP*TP*CP*TP*GP*G)-3'), ...
Authors:Halabelian, L, Li, Y, Zeng, H, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2019-03-27
Release date:2019-04-24
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.
Nat.Struct.Mol.Biol., 26, 2019
6OEA
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BU of 6oea by Molmil
Crystal structure of HMCES SRAP domain in complex with longer 3' overhang DNA
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*CP*AP*GP*AP*CP*GP*TP*TP*GP*TP*T)-3'), DNA (5'-D(*GP*TP*CP*TP*GP*G)-3'), ...
Authors:Halabelian, L, Ravichandran, M, Li, Y, Zeng, H, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2019-03-27
Release date:2019-04-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.
Nat.Struct.Mol.Biol., 26, 2019
6N31
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BU of 6n31 by Molmil
WD repeats of human WDR12
Descriptor: Ribosome biogenesis protein WDR12, UNKNOWN ATOM OR ION
Authors:Halabelian, L, Zeng, H, Tempel, W, Li, Y, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2018-11-14
Release date:2018-12-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:WD repeats of human WDR12
To Be Published
6MIW
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BU of 6miw by Molmil
WWE domain of human HUWE1
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, E3 ubiquitin-protein ligase HUWE1, UNKNOWN ATOM OR ION
Authors:Halabelian, L, Loppnau, P, Tempel, W, Wong, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
Deposit date:2018-09-20
Release date:2018-10-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:WWE domain of human HUWE1
To Be Published
6OOV
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BU of 6oov by Molmil
Crystal structure of HMCES SRAP domain in complex with palindromic 3' overhang DNA
Descriptor: DNA (5'-D(*CP*AP*AP*CP*GP*TP*TP*GP*TP*TP*TP*TP*T)-3'), Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, UNKNOWN ATOM OR ION
Authors:Halabelian, L, Zeng, H, Li, Y, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2019-04-23
Release date:2019-05-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of HMCES SRAP domain in complex with palindromic 3' overhang DNA
To Be Published
6P0Q
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BU of 6p0q by Molmil
Crystal Structure of Ubiquitin-like Domain of Human WDR12
Descriptor: 1,2-ETHANEDIOL, Ribosome biogenesis protein WDR12
Authors:Halabelian, L, Dong, A, Zeng, H, Li, Y, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2019-05-17
Release date:2019-05-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Crystal Structure of Ubiquitin-like Domain of Human WDR12
to be published
6PDM
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BU of 6pdm by Molmil
Crystal structure of Human Protein Arginine Methyltransferase 9 (PRMT9)
Descriptor: Protein arginine N-methyltransferase 9, UNKNOWN ATOM OR ION
Authors:Halabelian, L, Tempel, W, Zeng, H, Li, Y, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2019-06-19
Release date:2019-07-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of Human Protein Arginine Methyltransferase 9 (PRMT9)
To Be Published
6P0R
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BU of 6p0r by Molmil
Methyltransferase domain of human suppressor of variegation 3-9 homolog 2 (SUV39H2) in complex with OTS186935 inhibitor
Descriptor: (3S)-1-[2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]-N-[(pyridin-4-yl)methyl]pyrrolidin-3-amine, Histone-lysine N-methyltransferase SUV39H2, UNKNOWN ATOM OR ION, ...
Authors:Halabelian, L, Dong, A, Zeng, H, Loppnau, P, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2019-05-17
Release date:2019-05-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Methyltransferase domain of human suppressor of variegation 3-9 homolog 2 (SUV39H2) in complex with OTS186935 inhibitor
to be published
6PBG
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BU of 6pbg by Molmil
Crystal structure of WD-repeat domain of human coatomer subunit Alpha (COPA)
Descriptor: Coatomer subunit alpha, L(+)-TARTARIC ACID, UNKNOWN ATOM OR ION
Authors:Halabelian, L, Zeng, H, Dong, A, Loppnau, P, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2019-06-13
Release date:2019-06-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Crystal structure of W repeat domain of human coatomer subunit Alpha (COPA)
to be published
6PFL
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BU of 6pfl by Molmil
Crystal structure of Human HUWE1 WWE domain in complex with ADPR
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, E3 ubiquitin-protein ligase HUWE1, UNKNOWN ATOM OR ION
Authors:Halabelian, L, Zeng, H, Dong, A, Loppnau, P, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2019-06-21
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of Human HUWE1 WWE domain in complex with ADPR
to be published
6W6D
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BU of 6w6d by Molmil
Crystal Structure of Human Protein arginine N-methyltransferase 6 (PRMT6) in complex with SGC6870 inhibitor
Descriptor: (5R)-4-(5-bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one, Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Halabelian, L, Zeng, H, Dong, A, Jin, J, Shen, Y, Kaniskan, H.U, Hutchinson, A, Seitova, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2020-03-16
Release date:2020-04-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6.
J.Med.Chem., 64, 2021

 

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