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4MXI
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BU of 4mxi by Molmil
ClpP Ser98dhA
Descriptor: ATP-dependent Clp protease proteolytic subunit
Authors:Gersch, M, Kolb, R, Alte, F, Groll, M, Sieber, S.A.
Deposit date:2013-09-26
Release date:2013-10-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Disruption of Oligomerization and Dehydroalanine Formation as Mechanisms for ClpP Protease Inhibition.
J.Am.Chem.Soc., 136, 2014
3V5E
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BU of 3v5e by Molmil
Crystal structure of ClpP from Staphylococcus aureus in the active, extended conformation
Descriptor: ATP-dependent Clp protease proteolytic subunit
Authors:Gersch, M, List, A, Groll, M, Sieber, S.
Deposit date:2011-12-16
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insights into structural network responsible for oligomerization and activity of bacterial virulence regulator caseinolytic protease P (ClpP) protein.
J.Biol.Chem., 287, 2012
5OHP
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BU of 5ohp by Molmil
Crystal structure of USP30 (C77A) in complex with Lys6-linked diubiquitin
Descriptor: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 30, ZINC ION
Authors:Gersch, M, Komander, D.
Deposit date:2017-07-17
Release date:2017-09-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Nat. Struct. Mol. Biol., 24, 2017
5OHK
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BU of 5ohk by Molmil
Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (high resolution)
Descriptor: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30, ZINC ION, ...
Authors:Gersch, M, Komander, D.
Deposit date:2017-07-17
Release date:2017-09-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Nat. Struct. Mol. Biol., 24, 2017
5OHN
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BU of 5ohn by Molmil
Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (low resolution)
Descriptor: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30, ZINC ION
Authors:Gersch, M, Komander, D.
Deposit date:2017-07-17
Release date:2017-09-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Nat. Struct. Mol. Biol., 24, 2017
6HEM
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BU of 6hem by Molmil
Structure of the C-terminal domain of USP25 (748-1048)
Descriptor: GLYCEROL, SODIUM ION, Ubiquitin carboxyl-terminal hydrolase 25
Authors:Gersch, M, Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6HEJ
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BU of 6hej by Molmil
Structure of human USP28
Descriptor: SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 28
Authors:Gersch, M, Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6HEK
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BU of 6hek by Molmil
Structure of human USP28 bound to Ubiquitin-PA
Descriptor: CHLORIDE ION, Polyubiquitin-B, TETRAETHYLENE GLYCOL, ...
Authors:Gersch, M, Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6HEH
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BU of 6heh by Molmil
Structure of the catalytic domain of USP28 (insertion deleted)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28
Authors:Gersch, M, Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6HEI
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BU of 6hei by Molmil
Structure of the catalytic domain of USP28 (insertion deleted) bound to Ubiquitin-PA
Descriptor: 1,2-ETHANEDIOL, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28
Authors:Gersch, M, Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6HEL
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BU of 6hel by Molmil
Structure of human USP25
Descriptor: Ubiquitin carboxyl-terminal hydrolase 25
Authors:Gersch, M, Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.941 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
3V5I
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BU of 3v5i by Molmil
The crystal structure of the mutant ClpP S98A (Staphylococcus aureus)
Descriptor: ATP-dependent Clp protease proteolytic subunit
Authors:List, A, Gersch, M, Groll, M, Sieber, S.
Deposit date:2011-12-16
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into structural network responsible for oligomerization and activity of bacterial virulence regulator caseinolytic protease P (ClpP) protein.
J.Biol.Chem., 287, 2012
7ZM0
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BU of 7zm0 by Molmil
Structure of UCHL1 in complex with GK13S inhibitor
Descriptor: (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide, Ubiquitin carboxyl-terminal hydrolase isozyme L1
Authors:Grethe, C, Gersch, M.
Deposit date:2022-04-18
Release date:2022-09-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural basis for specific inhibition of the deubiquitinase UCHL1.
Nat Commun, 13, 2022
7ZJU
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BU of 7zju by Molmil
Structure of human USPL1 in covalent complex with SUMO3-2Br probe
Descriptor: 2-bromanylethanamine, CALCIUM ION, CHLORIDE ION, ...
Authors:Zhao, Z, Gersch, M.
Deposit date:2022-04-12
Release date:2023-09-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Native Semisynthesis of Isopeptide-Linked Substrates for Specificity Analysis of Deubiquitinases and Ubl Proteases.
J.Am.Chem.Soc., 145, 2023
8PQ0
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BU of 8pq0 by Molmil
Structure of human PARK7 in complex with GK16R
Descriptor: (3~{R})-3-(pent-4-ynylcarbamoyl)pyrrolidine-1-carboximidothioic acid, Parkinson disease protein 7
Authors:Grethe, C, Gersch, M.
Deposit date:2023-07-10
Release date:2024-01-31
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1.
Angew.Chem.Int.Ed.Engl., 63, 2024
8PPW
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BU of 8ppw by Molmil
Structure of human PARK7 in complex with GK16S
Descriptor: (3~{S})-1-(iminomethyl)-~{N}-pent-4-ynyl-pyrrolidine-3-carboxamide, Parkinson disease protein 7
Authors:Grethe, C, Gersch, M.
Deposit date:2023-07-10
Release date:2024-01-31
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1.
Angew.Chem.Int.Ed.Engl., 63, 2024
8PW1
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BU of 8pw1 by Molmil
Structure of human UCHL1 in complex with CG341 inhibitor
Descriptor: (2~{S})-4-(iminomethyl)-1-methyl-~{N}-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]piperazine-2-carboxamide, Ubiquitin carboxyl-terminal hydrolase isozyme L1
Authors:Grethe, C, Gersch, M.
Deposit date:2023-07-19
Release date:2024-01-31
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1.
Angew.Chem.Int.Ed.Engl., 63, 2024
7ZJV
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BU of 7zjv by Molmil
Structure of human USPL1 in covalent complex with DeltaN-SUMO2/3-PA probe
Descriptor: CHLORIDE ION, SUMO-specific isopeptidase USPL1, Small ubiquitin-related modifier 2, ...
Authors:Zhao, Z, Gersch, M.
Deposit date:2022-04-12
Release date:2023-09-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Native Semisynthesis of Isopeptide-Linked Substrates for Specificity Analysis of Deubiquitinases and Ubl Proteases.
J.Am.Chem.Soc., 145, 2023
8BS3
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BU of 8bs3 by Molmil
Structure of USP36 in complex with Fubi-PA
Descriptor: 40S ribosomal protein S30, Ubiquitin carboxyl-terminal hydrolase 36, ZINC ION, ...
Authors:O'Dea, R, Gersch, M.
Deposit date:2022-11-24
Release date:2023-07-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36.
Nat.Chem.Biol., 19, 2023
8BS9
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BU of 8bs9 by Molmil
Structure of USP36 in complex with Ubiquitin-PA
Descriptor: Polyubiquitin-B, SODIUM ION, Ubiquitin carboxyl-terminal hydrolase 36, ...
Authors:O'Dea, R, Gersch, M.
Deposit date:2022-11-24
Release date:2023-07-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36.
Nat.Chem.Biol., 19, 2023
4R17
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BU of 4r17 by Molmil
Ligand-induced aziridine-formation at subunit beta5 of the yeast 20S proteasome
Descriptor: (2S,3S)-3-methylaziridine-2-carboxylic acid, MAGNESIUM ION, Proteasome subunit alpha type-1, ...
Authors:Dubiella, C, Cui, H, Gersch, M, Brouwer, A.J, Sieber, S.A, Krueger, A, Liskamp, R, Groll, M.
Deposit date:2014-08-04
Release date:2014-10-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.
Angew.Chem.Int.Ed.Engl., 53, 2014
4R18
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BU of 4r18 by Molmil
Ligand-induced Lys33-Thr1 crosslinking at subunit beta5 of the yeast 20S proteasome
Descriptor: ALPHA-AMINOBUTYRIC ACID, MAGNESIUM ION, PROTEASOME SUBUNIT ALPHA TYPE-1, ...
Authors:Dubiella, C, Cui, H, Gersch, M, Brouwer, A.J, Sieber, S.A, Krueger, A, Liskamp, R, Groll, M.
Deposit date:2014-08-04
Release date:2014-10-15
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.
Angew.Chem.Int.Ed.Engl., 53, 2014
4JCR
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BU of 4jcr by Molmil
ClpP1 N165D mutant from Listeria monocytogenes
Descriptor: ATP-dependent Clp protease proteolytic subunit
Authors:Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S.
Deposit date:2013-02-22
Release date:2013-06-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JCQ
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BU of 4jcq by Molmil
ClpP1 from Listeria monocytogenes
Descriptor: ATP-dependent Clp protease proteolytic subunit
Authors:Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S.
Deposit date:2013-02-22
Release date:2013-06-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JCT
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BU of 4jct by Molmil
ClpP2 from Listeria monocytogenes
Descriptor: ATP-dependent Clp protease proteolytic subunit
Authors:Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S.
Deposit date:2013-02-22
Release date:2013-06-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013

 

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