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8A11
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BU of 8a11 by Molmil
Cryo-EM structure of the Human SHMT1-RNA complex
Descriptor: SHMT2 5'UTR 1-50 (5'-R(P*CP*UP*AP*CP*AP*A)-3'), Serine hydroxymethyltransferase, cytosolic
Authors:Spizzichino, S, Marabelli, C, Bharadwaj, A, Jakobi, A.J, Chaves-Sanjuan, A, Giardina, G, Bolognesi, M, Cutruzzola, F.
Deposit date:2022-05-30
Release date:2023-06-14
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Cryo-EM structure of the Human SHMT1-RNA complex
To Be Published
5M3C
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BU of 5m3c by Molmil
Structure of the hybrid domain (GGDEF-EAL) of PA0575 from Pseudomonas aeruginosa PAO1 at 2.8 Ang. with GTP and Ca2+ bound to the active site of the GGDEF domain
Descriptor: CALCIUM ION, Diguanylate cyclase, GUANOSINE-5'-TRIPHOSPHATE
Authors:Giardina, G, Brunotti, P, Cutruzzola, F, Rinaldo, S.
Deposit date:2016-10-14
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa.
FEBS J., 285, 2018
5HHY
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BU of 5hhy by Molmil
Structure of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) showing X-Ray induced reduction of PLP internal aldimine to 4'-deoxy-piridoxine-phosphate (PLR)
Descriptor: (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, Serine--pyruvate aminotransferase
Authors:Giardina, G, Cutruzzola, F, Borri Voltattorni, C, Cellini, B, Montioli, R.
Deposit date:2016-01-11
Release date:2017-01-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
6FL5
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BU of 6fl5 by Molmil
Structure of human SHMT1-H135N-R137A-E168N mutant at 3.6 Ang. resolution
Descriptor: CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE, Serine hydroxymethyltransferase, ...
Authors:Giardina, G, Cutruzzola, F, Lucchi, R.
Deposit date:2018-01-25
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.
FEBS J., 285, 2018
6S8W
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BU of 6s8w by Molmil
Aromatic aminotransferase AroH (Aro8) form Aspergillus fumigatus in complex with PLP (internal aldimine)
Descriptor: Aromatic aminotransferase Aro8, putative, FORMIC ACID, ...
Authors:Giardina, G, Mirco, D, Spizzichino, S, Zelante, T, Cutruzzola, F, Romani, L, Cellini, B.
Deposit date:2019-07-10
Release date:2020-08-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of Aspergillus fumigatus AroH, an aromatic amino acid aminotransferase
Proteins, 2021
5F9S
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BU of 5f9s by Molmil
Crystal structure of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at 1.7 Angstrom; internal aldimine with PLP in the active site
Descriptor: PYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase
Authors:Giardina, G, Cutruzzola, F, Borri Voltattorni, C, Cellini, B, Montioli, R.
Deposit date:2015-12-10
Release date:2016-12-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
3RBF
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BU of 3rbf by Molmil
Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the apo form
Descriptor: Aromatic-L-amino-acid decarboxylase, CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Giardina, G, Montioli, R, Gianni, S, Cellini, B, Paiardini, A, Borri Voltattorni, C, Cutruzzola, F.
Deposit date:2011-03-29
Release date:2011-10-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.
Proc.Natl.Acad.Sci.USA, 108, 2011
4IOB
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BU of 4iob by Molmil
Crystal structure of the GGDEF domain of PA1120 (YfiN or TpbB) from Pseudomonas aeruginosa at 2.7 Ang.
Descriptor: Diguanylate cyclase TpbB, GLYCEROL, TERTIARY-BUTYL ALCOHOL
Authors:Giardina, G, Cutruzzola, F.
Deposit date:2013-01-07
Release date:2013-12-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Investigating the Allosteric Regulation of YfiN from Pseudomonas aeruginosa: Clues from the Structure of the Catalytic Domain.
Plos One, 8, 2013
4PVF
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BU of 4pvf by Molmil
Crystal structure of Homo sapiens holo serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), isoform 3, transcript variant 5, 483 aa, at 2.6 ang. resolution
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Serine hydroxymethyltransferase, ...
Authors:Giardina, G, Brunotti, P, Fiascarelli, A, Contestabile, R, Cutruzzola, F.
Deposit date:2014-03-17
Release date:2015-01-28
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.
Febs J., 282, 2015
6HX7
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BU of 6hx7 by Molmil
Crystal structure of human R180T variant of ORNITHINE AMINOTRANSFERASE at 1.8 Angstrom
Descriptor: Ornithine aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE
Authors:Giardina, G, Montioli, R, Cellini, B, Cutruzzola, F, Borri Voltattorni, C.
Deposit date:2018-10-16
Release date:2019-06-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:R180T variant of delta-ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X-ray and NMR studies provide insight into its catalytic features.
Febs J., 286, 2019
1F63
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BU of 1f63 by Molmil
CRYSTAL STRUCTURE OF DEOXY SPERM WHALE MYOGLOBIN MUTANT Y(B10)Q(E7)R(E10)
Descriptor: MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Brunori, M, Cutruzzola, F, Savino, C, Travaglini-Allocatelli, C, Vallone, B, Gibson, Q.H.
Deposit date:2000-06-20
Release date:2000-07-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural dynamics of ligand diffusion in the protein matrix: A study on a new myoglobin mutant Y(B10) Q(E7) R(E10).
Biophys.J., 76, 1999
1F65
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BU of 1f65 by Molmil
CRYSTAL STRUCTURE OF OXY SPERM WHALE MYOGLOBIN MUTANT Y(B10)Q(E7)R(E10)
Descriptor: MYOGLOBIN, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Brunori, M, Cutruzzola, F, Savino, C, Travaglini-Allocatelli, C, Vallone, B, Gibson, Q.H.
Deposit date:2000-06-20
Release date:2000-07-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural dynamics of ligand diffusion in the protein matrix: A study on a new myoglobin mutant Y(B10) Q(E7) R(E10).
Biophys.J., 76, 1999
1DXD
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BU of 1dxd by Molmil
Photolyzed CO complex of Myoglobin Mb-YQR at 20K
Descriptor: CARBON MONOXIDE, MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Brunori, M, Vallone, B, Cutruzzola, F, Travaglini-Allocatelli, C, Berendzen, J, Chu, K, Sweet, R.M, Schlichting, I.
Deposit date:2000-01-03
Release date:2000-03-27
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Role of Cavities in Protein Dynamics: Crystal Structure of a Photolytic Intermediate of a Mutant Myoglobin.
Proc.Natl.Acad.Sci.USA, 97, 2000
1DXC
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BU of 1dxc by Molmil
CO complex of Myoglobin Mb-YQR at 100K
Descriptor: CARBON MONOXIDE, MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Brunori, M, Vallone, B, Cutruzzola, F, Travaglini-Allocatelli, C, Berendzen, J, Chu, K, Sweet, R.M, Schlichting, I.
Deposit date:2000-01-03
Release date:2000-04-02
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Role of Cavities in Protein Dynamics: Crystal Structure of a Novel Photolytic Intermediate of Myoglobin
Proc.Natl.Acad.Sci.USA, 97, 2000
1YNR
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BU of 1ynr by Molmil
Crystal structure of the cytochrome c-552 from Hydrogenobacter thermophilus at 2.0 resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Cytochrome c-552, HEME C, ...
Authors:Travaglini-Allocatelli, C, Gianni, S, Dubey, V.K, Borgia, A, Di Matteo, A, Bonivento, D, Cutruzzola, F, Bren, K.L, Brunori, M.
Deposit date:2005-01-25
Release date:2005-05-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:An Obligatory Intermediate in the Folding Pathway of Cytochrome c552 from Hydrogenobacter thermophilus
J.Biol.Chem., 280, 2005
6RV0
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BU of 6rv0 by Molmil
human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma); with PMP in the active site
Descriptor: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase
Authors:Giardina, G, Cutruzzola, F, Cellini, B, Mirco, D.
Deposit date:2019-05-30
Release date:2020-04-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: implications for Primary Hyperoxaluria type 1.
Biochem.J., 476, 2019
6RV1
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BU of 6rv1 by Molmil
human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma)
Descriptor: PYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase
Authors:Giardina, G, Cutruzzola, F, Cellini, B, Mirco, D.
Deposit date:2019-05-30
Release date:2020-04-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: implications for Primary Hyperoxaluria type 1.
Biochem.J., 476, 2019
5LUC
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BU of 5luc by Molmil
Crystal structure of the D183N variant of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at 1.8 Angstrom; internal aldimine with PLP in the active site
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase
Authors:Giardina, G, Cutruzzola, F, Cellini, B, Borri Voltattorni, C, Montioli, R.
Deposit date:2016-09-08
Release date:2017-09-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
1HZU
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BU of 1hzu by Molmil
DOMAIN SWING UPON HIS TO ALA MUTATION IN NITRITE REDUCTASE OF PSEUDOMONAS AERUGINOSA
Descriptor: HEME C, HEME D, NITRITE REDUCTASE
Authors:Brown, K, Cutruzzola, F, Brunori, M, Tegoni, M, Cambillau, C.
Deposit date:2001-01-26
Release date:2001-09-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Domain swing upon His to Ala mutation in nitrite reductase of Pseudomonas aeruginosa.
J.Mol.Biol., 312, 2001
1FCS
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BU of 1fcs by Molmil
CRYSTAL STRUCTURE OF A DISTAL SITE DOUBLE MUTANT OF SPERM WHALE MYOGLOBIN AT 1.6 ANGSTROMS RESOLUTION
Descriptor: MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Rizzi, M, Bolognesi, M, Coda, A, Cutruzzola, F, Travaglini Allocatelli, C, Brancaccio, A, Brunori, M.
Deposit date:1993-04-20
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of a distal site double mutant of sperm whale myoglobin at 1.6 A resolution.
FEBS Lett., 320, 1993
3RBL
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BU of 3rbl by Molmil
Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the apo form
Descriptor: CHLORIDE ION, aromatic L-amino acid decarboxylase
Authors:Giardina, G, Montioli, R, Gianni, S, Cellini, B, Paiardini, A, Borri Voltattorni, C, Cutruzzola, F.
Deposit date:2011-03-29
Release date:2011-10-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.
Proc.Natl.Acad.Sci.USA, 108, 2011
3RCH
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BU of 3rch by Molmil
Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the open conformation with LLP and PLP bound to Chain-A and Chain-B respectively
Descriptor: PYRIDOXAL-5'-PHOSPHATE, aromatic L-amino acid decarboxylase
Authors:Giardina, G, Montioli, R, Gianni, S, Cellini, B, Paiardini, A, Borri Voltattorni, C, Cutruzzola, F.
Deposit date:2011-03-31
Release date:2011-10-19
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.
Proc.Natl.Acad.Sci.USA, 108, 2011
1DM1
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BU of 1dm1 by Molmil
2.0 A CRYSTAL STRUCTURE OF THE DOUBLE MUTANT H(E7)V, T(E10)R OF MYOGLOBIN FROM APLYSIA LIMACINA
Descriptor: MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Federici, L, Savino, C, Musto, R, Travaglini-Allocatelli, C, Cutruzzola, F, Brunori, M.
Deposit date:1999-12-13
Release date:2000-06-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Engineering His(E7) affects the control of heme reactivity in Aplysia limacina myoglobin.
Biochem.Biophys.Res.Commun., 269, 2000
5OFY
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BU of 5ofy by Molmil
Crystal structure of the D183N variant of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at pH 9.0. 2.8 Ang; internal aldimine with PLP in the active site
Descriptor: 1,4-DIETHYLENE DIOXIDE, PYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase
Authors:Giardina, G, Cutruzzola, F, Borri Voltattorni, C, Cellini, B, Montioli, R.
Deposit date:2017-07-11
Release date:2017-09-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
5OG0
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BU of 5og0 by Molmil
Crystal structure of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at 2.5 Angstrom; internal aldimine with PLP in the active site
Descriptor: PYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase
Authors:Giardina, G, Cutruzzola, F, Borri Voltattorni, C, Cellini, B, Montioli, R.
Deposit date:2017-07-11
Release date:2017-09-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017

 

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