5FZT
 
 | | The crystal structure of R7R8 in complex with a DLC1 fragment. | | Descriptor: | MALONATE ION, RHO GTPASE-ACTIVATING PROTEIN 7, TALIN-1 | | Authors: | Zacharchenko, T, Qian, X, Goult, B.T, Jethwa, D, Almeida, T, Ballestrem, C, Critchley, D.R, Lowy, D.R, Barsukov, I.L. | | Deposit date: | 2016-03-15 | | Release date: | 2016-04-27 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Ld Motif Recognition by Talin: Structure of the Talin-Dlc1 Complex.
Structure, 24, 2016
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3DYJ
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3G9W
 | | Crystal Structure of Talin2 F2-F3 in Complex with the Integrin Beta1D Cytoplasmic Tail | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Integrin beta-1D, ... | | Authors: | Anthis, N.J, Wegener, K.L, Ye, F, Kim, C, Lowe, E.D, Vakonakis, I, Bate, N, Critchley, D.R, Ginsberg, M.H, Campbell, I.D. | | Deposit date: | 2009-02-15 | | Release date: | 2009-10-20 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.165 Å) | | Cite: | The structure of an integrin/talin complex reveals the basis of inside-out signal transduction
Embo J., 28, 2009
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3IVF
 | | Crystal structure of the talin head FERM domain | | Descriptor: | Talin-1 | | Authors: | Elliott, P.R, Goult, B.T, Bate, N, Grossmann, J.G, Roberts, G.C.K, Critchley, D.R, Barsukov, I.L. | | Deposit date: | 2009-09-01 | | Release date: | 2010-08-18 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | The Structure of the talin head reveals a novel extended conformation of the FERM domain
Structure, 18, 2010
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1XWJ
 | | Vinculin head (1-258) in complex with the talin vinculin binding site 3 (1945-1969) | | Descriptor: | Talin, Vinculin | | Authors: | Gingras, A.R, Papagrigoriou, E, Barsukov, I.L, Critchley, D.R, Emsley, J. | | Deposit date: | 2004-11-01 | | Release date: | 2005-10-11 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural and Dynamic Characterization of a Vinculin Binding Site in the Talin Rod
Biochemistry, 45, 2006
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1Y19
 | | Structural basis for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions | | Descriptor: | Phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma, Talin 1 | | Authors: | de Pereda, J.M, Wegener, K, Santelli, E, Bate, N, Ginsberg, M.H, Critchley, D.R, Campbell, I.D, Liddington, R.C. | | Deposit date: | 2004-11-17 | | Release date: | 2005-01-04 | | Last modified: | 2016-11-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural bases for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions
J.Biol.Chem., 280, 2005
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1ZW3
 | | Vinculin Head (0-258) in Complex with the Talin Rod residues 1630-1652 | | Descriptor: | Talin 1, Vinculin | | Authors: | Gingras, A.R, Ziegler, W.H, Barsukov, I.L, Roberts, G.C, Critchley, D.R, Emsley, J. | | Deposit date: | 2005-06-03 | | Release date: | 2005-09-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod
J.Biol.Chem., 280, 2005
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1ZVZ
 | | Vinculin Head (0-258) in Complex with the Talin Rod Residue 820-844 | | Descriptor: | Talin 1, Vinculin | | Authors: | Gingras, A.R, Ziegler, W.H, Barsukov, I.L, Roberts, G.C, Critchley, D.R, Emsley, J. | | Deposit date: | 2005-06-03 | | Release date: | 2005-09-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod
J.Biol.Chem., 280, 2005
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1ZW2
 | | Vinculin Head (0-258) in Complex with the Talin Rod residues 2345-2369 | | Descriptor: | Vinculin, talin | | Authors: | Gingras, A.R, Ziegler, W.H, Barsukov, I.L, Roberts, G.C, Critchley, D.R, Emsley, J. | | Deposit date: | 2005-06-03 | | Release date: | 2005-09-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod
J.Biol.Chem., 280, 2005
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2B0H
 | | Solution structure of VBS3 fragment of talin | | Descriptor: | Talin-1 | | Authors: | Gingras, A.R, Vogel, K.P, Steinhoff, H.J, Ziegler, W.H, Patel, B, Emsley, J, Critchley, D.R, Roberts, G.C, Barsukov, I.L. | | Deposit date: | 2005-09-14 | | Release date: | 2006-01-17 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | Structural and Dynamic Characterization of a Vinculin Binding Site in the Talin Rod
Biochemistry, 45, 2006
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1QKR
 | | Crystal structure of the vinculin tail and a pathway for activation | | Descriptor: | SULFATE ION, VINCULIN | | Authors: | Bakolitsa, C, De Pereda, J.M, Bagshaw, C.R, Critchley, D.R, Liddington, R.C. | | Deposit date: | 1999-08-04 | | Release date: | 2000-08-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structure of the Vinculin Tail and a Pathway for Activation
Cell(Cambridge,Mass.), 99, 1999
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1SJ8
 | | Solution Structure of the R1R2 Domains of Talin | | Descriptor: | Talin 1 | | Authors: | Papagrigoriou, E, Gingras, A.R, Barsukov, I.L, Critchley, D.R, Emsley, J. | | Deposit date: | 2004-03-03 | | Release date: | 2004-08-24 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle
EMBO J., 23, 2004
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1SJ7
 | | Crystal Structure of Talin Rod 482-655 | | Descriptor: | PLATINUM (II) ION, Talin 1 | | Authors: | Papagrigoriou, E, Gingras, A.R, Barsukov, I.L, Critchley, D.R, Emsley, J. | | Deposit date: | 2004-03-03 | | Release date: | 2004-08-24 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle
EMBO J., 23, 2004
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1T01
 | | Vinculin complexed with the VBS1 helix from talin | | Descriptor: | Talin 1, unnamed protein product | | Authors: | Papagrigoriou, E, Gingras, A.R, Barsukov, I.L, Critchley, D.R, Emsley, J. | | Deposit date: | 2004-04-07 | | Release date: | 2004-08-24 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle
Embo J., 23, 2004
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1U89
 | | Solution structure of VBS2 fragment of talin | | Descriptor: | Talin 1 | | Authors: | Fillingham, I, Gingras, A.R, Papagrigoriou, E, Patel, B, Emsley, J, Roberts, G.C.K, Critchley, D.R, Barsukov, I.L. | | Deposit date: | 2004-08-05 | | Release date: | 2005-01-18 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.
Structure, 13, 2005
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1U6H
 | | Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879) | | Descriptor: | Talin, Vinculin | | Authors: | Fillingham, I, Gingras, A.R, Papagrigoriou, E, Patel, B, Emsley, J, Roberts, G.C.K, Critchley, D.R, Barsukov, I.L. | | Deposit date: | 2004-07-30 | | Release date: | 2005-01-18 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.
Structure, 13, 2005
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2KBB
 | | Solution Structure of the R9 Domain of Talin | | Descriptor: | Talin-1 | | Authors: | Goult, B.T, Gingras, A.R, Bate, N, Critchley, D.R, Barsukov, I.L. | | Deposit date: | 2008-11-24 | | Release date: | 2009-03-17 | | Last modified: | 2021-08-25 | | Method: | SOLUTION NMR | | Cite: | The structure of an interdomain complex that regulates talin activity.
J.Biol.Chem., 284, 2009
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2KGX
 | | HADDOCK structure of the talin F3 domain in complex with talin 1655-1822 | | Descriptor: | MKIAA1027 protein, Talin-1 | | Authors: | Goult, B.T, Gingras, A.R, Bate, N, Critchley, D.R, Barsukov, I.L. | | Deposit date: | 2009-03-23 | | Release date: | 2009-03-31 | | Last modified: | 2021-10-20 | | Method: | SOLUTION NMR | | Cite: | The structure of an interdomain complex that regulates talin activity.
J.Biol.Chem., 284, 2009
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2KMC
 | | Solution Structure of the N-terminal domain of kindlin-1 | | Descriptor: | Fermitin family homolog 1 | | Authors: | Goult, B.T, Bate, N, Roberts, G.C, Barsukov, I.L, Critchley, D.R. | | Deposit date: | 2009-07-27 | | Release date: | 2009-10-06 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | The Structure of the N-Terminus of Kindlin-1: A Domain Important for alphaIIbbeta3 Integrin Activation
J.Mol.Biol., 394, 2009
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2KC1
 | | NMR structure of the F0 domain (residues 0-85) of the talin ferm domain | | Descriptor: | MKIAA1027 protein | | Authors: | Goult, B.T, Elliott, P.R, Roberts, G.C.K, Critchley, D.R, Barsukov, I.L. | | Deposit date: | 2008-12-13 | | Release date: | 2010-01-19 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
Embo J., 29, 2010
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2KMA
 | | NMR structure of the F0F1 double domain (residues 1-202) of the talin ferm domain | | Descriptor: | Talin 1 | | Authors: | Goult, B.T, Elliott, P.R, Bate, N, Roberts, G.C, Critchley, D.R, Barsukov, I.L. | | Deposit date: | 2009-07-25 | | Release date: | 2010-03-02 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
Embo J., 2010
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2KVP
 | | Solution Structure of the R10 Domain of Talin | | Descriptor: | Talin-1 | | Authors: | Goult, B.T, Gingras, A.R, Bate, N, Critchley, D.R, Barsukov, I.L, Roberts, G.C. | | Deposit date: | 2010-03-24 | | Release date: | 2010-05-05 | | Last modified: | 2021-08-25 | | Method: | SOLUTION NMR | | Cite: | The domain structure of talin: Residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.
Febs Lett., 584, 2010
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2L7N
 | | Solution Structure of the R5 Domain of Talin | | Descriptor: | Talin-1 | | Authors: | Goult, B.T, Gingras, A.R, Bate, N, Barsukov, I.L, Roberts, G.C.K, Critchley, D.R. | | Deposit date: | 2010-12-14 | | Release date: | 2011-12-14 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.
J.Biol.Chem., 288, 2013
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2L7A
 | | Solution Structure of the R3 Domain of Talin | | Descriptor: | Talin-1 | | Authors: | Goult, B.T, Gingras, A.R, Bate, N, Roberts, G.C.K, Barsukov, I.L, Critchley, D.R. | | Deposit date: | 2010-12-06 | | Release date: | 2011-12-21 | | Last modified: | 2021-08-25 | | Method: | SOLUTION NMR | | Cite: | RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.
J.Biol.Chem., 288, 2013
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2L10
 | | Solution Structure of the R6 Domain of Talin | | Descriptor: | Talin-1 | | Authors: | Goult, B.T, Gingras, A.R, Bate, N, Roberts, G.C.K, Barsukov, I.L, Critchley, D.R. | | Deposit date: | 2010-07-22 | | Release date: | 2011-08-31 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.
J.Biol.Chem., 288, 2013
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