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2F2L
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BU of 2f2l by Molmil
Crystal structure of tracheal cytotoxin (TCT) bound to the ectodomain complex of peptidoglycan recognition proteins LCa (PGRP-LCa) and LCx (PGRP-LCx)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetylamino-2-deoxy-alpha-L-idopyranose, CITRIC ACID, ...
Authors:Chang, C.I, Deisenhofer, J.
Deposit date:2005-11-17
Release date:2006-04-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor.
Science, 311, 2006
4FWG
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BU of 4fwg by Molmil
Crystal structure of the Lon-like protease MtaLonC in complex with lactacystin
Descriptor: Omuralide, open form, PHOSPHATE ION, ...
Authors:Chang, C.I, Kuo, C.I, Huang, K.F.
Deposit date:2012-07-01
Release date:2013-06-26
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors
Acta Crystallogr.,Sect.D, 69, 2013
4FWD
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BU of 4fwd by Molmil
Crystal structure of the Lon-like protease MtaLonC in complex with bortezomib
Descriptor: N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, PHOSPHATE ION, TTC1975 peptidase
Authors:Chang, C.I, Kuo, C.I, Huang, K.F.
Deposit date:2012-06-30
Release date:2013-06-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors
Acta Crystallogr.,Sect.D, 69, 2013
4FW9
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BU of 4fw9 by Molmil
Crystal structure of the Lon-like protease MtaLonC
Descriptor: PHOSPHATE ION, TTC1975 peptidase
Authors:Chang, C.I, Ihara, K, Kuo, C.I, Huang, K.F, Wakatsuki, S.
Deposit date:2012-06-30
Release date:2013-06-26
Last modified:2013-09-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors
Acta Crystallogr.,Sect.D, 69, 2013
4FWH
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BU of 4fwh by Molmil
Crystal structure of the Lon-like protease MtaLonC in complex with MG262
Descriptor: N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-L-leucinamide, PHOSPHATE ION, TTC1975 peptidase
Authors:Chang, C.I, Kuo, C.I, Huang, K.F.
Deposit date:2012-07-01
Release date:2013-06-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors
Acta Crystallogr.,Sect.D, 69, 2013
4FWV
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BU of 4fwv by Molmil
Crystal structure of the N-terminal domain of the Lon-like protease MtaLonC
Descriptor: SULFATE ION, TTC1975 peptidase
Authors:Chang, C.I, Li, J.K, Kuo, C.I, Huang, K.F.
Deposit date:2012-07-02
Release date:2013-06-26
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The N-terminal substrate-recognition domain of a LonC protease exhibits structural and functional similarity to cytosolic chaperones
Acta Crystallogr.,Sect.D, 69, 2013
8K3Y
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BU of 8k3y by Molmil
The "5+1" heteromeric structure of Lon protease consisting of a spiral pentamer with Y224S mutation and an N-terminal-truncated monomeric E613K mutant
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Lon protease
Authors:Li, S, Hsieh, K.Y, Kuo, C.I, Zhang, K, Chang, C.I.
Deposit date:2023-07-17
Release date:2023-10-25
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (4.42 Å)
Cite:A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
7W1G
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BU of 7w1g by Molmil
Crystal structure of YfiH with C107A mutation in complex with UDP-MurNAc-L-Serine
Descriptor: (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid, (2S)-2-[[(2R)-2-[(2R,3R,4R,5S,6R)-3-acetamido-2-[[[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-6-(hydroxymethyl)-5-oxidanyl-oxan-4-yl]oxypropanoyl]amino]-3-oxidanyl-propanoic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Lee, S.H, Hsieh, K.Y, Lee, M.S, Chang, C.I.
Deposit date:2021-11-19
Release date:2021-12-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural Basis for the Peptidoglycan-Editing Activity of YfiH.
Mbio, 13, 2021
2M5V
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BU of 2m5v by Molmil
Three-dimensional structure of human NLRP10/PYNOD pyrin domain
Descriptor: NACHT, LRR and PYD domains-containing protein 10
Authors:Su, M.Y, Chang, C.F, Chang, C.I.
Deposit date:2013-03-11
Release date:2013-04-03
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Three-Dimensional Structure of Human NLRP10/PYNOD Pyrin Domain Reveals a Homotypic Interaction Site Distinct from Its Mouse Homologue.
Plos One, 8, 2013
7F3V
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BU of 7f3v by Molmil
Crystal structure of YfiH with C107A mutation in complex with endogenous UDP-MurNAc
Descriptor: (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, ...
Authors:Lee, M.S, Hsieh, K.Y, Chang, C.I.
Deposit date:2021-06-17
Release date:2021-12-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structural Basis for the Peptidoglycan-Editing Activity of YfiH.
Mbio, 13, 2021
7YPH
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BU of 7yph by Molmil
Open-spiral pentamer of the substrate-free Lon protease with a Y224S mutation
Descriptor: Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I.
Deposit date:2022-08-03
Release date:2023-10-25
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
7YPK
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BU of 7ypk by Molmil
Close-ring hexamer of the substrate-bound Lon protease with an S678A mutation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Lon protease, alpha-S1-casein
Authors:Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I.
Deposit date:2022-08-03
Release date:2023-10-25
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
7YPI
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BU of 7ypi by Molmil
Spiral hexamer of the substrate-free Lon protease with a Y224S mutation
Descriptor: Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I.
Deposit date:2022-08-03
Release date:2023-10-25
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
7YPJ
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BU of 7ypj by Molmil
Spiral pentamer of the substrate-free Lon protease with a S678A mutation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Lon protease
Authors:Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I.
Deposit date:2022-08-03
Release date:2023-10-25
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
7EUX
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BU of 7eux by Molmil
Crystal structure of the Lon-like protease MtaLonC with D581A mutation in complex with substrate polypeptide
Descriptor: ALA-PRO-GLU-ALA-VAL, Endopeptidase La, PHOSPHATE ION
Authors:Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I.
Deposit date:2021-05-19
Release date:2021-11-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
7EV6
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BU of 7ev6 by Molmil
Crystal structure of the Lon-like protease MtaLonC with D581A mutation in complex with F-b20-Q
Descriptor: Endopeptidase La, F-b20-Q peptide {ortho-aminobenzoic acid (Abz)- QLRSLNGEWRFAWFPAPEAV[Tyr(3-NO2)]A}, PHOSPHATE ION
Authors:Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I.
Deposit date:2021-05-20
Release date:2021-11-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
4OM5
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BU of 4om5 by Molmil
Crystal structure of CTX A4 from Taiwan Cobra (Naja naja atra)
Descriptor: Cytotoxin 4
Authors:Lin, C.C, Chang, C.I, Wu, W.G.
Deposit date:2014-01-26
Release date:2014-06-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Endocytotic Routes of Cobra Cardiotoxins Depend on Spatial Distribution of Positively Charged and Hydrophobic Domains to Target Distinct Types of Sulfated Glycoconjugates on Cell Surface.
J.Biol.Chem., 289, 2014
4OM4
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BU of 4om4 by Molmil
Crystal structure of CTX A2 from Taiwan Cobra (Naja naja atra)
Descriptor: Cytotoxin 2
Authors:Lin, C.C, Chang, C.I, Wu, W.G.
Deposit date:2014-01-26
Release date:2014-06-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Endocytotic Routes of Cobra Cardiotoxins Depend on Spatial Distribution of Positively Charged and Hydrophobic Domains to Target Distinct Types of Sulfated Glycoconjugates on Cell Surface.
J.Biol.Chem., 289, 2014
7EUY
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BU of 7euy by Molmil
Crystal structure of the Lon-like protease MtaLonC with D582A mutation in complex with substrate polypeptide
Descriptor: ALA-PRO-GLU-ALA-VAL, Endopeptidase La, PHOSPHATE ION
Authors:Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I.
Deposit date:2021-05-19
Release date:2021-11-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
7EV4
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BU of 7ev4 by Molmil
Crystal structure of the Lon-like protease MtaLonC with S582A mutation in complex with F-b20-Q
Descriptor: Endopeptidase La, F-b20-Q peptide {ortho-aminobenzoic acid (Abz)- QLRSLNGEWRFAWFPAPEAV[Tyr(3-NO2)]A}, PHOSPHATE ION
Authors:Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I.
Deposit date:2021-05-20
Release date:2021-11-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
6IQQ
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BU of 6iqq by Molmil
Crystal structure of Prc with S452I and L252Y mutations in complex with NlpI
Descriptor: CALCIUM ION, Lipoprotein NlpI, Tail-specific protease
Authors:Chueh, C.K, Chang, C.I.
Deposit date:2018-11-08
Release date:2019-07-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for the Differential Regulatory Roles of the PDZ Domain in C-Terminal Processing Proteases.
Mbio, 10, 2019
7FID
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BU of 7fid by Molmil
Processive cleavage of substrate at individual proteolytic active sites of the Lon proteasecomplex (conformation 1)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I.
Deposit date:2021-07-31
Release date:2021-11-24
Method:ELECTRON MICROSCOPY (2.44 Å)
Cite:Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
7FIZ
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BU of 7fiz by Molmil
Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex (conformation 3)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I.
Deposit date:2021-08-01
Release date:2021-11-24
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
7FIE
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BU of 7fie by Molmil
Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex (conformation 2)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I.
Deposit date:2021-07-31
Release date:2021-11-24
Method:ELECTRON MICROSCOPY (2.36 Å)
Cite:Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
6IQU
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BU of 6iqu by Molmil
Crystal structure of Prc with PDZ domain deletion in complex with NlpI
Descriptor: Lipoprotein NlpI, Tail-specific protease
Authors:Chueh, C.K, Chang, C.I.
Deposit date:2018-11-08
Release date:2019-07-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for the Differential Regulatory Roles of the PDZ Domain in C-Terminal Processing Proteases.
Mbio, 10, 2019

 

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