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5W2J
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BU of 5w2j by Molmil
Crystal structure of dimeric form of mouse Glutaminase C
Descriptor: CHLORIDE ION, Glutaminase kidney isoform, mitochondrial, ...
Authors:Cerione, R.A, Li, Y.
Deposit date:2017-06-06
Release date:2018-10-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS.
J. Biol. Chem., 291, 2016
7JSN
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BU of 7jsn by Molmil
Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6
Descriptor: 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE, GUANOSINE-3',5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Gao, Y, Eskici, G, Ramachandran, S, Skiniotis, G, Cerione, R.A.
Deposit date:2020-08-15
Release date:2020-10-21
Last modified:2021-03-31
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.
Mol.Cell, 80, 2020
6OYA
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BU of 6oya by Molmil
Structure of the Rhodopsin-Transducin-Nanobody Complex
Descriptor: Camelid antibody VHH fragment, Gt-alpha/Gi1-alpha chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Gao, Y, Hu, H, Ramachandran, S, Erickson, J.W, Cerione, R.A, Skiniotis, G.
Deposit date:2019-05-14
Release date:2019-07-24
Last modified:2019-12-04
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Mol.Cell, 75, 2019
5WJ6
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BU of 5wj6 by Molmil
Crystal structure of glutaminase C in complex with inhibitor 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (UPGL-00004)
Descriptor: 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2017-07-21
Release date:2018-01-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.445 Å)
Cite:Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism.
J. Biol. Chem., 293, 2018
6OY9
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BU of 6oy9 by Molmil
Structure of the Rhodopsin-Transducin Complex
Descriptor: Gt-alpha/Gi1-alpha chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ...
Authors:Gao, Y, Hu, H, Ramachandran, S, Erickson, J.W, Cerione, R.A, Skiniotis, G.
Deposit date:2019-05-14
Release date:2019-07-24
Last modified:2019-12-04
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Mol.Cell, 75, 2019
6ULJ
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BU of 6ulj by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: 2-phenyl-N-{6-[4-({6-[(phenylacetyl)amino]pyridazin-3-yl}oxy)piperidin-1-yl]pyridazin-3-yl}acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-08
Release date:2020-10-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00045
To Be Published
6UK6
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BU of 6uk6 by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00018
Descriptor: 5-{4-[(5-amino-1,3,4-thiadiazol-2-yl)oxy]piperidin-1-yl}-1,3,4-thiadiazol-2-amine, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-04
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00018
To Be Published
6ULA
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BU of 6ula by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: 2-cyclopropyl-N-{5-[4-({5-[(cyclopropylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-07
Release date:2020-10-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00030
To Be Published
6UJM
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BU of 6ujm by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00013
Descriptor: Glutaminase kidney isoform, mitochondrial, N-{5-[(3R)-3-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]amino}pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-03
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00013
To Be Published
6UL9
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BU of 6ul9 by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00023
Descriptor: 2-phenyl-N-{5-[(1-{5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}azetidin-3-yl)oxy]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q.Q, Cerione, R.A.
Deposit date:2019-10-07
Release date:2020-10-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
1KV3
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BU of 1kv3 by Molmil
HUMAN TISSUE TRANSGLUTAMINASE IN GDP BOUND FORM
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase
Authors:Liu, S, Cerione, R.A, Clardy, J.
Deposit date:2002-01-24
Release date:2002-03-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity.
Proc.Natl.Acad.Sci.USA, 99, 2002
6UJG
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BU of 6ujg by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: Glutaminase kidney isoform, mitochondrial, N-{5-[(3S)-3-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]amino}pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-03
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
6UMD
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BU of 6umd by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: 2-(pyridin-3-yl)-N-(5-{4-[(5-{[(pyridin-3-yl)acetyl]amino}-1,3,4-thiadiazol-2-yl)amino]piperidin-1-yl}-1,3,4-thiadiazol-2-yl)acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-09
Release date:2020-10-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
6UME
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BU of 6ume by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: 2-(pyridin-3-yl)-N-(5-{4-[(5-{[(pyridin-3-yl)acetyl]amino}-1,3,4-thiadiazol-2-yl)amino]piperidin-1-yl}-1,3,4-thiadiazol-2-yl)acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-09
Release date:2020-10-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
6UMC
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BU of 6umc by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: 2-phenyl-N-{5-[(3R)-3-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-09
Release date:2020-10-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
6UMF
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BU of 6umf by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: Glutaminase kidney isoform, mitochondrial, N-(5-{[1-(5-amino-1,3,4-thiadiazol-2-yl)piperidin-4-yl]oxy}-1,3,4-thiadiazol-2-yl)-2-phenylacetamide
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-09
Release date:2020-10-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
6UKB
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BU of 6ukb by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: Glutaminase kidney isoform, mitochondrial, N-[5-(4-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]oxy}piperidin-1-yl)-1,3,4-thiadiazol-2-yl]acetamide
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-04
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00020
To Be Published
2QRZ
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BU of 2qrz by Molmil
Cdc42 bound to GMP-PCP: Induced Fit by Effector is Required
Descriptor: Cell division control protein 42 homolog precursor, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
Authors:Phillips, M.J, Calero, G, Chan, B, Cerione, R.A.
Deposit date:2007-07-30
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Effector Proteins Exert an Important Influence on the Signaling-active State of the Small GTPase Cdc42.
J.Biol.Chem., 283, 2008
5HL1
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BU of 5hl1 by Molmil
Crystal structure of glutaminase C in complex with inhibitor CB-839
Descriptor: 2-(pyridin-2-yl)-N-(5-{4-[6-({[3-(trifluoromethoxy)phenyl]acetyl}amino)pyridazin-3-yl]butyl}-1,3,4-thiadiazol-2-yl)acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2016-01-14
Release date:2016-08-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the clinically relevant glutaminase inhibitot CB-839 in complex with glutaminase C
To Be Published
8SZJ
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BU of 8szj by Molmil
Human glutaminase C (Y466W) with L-Gln and Pi, filamentous form
Descriptor: GLUTAMINE, Glutaminase kidney isoform, mitochondrial, ...
Authors:Feng, S, Aplin, C, Nguyen, T.-T.T, Milano, S.K, Cerione, R.A.
Deposit date:2023-05-29
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Filament formation drives catalysis by glutaminase enzymes important in cancer progression.
Nat Commun, 15, 2024
8T0Z
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BU of 8t0z by Molmil
Human liver-type glutaminase (K253A) with L-Gln, filamentous form
Descriptor: GLUTAMINE, Glutaminase liver isoform, mitochondrial
Authors:Feng, S, Aplin, C, Nguyen, T.-T.T, Milano, S.K, Cerione, R.A.
Deposit date:2023-06-01
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Filament formation drives catalysis by glutaminase enzymes important in cancer progression.
Nat Commun, 15, 2024
8SZL
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BU of 8szl by Molmil
Human liver-type glutaminase (Apo form)
Descriptor: Glutaminase liver isoform, mitochondrial
Authors:Feng, S, Aplin, C, Nguyen, T.-T.T, Milano, S.K, Cerione, R.A.
Deposit date:2023-05-30
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Filament formation drives catalysis by glutaminase enzymes important in cancer progression.
Nat Commun, 15, 2024
8UFI
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BU of 8ufi by Molmil
Cryo-EM structure of bovine phosphodiesterase 6
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, MAGNESIUM ION, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ...
Authors:Aplin, C, Cerione, R.A.
Deposit date:2023-10-04
Release date:2024-01-17
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6.
J.Biol.Chem., 300, 2023
8ULG
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BU of 8ulg by Molmil
Cryo-EM structure of bovine phosphodiesterase 6 bound to IBMX
Descriptor: 3-ISOBUTYL-1-METHYLXANTHINE, CYCLIC GUANOSINE MONOPHOSPHATE, MAGNESIUM ION, ...
Authors:Aplin, C, Cerione, R.A.
Deposit date:2023-10-16
Release date:2024-01-17
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6.
J.Biol.Chem., 300, 2023
8UGB
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BU of 8ugb by Molmil
Cryo-EM structure of bovine phosphodiesterase 6 bound to udenafil
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, MAGNESIUM ION, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ...
Authors:Aplin, C, Cerione, R.A.
Deposit date:2023-10-05
Release date:2024-01-17
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6.
J.Biol.Chem., 300, 2023

 

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