Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
8SNX
DownloadVisualize
BU of 8snx by Molmil
Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) bound to the leader promoter
Descriptor: Phosphoprotein, RNA (5'-R(*UP*UP*UP*UP*UP*CP*GP*CP*GP*U)-3'), RNA-directed RNA polymerase L
Authors:Cao, D, Gao, Y, Chen, Z, Gooneratne, I, Roesler, C, Mera, C, Liang, B.
Deposit date:2023-04-28
Release date:2023-12-20
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structures of the promoter-bound respiratory syncytial virus polymerase.
Nature, 625, 2024
8SNY
DownloadVisualize
BU of 8sny by Molmil
Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) bound to the trailer complementary promoter
Descriptor: Phosphoprotein, RNA (5'-R(*UP*UP*UP*UP*UP*CP*UP*CP*GP*U)-3'), RNA-directed RNA polymerase L
Authors:Cao, D, Gao, Y, Chen, Z, Gooneratne, I, Roesler, C, Mera, C, Liang, B.
Deposit date:2023-04-28
Release date:2023-12-20
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Structures of the promoter-bound respiratory syncytial virus polymerase.
Nature, 625, 2024
5BTR
DownloadVisualize
BU of 5btr by Molmil
Crystal structure of SIRT1 in complex with resveratrol and an AMC-containing peptide
Descriptor: AMC-containing peptide, NAD-dependent protein deacetylase sirtuin-1, RESVERATROL, ...
Authors:Cao, D, Wang, M, Qiu, X, Liu, D, Jiang, H, Yang, N, Xu, R.M.
Deposit date:2015-06-03
Release date:2015-07-08
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
Genes Dev., 29, 2015
8IHP
DownloadVisualize
BU of 8ihp by Molmil
Structure of Semliki Forest virus VLP in complex with the receptor VLDLR-LA3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Capsid protein, ...
Authors:Cao, D, Ma, B, Cao, Z, Zhang, X, Xiang, Y.
Deposit date:2023-02-23
Release date:2023-04-12
Last modified:2023-05-24
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of Semliki Forest virus in complex with its receptor VLDLR.
Cell, 186, 2023
6UEN
DownloadVisualize
BU of 6uen by Molmil
Cryo-EM structure of the respiratory syncytial virus RNA polymerase
Descriptor: RNA-directed RNA polymerase L, the phosphoprotein (P) of human respiratory syncytial virus
Authors:Cao, D, Gao, Y, Liang, B.
Deposit date:2019-09-22
Release date:2020-01-22
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Cryo-EM structure of the respiratory syncytial virus RNA polymerase.
Nat Commun, 11, 2020
7CCR
DownloadVisualize
BU of 7ccr by Molmil
Structure of the 2:2 cGAS-nucleosome complex
Descriptor: Cyclic GMP-AMP synthase, DNA (147-MER), Histone H2A type 1-B/E, ...
Authors:Cao, D, Han, X, Fan, X, Xu, R.M, Zhang, X.
Deposit date:2020-06-17
Release date:2020-10-07
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structural basis for nucleosome-mediated inhibition of cGAS activity.
Cell Res., 30, 2020
7CCQ
DownloadVisualize
BU of 7ccq by Molmil
Structure of the 1:1 cGAS-nucleosome complex
Descriptor: Cyclic GMP-AMP synthase, DNA (147-MER), Histone H2A type 1-B/E, ...
Authors:Cao, D, Han, X, Fan, X, Xu, R.M, Zhang, X.
Deposit date:2020-06-17
Release date:2020-10-07
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis for nucleosome-mediated inhibition of cGAS activity.
Cell Res., 30, 2020
7WC5
DownloadVisualize
BU of 7wc5 by Molmil
Crystal structure of serotonin 2A receptor in complex with psilocin
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol, 5-hydroxytryptamine receptor 2A, ...
Authors:Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S.
Deposit date:2021-12-18
Release date:2022-01-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure-based discovery of nonhallucinogenic psychedelic analogs.
Science, 375, 2022
7WC4
DownloadVisualize
BU of 7wc4 by Molmil
Crystal structure of serotonin 2A receptor in complex with serotonin
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, CHOLESTEROL, ...
Authors:Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S.
Deposit date:2021-12-18
Release date:2022-01-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure-based discovery of nonhallucinogenic psychedelic analogs.
Science, 375, 2022
7WC8
DownloadVisualize
BU of 7wc8 by Molmil
Crystal structure of serotonin 2A receptor in complex with lumateperone
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-(4-fluorophenyl)-4-[(10~{R},15~{S})-4-methyl-1,4,12-triazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ...
Authors:Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S.
Deposit date:2021-12-18
Release date:2022-01-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure-based discovery of nonhallucinogenic psychedelic analogs.
Science, 375, 2022
7WC7
DownloadVisualize
BU of 7wc7 by Molmil
Crystal structure of serotonin 2A receptor in complex with lisuride
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, CHOLESTEROL, ...
Authors:Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S.
Deposit date:2021-12-18
Release date:2022-01-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-based discovery of nonhallucinogenic psychedelic analogs.
Science, 375, 2022
7WC9
DownloadVisualize
BU of 7wc9 by Molmil
Crystal structure of serotonin 2A receptor in complex with non-hallucinogenic psychedelic analog
Descriptor: (10~{R},15~{S})-12-[3-(2-methoxyphenyl)propyl]-4-methyl-1,4,12-triazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-5(16),6,8-triene, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ...
Authors:Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S.
Deposit date:2021-12-18
Release date:2022-01-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based discovery of nonhallucinogenic psychedelic analogs.
Science, 375, 2022
7WC6
DownloadVisualize
BU of 7wc6 by Molmil
Crystal structure of serotonin 2A receptor in complex with LSD
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ...
Authors:Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S.
Deposit date:2021-12-18
Release date:2022-01-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-based discovery of nonhallucinogenic psychedelic analogs.
Science, 375, 2022
8WIU
DownloadVisualize
BU of 8wiu by Molmil
Bromodomain and Extra-terminal Domain (BET) BRD4
Descriptor: 7-[5-[1-(cyclopropylmethyl)-3,5-dimethyl-pyrazol-4-yl]pyridin-3-yl]-1~{H}-imidazo[4,5-b]pyridine, Isoform C of Bromodomain-containing protein 4
Authors:Cao, D, Zhiyan, D, Xiong, B.
Deposit date:2023-09-25
Release date:2024-01-03
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Discovery of a brain-permeable bromodomain and extra terminal domain (BET) inhibitor with selectivity for BD1 for the treatment of multiple sclerosis.
Eur.J.Med.Chem., 265, 2023
8IBQ
DownloadVisualize
BU of 8ibq by Molmil
Bromodomain and Extra-terminal Domain (BET) BRD4
Descriptor: 7-[2-fluoranyl-3-(1,3,5-trimethylpyrazol-4-yl)phenyl]-1~{H}-imidazo[4,5-b]pyridine, Bromodomain-containing protein 4
Authors:Cao, D, Zhiyan, D, Xiong, B.
Deposit date:2023-02-10
Release date:2023-10-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Discovery of 1 H -Imidazo[4,5- b ]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain.
J.Med.Chem., 66, 2023
8IDH
DownloadVisualize
BU of 8idh by Molmil
Bromodomain and Extra-terminal Domain (BET) BRD4
Descriptor: 7-[2-fluoranyl-3-(1,3,5-trimethylpyrazol-4-yl)phenyl]-1~{H}-imidazo[4,5-b]pyridine, Bromodomain-containing protein 4
Authors:Cao, D, Zhiyan, D, Xiong, B.
Deposit date:2023-02-13
Release date:2023-10-04
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Discovery of 1 H -Imidazo[4,5- b ]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain.
J.Med.Chem., 66, 2023
7X6T
DownloadVisualize
BU of 7x6t by Molmil
Discovery of Selective BRD4 BD1 Inhibitor Based on [1,2,4] triazolo [4,3-b] pyridazine Scaffold
Descriptor: (2~{R})-2-[[3-methyl-6-(2-phenoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]amino]propanamide, Isoform C of Bromodomain-containing protein 4
Authors:Cao, D, Xiong, B.
Deposit date:2022-03-08
Release date:2023-03-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Discovery of Selective BRD4 BD1 Inhibitor Based on [1,2,4] triazolo [4,3-b] pyridazine Scaffold
To Be Published
7XY3
DownloadVisualize
BU of 7xy3 by Molmil
Cryo-EM structure of SARS-CoV-2 spike in complex with VHH14
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, VHH14
Authors:Cao, D, Fan, X, Zhang, X.
Deposit date:2022-05-31
Release date:2023-09-13
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Identification of nano-abzymes to catalyze the spike-trimer of SARS-CoV-2
To Be Published
7XY4
DownloadVisualize
BU of 7xy4 by Molmil
Cryo-EM structure of SARS-CoV-2 spike in complex with VHH21
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, VHH21
Authors:Cao, D, Fan, X, Zhang, X.
Deposit date:2022-05-31
Release date:2023-09-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Identification of nano-abzymes to catalyze the spike-trimer of SARS-CoV-2
To Be Published
6PZQ
DownloadVisualize
BU of 6pzq by Molmil
Structure of the human respiratory syncytial virus M2-1 protein in complex with a short positive-sense gene-end RNA
Descriptor: Matrix M2-1, RNA (5'-R(P*GP*UP*UP*AP*AP*U)-3'), ZINC ION
Authors:Gao, Y, Cao, D, Liang, B.
Deposit date:2019-08-01
Release date:2020-08-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with a Short Positive-Sense Gene-End RNA.
Structure, 28, 2020
7DNO
DownloadVisualize
BU of 7dno by Molmil
Characterization of Peptide Ligands Against WDR5 Isolated Using Phage Display Technique
Descriptor: CYS-ARG-THR-LEU-PRO-PHE, WD repeat-containing protein 5
Authors:Cao, J, Cao, D, Xiong, B, Li, Y, Fan, T.
Deposit date:2020-12-10
Release date:2021-02-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Phage-Display Based Discovery and Characterization of Peptide Ligands against WDR5.
Molecules, 26, 2021
6KHJ
DownloadVisualize
BU of 6khj by Molmil
Supercomplex for electron transfer
Descriptor: 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ...
Authors:Pan, X, Cao, D, Xie, F, Zhang, X, Li, M.
Deposit date:2019-07-15
Release date:2020-02-12
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for electron transport mechanism of complex I-like photosynthetic NAD(P)H dehydrogenase.
Nat Commun, 11, 2020
6KHI
DownloadVisualize
BU of 6khi by Molmil
Supercomplex for cylic electron transport in cyanobacteria
Descriptor: 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ...
Authors:Pan, X, Cao, D, Xie, F, Zhang, X, Li, M.
Deposit date:2019-07-15
Release date:2020-02-12
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for electron transport mechanism of complex I-like photosynthetic NAD(P)H dehydrogenase.
Nat Commun, 11, 2020
6LIH
DownloadVisualize
BU of 6lih by Molmil
BRD4 BD1 bound with compound 10
Descriptor: (3~{R})-1,3-dimethyl-6-[(4-phenylpyrimidin-2-yl)amino]-4-propan-2-yl-3~{H}-quinoxalin-2-one, Bromodomain-containing protein 4
Authors:Xiong, B, Cao, D.
Deposit date:2019-12-11
Release date:2020-12-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.62030542 Å)
Cite:BRD4 BD1 bound with compound 10
To Be Published
6LIM
DownloadVisualize
BU of 6lim by Molmil
BRD4-BD1 bound with compound 40
Descriptor: (3~{R})-6-[(4-isoquinolin-4-ylpyrimidin-2-yl)amino]-1,3-dimethyl-4-propan-2-yl-3~{H}-quinoxalin-2-one, Bromodomain-containing protein 4
Authors:Xiong, B, Cao, D, Li, Y.
Deposit date:2019-12-12
Release date:2020-12-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.75909507 Å)
Cite:BRD4-BD1 bound with compound 40
To Be Published

 

1234>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon