Author results

1FRO
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HUMAN GLYOXALASE I WITH BENZYL-GLUTATHIONE INHIBITOR
分子名称:LACTOYLGLUTATHIONE LYASE, ZINC ION, S-BENZYL-GLUTATHIONE
著者Cameron, A.D., Jones, T.A.
登録日1997-02-25
公開日1997-06-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping.
EMBO J., 16, 1997
1GSE
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GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH AN ETHACRYNIC ACID GLUTATHIONE CONJUGATE (MUTANT R15K)
分子名称:GLUTATHIONE TRANSFERASE, GLUTATHIONE, ETHACRYNIC ACID, ...
著者Cameron, A.D., Jones, T.A.
登録日1995-06-09
公開日1995-09-15
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure, 3, 1995
1QH3
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HUMAN GLYOXALASE II WITH CACODYLATE AND ACETATE IONS PRESENT IN THE ACTIVE SITE
分子名称:PROTEIN (HYDROXYACYLGLUTATHIONE HYDROLASE), ZINC ION, CACODYLATE ION, ...
著者Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
登録日1999-05-10
公開日1999-09-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.
Structure Fold.Des., 7, 1999
1QH5
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HUMAN GLYOXALASE II WITH S-(N-HYDROXY-N-BROMOPHENYLCARBAMOYL)GLUTATHIONE
分子名称:PROTEIN (HYDROXYACYLGLUTATHIONE HYDROLASE), ZINC ION, GLUTATHIONE, ...
著者Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
登録日1999-05-11
公開日1999-09-24
最終更新日2011-12-14
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.
Structure Fold.Des., 7, 1999
1QIN
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HUMAN GLYOXALASE I COMPLEXED WITH S-(N-HYDROXY-N-P-IODOPHENYLCARBAMOYL) GLUTATHIONE
分子名称:PROTEIN (LACTOYLGLUTATHIONE LYASE), ZINC ION, S-(N-HYDROXY-N-IODOPHENYLCARBAMOYL)GLUTATHIONE
著者Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
登録日1999-06-14
公開日1999-11-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.
Biochemistry, 38, 1999
1QIP
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HUMAN GLYOXALASE I COMPLEXED WITH S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE
分子名称:PROTEIN (LACTOYLGLUTATHIONE LYASE), ZINC ION, S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE, ...
著者Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
登録日1999-06-14
公開日1999-11-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.
Biochemistry, 38, 1999
1YCA
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DISTAL POCKET POLARITY IN LIGAND BINDING TO MYOGLOBIN: DEOXY AND CARBONMONOXY FORMS OF A THREONINE68 (E11) MUTANT INVESTIGATED BY X-RAY CRYSTALLOGRAPHY AND INFRARED SPECTROSCOPY
分子名称:MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE
著者Cameron, A.D., Smerdon, S.J., Wilkinson, A.J., Habash, J., Helliwell, J.R.
登録日1993-08-10
公開日1994-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Distal pocket polarity in ligand binding to myoglobin: deoxy and carbonmonoxy forms of a threonine68(E11) mutant investigated by X-ray crystallography and infrared spectroscopy.
Biochemistry, 32, 1993
1YCB
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DISTAL POCKET POLARITY IN LIGAND BINDING TO MYOGLOBIN: DEOXY AND CARBONMONOXY FORMS OF A THREONINE68 (E11) MUTANT INVESTIGATED BY X-RAY CRYSTALLOGRAPHY AND INFRARED SPECTROSCOPY
分子名称:MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
著者Cameron, A.D., Smerdon, S.J., Wilkinson, A.J., Habash, J., Helliwell, J.R.
登録日1993-08-10
公開日1994-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Distal pocket polarity in ligand binding to myoglobin: deoxy and carbonmonoxy forms of a threonine68(E11) mutant investigated by X-ray crystallography and infrared spectroscopy.
Biochemistry, 32, 1993
1BH5
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HUMAN GLYOXALASE I Q33E, E172Q DOUBLE MUTANT
分子名称:LACTOYLGLUTATHIONE LYASE, ZINC ION, S-HEXYLGLUTATHIONE
著者Cameron, A.D., Jones, T.A.
登録日1998-06-13
公開日1998-11-04
最終更新日2018-03-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I.
J.Biol.Chem., 273, 1998
1GSD
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GLUTATHIONE TRANSFERASE A1-1 IN UNLIGANDED FORM
分子名称:GLUTATHIONE TRANSFERASE A1-1
著者L'Hermite, G., Sinning, I., Cameron, A.D., Jones, T.A.
登録日1995-06-09
公開日1995-09-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure, 3, 1995
1GSF
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GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH ETHACRYNIC ACID
分子名称:GLUTATHIONE TRANSFERASE A1-1, ETHACRYNIC ACID
著者L'Hermite, G., Sinning, I., Cameron, A.D., Jones, T.A.
登録日1995-06-09
公開日1995-09-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure, 3, 1995
2J50
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STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-739358
分子名称:SERINE/THREONINE-PROTEIN KINASE 6, N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, SULFATE ION
著者Cameron, A.D., Izzo, G., Storici, P., Rusconi, L., Fancelli, D., Varasi, M., Berta, D., Bindi, S., Forte, B., Severino, D., Tonani, R., Vianello, P.
登録日2006-09-08
公開日2006-11-06
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazoles: Identification of a Potent Aurora Kinase Inhibitor with a Favorable Antitumor Kinase Inhibition Profile.
J.Med.Chem., 49, 2006
2JGB
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STRUCTURE OF HUMAN EIF4E HOMOLOGOUS PROTEIN 4EHP WITH M7GTP
分子名称:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE
著者Cameron, A.D., Rosettani, P., Knapp, S., Vismara, M.G., Rusconi, L.
登録日2007-02-12
公開日2007-02-27
最終更新日2018-03-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.
J. Mol. Biol., 368, 2007
2JGC
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STRUCTURE OF THE HUMAN EIF4E HOMOLOGOUS PROTEIN, 4EHP WITHOUT LIGAND BOUND
分子名称:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
著者Cameron, A.D., Rosettani, P., Knapp, S., Vismara, M.G., Rusconi, L.
登録日2007-02-12
公開日2007-02-27
最終更新日2018-03-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.
J. Mol. Biol., 368, 2007
6H7A
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STRUCTURE OF LEISHMANIA PABP1 (DOMAIN J).
分子名称:PABP1 domain J
著者Cameron, A.D., Firczuk, H., dos Santos Rodrigues, F.H., McCarthy, J.E.G.
登録日2018-07-31
公開日2018-12-12
最終更新日2019-07-03
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献The Leishmania PABP1-eIF4E4 interface: a novel 5'-3' interaction architecture for trans-spliced mRNAs.
Nucleic Acids Res., 47, 2019
6H7B
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STRUCTURE OF LEISHMANIA PABP1 (DOMAIN J) COMPLEXED WITH A PEPTIDE CONTAINING THE PAM2 MOTIF OF EIF4E4.
分子名称:Polyadenylate-binding protein, HIS-HIS-MET-ASN-PRO-ASN-ALA-THR-GLU-PHE-MET-PRO
著者Cameron, A.D., Firczuk, H., dos Santos Rodrigues, F.H., McCarthy, J.E.G.
登録日2018-07-31
公開日2018-12-12
最終更新日2019-07-03
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献The Leishmania PABP1-eIF4E4 interface: a novel 5'-3' interaction architecture for trans-spliced mRNAs.
Nucleic Acids Res., 47, 2019
1RK2
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E. COLI RIBOKINASE COMPLEXED WITH RIBOSE AND ADP, SOLVED IN SPACE GROUP P212121
分子名称:RIBOKINASE, RIBOSE, TETRAFLUOROALUMINATE ION, ...
著者Sigrell, J.A., Cameron, A.D., Mowbray, S.L.
登録日1999-05-20
公開日1999-09-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Induced fit on sugar binding activates ribokinase.
J.Mol.Biol., 290, 1999
1RKA
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THE APO FORM OF E. COLI RIBOKINASE
分子名称:PROTEIN (RIBOKINASE)
著者Sigrell, J.A., Cameron, A.D., Mowbray, S.L.
登録日1999-03-22
公開日1999-08-31
最終更新日2018-03-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Induced fit on sugar binding activates ribokinase.
J.Mol.Biol., 290, 1999
1RKS
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E. COLI RIBOKINASE IN COMPLEX WITH D-RIBOSE
分子名称:PROTEIN (RIBOKINASE), RIBOSE, PHOSPHATE ION
著者Sigrell, J.A., Cameron, A.D., Mowbray, S.L.
登録日1999-05-17
公開日1999-08-31
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Induced fit on sugar binding activates ribokinase.
J.Mol.Biol., 290, 1999
1RKD
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E. COLI RIBOKINASE COMPLEXED WITH RIBOSE AND ADP
分子名称:RIBOKINASE, RIBOSE, PHOSPHATE ION, ...
著者Sigrell, J.A., Cameron, A.D., Jones, T.A., Mowbray, S.L.
登録日1997-11-29
公開日1998-03-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Structure of Escherichia coli ribokinase in complex with ribose and dinucleotide determined to 1.8 A resolution: insights into a new family of kinase structures.
Structure, 6, 1998
1H8V
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THE X-RAY CRYSTAL STRUCTURE OF THE TRICHODERMA REESEI FAMILY 12 ENDOGLUCANASE 3, CEL12A, AT 1.9 A RESOLUTION
分子名称:ENDO-BETA-1,4-GLUCANASE, N-ACETYL-D-GLUCOSAMINE
著者Sandgren, M., Shaw, A., Ropp, T.H., Wu, S., Bott, R., Cameron, A.D., Stahlberg, J., Mitchinson, C., Jones, T.A.
登録日2001-02-16
公開日2001-04-24
最終更新日2011-12-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The X-Ray Crystal Structure of the Trichoderma Reesei Family 12 Endoglucanase 3, Cel12A, at 1.9 A Resolution
J.Mol.Biol., 308, 2001
2JLN
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STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER
分子名称:MHP1, SODIUM ION, MERCURY (II) ION
著者Weyand, S., Shimamura, T., Yajima, S., Suzuki, S., Mirza, O., Krusong, K., Carpenter, E.P., Rutherford, N.G., Hadden, J.M., O'Reilly, J., Ma, P., Saidijam, M., Patching, S.G., Hope, R.J., Norbertczak, H.T., Roach, P.C.J., Iwata, S., Henderson, P.J.F., Cameron, A.D.
登録日2008-09-11
公開日2008-10-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter.
Science, 322, 2008
2V7A
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CRYSTAL STRUCTURE OF THE T315I ABL MUTANT IN COMPLEX WITH THE INHIBITOR PHA-739358
分子名称:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1, N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, MAGNESIUM ION
著者Modugno, M., Casale, E., Soncini, C., Rosettani, P., Colombo, R., Lupi, R., Rusconi, L., Fancelli, D., Carpinelli, P., Cameron, A.D., Isacchi, A., Moll, J.
登録日2007-07-27
公開日2007-09-18
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of the T315I Abl Mutant in Complex with the Aurora Kinases Inhibitor Pha-739358.
Cancer Res., 67, 2007
2WIH
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STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125
分子名称:CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE, ...
著者Brasca, M.G., Amboldi, N., Ballinari, D., Cameron, A.D., Casale, E., Cervi, G., Colombo, M., Colotta, F., Croci, V., Dalessio, R., Fiorentini, F., Isacchi, A., Mercurio, C., Moretti, W., Panzeri, A., Pastori, W., Pevarello, P., Quartieri, F., Roletto, F., Traquandi, G., Vianello, P., Vulpetti, A., Ciomei, M.
登録日2009-05-13
公開日2009-07-28
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Identification of N,1,4,4-Tetramethyl-8-{[4-(4-Methylpiperazin-1-Yl)Phenyl]Amino}-4,5-Dihydro-1H-Pyrazolo[4,3-H]Quinazoline-3-Carboxamide (Pha-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor.
J.Med.Chem., 52, 2009
2X79
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INWARD FACING CONFORMATION OF MHP1
分子名称:HYDANTOIN TRANSPORT PROTEIN
著者Shimamura, T., Weyand, S., Beckstein, O., Rutherford, N.G., Hadden, J.M., Sharples, D., Sansom, M.S.P., Iwata, S., Henderson, P.J.F., Cameron, A.D.
登録日2010-02-25
公開日2010-05-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1.
Science, 328, 2010
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