Author results

6O1T
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BOVINE SALIVARY PROTEIN FORM 30B WITH OLEIC ACID
分子名称:Short palate, lung and nasal epithelium carcinoma-associated protein 2B, CALCIUM ION, ...
著者Zhang, H., Arcus, V.L.
登録日2019-02-21
公開日2019-03-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of BSP30B with oleic acid at 2.3 Angstroms resolution
To Be Published
6NPV
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C-ABL KINASE DOMAIN WITH THE ACTIVATOR(CMPD51), N-(1-(3,4-DICHLOROPHENYL)-4-(2-HYDROXYETHYL)-4,5-DIHYDRO-1H-PYRAZOL-3-YL)ISONICOTINAMIDE
分子名称:Tyrosine-protein kinase ABL1, SULFATE ION, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ...
著者campobasso, N.
登録日2019-01-18
公開日2019-03-13
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Identification and Optimization of Novel Small c-Abl Kinase Activators Using Fragment and HTS Methodologies.
J. Med. Chem., 62, 2019
6NPU
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C-ABL KINASE DOMAIN WITH THE ACTIVATOR(CMPD29), N-(1-(3,4-DICHLOROPHENYL)-4,5-DIHYDRO-1H-PYRAZOL-3-YL)ACETAMIDE
分子名称:Tyrosine-protein kinase ABL1, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ~{N}-[2-(3,4-dichlorophenyl)-3,4-dihydropyrazol-5-yl]ethanamide, ...
著者Campobasso, N.
登録日2019-01-18
公開日2019-03-13
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Identification and Optimization of Novel Small c-Abl Kinase Activators Using Fragment and HTS Methodologies.
J. Med. Chem., 62, 2019
6NPE
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C-ABL KINASE DOMAIN WITH THE ACTIVATOR(CMPD6), 2-CYANO-N-(4-(3,4-DICHLOROPHENYL)THIAZOL-2-YL)ACETAMIDE
分子名称:Tyrosine-protein kinase ABL1, SULFATE ION, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ...
著者campobasso, N.
登録日2019-01-17
公開日2019-03-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Identification and Optimization of Novel Small c-Abl Kinase Activators Using Fragment and HTS Methodologies.
J. Med. Chem., 62, 2019
6NFX
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MBTD1 MBT REPEATS
分子名称:MBT domain-containing protein 1,Enhancer of polycomb homolog 1, UNKNOWN ATOM OR ION, SODIUM ION, ...
著者Zhang, H., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-12-21
公開日2019-01-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献MBTD1 MBT repeats
To Be Published
6J71
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HUA21-SCFV IN COMPLEX WITH THE EXTRACELLULAR DOMAIN(ECD) OF HER2
分子名称:Receptor tyrosine-protein kinase erbB-2, anti-HER2 humanized antibody HuA21, BETA-D-MANNOSE, ...
著者Wang, Z., Guo, G., Cheng, B., Zhu, Z., Niu, L., Zhang, H.
登録日2019-01-16
公開日2019-02-27
実験手法X-RAY DIFFRACTION (2.918 Å)
主引用文献Structural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells
To Be Published
6J6F
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LIGAND BINDING DOMAIN 1 AND 2 OF TALAROMYCES MARNEFFEI MP1 PROTEIN
分子名称:Envelope glycoprotein, NICKEL (II) ION
著者Lam, W.H., Zhang, H., Hao, Q.
登録日2019-01-15
公開日2019-03-06
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Talaromyces marneffeiMp1 protein, a novel virulence factor, carries two arachidonic acid-binding domains to suppress inflammatory responses in hosts.
Infect. Immun., 2019
6J21
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CRYSTAL STRUCTURE OF THE HUMAN NK1 SUBSTANCE P RECEPTOR
分子名称:Substance-P receptor,Endolysin, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
著者Chen, S., Lu, M., Zhang, H., Wu, B., Zhao, Q.
登録日2018-12-30
公開日2019-03-06
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
6J20
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CRYSTAL STRUCTURE OF THE HUMAN NK1 SUBSTANCE P RECEPTOR
分子名称:Substance-P receptor,Endolysin, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
著者Chen, S., Lu, M., Zhang, H., Wu, B., Zhao, Q.
登録日2018-12-30
公開日2019-03-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
6ITW
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CRYSTAL STRUCTURE OF ATU4351 FROM AGROBACTERIUM TUMEFACIENS
分子名称:Type VI immunity protein Atu4351
著者Shi, L., Gao, Z., Zhang, H., Dong, Y.
登録日2018-11-26
公開日2019-03-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the type VI immunity protein Tdi1 (Atu4351) from Agrobacterium tumefaciens.
Acta Crystallogr F Struct Biol Commun, 75, 2019
6INC
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CRYSTAL STRUCTURE OF AN ACETOLACTATE DECARBOXYLASE FROM KLEBSIELLA PNEUMONIAE
分子名称:Alpha-acetolactate decarboxylase, ZINC ION, CHLORIDE ION, ...
著者Wu, W., Zhang, Q., Bartlam, M.
登録日2018-10-24
公開日2019-01-16
実験手法X-RAY DIFFRACTION (1.604 Å)
主引用文献Structural characterization of an acetolactate decarboxylase from Klebsiella pneumoniae
Biochem. Biophys. Res. Commun., 509, 2019
6INB
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CRYSTAL STRUCTURE OF AN ACETOLACTATE DECARBOXYLASE FROM KLEBSIELLA PNEUMONIAE
分子名称:Alpha-acetolactate decarboxylase, ZINC ION, CHLORIDE ION
著者Wu, W., Zhang, Q., Bartlam, M.
登録日2018-10-24
公開日2019-01-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural characterization of an acetolactate decarboxylase from Klebsiella pneumoniae
Biochem. Biophys. Res. Commun., 509, 2019
6IIV
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CRYSTAL STRUCTURE OF THE HUMAN THROMBOXANE A2 RECEPTOR BOUND TO DALTROBAN
分子名称:Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane A2 receptor, 2-[4-[2-[(4-chlorophenyl)sulfonylamino]ethyl]phenyl]ethanoic acid, ZINC ION, ...
著者Fan, H., Zhao, Q., Wu, B.
登録日2018-10-07
公開日2018-12-19
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural basis for ligand recognition of the human thromboxane A2receptor.
Nat. Chem. Biol., 15, 2019
6IIU
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CRYSTAL STRUCTURE OF THE HUMAN THROMBOXANE A2 RECEPTOR BOUND TO RAMATROBAN
分子名称:Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane A2 receptor, 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid, ZINC ION, ...
著者Fan, H., Zhao, Q., Wu, B.
登録日2018-10-07
公開日2018-12-19
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for ligand recognition of the human thromboxane A2receptor.
Nat. Chem. Biol., 15, 2019
6GK8
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CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY DMCBTAU-28.1, DOUBLE MUTANT (S32R, E35K) OF CBTAU-28.1, IN COMPLEX WITH TAU PEPTIDE A7731 (RESIDUES 52-71)
分子名称:HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-28.1(S32R;E35K), TAU PEPTIDE A7731 (RESIDUES 52-71), CHLORIDE ION
著者Steinbacher, S., Mrosek, M., Juraszek, J.
登録日2018-05-18
公開日2018-06-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
6GK7
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CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY DMCBTAU-27.1, DOUBLE MUTANT (S31Y, T100I) OF CBTAU-27.1, IN COMPLEX WITH TAU PEPTIDE A8119B (RESIDUES 299-318)
分子名称:HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I), HUMAN TAU PEPTIDE A8119 RESIDUES 299-318, CHLORIDE ION
著者Steinbacher, S., Mrosek, M., Juraszek, J.
登録日2018-05-18
公開日2018-06-13
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
6FBV
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SINGLE PARTICLE CRYO EM STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS RNA POLYMERASE IN COMPLEX WITH FIDAXOMICIN
分子名称:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Das, K., Lin, W., Ebright, E.
登録日2017-12-19
公開日2018-02-28
最終更新日2018-10-17
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).
Mol. Cell, 70, 2018
6E31
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CRYSTAL STRUCTURE OF RIAM IN AN AUTOINHIBITED CONFIGURATION.
分子名称:Rap1-interacting adapter molecule
著者Chang, Y.C., Su, W., Zhang, H., Huang, Q., Philips, M.R., Wu, J.
登録日2018-07-12
公開日2019-02-20
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6DCW
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CRYSTAL STRUCTURE OF HUMAN ANTI-TAU ANTIBODY CBTAU-27.1 FAB IN COMPLEX WITH A HUMAN TAU PEPTIDE
分子名称:Light chain of CBTAU27.1 Fab, Heavy chain of CBTAU27.1 Fab, tau peptide
著者Zhu, X., Zhang, H., Wilson, I.A.
登録日2018-05-08
公開日2018-06-06
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
6DCV
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CRYSTAL STRUCTURE OF HUMAN ANTI-TAU ANTIBODY CBTAU-27.1
分子名称:Light chain of CBTAU27.1 Fab, heavy chain of CBTAU-27.1 Fab, GLYCEROL
著者Zhu, X., Zhang, H., Wilson, I.A.
登録日2018-05-08
公開日2018-06-06
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
6CQS
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SEDIMINISPIROCHAETA SMARAGDINAE SPS-1 METALLO-BETA-LACTAMASE
分子名称:Beta-lactamase, ZINC ION
著者Page, R.C., VanPelt, J., Cheng, Z., Crowder, M.W.
登録日2018-03-16
公開日2018-08-29
最終更新日2018-09-12
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A Noncanonical Metal Center Drives the Activity of the Sediminispirochaeta smaragdinae Metallo-beta-lactamase SPS-1.
Biochemistry, 57, 2018
6CKO
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CRYSTAL STRUCTURE OF AN AF10 FRAGMENT
分子名称:Protein AF-10, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ...
著者Zhang, H., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-02-28
公開日2018-03-21
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Genes Dev., 32, 2018
6CKN
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CRYSTAL STRUCTURE OF AN AF10 FRAGMENT
分子名称:Protein AF-10, UNKNOWN ATOM OR ION
著者Qin, S., Tempel, W., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-02-28
公開日2018-03-21
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Genes Dev., 32, 2018
6CDG
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GID4 FRAGMENT IN COMPLEX WITH A PEPTIDE
分子名称:Glucose-induced degradation protein 4 homolog, Hexapeptide PGLWKS, UNKNOWN ATOM OR ION
著者Dong, C., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-02-08
公開日2018-03-07
最終更新日2018-04-25
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Nat. Chem. Biol., 14, 2018
6CDC
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GID4 IN COMPLEX WITH A TETRAPEPTIDE
分子名称:Glucose-induced degradation protein 4 homolog, Tetrapeptide PGLW, UNKNOWN ATOM OR ION
著者Dong, C., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-02-08
公開日2018-03-07
最終更新日2018-04-25
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Nat. Chem. Biol., 14, 2018