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7QZ1
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BU of 7qz1 by Molmil
Formate dehydrogenase from Starkeya novella
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Formate dehydrogenase, ...
Authors:Pontillo, N, Slotboom, D.J, Guskov, A.
Deposit date:2022-01-30
Release date:2023-02-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Biochemical and structural insight into the chemical resistance and cofactor specificity of the formate dehydrogenase from Starkeya novella.
Febs J., 290, 2023
4QTN
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BU of 4qtn by Molmil
Crystal structure of the Vitamin B3 transporter PnuC
Descriptor: Nicotinamide riboside, Nicotinamide riboside transporter PnuC, octyl beta-D-glucopyranoside
Authors:Guskov, A, Jaehme, M, Slotboom, D.J.
Deposit date:2014-07-08
Release date:2014-10-08
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the Vitamin B3 transporter PnuC
Nat.Struct.Mol.Biol., 2014
5JSZ
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BU of 5jsz by Molmil
Folate ECF transporter: apo state
Descriptor: Conserved hypothetical membrane protein, Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, ...
Authors:Swier, L.J.Y.M, Guskov, A, Slotboom, D.J.
Deposit date:2016-05-09
Release date:2016-05-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.004 Å)
Cite:Structural insight in the toppling mechanism of an energy-coupling factor transporter.
Nat Commun, 7, 2016
5N9Y
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BU of 5n9y by Molmil
The full-length structure of ZntB
Descriptor: Zinc transport protein ZntB
Authors:Cornelius, G, Stetsenko, A, Scheres, S.H.W, Slotboom, D.J, Guskov, A.
Deposit date:2017-02-27
Release date:2017-11-15
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:The structural basis of proton driven zinc transport by ZntB.
Nat Commun, 8, 2017
3L6G
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BU of 3l6g by Molmil
Crystal structure of lactococcal OpuAC in its open conformation
Descriptor: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Betaine ABC transporter permease and substrate binding protein
Authors:Berntsson, R.P.A, Wolters, J.C, Gul, N, Karasawa, A, Thunnissen, A.M.W.H, Slotboom, D.J, Poolman, B.
Deposit date:2009-12-23
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ligand binding and crystal structures of the substrate-binding domain of the ABC transporter OpuA.
Plos One, 5, 2010
7BCS
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BU of 7bcs by Molmil
ASCT2 in the presence of the inhibitor Lc-BPE (position "down") in the outward-open conformation.
Descriptor: (2~{S},4~{S})-4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0)
Authors:Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A.
Deposit date:2020-12-21
Release date:2021-09-22
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Rational design of ASCT2 inhibitors using an integrated experimental-computational approach.
Proc.Natl.Acad.Sci.USA, 118, 2021
6FNP
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BU of 6fnp by Molmil
Crystal structure of ECF-CbrT, a cobalamin transporter
Descriptor: Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, Energy-coupling factor transporter transmembrane protein EcfT, ...
Authors:Santos, J.A, Rempel, S, Guskov, A, Slotboom, D.J.
Deposit date:2018-02-05
Release date:2018-07-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Functional and structural characterization of an ECF-type ABC transporter for vitamin B12.
Elife, 7, 2018
6GCT
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BU of 6gct by Molmil
cryo-EM structure of the human neutral amino acid transporter ASCT2
Descriptor: GLUTAMINE, Neutral amino acid transporter B(0)
Authors:Garaeva, A.A, Oostergetel, G.T, Gati, C, Guskov, A, Paulino, C, Slotboom, D.J.
Deposit date:2018-04-19
Release date:2018-06-13
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.85 Å)
Cite:Cryo-EM structure of the human neutral amino acid transporter ASCT2.
Nat. Struct. Mol. Biol., 25, 2018
7P78
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BU of 7p78 by Molmil
SARS-CoV-2 spike protein in complex with sybody#15 and sybody#68 in a 1up/1up-out/1down conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(5-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Walter, J.D, Hutter, C.A.J, Garaeva, A.A, Scherer, M, Zimmermann, I, Wyss, M, Rheinberger, J, Ruedin, Y, Earp, J.C, Egloff, P, Sorgenfrei, M, Huerlimann, L.M, Gonda, I, Meier, G, Remm, S, Thavarasah, S, Zimmer, G, Slotboom, D.J, Paulino, C, Plattet, P, Seeger, M.A.
Deposit date:2021-07-19
Release date:2021-08-04
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance.
Embo Rep., 23, 2022
7P79
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BU of 7p79 by Molmil
SARS-CoV-2 spike protein in complex with sybodyb#15 in a 1up/1up-out/1down conformation.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(5-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Walter, J.D, Hutter, C.A.J, Garaeva, A.A, Scherer, M, Zimmermann, I, Wyss, M, Rheinberger, J, Ruedin, Y, Earp, J.C, Egloff, P, Sorgenfrei, M, Huerlimann, L.M, Gonda, I, Meier, G, Remm, S, Thavarasah, S, Zimmer, G, Slotboom, D.J, Paulino, C, Plattet, P, Seeger, M.A.
Deposit date:2021-07-19
Release date:2021-08-04
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance.
Embo Rep., 23, 2022
7P7A
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BU of 7p7a by Molmil
SARS-CoV-2 spike protein in complex with sybody#68 in a 2up/1flexible conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(5-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Walter, J.D, Hutter, C.A.J, Garaeva, A.A, Scherer, M, Zimmermann, I, Wyss, M, Rheinberger, J, Ruedin, Y, Earp, J.C, Egloff, P, Sorgenfrei, M, Huerlimann, L.M, Gonda, I, Meier, G, Remm, S, Thavarasah, S, Zimmer, G, Slotboom, D.J, Paulino, C, Plattet, P, Seeger, M.A.
Deposit date:2021-07-19
Release date:2021-08-04
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (4.76 Å)
Cite:Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance.
Embo Rep., 23, 2022
7P7B
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BU of 7p7b by Molmil
SARS-CoV-2 spike protein in complex with sybody no68 in a 1up/2down conformation
Descriptor: Spike glycoprotein
Authors:Walter, J.D, Hutter, C.A.J, Garaeva, A.A, Scherer, M, Zimmermann, I, Wyss, M, Rheinberger, J, Ruedin, Y, Earp, J.C, Egloff, P, Sorgenfrei, M, Huerlimann, L.M, Gonda, I, Meier, G, Remm, S, Thavarasah, S, Zimmer, G, Slotboom, D.J, Paulino, C, Plattet, P, Seeger, M.A.
Deposit date:2021-07-19
Release date:2021-08-04
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance.
Embo Rep., 23, 2022
7P77
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BU of 7p77 by Molmil
SARS-CoV-2 spike protein in complex with sybody#15 and sybody#68 in a 3up conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(5-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Walter, J.D, Hutter, C.A.J, Garaeva, A.A, Scherer, M, Zimmermann, I, Wyss, M, Rheinberger, J, Ruedin, Y, Earp, J.C, Egloff, P, Sorgenfrei, M, Huerlimann, L.M, Gonda, I, Meier, G, Remm, S, Thavarasah, S, Zimmer, G, Slotboom, D.J, Paulino, C, Plattet, P, Seeger, M.A.
Deposit date:2021-07-19
Release date:2021-08-04
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance.
Embo Rep., 23, 2022
3L6H
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BU of 3l6h by Molmil
Crystal structure of lactococcal OpuAC in its closed-liganded conformation complexed with glycine betaine
Descriptor: Betaine ABC transporter permease and substrate binding protein, CHLORIDE ION, TRIMETHYL GLYCINE
Authors:Berntsson, R.P.A, Wolters, J.C, Gul, N, Karasawa, A, Thunnissen, A.M.W.H, Slotboom, D.J, Poolman, B.
Deposit date:2009-12-23
Release date:2010-05-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ligand binding and crystal structures of the substrate-binding domain of the ABC transporter OpuA.
Plos One, 5, 2010
4ZS9
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BU of 4zs9 by Molmil
Raffinose and panose binding protein from Bifidobacterium animalis subsp. lactis Bl-04, bound with raffinose
Descriptor: CHLORIDE ION, MAGNESIUM ION, Sugar binding protein of ABC transporter system, ...
Authors:Fredslund, F, Ejby, M, Andersen, J.M, Slotboom, D.J, Abou Hachem, M.
Deposit date:2015-05-13
Release date:2016-06-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:An ATP Binding Cassette Transporter Mediates the Uptake of alpha-(1,6)-Linked Dietary Oligosaccharides in Bifidobacterium and Correlates with Competitive Growth on These Substrates.
J. Biol. Chem., 291, 2016
7NNT
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BU of 7nnt by Molmil
Cryo-EM structure of the folate-specific ECF transporter complex in DDM micelles
Descriptor: Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, Energy-coupling factor transporter transmembrane protein EcfT, ...
Authors:Thangaratnarajah, C, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2021-02-25
Release date:2021-08-18
Last modified:2021-09-22
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Insights into the bilayer-mediated toppling mechanism of a folate-specific ECF transporter by cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
7NNU
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BU of 7nnu by Molmil
Cryo-EM structure of the folate-specific ECF transporter complex in MSP2N2 lipid nanodiscs
Descriptor: Conserved hypothetical membrane protein, Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, ...
Authors:Thangaratnarajah, C, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2021-02-25
Release date:2021-08-18
Last modified:2021-09-22
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Insights into the bilayer-mediated toppling mechanism of a folate-specific ECF transporter by cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
7NGH
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BU of 7ngh by Molmil
Structure of glutamate transporter homologue in complex with Sybody
Descriptor: ASPARTIC ACID, Proton/glutamate symporter, SDF family, ...
Authors:Arkhipova, V, Slotboom, D.J, Guskov, A.
Deposit date:2021-02-09
Release date:2021-09-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Kinetic mechanism of Na + -coupled aspartate transport catalyzed by Glt Tk .
Commun Biol, 4, 2021
4ZZE
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BU of 4zze by Molmil
Raffinose and panose binding protein from Bifidobacterium animalis subsp. lactis Bl-04, bound with panose
Descriptor: CHLORIDE ION, MAGNESIUM ION, Sugar binding protein of ABC transporter system, ...
Authors:Fredslund, F, Ejby, M, Andersen, J.M, Slotboom, D.J, Hachem, M.A.
Deposit date:2015-05-22
Release date:2016-06-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:An ATP Binding Cassette Transporter Mediates the Uptake of alpha-(1,6)-Linked Dietary Oligosaccharides in Bifidobacterium and Correlates with Competitive Growth on These Substrates.
J. Biol. Chem., 291, 2016
4ZZA
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BU of 4zza by Molmil
Raffinose and panose binding protein from Bifidobacterium animalis subsp. lactis Bl-04, bound with raffinose, selenomethionine derivative
Descriptor: Sugar binding protein of ABC transporter system, alpha-D-galactopyranose-(1-6)-alpha-D-glucopyranose-(1-2)-beta-D-fructofuranose
Authors:Fredslund, F, Ejby, M, Andersen, J.M, Slotboom, D.J, Abou Hachem, M.
Deposit date:2015-05-22
Release date:2016-06-29
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:An ATP Binding Cassette Transporter Mediates the Uptake of alpha-(1,6)-Linked Dietary Oligosaccharides in Bifidobacterium and Correlates with Competitive Growth on These Substrates.
J. Biol. Chem., 291, 2016
6TQF
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BU of 6tqf by Molmil
The structure of ABC transporter Rv1819c in AMP-PNP bound state
Descriptor: ABC transporter ATP-binding protein/permease, DODECYL-BETA-D-MALTOSIDE, MAGNESIUM ION, ...
Authors:Rempel, S, Gati, C, Slotboom, D.J, Guskov, A.
Deposit date:2019-12-16
Release date:2020-04-01
Last modified:2021-02-10
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds.
Nature, 580, 2020
6TQE
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BU of 6tqe by Molmil
The structure of ABC transporter Rv1819c without addition of substrate
Descriptor: ABC transporter ATP-binding protein/permease, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Rempel, S, Gati, C, Slotboom, D.J, Guskov, A.
Deposit date:2019-12-16
Release date:2020-04-01
Last modified:2021-02-10
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds.
Nature, 580, 2020
8BMP
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BU of 8bmp by Molmil
Cryo-EM structure of the folate-specific ECF transporter complex in MSP2N2 lipid nanodiscs bound to ATP and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Energy-coupling factor transporter ATP-binding protein EcfA1, ...
Authors:Thangaratnarajah, C, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2022-11-10
Release date:2023-08-02
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Expulsion mechanism of the substrate-translocating subunit in ECF transporters.
Nat Commun, 14, 2023
8BMS
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BU of 8bms by Molmil
Cryo-EM structure of the mutant solitary ECF module 2EQ in MSP2N2 lipid nanodiscs in the ATPase closed and ATP-bound conformation
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, ...
Authors:Thangaratnarajah, C, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2022-11-10
Release date:2023-08-02
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Expulsion mechanism of the substrate-translocating subunit in ECF transporters.
Nat Commun, 14, 2023
8BMQ
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BU of 8bmq by Molmil
Cryo-EM structure of the folate-specific ECF transporter complex in MSP2N2 lipid nanodiscs bound to AMP-PNP
Descriptor: Energy-coupling factor transporter ATP-binding protein EcfA1, Energy-coupling factor transporter ATP-binding protein EcfA2, Energy-coupling factor transporter transmembrane protein EcfT, ...
Authors:Thangaratnarajah, C, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2022-11-10
Release date:2023-08-02
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Expulsion mechanism of the substrate-translocating subunit in ECF transporters.
Nat Commun, 14, 2023

 

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