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1QL6
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BU of 1ql6 by Molmil
THE CATALYTIC MECHANISM OF PHOSPHORYLASE KINASE PROBED BY MUTATIONAL STUDIES
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PHOSPHORYLASE KINASE, ...
Authors:Skamnaki, V.T, Owen, D.J, Noble, M.E.M, Lowe, E.D, Oikonomakos, N.G, Johnson, L.N.
Deposit date:1999-08-24
Release date:1999-12-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Catalytic Mechanism of Phosphorylase Kinase Probed by Mutational Studies.
Biochemistry, 38, 1999
4G9M
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BU of 4g9m by Molmil
Crystal structure of the Rhizoctonia solani agglutinin
Descriptor: agglutinin
Authors:Skamnaki, V.T, Kantsadi, A.L, Leonidas, D.D.
Deposit date:2012-07-24
Release date:2013-06-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Structural analysis of the Rhizoctonia solani agglutinin reveals a domain-swapping dimeric assembly.
Febs J., 280, 2013
4G9N
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BU of 4g9n by Molmil
Crystal structure of the Rhizoctonia solani agglutinin in complex with N'-acetyl-galactosamine
Descriptor: 2-acetamido-2-deoxy-beta-D-galactopyranose, agglutinin
Authors:Skamnaki, V.T, Kantsadi, A.L, Leonidas, D.D.
Deposit date:2012-07-24
Release date:2013-06-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural analysis of the Rhizoctonia solani agglutinin reveals a domain-swapping dimeric assembly.
Febs J., 280, 2013
3SYR
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BU of 3syr by Molmil
Glycogen phosphorylase b in complex with beta-D-glucopyranonucleoside 5-fluorouracil
Descriptor: 5-fluoro-1-(beta-D-glucopyranosyl)pyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form
Authors:Skamnaki, V.T, Kantsadi, A.L, Kontou, M, Leonidas, D.D.
Deposit date:2011-07-18
Release date:2012-02-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:3'-Axial CH(2) OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM-PBSA Calculations Suggest Why.
Chem.Biol.Drug Des., 79, 2012
3SYM
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BU of 3sym by Molmil
Glycogen Phosphorylase b in complex with 3 -C-(hydroxymethyl)-beta-D-glucopyranonucleoside of 5-fluorouracil
Descriptor: 5-fluoro-1-[3-C-(hydroxymethyl)-beta-D-glucopyranosyl]pyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form
Authors:Skamnaki, V.T, Katsandi, A.L, Kontou, M, Leonidas, D.D.
Deposit date:2011-07-18
Release date:2012-02-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:3'-Axial CH(2) OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM-PBSA Calculations Suggest Why.
Chem.Biol.Drug Des., 79, 2012
2GPA
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BU of 2gpa by Molmil
ALLOSTERIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG
Descriptor: GLYCEROL, PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Oikonomakos, N.G, Tsitsanou, K.E, Zographos, S.E, Skamnaki, V.T.
Deposit date:1999-02-18
Release date:1999-02-26
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate.
Protein Sci., 8, 1999
1B4D
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BU of 1b4d by Molmil
AMIDOCARBAMATE INHIBITOR OF GLYCOGEN PHOSPHORYLASE
Descriptor: 1-DEOXY-1-METHOXYCARBAMIDO-BETA-D-GLUCO-2-HEPTULOPYRANOSONAMIDE, INOSINIC ACID, PROTEIN (GLYCOGEN PHOSPHORYLASE B), ...
Authors:Tsitsanou, K.E, Oikonomakos, N.G, Zographos, S.E, Skamnaki, V.T, Gregoriou, M, Watson, K.A, Johnson, L.N, Fleet, G.W.J.
Deposit date:1998-12-18
Release date:1998-12-23
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure.
Protein Sci., 8, 1999
3AMV
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BU of 3amv by Molmil
ALLOSTERIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG
Descriptor: 2,3-DICARBOXY-4-(2-CHLORO-PHENYL)-1-ETHYL-5-ISOPROPOXYCARBONYL-6-METHYL-PYRIDINIUM, GLYCEROL, PROTEIN (GLYCOGEN PHOSPHORYLASE), ...
Authors:Oikonomakos, N.G, Tsitsanou, K.E, Zographos, S.E, Skamnaki, V.T.
Deposit date:1999-02-18
Release date:1999-02-26
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate.
Protein Sci., 8, 1999
6S4R
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BU of 6s4r by Molmil
The crystal structure of glycogen phosphorylase in complex with 11
Descriptor: (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-(2-naphthalen-2-yl-1,3-thiazol-4-yl)oxane-3,4,5-triol, Glycogen phosphorylase, muscle form, ...
Authors:Kyriakis, E, Papaioannou, O.S.E, Solovou, T.G.A, Skamnaki, V.T, Leonidas, D.D.
Deposit date:2019-06-28
Release date:2020-02-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The architecture of hydrogen and sulfur sigma-hole interactions explain differences in the inhibitory potency of C-beta-d-glucopyranosyl thiazoles, imidazoles and an N-beta-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design.
Bioorg.Med.Chem., 28, 2020
1C50
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BU of 1c50 by Molmil
IDENTIFICATION AND STRUCTURAL CHARACTERIZATION OF A NOVEL ALLOSTERIC BINDING SITE OF GLYCOGEN PHOSPHORYLASE B
Descriptor: 5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID [1-(4-FLUOROBENZYL)-2-(4-HYDROXYPIPERIDIN-1YL)-2-OXOETHYL]AMIDE, PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE
Authors:Oikonomakos, N.G, Skamnaki, V.T, Tsitsanou, K.E, Gavalas, N.G, Johnson, L.N.
Deposit date:1999-12-15
Release date:1999-12-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A new allosteric site in glycogen phosphorylase b as a target for drug interactions.
Structure Fold.Des., 8, 2000
1C8K
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BU of 1c8k by Molmil
FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE
Descriptor: 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE
Authors:Oikonomakos, N.G, Zographos, S.E, Skamnaki, V.T, Tsitsanou, K.E, Johnson, L.N.
Deposit date:2000-05-11
Release date:2000-05-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site.
J.Biol.Chem., 275, 2000
1C8L
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BU of 1c8l by Molmil
SYNERGISTIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG AND CAFFEINE
Descriptor: 2,3-DICARBOXY-4-(2-CHLORO-PHENYL)-1-ETHYL-5-ISOPROPOXYCARBONYL-6-METHYL-PYRIDINIUM, CAFFEINE, GLYCEROL, ...
Authors:Tsitsanou, K.E, Skamnaki, V.T, Oikonomakos, N.G.
Deposit date:2000-05-16
Release date:2000-05-31
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of the synergistic inhibition of glycogen phosphorylase a by caffeine and a potential antidiabetic drug.
Arch.Biochem.Biophys., 384, 2000
2PHK
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BU of 2phk by Molmil
THE CRYSTAL STRUCTURE OF A PHOSPHORYLASE KINASE PEPTIDE SUBSTRATE COMPLEX: KINASE SUBSTRATE RECOGNITION
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ...
Authors:Lowe, E.D, Noble, M.E.M, Skamnaki, V.T, Oikonomakos, N.G, Owen, D.J, Johnson, L.N.
Deposit date:1998-06-18
Release date:1999-01-13
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.
EMBO J., 16, 1997
6Y5O
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BU of 6y5o by Molmil
The crystal structure of glycogen phosphorylase in complex with 20
Descriptor: 2-(4-fluorophenyl)-5,7-bis(oxidanyl)chromen-4-one, Glycogen phosphorylase, muscle form
Authors:Kyriakis, E, Koulas, S.M, Skamnaki, V.T, Leonidas, D.D.
Deposit date:2020-02-25
Release date:2020-08-19
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors.
Bioorg.Chem., 102, 2020
6Y55
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BU of 6y55 by Molmil
The crystal structure of glycogen phosphorylase in complex with 43
Descriptor: 2-(3-methylphenyl)-5,7-bis(oxidanyl)chromen-4-one, Glycogen phosphorylase, muscle form
Authors:Kyriakis, E, Koulas, S.M, Skamnaki, V.T, Leonidas, D.D.
Deposit date:2020-02-24
Release date:2020-08-19
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors.
Bioorg.Chem., 102, 2020
6Y5C
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BU of 6y5c by Molmil
The crystal structure of glycogen phosphorylase in complex with 52
Descriptor: 2-(4-methylphenyl)-5,7-bis(oxidanyl)chromen-4-one, Glycogen phosphorylase, muscle form
Authors:Kyriakis, E, Koulas, S.M, Skamnaki, V.T, Leonidas, D.D.
Deposit date:2020-02-25
Release date:2020-08-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors.
Bioorg.Chem., 102, 2020
6YVE
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BU of 6yve by Molmil
Glycogen phosphorylase b in complex with pelargonidin 3-O-beta-D-glucoside
Descriptor: DIMETHYL SULFOXIDE, Glycogen phosphorylase, muscle form, ...
Authors:Drakou, C.E, Gardeli, C, Tsialtas, I, Alexopoulos, S, Mallouchos, A, Koulas, S, Tsagkarakou, A, Asimakopoulos, D, Leonidas, D.D, Psarra, A.M, Skamnaki, V.T.
Deposit date:2020-04-28
Release date:2020-11-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Affinity Crystallography Reveals Binding of Pomegranate Juice Anthocyanins at the Inhibitor Site of Glycogen Phosphorylase: The Contribution of a Sugar Moiety to Potency and Its Implications to the Binding Mode.
J.Agric.Food Chem., 68, 2020
1E1Y
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BU of 1e1y by Molmil
Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site
Descriptor: 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, ...
Authors:Oikonomakos, N.G, Zographos, S.E, Skamnaki, V.T, Tsitsanou, K.E, Johnson, L.N.
Deposit date:2000-05-11
Release date:2000-05-17
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Flavopiridol Inhibits Glycogen Phosphorylase by Binding at the Inhibitor Site
J.Biol.Chem., 275, 2000
1GFZ
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BU of 1gfz by Molmil
FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE
Descriptor: CAFFEINE, GLYCOGEN PHOSPHORYLASE, INOSINIC ACID, ...
Authors:Oikonomakos, N.G, Zographos, S.E, Skamnaki, V.T, Tsitsanou, K.E, Johnson, L.N.
Deposit date:2000-06-29
Release date:2000-07-26
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site.
J.Biol.Chem., 275, 2000
1BX3
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BU of 1bx3 by Molmil
EFFECTS OF COMMONLY USED CRYOPROTECTANTS ON GLYCOGEN PHOSPHORYLASE ACTIVITY AND STRUCTURE
Descriptor: PROTEIN (GLYCOGEN PHOSPHORYLASE B), PYRIDOXAL-5'-PHOSPHATE
Authors:Tsitsanou, K.E, Oikonomakos, N.G, Zographos, S.E, Skamnaki, V.T, Gregoriou, M, Watson, K.A, Johnson, L.N, Fleet, G.W.J.
Deposit date:1999-10-13
Release date:1999-10-21
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure.
Protein Sci., 8, 1999
6F3L
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BU of 6f3l by Molmil
The crystal structure of Glycogen Phosphorylase in complex with 10b
Descriptor: 6-[5-[(2~{S},3~{R},4~{R},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]-1~{H}-1,2,4-triazol-3-yl]naphthalene-2-carboxylic acid, Glycogen phosphorylase, muscle form, ...
Authors:Kyriakis, E, Barkas, T.A, Stravodimos, G.A, Skamnaki, V.T, Leonidas, D.D.
Deposit date:2017-11-28
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A multidisciplinary study of 3-( beta-d-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors.
Eur J Med Chem, 147, 2018
6F3J
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BU of 6f3j by Molmil
The crystal structure of Glycogen Phosphorylase in complex with 10a
Descriptor: 4-[4-[5-[(2~{S},3~{R},4~{R},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]-4~{H}-1,2,4-triazol-3-yl]phenyl]benzoic acid, Glycogen phosphorylase, muscle form, ...
Authors:Kyriakis, E, Stamati, E.C.V, Stravodimos, G.A, Skamnaki, V.T, Leonidas, D.D.
Deposit date:2017-11-28
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A multidisciplinary study of 3-( beta-d-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors.
Eur J Med Chem, 147, 2018
6F3U
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BU of 6f3u by Molmil
The crystal structure of Glycogen Phosphorylase in complex with 10h
Descriptor: (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-(5-naphthalen-1-yl-4~{H}-1,2,4-triazol-3-yl)oxane-3,4,5-triol, Glycogen phosphorylase, muscle form, ...
Authors:Kyriakis, E, Gkerdi, A, Stravodimos, G.A, Skamnaki, V.T, Leonidas, D.D.
Deposit date:2017-11-28
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A multidisciplinary study of 3-( beta-d-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors.
Eur J Med Chem, 147, 2018
6F3R
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BU of 6f3r by Molmil
The crystal structure of Glycogen Phosphorylase in complex with 10c
Descriptor: (2~{S},3~{R},4~{R},5~{S},6~{R})-2-[5-(9~{H}-fluoren-2-yl)-4~{H}-1,2,4-triazol-3-yl]-6-(hydroxymethyl)oxane-3,4,5-triol, Glycogen phosphorylase, muscle form, ...
Authors:Kyriakis, E, Barkas, T.A, Stravodimos, G.A, Skamnaki, V.T, Leonidas, D.D.
Deposit date:2017-11-28
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A multidisciplinary study of 3-( beta-d-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors.
Eur J Med Chem, 147, 2018
6F3S
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BU of 6f3s by Molmil
The crystal structure of Glycogen Phosphorylase in complex with 10d
Descriptor: (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-[5-(4-phenylphenyl)-4~{H}-1,2,4-triazol-3-yl]oxane-3,4,5-triol, Glycogen phosphorylase, muscle form, ...
Authors:Kyriakis, E, Stamati, E.C.V, Stravodimos, G.A, Skamnaki, V.T, Leonidas, D.D.
Deposit date:2017-11-28
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A multidisciplinary study of 3-( beta-d-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors.
Eur J Med Chem, 147, 2018

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