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1KL9
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BU of 1kl9 by Molmil
Crystal structure of the N-terminal segment of Human eukaryotic initiation factor 2alpha
Descriptor: EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1, ZINC ION
Authors:Nonato, M.C, Widom, J, Clardy, J.
Deposit date:2001-12-11
Release date:2002-03-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha
J.Biol.Chem., 277, 2002
1KQ0
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BU of 1kq0 by Molmil
Human methionine aminopeptidase type II in complex with D-methionine
Descriptor: D-METHIONINE, Methionine aminopeptidase 2, TERTIARY-BUTYL ALCOHOL, ...
Authors:Nonato, M.C, Widom, J, Clardy, J.
Deposit date:2002-01-03
Release date:2003-12-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human methionine aminopeptidase type 2 in complex with L- and D-methionine
Bioorg.Med.Chem.Lett., 16, 2006
1KQ9
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BU of 1kq9 by Molmil
Human methionine aminopeptidase type II in complex with L-methionine
Descriptor: METHIONINE, Methionine aminopeptidase 2, TERTIARY-BUTYL ALCOHOL, ...
Authors:Nonato, M.C, Widom, J, Clardy, J.
Deposit date:2002-01-04
Release date:2003-12-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Human methionine aminopeptidase type 2 in complex with L- and D-methionine
Bioorg.Med.Chem.Lett., 16, 2006
6DU9
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BU of 6du9 by Molmil
Crystal Structure of Human Prion Protein 90-231
Descriptor: CADMIUM ION, CHLORIDE ION, Major prion protein
Authors:Nonato, M.C, Rangel, V.L, Pavlovici, F.A.
Deposit date:2018-06-20
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Crystal Structure of Human Prion Protein 90-231
To Be Published
7RRM
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BU of 7rrm by Molmil
Structure of the human TMED1 (p24gamma1) Golgi dynamics Domain
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, Transmembrane emp24 domain-containing protein 1
Authors:Mota, D.C.A.M, Cardoso, I.A, Mori, R.M, Mendes, L.F.S, Nonato, M.C, Filho, A.J.C.
Deposit date:2021-08-10
Release date:2021-10-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural and thermodynamic analyses of human TMED1 (p24 gamma 1) Golgi dynamics.
Biochimie, 192, 2022
4LBQ
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BU of 4lbq by Molmil
Crystal structure of mouse galectin-1
Descriptor: GLYCEROL, Galectin-1
Authors:Rustiguel, J.K, Trabuco, A.C, Del Cistia Andrade, C, Stowell, S.R, Cummings, R.D, Dias-Baruffi, M, Nonato, M.C.
Deposit date:2013-06-20
Release date:2014-07-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of mouse galectin-1
To be Published
5K9Y
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BU of 5k9y by Molmil
Crystal structure of a thermophilic xylanase A from Bacillus subtilis 1A1 quadruple mutant Q7H/G13R/S22P/S179C
Descriptor: Endo-1,4-beta-xylanase A
Authors:Pinheiro, M.P, Ferreira, T.L, Silva, S.R.B, Fuzo, C.A, Silva, S.R, Lourenzoni, M.R, Vieira, D.S, Ward, R.J, Nonato, M.C.
Deposit date:2016-06-01
Release date:2017-04-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The role of local residue environmental changes in thermostable mutants of the GH11 xylanase from Bacillus subtilis.
Int. J. Biol. Macromol., 97, 2017
5L2R
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BU of 5l2r by Molmil
Crystal structure of fumarate hydratase from Leishmania major
Descriptor: (2S)-2-hydroxybutanedioic acid, DI(HYDROXYETHYL)ETHER, Fumarate hydratase, ...
Authors:Feliciano, P.R, Drennan, C.L, Nonato, M.C.
Deposit date:2016-08-02
Release date:2016-08-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.054 Å)
Cite:Crystal structure of an Fe-S cluster-containing fumarate hydratase enzyme from Leishmania major reveals a unique protein fold.
Proc.Natl.Acad.Sci.USA, 113, 2016
6MSO
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BU of 6mso by Molmil
Crystal structure of mitochondrial fumarate hydratase from Leishmania major in a complex with inhibitor thiomalate
Descriptor: (2S)-2-sulfanylbutanedioic acid, GLYCEROL, IRON/SULFUR CLUSTER, ...
Authors:Feliciano, P.R, Drennan, C.L, Nonato, M.C.
Deposit date:2018-10-17
Release date:2019-01-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.053 Å)
Cite:Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate.
ACS Chem. Biol., 14, 2019
6MSN
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BU of 6msn by Molmil
Crystal structure of cytosolic fumarate hydratase from Leishmania major in a complex with inhibitor thiomalate
Descriptor: (2S)-2-sulfanylbutanedioic acid, IRON/SULFUR CLUSTER, fumarate hydratase
Authors:Feliciano, P.R, Drennan, C.L, Nonato, M.C.
Deposit date:2018-10-17
Release date:2019-01-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.591 Å)
Cite:Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate.
ACS Chem. Biol., 14, 2019
5K9D
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BU of 5k9d by Molmil
Crystal structure of human dihydroorotate dehydrogenase at 1.7 A resolution
Descriptor: 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, ACETATE ION, CHLORIDE ION, ...
Authors:Lewis, T.A, Sykes, D.B, Law, J.M, Munoz, B, Scadden, D.T, Rustiguel, J.K, Nonato, M.C, Schreiber, S.L.
Deposit date:2016-05-31
Release date:2016-10-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.
ACS Med Chem Lett, 7, 2016
5K9C
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BU of 5k9c by Molmil
Crystal structure of human dihydroorotate dehydrogenase with ML390
Descriptor: 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, ACETATE ION, CHLORIDE ION, ...
Authors:Lewis, T.A, Sykes, D.B, Law, J.M, Munoz, B, Scadden, D.T, Rustiguel, J.K, Nonato, M.C, Schreiber, S.L.
Deposit date:2016-05-31
Release date:2016-10-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.
ACS Med Chem Lett, 7, 2016
4WZH
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BU of 4wzh by Molmil
Dihydroorotate dehydrogenase from Leishmania Viannia braziliensis
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ...
Authors:Reis, R.A.G, Lorenzato, E, Silva, V.C, Nonato, M.C.
Deposit date:2014-11-19
Release date:2015-05-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Recombinant production, crystallization and crystal structure determination of dihydroorotate dehydrogenase from Leishmania (Viannia) braziliensis.
Acta Crystallogr.,Sect.F, 71, 2015
4XZP
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BU of 4xzp by Molmil
Crystal structure of the N-terminal domain of human galectin-4
Descriptor: CALCIUM ION, Galectin-4
Authors:Rustiguel, J.K, Nonato, M.C.
Deposit date:2015-02-04
Release date:2016-03-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Full-length model of the human galectin-4 and insights into dynamics of inter-domain communication.
Sci Rep, 6, 2016
5UPP
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BU of 5upp by Molmil
Crystal structure of human fumarate hydratase
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Fumarate hydratase, mitochondrial
Authors:Rangel, V.L, Ajalla, M.A, Rustiguel, J.K, Pereira de Padua, R.A, Nonato, M.C.
Deposit date:2017-02-03
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural, biochemical and biophysical characterization of recombinant human fumarate hydratase.
Febs J., 2019
4EF8
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BU of 4ef8 by Molmil
Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate
Descriptor: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Pinheiro, M.P, Emery, F.S, Nonato, M.C.
Deposit date:2012-03-29
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase.
Curr.Pharm.Des., 19, 2013
4EF9
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BU of 4ef9 by Molmil
Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 4-Nitrophenyl isothiocyanate
Descriptor: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
Authors:Pinheiro, M.P, Emery, F.S, Nonato, M.C.
Deposit date:2012-03-29
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase.
Curr.Pharm.Des., 19, 2013
3GYE
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BU of 3gye by Molmil
Didydroorotate dehydrogenase from Leishmania major
Descriptor: Dihydroorotate dehydrogenase, putative, FLAVIN MONONUCLEOTIDE, ...
Authors:Cordeiro, A.T, Feliciano, P.R, Nonato, M.C.
Deposit date:2009-04-03
Release date:2010-04-07
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Leishmania major Dihydroorotate dehydrogenase
To be Published
3GZ3
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BU of 3gz3 by Molmil
Leishmania major Dihydroorotate Dehydrogenase in complex with orotate
Descriptor: Dihydroorotate dehydrogenase, putative, FLAVIN MONONUCLEOTIDE, ...
Authors:Cordeiro, A.T, Feliciano, P.R, Nonato, M.C.
Deposit date:2009-04-06
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Leismania major dihydroorotate in complex with orotate
To be Published
7LUB
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BU of 7lub by Molmil
Crystal structure of recombinant human fumarase in complex with D-2-amino-3-phosphono-propionic acid
Descriptor: D-2-AMINO-3-PHOSPHONO-PROPIONIC ACID, Fumarate hydratase, mitochondrial, ...
Authors:Cardoso, I.A, Nonato, M.C.
Deposit date:2021-02-21
Release date:2022-02-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase.
Science, 379, 2023
7MX6
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BU of 7mx6 by Molmil
Leishmania major dihydroorotate dehydrogenase in complex with [4-(1H-pyrrol-1-yl)phenyl]methanol
Descriptor: 4-(1H-pyrrol-1-yl)aniline, Dihydroorotate dehydrogenase (fumarate), FLAVIN MONONUCLEOTIDE, ...
Authors:Pinheiro, M.P, Hunter, W.N, Cardoso, I.A, Nonato, M.C.
Deposit date:2021-05-18
Release date:2022-05-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Leishmania major dihydroorotate dehydrogenase in complex with [4-(1H-pyrrol-1-yl)phenyl]methanol
To be Published
7MYD
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BU of 7myd by Molmil
Leishmania major dihydroorotate dehydrogenase in complex with 5-amino-2-(1H-pyrrol-1-yl)benzonitrile
Descriptor: 5-azanyl-2-pyrrol-1-yl-benzenecarbonitrile, Dihydroorotate dehydrogenase (fumarate), FLAVIN MONONUCLEOTIDE, ...
Authors:Pinheiro, M.P, Cardoso, I.A, Hunter, W.N, Nonato, M.C.
Deposit date:2021-05-20
Release date:2022-05-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Leishmania major dihydroorotate dehydrogenase in complex with 5-amino-2-(1H-pyrrol-1-yl)benzonitrile
To Be Published
3MHU
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BU of 3mhu by Molmil
Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Nitroorotic acid
Descriptor: 5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ...
Authors:Pinheiro, M.P, Rocha, J.R, Cheleski, J, Montanari, C.A, Nonato, M.C.
Deposit date:2010-04-08
Release date:2011-02-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery.
Eur.J.Med.Chem., 45, 2010
3MJY
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BU of 3mjy by Molmil
Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid
Descriptor: 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ...
Authors:Pinheiro, M.P, Rocha, J.R, Cheleski, J, Montanari, C.A, Nonato, M.C.
Deposit date:2010-04-13
Release date:2011-02-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery.
Eur.J.Med.Chem., 45, 2010
5CBL
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BU of 5cbl by Molmil
Crystal structure of the C-terminal domain of human galectin-4 with lactose
Descriptor: BETA-MERCAPTOETHANOL, GLYCEROL, Galectin-4, ...
Authors:Rustiguel, J.K, Nonato, M.C.
Deposit date:2015-07-01
Release date:2015-11-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.781 Å)
Cite:Recombinant expression, purification and preliminary biophysical and structural studies of C-terminal carbohydrate recognition domain from human galectin-4.
Protein Expr.Purif., 118, 2015

 

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