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1A71
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TERNARY COMPLEX OF AN ACTIVE SITE DOUBLE MUTANT OF HORSE LIVER ALCOHOL DEHYDROGENASE, PHE93=>TRP, VAL203=>ALA WITH NAD AND TRIFLUOROETHANOL
分子名称:LIVER ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Colby, T.D., Bahnson, B.J., Chin, J.K., Klinman, J.P., Goldstein, B.M.
登録日1998-03-19
公開日1998-06-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.
Biochemistry, 37, 1998
1A72
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AN ACTIVE-SITE DOUBLE MUTANT (PHE93->TRP, VAL203->ALA) OF HORSE LIVER ALCOHOL DEHYDROGENASE IN COMPLEX WITH THE ISOSTERIC NAD ANALOG CPAD
分子名称:HORSE LIVER ALCOHOL DEHYDROGENASE, ZINC ION, 5-BETA-D-RIBOFURANOSYLPICOLINAMIDE ADENINE-DINUCLEOTIDE
著者Colby, T.D., Bahnson, B.J., Chin, J.K., Klinman, J.P., Goldstein, B.M.
登録日1998-03-19
公開日1998-06-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.
Biochemistry, 37, 1998
1ADB
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CRYSTALLOGRAPHIC STUDIES OF ISOSTERIC NAD ANALOGUES BOUND TO ALCOHOL DEHYDROGENASE: SPECIFICITY AND SUBSTRATE BINDING IN TWO TERNARY COMPLEXES
分子名称:ALCOHOL DEHYDROGENASE, ZINC ION, 5-BETA-D-RIBOFURANOSYLNICOTINAMIDE ADENINE DINUCLEOTIDE, ...
著者Li, H., Hallows, W.A., Punzi, J.S., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.
登録日1993-12-13
公開日1995-06-03
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes.
Biochemistry, 33, 1994
1ADC
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CRYSTALLOGRAPHIC STUDIES OF ISOSTERIC NAD ANALOGUES BOUND TO ALCOHOL DEHYDROGENASE: SPECIFICITY AND SUBSTRATE BINDING IN TWO TERNARY COMPLEXES
分子名称:ALCOHOL DEHYDROGENASE, ZINC ION, 5-BETA-D-RIBOFURANOSYLPICOLINAMIDE ADENINE-DINUCLEOTIDE, ...
著者Li, H., Hallows, W.A., Punzi, J.S., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.
登録日1993-12-13
公開日1995-06-03
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes.
Biochemistry, 33, 1994
1ADF
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CRYSTALLOGRAPHIC STUDIES OF TWO ALCOHOL DEHYDROGENASE-BOUND ANALOGS OF THIAZOLE-4-CARBOXAMIDE ADENINE DINUCLEOTIDE (TAD), THE ACTIVE ANABOLITE OF THE ANTITUMOR AGENT TIAZOFURIN
分子名称:ALCOHOL DEHYDROGENASE, ZINC ION, BETA-METHYLENE-THIAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE
著者Li, H., Hallows, W.A., Punzi, J.S., Marquez, V.E., Carrell, H.L., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.
登録日1993-10-18
公開日1994-01-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.
Biochemistry, 33, 1994
1ADG
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CRYSTALLOGRAPHIC STUDIES OF TWO ALCOHOL DEHYDROGENASE-BOUND ANALOGS OF THIAZOLE-4-CARBOXAMIDE ADENINE DINUCLEOTIDE (TAD), THE ACTIVE ANABOLITE OF THE ANTITUMOR AGENT TIAZOFURIN
分子名称:ALCOHOL DEHYDROGENASE, ZINC ION, BETA-METHYLENE-SELENAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE
著者Li, H., Hallows, W.A., Punzi, J.S., Marquez, V.E., Carrell, H.L., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.
登録日1993-10-18
公開日1994-01-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.
Biochemistry, 33, 1994
1AXE
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CRYSTAL STRUCTURE OF THE ACTIVE-SITE MUTANT PHE93->TRP OF HORSE LIVER ALCOHOL DEHYDROGENASE IN COMPLEX WITH NAD AND INHIBITOR TRIFLUOROETHANOL
分子名称:ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Colby, T.D., Chin, J.K., Goldstein, B.M.
登録日1997-10-15
公開日1998-04-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A link between protein structure and enzyme catalyzed hydrogen tunneling.
Proc.Natl.Acad.Sci.USA, 94, 1997
1AXG
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CRYSTAL STRUCTURE OF THE VAL203->ALA MUTANT OF LIVER ALCOHOL DEHYDROGENASE COMPLEXED WITH COFACTOR NAD AND INHIBITOR TRIFLUOROETHANOL SOLVED TO 2.5 ANGSTROM RESOLUTION
分子名称:ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Colby, T.D., Chin, J.K., Bahnson, B.J., Goldstein, B.M., Klinman, J.P.
登録日1997-10-15
公開日1998-04-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A link between protein structure and enzyme catalyzed hydrogen tunneling.
Proc.Natl.Acad.Sci.USA, 94, 1997
1B3O
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TERNARY COMPLEX OF HUMAN TYPE-II INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP AND SELENAZOLE ADENINE DINUCLEOTIDE
分子名称:PROTEIN (INOSINE MONOPHOSPHATE DEHYDROGENASE 2), 6-CHLOROPURINE RIBOSIDE, 5'-MONOPHOSPHATE, ...
著者Colby, T.D., Vanderveen, K., Strickler, M.D., Goldstein, B.M.
登録日1998-12-14
公開日1999-04-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design.
Proc.Natl.Acad.Sci.USA, 96, 1999
1JCN
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BINARY COMPLEX OF HUMAN TYPE-I INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP
分子名称:INOSINE MONOPHOSPHATE DEHYDROGENASE I, 6-CHLOROPURINE RIBOSIDE, 5'-MONOPHOSPHATE
著者Risal, D., Strickler, M.D., Goldstein, B.M.
登録日2001-06-11
公開日2003-06-17
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of the Human Type I Inosine Monophosphate Dehydrogenase and Implications for Isoform Specificity
To be Published
1NF7
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TERNARY COMPLEX OF THE HUMAN TYPE II INOSINE MONOPHOSPHATE DEDHYDROGENASE WITH RIBAVIRIN MONOPHOSPHATE AND C2-MYCOPHENOLIC ADENINE DINUCLEOTIDE
分子名称:Inosine-5'-monophosphate dehydrogenase 2, POTASSIUM ION, RIBAVIRIN MONOPHOSPHATE, ...
著者Risal, D., Strickler, M.D., Goldstein, B.M.
登録日2002-12-13
公開日2004-01-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal Structure of Human Inosine Monophosphate Dehydrogenase type II complexed with the MPA/NAD analog C2-MAD
To be Published
1NFB
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TERNARY COMPLEX OF THE HUMAN TYPE II INOSINE MONOPHOSPHATE DEDHYDROGENASE WITH 6CL-IMP AND NAD
分子名称:Inosine-5'-monophosphate dehydrogenase 2, 6-CHLOROPURINE RIBOSIDE, 5'-MONOPHOSPHATE, ...
著者Risal, D., Strickler, M.D., Goldstein, B.M.
登録日2002-12-13
公開日2004-01-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The Conformation of NAD Bound to Human Inosine Monophosphate Dehydrogenase Type II
To be Published
1P2Y
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CRYSTAL STRUCTURE OF CYTOCHROME P450CAM IN COMPLEX WITH (S)-(-)-NICOTINE
分子名称:Cytochrome P450-cam, PROTOPORPHYRIN IX CONTAINING FE, (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE
著者Strickler, M., Goldstein, B.M., Maxfield, K., Shireman, L., Kim, G., Matteson, D., Jones, J.P.
登録日2003-04-16
公開日2003-10-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystallographic Studies on the Complex Behavior of Nicotine Binding to P450cam (CYP101)(dagger).
Biochemistry, 42, 2003
1P7R
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CRYSTAL STRUCTURE OF REDUCED, CO-EXPOSED COMPLEX OF CYTOCHROME P450CAM WITH (S)-(-)-NICOTINE
分子名称:Cytochrome P450-cam, PROTOPORPHYRIN IX CONTAINING FE, (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE
著者Strickler, M., Goldstein, B.M., Maxfield, K., Shireman, L., Kim, G., Matteson, D., Jones, J.P.
登録日2003-05-05
公開日2003-10-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Crystallographic Studies on the Complex Behavior of Nicotine Binding to P450cam (CYP101)(dagger).
Biochemistry, 42, 2003
1RJW
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CRYSTAL STRUCTURE OF NAD(+)-DEPENDENT ALCOHOL DEHYDROGENASE FROM BACILLUS STEAROTHERMOPHILUS STRAIN LLD-R
分子名称:Alcohol dehydrogenase, ZINC ION, TRIFLUOROETHANOL
著者Ceccarelli, C., Bahnson, B.J.
登録日2003-11-20
公開日2004-05-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal Structure and Amide H/D Exchange of Binary Complexes of Alcohol Dehydrogenase from Bacillus stearothermophilus: Insight into Thermostability and Cofactor Binding
Biochemistry, 43, 2004
6OWM
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HORSE LIVER F93W ALCOHOL DEHYDROGENASE COMPLEXED WITH NAD AND PENTAFLUOROBENZYL ALCOHOL
分子名称:Alcohol dehydrogenase E chain, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM), ...
著者Plapp, B.V.
登録日2019-05-10
公開日2019-05-22
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Substitutions of amino acid residues in the substrate binding site of horse liver alcohol dehydrogenase have small effects on structure but significantly affect catalysis of hydrogen transfer.
To Be Published
6OWP
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HORSE LIVER F93W ALCOHOL DEHYDROGENASE COMPLEXED WITH NAD AND TRIFLUOROETHANOL
分子名称:Alcohol dehydrogenase E chain, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM), ...
著者Plapp, B.V.
登録日2019-05-10
公開日2019-05-22
実験手法X-RAY DIFFRACTION (1.14 Å)
主引用文献Substitutions of amino acid residues in the substrate binding site of horse liver alcohol dehydrogenase have small effects on structure but significantly affect catalysis of hydrogen transfer.
To Be Published