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1ULB
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BU of 1ulb by Molmil
APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS
Descriptor: GUANINE, PURINE NUCLEOSIDE PHOSPHORYLASE, SULFATE ION
Authors:Ealick, S.E, Rule, S.A, Carter, D.C, Greenhough, T.J, Babu, Y.S, Cook, W.J, Habash, J, Helliwell, J.R, Stoeckler, J.D, Parksjunior, R.E, Chen, S.-F, Bugg, C.E.
Deposit date:1991-11-05
Release date:1993-01-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.
Proc.Natl.Acad.Sci.USA, 88, 1991
1ULA
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BU of 1ula by Molmil
APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS
Descriptor: PURINE NUCLEOSIDE PHOSPHORYLASE, SULFATE ION
Authors:Ealick, S.E, Rule, S.A, Carter, D.C, Greenhough, T.J, Babu, Y.S, Cook, W.J, Habash, J, Helliwell, J.R, Stoeckler, J.D, Parksjunior, R.E, Chen, S.-F, Bugg, C.E.
Deposit date:1991-11-05
Release date:1993-01-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.
Proc.Natl.Acad.Sci.USA, 88, 1991
1HIG
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BU of 1hig by Molmil
THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.
Descriptor: INTERFERON-GAMMA
Authors:Ealick, S.E, Cook, W.J, Vijay-Kumar, S, Carson, M, Nagabhushan, T.L, Trotta, P.P, Bugg, C.E.
Deposit date:1991-10-03
Release date:1992-04-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Three-dimensional structure of recombinant human interferon-gamma.
Science, 252, 1991
2HS0
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BU of 2hs0 by Molmil
T. maritima PurL complexed with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Phosphoribosylformylglycinamidine synthase II
Authors:Ealick, S.E, Morar, M.
Deposit date:2006-07-20
Release date:2007-01-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Complexed Structures of Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima Describe a Novel ATP Binding Protein Superfamily
Biochemistry, 45, 2006
2HRY
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BU of 2hry by Molmil
T. maritima PurL complexed with AMPPCP
Descriptor: MAGNESIUM ION, PHOSPHATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Ealick, S.E, Morar, M.
Deposit date:2006-07-20
Release date:2007-01-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Complexed Structures of Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima Describe a Novel ATP Binding Protein Superfamily
Biochemistry, 45, 2006
2HS4
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BU of 2hs4 by Molmil
T. maritima PurL complexed with FGAR and AMPPCP
Descriptor: MAGNESIUM ION, N-(N-FORMYLGLYCYL)-5-O-PHOSPHONO-BETA-D-RIBOFURANOSYLAMINE, PHOSPHATE ION, ...
Authors:Ealick, S.E, Morar, M.
Deposit date:2006-07-21
Release date:2007-01-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Complexed Structures of Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima Describe a Novel ATP Binding Protein Superfamily
Biochemistry, 45, 2006
2HRU
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BU of 2hru by Molmil
T. maritima PurL complexed with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Phosphoribosylformylglycinamidine synthase II
Authors:Ealick, S.E, Morar, M.
Deposit date:2006-07-20
Release date:2007-01-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Complexed Structures of Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima Describe a Novel ATP Binding Protein Superfamily
Biochemistry, 45, 2006
2HS3
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BU of 2hs3 by Molmil
T. maritima PurL complexed with FGAR
Descriptor: N-(N-FORMYLGLYCYL)-5-O-PHOSPHONO-BETA-D-RIBOFURANOSYLAMINE, PHOSPHATE ION, Phosphoribosylformylglycinamidine synthase II
Authors:Ealick, S.E, Morar, M.
Deposit date:2006-07-21
Release date:2007-01-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Complexed Structures of Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima Describe a Novel ATP Binding Protein Superfamily
Biochemistry, 45, 2006
5HFT
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BU of 5hft by Molmil
Crystal structure of HpxW
Descriptor: Gamma-glutamyltranspeptidase
Authors:Ealick, S.E, Hicks, K.A.
Deposit date:2016-01-07
Release date:2016-06-29
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.646 Å)
Cite:Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway.
Acta Crystallogr D Struct Biol, 72, 2016
1ZUD
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BU of 1zud by Molmil
Structure of ThiS-ThiF protein complex
Descriptor: Adenylyltransferase thiF, CALCIUM ION, SODIUM ION, ...
Authors:Ealick, S.E, Lehmann, C.
Deposit date:2005-05-30
Release date:2006-01-31
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structure of the Escherichia coli ThiS-ThiF Complex, a Key Component of the Sulfur Transfer System in Thiamin Biosynthesis.
Biochemistry, 45, 2006
3D54
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BU of 3d54 by Molmil
Structure of PurLQS from Thermotoga maritima
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Formylglycinamide ribonucleotide amidotransferase, Phosphoribosylformylglycinamidine synthase 1, ...
Authors:Ealick, S.E, Morar, M.
Deposit date:2008-05-15
Release date:2008-07-22
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation.
Biochemistry, 47, 2008
2NSJ
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BU of 2nsj by Molmil
E. coli PurE H45Q mutant complexed with CAIR
Descriptor: 5-AMINO-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID, Phosphoribosylaminoimidazole carboxylase catalytic subunit
Authors:Ealick, S.E, Morar, M.
Deposit date:2006-11-04
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:N(5)-CAIR Mutase: Role of a CO(2) Binding Site and Substrate Movement in Catalysis.
Biochemistry, 46, 2007
2NSL
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BU of 2nsl by Molmil
E. coli PurE H45N mutant complexed with CAIR
Descriptor: 5-AMINO-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID, Phosphoribosylaminoimidazole carboxylase catalytic subunit
Authors:Ealick, S.E, Morar, M.
Deposit date:2006-11-04
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:N(5)-CAIR Mutase: Role of a CO(2) Binding Site and Substrate Movement in Catalysis.
Biochemistry, 46, 2007
2NSH
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BU of 2nsh by Molmil
E. coli PurE H45Q mutant complexed with nitro-AIR
Descriptor: ((2R,3S,4R,5R)-5-(5-AMINO-4-NITRO-1H-IMIDAZOL-1-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL DIHYDROGEN PHOSPHATE, Phosphoribosylaminoimidazole carboxylase catalytic subunit
Authors:Ealick, S.E, Morar, M.
Deposit date:2006-11-04
Release date:2007-04-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:N(5)-CAIR Mutase: Role of a CO(2) Binding Site and Substrate Movement in Catalysis.
Biochemistry, 46, 2007
2QJI
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BU of 2qji by Molmil
M. jannaschii ADH synthase complexed with dihydroxyacetone phosphate and glycerol
Descriptor: 1,3-DIHYDROXYACETONEPHOSPHATE, GLYCEROL, Putative aldolase MJ0400
Authors:Ealick, S.E, Morar, M.
Deposit date:2007-07-07
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
Biochemistry, 46, 2007
2QQD
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BU of 2qqd by Molmil
N47A mutant of Pyruvoyl-dependent Arginine Decarboxylase from Methanococcus jannashii
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, AGMATINE, PYRUVIC ACID, ...
Authors:Ealick, S.E, Soriano, E.S.
Deposit date:2007-07-26
Release date:2008-03-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii.
Acta Crystallogr.,Sect.D, 64, 2008
2QRO
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BU of 2qro by Molmil
Human Deoxycytidine kinase dAMP, UDP, Mg ion product complex
Descriptor: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, Deoxycytidine kinase, MAGNESIUM ION, ...
Authors:Ealick, S.E, Soriano, E.V.
Deposit date:2007-07-28
Release date:2007-12-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Structures of human deoxycytidine kinase product complexes.
Acta Crystallogr.,Sect.D, 63, 2007
2QQC
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BU of 2qqc by Molmil
E109Q mutant of Pyruvoyl-dependent Arginine Decarboxylase from Methanococcus jannashii
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, AGMATINE, Pyruvoyl-dependent arginine decarboxylase subunit alpha, ...
Authors:Ealick, S.E, Soriano, E.S.
Deposit date:2007-07-26
Release date:2008-03-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii.
Acta Crystallogr.,Sect.D, 64, 2008
2QRN
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BU of 2qrn by Molmil
Human Deoxycytidine kinase dCMP, UDP, Mg ion product complex
Descriptor: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, Deoxycytidine kinase, MAGNESIUM ION, ...
Authors:Ealick, S.E, Soriano, E.V.
Deposit date:2007-07-28
Release date:2007-12-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structures of human deoxycytidine kinase product complexes.
Acta Crystallogr.,Sect.D, 63, 2007
2QJG
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BU of 2qjg by Molmil
M. jannaschii ADH synthase complexed with F1,6P
Descriptor: 1,6-DI-O-PHOSPHONO-D-ALLITOL, Putative aldolase MJ0400
Authors:Ealick, S.E, Morar, M.
Deposit date:2007-07-07
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
Biochemistry, 46, 2007
2QRY
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BU of 2qry by Molmil
Periplasmic thiamin binding protein
Descriptor: THIAMIN PHOSPHATE, Thiamine-binding periplasmic protein
Authors:Ealick, S.E, Soriano, E.V.
Deposit date:2007-07-30
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Similarities between Thiamin-Binding Protein and Thiaminase-I Suggest a Common Ancestor
Biochemistry, 47, 2008
2QJH
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BU of 2qjh by Molmil
M. jannaschii ADH synthase covalently bound to dihydroxyacetone phosphate
Descriptor: 1,3-DIHYDROXYACETONEPHOSPHATE, Putative aldolase MJ0400
Authors:Ealick, S.E, Morar, M.
Deposit date:2007-07-07
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
Biochemistry, 46, 2007
1T3T
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BU of 1t3t by Molmil
Structure of Formylglycinamide synthetase
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Phosphoribosylformylglycinamidine synthase, ...
Authors:Ealick, S.E, Anand, R, Hoskin, A.A, Stubbe, J.
Deposit date:2004-04-27
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Domain Organization of Salmonella typhimurium Formylglycinamide Ribonucleotide Amidotransferase Revealed by X-ray crystallography
Biochemistry, 43, 2004
1OV6
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BU of 1ov6 by Molmil
M64V PNP + ALLO
Descriptor: 9-(6-DEOXY-BETA-D-ALLOFURANOSYL)-6-METHYLPURINE, PHOSPHATE ION, Purine nucleoside phosphorylase
Authors:Ealick, S.E, Bennett, E.M, Anand, R, Secrist, J.A, Parker, P.W, Hassan, A.E, Allan, P.W, McPherson, D.T, Sorscher, E.J.
Deposit date:2003-03-25
Release date:2004-02-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem.Biol., 10, 2003
1OVG
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BU of 1ovg by Molmil
M64V PNP +MePdr
Descriptor: 9-(2-DEOXY-BETA-D-RIBOFURANOSYL)-6-METHYLPURINE, PHOSPHATE ION, Purine nucleoside phosphorylase
Authors:Ealick, S.E, Bennett, E.M, Anand, R, Secrist, J.A, Parker, P.W, Hassan, A.E, Allan, P.W, McPherson, D.T, Sorscher, E.J.
Deposit date:2003-03-26
Release date:2004-02-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem.Biol., 10, 2003

217705

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