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1FA0
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STRUCTURE OF YEAST POLY(A) POLYMERASE BOUND TO MANGANATE AND 3'-DATP
分子名称:POLY(A)-POLYMERASE, MANGANESE (II) ION, 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, ...
著者Bard, J., Zhelkovsky, A.M., Helmling, S., Moore, C.L., Bohm, A.
登録日2000-07-11
公開日2000-08-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of yeast poly(A) polymerase alone and in complex with 3'-dATP.
Science, 289, 2000
1IKO
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CRYSTAL STRUCTURE OF THE MURINE EPHRIN-B2 ECTODOMAIN
分子名称:EPHRIN-B2, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE
著者Toth, J., Cutforth, T., Gelinas, A.D., Bethoney, K.A., Bard, J., Harrison, C.J.
登録日2001-05-03
公開日2002-05-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Crystal structure of an ephrin ectodomain.
Dev.Cell, 1, 2001
1K8T
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CRYSTAL STRUCTURE OF THE ADENYLYL CYCLASE DOMAIN OF ANTHRAX EDEMA FACTOR (EF)
分子名称:CALMODULIN-SENSITIVE ADENYLATE CYCLASE, SULFATE ION, NICKEL (II) ION
著者Drum, C.L., Yan, S.-Z., Bard, J., Shen, Y.-Q., Lu, D., Soelaiman, S., Grabarek, Z., Bohm, A., Tang, W.-J.
登録日2001-10-25
公開日2002-01-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin
Nature, 415, 2002
1K90
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CRYSTAL STRUCTURE OF THE ADENYLYL CYCLASE DOMAIN OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN AND 3' DEOXY-ATP
分子名称:CALMODULIN-SENSITIVE ADENYLATE CYCLASE, CALMODULIN, YTTERBIUM (III) ION, ...
著者Drum, C.L., Yan, S.-Z., Bard, J., Shen, Y.-Q., Lu, D., Soelaiman, S., Grabarek, Z., Bohm, A., Tang, W.-J.
登録日2001-10-26
公開日2002-01-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
Nature, 415, 2002
1K93
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CRYSTAL STRUCTURE OF THE ADENYLYL CYCLASE DOMAIN OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN
分子名称:CALMODULIN-SENSITIVE ADENYLATE CYCLASE, CALMODULIN, SULFATE ION, ...
著者Drum, C.L., Yan, S.-Z., Bard, J., Shen, Y.-Q., Lu, D., Soelaiman, S., Grabarek, Z., Bohm, A., Tang, W.-J.
登録日2001-10-26
公開日2002-01-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
Nature, 415, 2002
1KAM
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STRUCTURE OF BACILLUS SUBTILIS NICOTINIC ACID MONONUCLEOTIDE ADENYLYL TRANSFERASE
分子名称:NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE
著者Olland, A.M., Underwood, K.W., Czerwinski, R.M., Lo, M.C., Aulabaugh, A., Bard, J., Stahl, M.L., Somers, W.S., Sullivan, F.X., Chopra, R.
登録日2001-11-02
公開日2002-07-12
最終更新日2014-11-12
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase.
J.Biol.Chem., 277, 2002
1KAQ
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STRUCTURE OF BACILLUS SUBTILIS NICOTINIC ACID MONONUCLEOTIDE ADENYLYL TRANSFERASE
分子名称:NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE, NICOTINIC ACID ADENINE DINUCLEOTIDE
著者Olland, A.M., Underwood, K.W., Czerwinski, R.M., Lo, M.C., Aulabaugh, A., Bard, J., Stahl, M.L., Somers, W.S., Sullivan, F.X., Chopra, R.
登録日2001-11-02
公開日2002-07-12
最終更新日2014-11-19
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase.
J.Biol.Chem., 277, 2002
1LVC
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CRYSTAL STRUCTURE OF THE ADENYLYL CYCLASE DOMAIN OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN AND 2' DEOXY, 3' ANTHRANILOYL ATP
分子名称:calmodulin-sensitive adenylate cyclase, calmodulin, YTTERBIUM (III) ION, ...
著者Shen, Y., Lee, Y.-S., Soelaiman, S., Bergson, P., Lu, D., Chen, A., Beckingham, K., Grabarek, Z., Mrksich, M., Tang, W.-J.
登録日2002-05-28
公開日2002-12-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
Embo J., 21, 2002
1S26
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STRUCTURE OF ANTHRAX EDEMA FACTOR-CALMODULIN-ALPHA,BETA-METHYLENEADENOSINE 5'-TRIPHOSPHATE COMPLEX REVEALS AN ALTERNATIVE MODE OF ATP BINDING TO THE CATALYTIC SITE
分子名称:Calmodulin-sensitive adenylate cyclase, Calmodulin, YTTERBIUM (III) ION, ...
著者Shen, Y., Zhukovskaya, N.L., Bohm, A., Tang, W.-J.
登録日2004-01-08
公開日2004-04-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of anthrax edema factor-calmodulin-adenosine-5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site
Biochem.Biophys.Res.Commun., 317, 2004
1T0Q
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STRUCTURE OF THE TOLUENE/O-XYLENE MONOOXYGENASE HYDROXYLASE
分子名称:toluene, o-xylene monooxygenase oxygenase subunit, touB, ...
著者Sazinsky, M.H., Bard, J., Di Donato, A., Lippard, S.J.
登録日2004-04-12
公開日2004-07-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase from Pseudomonas stutzeri OX1: INSIGHT INTO THE SUBSTRATE SPECIFICITY, SUBSTRATE CHANNELING, AND ACTIVE SITE TUNING OF MULTICOMPONENT MONOOXYGENASES.
J.Biol.Chem., 279, 2004
1T0R
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CRYSTAL STRUCTURE OF THE TOLUENE/O-XYLENE MONOOXYGENASE HYDROXUYLASE FROM PSEUDOMONAS STUTZERI-AZIDE BOUND
分子名称:toluene, o-xylene monooxygenase oxygenase subunit, touB, ...
著者Sazinsky, M.H., Bard, J., Di Donato, A., Lippard, S.J.
登録日2004-04-12
公開日2004-07-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase from Pseudomonas stutzeri OX1: INSIGHT INTO THE SUBSTRATE SPECIFICITY, SUBSTRATE CHANNELING, AND ACTIVE SITE TUNING OF MULTICOMPONENT MONOOXYGENASES.
J.Biol.Chem., 279, 2004
1T0S
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STRUCTURE OF THE TOLUENE/O-XYLENE MONOOXYGENASE HYDROXYLASE WITH 4-BROMOPHENOL BOUND
分子名称:toluene, o-xylene monooxygenase oxygenase subunit, touB, ...
著者Sazinsky, M.H., Bard, J., Di Donato, A., Lippard, S.J.
登録日2004-04-12
公開日2004-07-27
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase from Pseudomonas stutzeri OX1: INSIGHT INTO THE SUBSTRATE SPECIFICITY, SUBSTRATE CHANNELING, AND ACTIVE SITE TUNING OF MULTICOMPONENT MONOOXYGENASES.
J.Biol.Chem., 279, 2004
2GC8
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STRUCTURE OF A PROLINE SULFONAMIDE INHIBITOR BOUND TO HCV NS5B POLYMERASE
分子名称:RNA-directed RNA polymerase, 1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE
著者Gopalsamy, A., Chopra, R., Lim, K., Ciszewski, G., Shi, M., Curran, K.J., Sukits, S.F., Svenson, K., Bard, J., Ellingboe, J.W., Agarwal, A., Krishnamurthy, G., Howe, A.Y., Orlowski, M., Feld, B., O'connell, J., Mansour, T.S.
登録日2006-03-13
公開日2006-06-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of Proline Sulfonamides as Potent and Selective Hepatitis C Virus NS5b Polymerase Inhibitors. Evidence for a New NS5b Polymerase Binding Site.
J.Med.Chem., 49, 2006
2Q85
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CRYSTAL STRUCTURE OF E. COLI MUR B BOUND TO A NAPHTHYL TETRONIC ACID INIHIBITOR
分子名称:UDP-N-acetylenolpyruvoylglucosamine reductase, (5Z)-3-(4-CHLOROPHENYL)-4-HYDROXY-5-(1-NAPHTHYLMETHYLENE)FURAN-2(5H)-ONE, FLAVIN-ADENINE DINUCLEOTIDE
著者Chopra, R., Bard, J., Svenson, K., Mansour, T.
登録日2007-06-08
公開日2007-06-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Crystal Structure of E. Coli Mur B bound to a napthyl tetronic acid inhibitor
TO BE PUBLISHED
2QE2
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STRUCTURE OF HCV NS5B BOUND TO AN ANTHRANILIC ACID INHIBITOR
分子名称:RNA-directed RNA polymerase, 2-{[N-(2-ACETYL-5-CHLORO-4-FLUOROPHENYL)GLYCYL]AMINO}BENZOIC ACID
著者Chopra, R., Svenson, K., Bard, J.
登録日2007-06-22
公開日2007-10-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase
J.Med.Chem., 50, 2007
2QE5
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STRUCTURE OF HCV NS5B BOUND TO AN ANTHRANILIC ACID INHIBITOR
分子名称:RNA-directed RNA polymerase, 2-{[(4-CHLOROPHENOXY)ACETYL]AMINO}BENZOIC ACID
著者Chopra, R., Svenson, K., Bard, J.
登録日2007-06-22
公開日2007-10-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase
J.Med.Chem., 50, 2007
2QU2
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BACE1 WITH COMPOUND 1
分子名称:Beta-secretase 1, N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide
著者Chopra, R.
登録日2007-08-03
公開日2008-08-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Thiophene substituted acylguanidines as BACE1 inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
2QU3
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BACE1 WITH COMPOUND 2
分子名称:Beta-secretase 1, N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide
著者Chopra, R.
登録日2007-08-03
公開日2008-08-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Thiophene substituted acylguanidines as BACE1 inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
2ZDZ
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X-RAY STRUCTURE OF BACE-1 IN COMPLEX WITH COMPOUND 3.B.10
分子名称:Beta-secretase 1, N-carbamimidoyl-2-[2-(2-chlorophenyl)-5-[4-(4-ethanoylphenoxy)phenyl]pyrrol-1-yl]ethanamide
著者Chopra, R., Olland, A.
登録日2007-12-04
公開日2008-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.
Bioorg.Med.Chem.Lett., 18, 2008
2ZE1
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X-RAY STRUCTURE OF BACE-1 IN COMPLEX WITH COMPOUND 6G
分子名称:Beta-secretase 1, 3-bromo-N-[4-[1-(2-carbamimidamido-2-oxo-ethyl)-5-phenyl-pyrrol-2-yl]phenyl]benzamide
著者Chopra, R., Olland, A.
登録日2007-12-05
公開日2008-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.
Bioorg.Med.Chem.Lett., 18, 2008
3H6K
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CRYSTAL STRUCTURE OF HUMAN 11-BETA-HYDROXYSTEROID-DEHYDROGENASE BOUND TO AN ORTHO-CHLRO-SULFONYL-PIPERAZINE INHIBITOR
分子名称:Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-chloro-4-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)benzamide
著者Bard, J., Svenson, K.
登録日2009-04-23
公開日2009-12-01
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.187 Å)
主引用文献Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.
J.Med.Chem., 52, 2009
3HFG
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CRYSTAL STRUCTURE OF HUMAN 11-BETA-HYDROXYSTEROID-DEHYDROGENASE BOUND TO AN SULFONYL-PIPERAZINE INHIBITOR
分子名称:Corticosteroid 11-beta-dehydrogenase isozyme 1, (2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-{[3-(1H-1,2,4-triazol-1-yl)phenyl]sulfonyl}piperazine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Bard, J., Svenson, K.
登録日2009-05-11
公開日2009-09-29
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.
J.Med.Chem., 52, 2009
3IBE
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CRYSTAL STRUCTURE OF A PYRAZOLOPYRIMIDINE INHIBITOR BOUND TO PI3 KINASE GAMMA
分子名称:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 1-(4-{4-morpholin-4-yl-1-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenyl)-3-pyridin-4-ylurea
著者Bard, J., Svenson, K.
登録日2009-07-15
公開日2009-09-01
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.798 Å)
主引用文献ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines.
J.Med.Chem., 52, 2009
3IGB
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BACE-1 WITH COMPOUND 3
分子名称:Beta-secretase 1, 8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
著者Olland, A.M.
登録日2009-07-27
公開日2009-11-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.238 Å)
主引用文献Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors
J.Med.Chem., 52, 2009
3IN3
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BACE1 WITH COMPOUND 30
分子名称:Beta-secretase 1, (5S)-2-amino-3-methyl-5-pyridin-4-yl-5-(3-pyridin-3-ylphenyl)-3,5-dihydro-4H-imidazol-4-one
著者Olland, A.M.
登録日2009-08-11
公開日2010-01-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Di-substituted pyridinyl aminohydantoins as potent and highly selective human beta-secretase (BACE1) inhibitors.
Bioorg.Med.Chem., 18, 2010
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