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6C9G
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AMP-ACTIVATED PROTEIN KINASE BOUND TO PHARMACOLOGICAL ACTIVATOR R739
分子名称:5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Yan, Y., Zhou, X.E., Novick, S., Shaw, S.J., Li, Y., Hitoshi, Y., Brunzelle, J.S., Griffin, P.R., Xu, H.E., Melcher, K.
登録日2018-01-26
公開日2018-11-28
最終更新日2019-04-17
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
6C9H
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NON-PHOSPHORYLATED AMP-ACTIVATED PROTEIN KINASE BOUND TO PHARMACOLOGICAL ACTIVATOR R734
分子名称:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Yan, Y., Zhou, X.E., Novick, S., Shaw, S.J., Li, Y., Hitoshi, Y., Brunzelle, J.S., Griffin, P.R., Xu, H.E., Melcher, K.
登録日2018-01-26
公開日2018-11-28
最終更新日2019-01-30
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
6C9J
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AMP-ACTIVATED PROTEIN KINASE BOUND TO PHARMACOLOGICAL ACTIVATOR R734
分子名称:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Yan, Y., Zhou, X.E., Novick, S., Shaw, S.J., Li, Y., Brunzelle, J.S., Hitoshi, Y., Griffin, P.R., Xu, H.E., Melcher, K.
登録日2018-01-26
公開日2018-11-28
最終更新日2019-01-30
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
6CMO
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RHODOPSIN-GI COMPLEX
分子名称:chimera protein of Soluble cytochrome b562 and Rhodopsin, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Kang, Y., Kuybeda, O., de Waal, P.W., Mukherjee, S., Van Eps, N., Dutka, P., Zhou, X.E., Bartesaghi, A., Erramilli, S., Morizumi, T., Gu, X., Yin, Y., Liu, P., Jiang, Y., Meng, X., Zhao, G., Melcher, K., Earnst, O.P., Kossiakoff, A.A., Subramaniam, S., Xu, H.E.
登録日2018-03-05
公開日2018-06-20
最終更新日2019-04-17
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Nature, 558, 2018
4PW2
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CRYSTAL STRUCTURE OF D-GLUCURONYL C5 EPIMERASE
分子名称:D-glucuronyl C5 epimerase B, CITRIC ACID
著者Ke, J., Qin, Y., Gu, X., Brunzelle, J.S., Xu, H.E., Ding, K.
登録日2014-03-18
公開日2015-01-14
最終更新日2015-03-18
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
4PXQ
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CRYSTAL STRUCTURE OF D-GLUCURONYL C5-EPIMERASE IN COMPLEX WITH HEPARIN HEXASACCHARIDE
分子名称:D-glucuronyl C5 epimerase B, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid, N,O6-DISULFO-GLUCOSAMINE, ...
著者Ke, J., Qin, Y., Gu, X., Tan, J., Brunzelle, J.S., Xu, H.E., Ding, K.
登録日2014-03-24
公開日2015-01-14
最終更新日2015-03-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
4XAI
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CRYSTAL STRUCTURE OF RED FLOUR BEETLE NR2E1/TLX
分子名称:Maltose-binding periplasmic protein,Tailless ortholog, Grunge, isoform J, ...
著者Zhi, X., Zhou, E., Xu, E.
登録日2014-12-14
公開日2015-03-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for corepressor assembly by the orphan nuclear receptor TLX.
Genes Dev., 29, 2015
4XAJ
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CRYSTAL STRUCTURE OF HUMAN NR2E1/TLX
分子名称:Maltose-binding periplasmic protein,Nuclear receptor subfamily 2 group E member 1, Atrophin/grunge, MALTOSE
著者Zhi, X., Zhou, E., Xu, E.
登録日2014-12-14
公開日2015-03-04
最終更新日2015-07-29
実験手法X-RAY DIFFRACTION (3.551 Å)
主引用文献Structural basis for corepressor assembly by the orphan nuclear receptor TLX.
Genes Dev., 29, 2015
5J9F
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HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (4-{[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)ETHYL]AMINO}BENZOYL)-L-GLUTAMIC ACID (AGF183)
分子名称:Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid
著者Wong, J., Deis, S.M., Dann III, C.E.
登録日2016-04-09
公開日2016-08-10
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
J.Med.Chem., 59, 2016
6BD4
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CRYSTAL STRUCTURE OF HUMAN APO-FRIZZLED4 RECEPTOR
分子名称:Frizzled-4/Rubredoxin chimeric protein, ZINC ION, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
著者Yang, S., Wu, Y., Pu, M., Chen, Y., Dong, S., Guo, Y., Han, G.Y., Stevens, R.C., Zhao, S., Xu, F.
登録日2017-10-21
公開日2018-08-22
最終更新日2018-09-12
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature, 560, 2018
5CL1
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COMPLEX STRUCTURE OF NORRIN WITH HUMAN FRIZZLED 4
分子名称:Maltose-binding periplasmic protein,Norrin, Frizzled-4, N-ACETYL-D-GLUCOSAMINE
著者Wang, Z., Ke, J., Shen, G., Cheng, Z., Xu, H.E., Xu, W.
登録日2015-07-16
公開日2015-08-12
最終更新日2015-09-16
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structural basis of the Norrin-Frizzled 4 interaction.
Cell Res., 25, 2015
5EJN
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CRYSTAL STRUCTURE OF JUNO, THE MAMMALIAN EGG RECEPTOR FOR SPERM IZUMO1
分子名称:Sperm-egg fusion protein Juno, N-ACETYL-D-GLUCOSAMINE
著者Nishimura, K., Han, L., Jovine, L.
登録日2015-11-02
公開日2016-02-24
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (2.703 Å)
主引用文献Divergent evolution of vitamin B9 binding underlies Juno-mediated adhesion of mammalian gametes.
Curr.Biol., 26, 2016