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3HHR
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BU of 3hhr by Molmil
HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX
Descriptor: HUMAN GROWTH HORMONE, HUMAN GROWTH HORMONE RECEPTOR (hGHbp)
Authors:De Vos, A.M, Ultsch, M, Kossiakoff, A.A.
Deposit date:1993-12-30
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Science, 255, 1992
1TPK
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BU of 1tpk by Molmil
CRYSTAL STRUCTURE OF THE KRINGLE-2 DOMAIN OF TISSUE PLASMINOGEN ACTIVATOR AT 2.4-ANGSTROMS RESOLUTION
Descriptor: CHLORIDE ION, TISSUE PLASMINOGEN ACTIVATOR
Authors:De vos, A.M, Ultsch, M.H, Kelley, R.F, Padmanabhan, K, Tulinsky, A, Westbrook, M.L, Kossiakoff, A.A.
Deposit date:1991-09-24
Release date:1992-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
Biochemistry, 31, 1992
1A22
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BU of 1a22 by Molmil
HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR
Descriptor: GROWTH HORMONE, GROWTH HORMONE RECEPTOR
Authors:De Vos, A.M, Ultsch, M.
Deposit date:1998-01-15
Release date:1998-04-29
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.
J.Mol.Biol., 277, 1998
2VPF
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BU of 2vpf by Molmil
VASCULAR ENDOTHELIAL GROWTH FACTOR REFINED TO 1.93 ANGSTROMS RESOLUTION
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR
Authors:Muller, Y.A, De Vos, A.M.
Deposit date:1997-07-29
Release date:1998-07-29
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding.
Structure, 5, 1997
1AXI
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BU of 1axi by Molmil
STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE
Descriptor: GROWTH HORMONE, GROWTH HORMONE RECEPTOR, SULFATE ION
Authors:Atwell, S, Ultsch, M, De Vos, A.M, Wells, J.A.
Deposit date:1997-10-15
Release date:1998-01-28
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural plasticity in a remodeled protein-protein interface.
Science, 278, 1997
1BHT
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BU of 1bht by Molmil
NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEPATOCYTE GROWTH FACTOR, SULFATE ION
Authors:Ultsch, M.H, Lokker, N.A, Godowski, P.J, De Vos, A.M.
Deposit date:1998-06-10
Release date:1998-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution.
Structure, 6, 1998
1BP3
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BU of 1bp3 by Molmil
THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX
Descriptor: PROTEIN (GROWTH HORMONE), PROTEIN (PROLACTIN RECEPTOR), ZINC ION
Authors:Somers, W, Ultsch, M, De Vos, A.M, Kossiakoff, A.A.
Deposit date:1998-08-12
Release date:1998-08-19
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The X-ray structure of a growth hormone-prolactin receptor complex.
Nature, 372, 1994
1BJ1
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BU of 1bj1 by Molmil
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY
Descriptor: Fab fragment, heavy chain, light chain, ...
Authors:Muller, Y.A, Christinger, H.W, De Vos, A.M.
Deposit date:1998-06-30
Release date:1999-01-13
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface.
Structure, 6, 1998
1A21
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BU of 1a21 by Molmil
TISSUE FACTOR (TF) FROM RABBIT
Descriptor: TISSUE FACTOR
Authors:Muller, Y.A, De Vos, A.M.
Deposit date:1998-01-14
Release date:1998-05-27
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Hinge bending within the cytokine receptor superfamily revealed by the 2.4 A crystal structure of the extracellular domain of rabbit tissue factor.
Protein Sci., 7, 1998
2HFT
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BU of 2hft by Molmil
THE CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN TISSUE FACTOR AT 1.7 ANGSTROMS RESOLUTION
Descriptor: HUMAN TISSUE FACTOR, SULFATE ION
Authors:Muller, Y.A, De Vos, A.M.
Deposit date:1995-09-08
Release date:1996-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:The crystal structure of the extracellular domain of human tissue factor refined to 1.7 A resolution.
J.Mol.Biol., 256, 1996
1VPF
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BU of 1vpf by Molmil
STRUCTURE OF HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR
Authors:Muller, Y.A, De Vos, A.M.
Deposit date:1997-04-08
Release date:1998-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.
Proc.Natl.Acad.Sci.USA, 94, 1997
1S78
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BU of 1s78 by Molmil
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Pertuzumab Fab heavy chain, ...
Authors:Franklin, M.C, Carey, K.D, Vajdos, F.F, Leahy, D.J, de Vos, A.M, Sliwkowski, M.X.
Deposit date:2004-01-29
Release date:2004-04-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.
Cancer Cell, 5, 2004
1CZ8
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BU of 1cz8 by Molmil
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY
Descriptor: HEAVY CHAIN OF NEUTRALIZING ANTIBODY, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, SULFATE ION, ...
Authors:Chen, Y, Wiesmann, C, Fuh, G, Li, B, Christinger, H.W, McKay, P, de Vos, A.M, Lowman, H.B.
Deposit date:1999-09-01
Release date:2000-03-20
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293, 1999
1QTY
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BU of 1qty by Molmil
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
Descriptor: FMS-LIKE TYROSINE KINASE 1, VASCULAR ENDOTHELIAL GROWTH FACTOR
Authors:Wiesmann, C, de Vos, A.M.
Deposit date:1999-06-29
Release date:2000-01-12
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
J.Mol.Biol., 293, 1999
1RV6
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BU of 1rv6 by Molmil
Crystal Structure of PlGF in Complex with Domain 2 of VEGFR1
Descriptor: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FLT1 protein, placenta growth factor (PlGF)
Authors:Christinger, H.W, Fuh, G, de Vos, A.M, Wiesmann, C.
Deposit date:2003-12-12
Release date:2004-01-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1.
J.Biol.Chem., 279, 2004
1F6F
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BU of 1f6f by Molmil
CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR
Descriptor: PLACENTAL LACTOGEN, PROLACTIN RECEPTOR
Authors:Elkins, P.A, Christinger, H.W, Sandowski, Y, Sakal, E, Gertler, A, De Vos, A.M, Kossiakoff, A.A.
Deposit date:2000-06-21
Release date:2000-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Nat.Struct.Biol., 7, 2000
1M1L
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BU of 1m1l by Molmil
Human Suppressor of Fused (N-terminal domain)
Descriptor: Suppressor of Fused
Authors:Merchant, M, Vajdos, F.F, Ultsch, M, Maun, H.R, Wendt, U, Cannon, J, Lazarus, R.A, de Vos, A.M, de Sauvage, F.J.
Deposit date:2002-06-19
Release date:2004-02-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Suppressor of fused regulates Gli activity through a dual binding mechanism
Mol.Cell.Biol., 24, 2004
1VPP
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BU of 1vpp by Molmil
COMPLEX BETWEEN VEGF AND A RECEPTOR BLOCKING PEPTIDE
Descriptor: PROTEIN (PEPTIDE V108), PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR)
Authors:Wiesmann, C, Christinger, H.W, Cochran, A.G, Cunningham, B.C, Fairbrother, W.J, Keenan, C.J, Meng, G, de Vos, A.M.
Deposit date:1998-10-09
Release date:1999-02-23
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the complex between VEGF and a receptor-blocking peptide.
Biochemistry, 37, 1998
1WWB
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BU of 1wwb by Molmil
LIGAND BINDING DOMAIN OF HUMAN TRKB RECEPTOR
Descriptor: PROTEIN (Brain Derived Neurotrophic Factor Receptor TrkB)
Authors:Wiesmann, C, Ultsch, M.H, Bass, S.H, De Vos, A.M.
Deposit date:1999-05-03
Release date:1999-07-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.
J.Mol.Biol., 290, 1999
1WWW
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BU of 1www by Molmil
NGF IN COMPLEX WITH DOMAIN 5 OF THE TRKA RECEPTOR
Descriptor: PROTEIN (NERVE GROWTH FACTOR), PROTEIN (TRKA RECEPTOR)
Authors:Wiesmann, C, Ultsch, M.H, De Vos, A.M.
Deposit date:1999-03-12
Release date:1999-09-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor.
Nature, 401, 1999
1WWC
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BU of 1wwc by Molmil
NT3 BINDING DOMAIN OF HUMAN TRKC RECEPTOR
Descriptor: PROTEIN (NT-3 GROWTH FACTOR RECEPTOR TRKC)
Authors:Ultsch, M.H, Wiesmann, C, Simmons, L.C, Henrich, J, Yang, M, Reilly, D, Bass, S.H, De Vos, A.M.
Deposit date:1999-04-30
Release date:1999-07-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.
J.Mol.Biol., 290, 1999
1WWA
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BU of 1wwa by Molmil
NGF BINDING DOMAIN OF HUMAN TRKA RECEPTOR
Descriptor: PROTEIN (NERVE GROWTH FACTOR RECEPTOR TRKA)
Authors:Wiesmann, C, Ultsch, M.H, Bass, S.H, De Vos, A.M.
Deposit date:1999-04-29
Release date:1999-07-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.
J.Mol.Biol., 290, 1999
1OQX
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BU of 1oqx by Molmil
G-2 glycovariant of human IgG Fc bound to minimized version of Protein A called Z34C
Descriptor: Protein A Z34C, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Raju, T.S, Mulkerrin, M.G, Parker, M, De Vos, A.M, Gazzano-Santoro, H, Totpal, K, Ultsch, M.H.
Deposit date:2003-03-11
Release date:2003-03-25
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Impact of Fc Glycans on The Effector Functions Vary with the Antibody mechanism of Action
To be Published
1OQO
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BU of 1oqo by Molmil
Complex between G0 version of an Fc bound to a minimized version of Protein A called Mini-Z
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Minimized version of Protein A (Z34C), ...
Authors:Raju, T.S, Mulkerrin, M.G, Parker, M, De Vos, A.M, Gazzano-Santoro, H, Totpal, K, Ultsch, M.H.
Deposit date:2003-03-10
Release date:2003-03-20
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Impact of Fc Glycans on The Effector Functions Vary with the Antibody mechanism of Action
To be Published
1QSV
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BU of 1qsv by Molmil
THE VEGF-BINDING DOMAIN OF FLT-1, 20 NMR STRUCTURES
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1
Authors:Starovasnik, M.A, Christinger, H.W, Wiesmann, C, Champe, M.A, de Vos, A.M, Skelton, N.J.
Deposit date:1999-06-23
Release date:1999-11-10
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
J.Mol.Biol., 293, 1999

 

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