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8B5E
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BU of 8b5e by Molmil
Exploring the ligand binding and conformational dynamics of receptor domain 1 of the ABC transporter GlnPQ
Descriptor: ABC transporter permease subunit, ARGININE, DI(HYDROXYETHYL)ETHER, ...
Authors:Whittaker, J, Guskov, A.
Deposit date:2022-09-22
Release date:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Exploring the ligand binding and conformational dynamics of receptor domain 1 of the ABC transporter GlnPQ
To Be Published
8B5D
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BU of 8b5d by Molmil
Exploring the ligand binding and conformational dynamics of receptor domain 1 of the ABC transporter GlnPQ
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ABC transporter permease subunit, DI(HYDROXYETHYL)ETHER, ...
Authors:Whittaker, J, Guskov, A.
Deposit date:2022-09-22
Release date:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Exploring the ligand binding and conformational dynamics of receptor domain 1 of the ABC transporter GlnPQ
To Be Published
8BAZ
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BU of 8baz by Molmil
The surface-exposed lipo-protein of BtuG2 in complex with cyanocobalamin.
Descriptor: COB(II)INAMIDE, CYANIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Whittaker, J, Martinez-Felices, J.M, Guskov, A, Slotboom, D.J.
Deposit date:2022-10-12
Release date:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:The surface-exposed lipo-protein of BtuG2 in complex with cyanocobinamide.
To Be Published
8BAI
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BU of 8bai by Molmil
The surface-exposed lipo-protein of BtuG2 in complex with cyanocobalamin.
Descriptor: CYANOCOBALAMIN, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Whittaker, J, Martinez Felices, J.M, Guskov, A, Slotboom, D.J.
Deposit date:2022-10-11
Release date:2023-10-25
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:The surface-exposed lipo-protein of BtuG2 in complex with cyanocobalamin.
To Be Published
8BB0
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BU of 8bb0 by Molmil
The surface-exposed lipo-protein of BtuG2 in complex with hydroxycobalamin.
Descriptor: ACETATE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Whittaker, J, Felices Martinez, J.M, Guskov, A, Slotboom, D.J.
Deposit date:2022-10-12
Release date:2023-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The surface-exposed lipo-protein of BtuG2 in complex with hydroxycobinamide.
To Be Published
3FQ9
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BU of 3fq9 by Molmil
Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications
Descriptor: Insulin, ZINC ION
Authors:Zhao, M, Wan, Z.L, Whittaker, L, Xu, B, Phillips, N, Katsoyannis, P, Whittaker, J, Weiss, M.A.
Deposit date:2009-01-07
Release date:2009-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
J.Biol.Chem., 284, 2009
4ZXB
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BU of 4zxb by Molmil
Structure of the human insulin receptor ectodomain, IRDeltabeta construct, in complex with four Fab molecules
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Croll, T, Smith, B.J, Margetts, M.B, Whittaker, J, Weiss, M.A, Ward, C.W, Lawrence, M.C.
Deposit date:2015-05-20
Release date:2016-02-24
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.
Structure, 24, 2016
1T1K
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BU of 1t1k by Molmil
NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-ALA, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor: Insulin
Authors:Huang, K, Xu, B, Hu, S.Q, Chu, Y.C, Hua, Q.X, Whittaker, J, Nakagawa, S.H, De Meyts, P, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
1T1Q
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BU of 1t1q by Molmil
NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-ABA, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor: Insulin, insulin
Authors:Huang, K, Xu, B, Hu, S.Q, Chu, Y.C, Hua, Q.X, Whittaker, J, Nakagawa, S.H, De Meyts, P, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
1T1P
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BU of 1t1p by Molmil
NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-THR, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor: Insulin, insulin
Authors:Huang, K, Xu, B, Hu, S.Q, Chu, Y.C, Hua, Q.X, Whittaker, J, Nakagawa, S.H, De Meyts, P, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
3KQ6
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BU of 3kq6 by Molmil
Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:Wan, Z.L, Hu, S.Q, Whittaker, L, Phillips, N.B, Whittake, J, Ismail-Beigi, F, Weiss, M.A.
Deposit date:2009-11-17
Release date:2010-02-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
3ROV
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BU of 3rov by Molmil
Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G.
Deposit date:2011-04-26
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3BXQ
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BU of 3bxq by Molmil
The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition
Descriptor: ZINC ION, insulin A chain, insulin B chain
Authors:Wan, Z.L, Huang, K, Hu, S.Q, Whittaker, J, Weiss, M.A.
Deposit date:2008-01-14
Release date:2008-05-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition.
J.Biol.Chem., 283, 2008
3V19
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BU of 3v19 by Molmil
Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3V1G
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BU of 3v1g by Molmil
Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3JSD
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BU of 3jsd by Molmil
Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G.
Deposit date:2009-09-10
Release date:2010-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
2JUU
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BU of 2juu by Molmil
allo-ThrA3 DKP-insulin
Descriptor: Insulin A chain, Insulin B chain
Authors:Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2007-09-03
Release date:2007-10-16
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
2JUM
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BU of 2jum by Molmil
ThrA3-DKP-insulin
Descriptor: Insulin A chain, Insulin B chain
Authors:Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2007-08-31
Release date:2007-10-16
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
2JUV
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BU of 2juv by Molmil
AbaA3-DKP-insulin
Descriptor: Insulin A chain, Insulin B chain
Authors:Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2007-09-05
Release date:2007-10-16
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
5KQV
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BU of 5kqv by Molmil
Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, Insulin receptor,Insulin receptor, ...
Authors:Lawrence, M.C, Smith, B.J, Croll, T.I.
Deposit date:2016-07-06
Release date:2017-07-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:How insulin engages its primary binding site on the insulin receptor.
Nature, 493, 2013
5EMS
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BU of 5ems by Molmil
Crystal Structure of an iodinated insulin analog
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Lawrence, M.C, Pandyarajan, V, Wan, Z, Weiss, M.A.
Deposit date:2015-11-06
Release date:2016-11-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.
J. Biol. Chem., 291, 2016
3W11
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BU of 3w11 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with human insulin, Alpha-CT peptide(704-719) and FAB 83-7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
Authors:Lawrence, M.C, Smith, B.J.
Deposit date:2012-11-06
Release date:2013-01-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W13
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BU of 3w13 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alphact peptide(693-719) and FAB 83-7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
Authors:Lawrence, M.C, Smith, B.J, Brzozowski, A.M.
Deposit date:2012-11-06
Release date:2013-01-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (4.303 Å)
Cite:How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W12
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BU of 3w12 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alpha-CT peptide(704-719) and FAB 83-7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
Authors:Lawrence, M.C, Smith, B.J, Brzozowsk, A.M.
Deposit date:2012-11-06
Release date:2013-01-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (4.301 Å)
Cite:How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
5WDM
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BU of 5wdm by Molmil
An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein
Descriptor: Single-chain insulin analog
Authors:Yee, V.C, Aldabbagh, K, Peng, Y.
Deposit date:2017-07-05
Release date:2017-11-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein.
J. Biol. Chem., 293, 2018

 

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