3J4J
 
 | | Model of full-length T. thermophilus Translation Initiation Factor 2 refined against its cryo-EM density from a 30S Initiation Complex map | | Descriptor: | Translation initiation factor IF-2 | | Authors: | Simonetti, A, Marzi, S, Billas, I.M.L, Tsai, A, Fabbretti, A, Myasnikov, A, Roblin, P, Vaiana, A.C, Hazemann, I, Eiler, D, Steitz, T.A, Puglisi, J.D, Gualerzi, C.O, Klaholz, B.P. | | Deposit date: | 2013-08-26 | | Release date: | 2013-09-25 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (11.5 Å) | | Cite: | Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor.
Proc.Natl.Acad.Sci.USA, 110, 2013
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5K1H
 | | eIF3b relocated to the intersubunit face to interact with eIF1 and below the eIF2 ternary-complex. from the structure of a partial yeast 48S preinitiation complex in closed conformation. | | Descriptor: | Eukaryotic translation initiation factor 3 subunit B, eIF3a C-terminal tail | | Authors: | Simonetti, A, Brito Querido, J, Myasnikov, A.G, Mancera-Martinez, E, Renaud, A, Kuhn, L, Hashem, Y. | | Deposit date: | 2016-05-18 | | Release date: | 2016-07-13 | | Last modified: | 2018-01-31 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Mol.Cell, 63, 2016
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5K0Y
 | | m48S late-stage initiation complex, purified from rabbit reticulocytes lysates, displaying eIF2 ternary complex and eIF3 i and g subunits relocated to the intersubunit face | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S12, 40S ribosomal protein S21, ... | | Authors: | Simonetti, A, Brito Querido, J, Myasnikov, A.G, Mancera-Martinez, E, Renaud, A, Kuhn, L, Hashem, Y. | | Deposit date: | 2016-05-17 | | Release date: | 2016-07-13 | | Last modified: | 2018-04-18 | | Method: | ELECTRON MICROSCOPY (5.8 Å) | | Cite: | eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Mol.Cell, 63, 2016
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4B3X
 | | Bacterial translation initiation factor IF2 (1-363), apo form | | Descriptor: | GLYCEROL, TRANSLATION INITIATION FACTOR IF-2 | | Authors: | Simonetti, A, Urzhumtsev, A, Klaholz, B.P. | | Deposit date: | 2012-07-26 | | Release date: | 2013-05-29 | | Last modified: | 2013-06-05 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013
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4B47
 | | Bacterial translation initiation factor IF2 (1-363), complex with GDP at pH6.5 | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, TRANSLATION INITIATION FACTOR IF-2 | | Authors: | Simonetti, A, Urzhumtsev, A, Klaholz, B.P. | | Deposit date: | 2012-07-27 | | Release date: | 2013-05-29 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.301 Å) | | Cite: | Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013
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4B44
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4B48
 | | Bacterial translation initiation factor IF2 (1-363), complex with GTP | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, TRANSLATION INITIATION FACTOR IF-2 | | Authors: | Simonetti, A, Urzhumtsev, A, Klaholz, B.P. | | Deposit date: | 2012-07-27 | | Release date: | 2013-05-29 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013
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4B43
 | | Bacterial translation initiation factor IF2 (1-363), apo form, double mutant K86L H130A | | Descriptor: | GLYCEROL, IODIDE ION, MAGNESIUM ION, ... | | Authors: | Simonetti, A, Urzhumtsev, A, Klaholz, B.P. | | Deposit date: | 2012-07-27 | | Release date: | 2013-09-18 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.937 Å) | | Cite: | Molecular Basis of GTP Hydrolysis by Bacterial Translation Initiation Factor If2
To be Published
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6YAM
 | | Mammalian 48S late-stage translation initiation complex (LS48S+eIF3 IC) with beta-globin mRNA | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein eS1, 40S ribosomal protein eS10, ... | | Authors: | Bochler, A, Simonetti, A, Guca, E, Hashem, Y. | | Deposit date: | 2020-03-12 | | Release date: | 2020-04-08 | | Last modified: | 2020-04-22 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural Insights into the Mammalian Late-Stage Initiation Complexes.
Cell Rep, 31, 2020
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6YAN
 | | Mammalian 48S late-stage translation initiation complex with histone 4 mRNA | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S12, 40S ribosomal protein S21, ... | | Authors: | Bochler, A, Simonetti, A, Guca, E, Hashem, Y. | | Deposit date: | 2020-03-12 | | Release date: | 2020-04-08 | | Last modified: | 2020-04-22 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Structural Insights into the Mammalian Late-Stage Initiation Complexes.
Cell Rep, 31, 2020
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6YAL
 | | Mammalian 48S late-stage initiation complex with beta-globin mRNA | | Descriptor: | 18S ribosomal RNA, 40S Ribosomal protein uS3, 40S Ribosomal protein uS7, ... | | Authors: | Bochler, A, Simonetti, A, Guca, E, Hashem, Y. | | Deposit date: | 2020-03-12 | | Release date: | 2020-04-08 | | Last modified: | 2020-04-22 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural Insights into the Mammalian Late-Stage Initiation Complexes.
Cell Rep, 31, 2020
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5ND9
 | | Hibernating ribosome from Staphylococcus aureus (Rotated state) | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Khusainov, I, Vicens, Q, Ayupov, R, Usachev, K, Myasnikov, A, Simonetti, A, Validov, S, Kieffer, B, Yusupova, G, Yusupov, M, Hashem, Y. | | Deposit date: | 2017-03-07 | | Release date: | 2017-06-28 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF.
EMBO J., 36, 2017
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5ND8
 | | Hibernating ribosome from Staphylococcus aureus (Unrotated state) | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Khusainov, I, Vicens, Q, Ayupov, R, Usachev, K, Myasnikov, A, Simonetti, A, Validov, S, Kieffer, B, Yusupova, G, Yusupov, M, Hashem, Y. | | Deposit date: | 2017-03-07 | | Release date: | 2017-06-28 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF.
EMBO J., 36, 2017
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6GQ1
 | | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP/sordarin) | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | | Authors: | Pellegrino, S, Demeshkina, N, Mancera-Martinez, E, Melnikov, S, Simonetti, A, Myasnikov, A, Yusupov, M, Yusupova, G, Hashem, Y. | | Deposit date: | 2018-06-07 | | Release date: | 2018-07-11 | | Last modified: | 2018-08-08 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
J. Mol. Biol., 430, 2018
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5OSG
 | | Structure of KSRP in context of Leishmania donovani 80S | | Descriptor: | 18S rRNA, 40S ribosomal protein S6, RNA binding protein, ... | | Authors: | Brito Querido, J, Mancera-Martinez, E, Vicens, Q, Bochler, A, Chicher, J, Simonetti, A, Hashem, Y. | | Deposit date: | 2017-08-17 | | Release date: | 2017-11-15 | | Last modified: | 2017-12-13 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein.
Structure, 25, 2017
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5OPT
 | | Structure of KSRP in context of Trypanosoma cruzi 40S | | Descriptor: | 18S rRNA, 40S ribosomal protein S10, putative, ... | | Authors: | Brito Querido, J, Mancera-Martinez, E, Vicens, Q, Bochler, A, Chicher, J, Simonetti, A, Hashem, Y. | | Deposit date: | 2017-08-10 | | Release date: | 2017-11-15 | | Last modified: | 2017-12-13 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein.
Structure, 25, 2017
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7A01
 | | The Halastavi arva virus intergenic region IRES promotes translation by the simplest possible initiation mechanism | | Descriptor: | 18S RIBOSOMAL RNA, 28S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN ES21, ... | | Authors: | Abaeva, I, Vicens, Q, Bochler, A, Soufari, H, Simonetti, A, Pestova, T.V, Hashem, Y, Hellen, C.U.T. | | Deposit date: | 2020-08-05 | | Release date: | 2020-12-30 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | The Halastavi arva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism.
Cell Rep, 33, 2020
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6ZVK
 | | The Halastavi arva virus (HalV) intergenic region IRES promotes translation by the simplest possible initiation mechanism | | Descriptor: | 18S RIBOSOMAL RNA, 28S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN ES17, ... | | Authors: | Abaeva, I.S, Vicens, Q, Bochler, A, Soufari, H, Simonetti, A, Pestova, T, Hashem, Y, Hellen, C.U.T. | | Deposit date: | 2020-07-24 | | Release date: | 2020-12-23 | | Method: | ELECTRON MICROSCOPY (3.49 Å) | | Cite: | The Halastavi arva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism.
Cell Rep, 33, 2020
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7ASK
 | | 43S preinitiation complex from Trypanosoma cruzi with the kDDX60 helicase bound with ATP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, kDDX60 | | Authors: | Bochler, A, Brito Querido, J, Prilepskaja, T, Soufari, H, Del Cistia, M.L, Kuhn, L, Rimoldi Ribeiro, A, Valasek, L.S, Hashem, Y. | | Deposit date: | 2020-10-27 | | Release date: | 2021-04-14 | | Last modified: | 2021-04-21 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts.
Cell Rep, 33, 2020
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7ASE
 | | 43S preinitiation complex from Trypanosoma cruzi with the kDDX60 helicase | | Descriptor: | 18S, 40S ribosomal protein S10, putative, ... | | Authors: | Bochler, A, Brito Querido, J, Prilepskaja, T, Soufari, H, Del Cistia, M.L, Kuhn, L, Rimoldi Ribeiro, A, Valasek, L.S, Hashem, Y. | | Deposit date: | 2020-10-27 | | Release date: | 2021-04-14 | | Last modified: | 2021-04-21 | | Method: | ELECTRON MICROSCOPY (3.33 Å) | | Cite: | Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts.
Cell Rep, 33, 2020
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4KJZ
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5NKO
 | | Solution structure of the C-terminal domain of S. aureus Hibernating Promoting Factor (CTD-SaHPF) | | Descriptor: | Ribosome hibernation promotion factor | | Authors: | Usachev, K.S, Khusainov, I.S, Ayupov, R.K, Validov, S.Z, Kieffer, B, Yusupov, M.M. | | Deposit date: | 2017-03-31 | | Release date: | 2017-07-05 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF.
EMBO J., 36, 2017
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6GQB
 | | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GDP+AlF4/sordarin) | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | | Authors: | Pellegrino, S, Yusupov, M, Yusupova, G, Hashem, Y. | | Deposit date: | 2018-06-07 | | Release date: | 2018-07-11 | | Last modified: | 2021-08-04 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
J. Mol. Biol., 430, 2018
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6GQV
 | | Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP) | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Pellegrino, S, Yusupov, M, Yusupova, G, Hashem, Y. | | Deposit date: | 2018-06-08 | | Release date: | 2018-07-11 | | Last modified: | 2018-08-08 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
J. Mol. Biol., 430, 2018
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