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1L9K
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BU of 1l9k by Molmil
dengue methyltransferase
Descriptor: RNA-DIRECTED RNA POLYMERASE, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION
Authors:Egloff, M.P, Benarroch, D, Selisko, B, Romette, J.L, Canard, B.
Deposit date:2002-03-25
Release date:2003-03-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:An RNA cap (nucleoside-2'-O-) methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization
Embo J., 21, 2002
7ED5
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BU of 7ed5 by Molmil
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Shannon, A, Fattorini, V, Sama, B, Selisko, B, Feracci, M, Falcou, C, Gauffre, P, El Kazzi, P, Delpal, A, Decroly, E, Alvarez, K, Eydoux, C, Guillemot, J.-C, Moussa, A, Good, S, Colla, P, Lin, K, Sommadossi, J.-P, Zhu, Y.X, Yan, X.D, Shi, H, Ferron, F, Canard, B.
Deposit date:2021-03-15
Release date:2022-02-16
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.
Nat Commun, 13, 2022
3CDU
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BU of 3cdu by Molmil
Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with a pyrophosphate
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Gruez, A, Selisko, B, Roberts, M, Bricogne, G, Bussetta, C, Canard, B.
Deposit date:2008-02-27
Release date:2008-07-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases
J.Virol., 82, 2008
3CDW
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BU of 3cdw by Molmil
Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with protein primer VPg and a pyrophosphate
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Gruez, A, Selisko, B, Roberts, M, Bricogne, G, Bussetta, C, Canard, B.
Deposit date:2008-02-27
Release date:2008-07-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases
J.Virol., 82, 2008
5M5B
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BU of 5m5b by Molmil
Crystal structure of Zika virus NS5 methyltransferase
Descriptor: CHLORIDE ION, GLYCEROL, NS5 methyltransferase, ...
Authors:Barral, K, Ortiz Lombardia, M, Coutard, B, Decroly, E, Lichiere, J.
Deposit date:2016-10-21
Release date:2016-12-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.
J. Virol., 91, 2017
8BCR
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BU of 8bcr by Molmil
DENV3 Methyltransferase in complexed with AT-9010 and SAH
Descriptor: Genome polyprotein, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Gauffre, P, Fattorini, V, Canard, B, Ferron, F.
Deposit date:2022-10-17
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5.
Antiviral Res., 212, 2023
8PYW
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BU of 8pyw by Molmil
Crystal structure of the human Nucleoside-diphosphate kinase B domain bound to compound diphosphate form of AT-9052-Sp.
Descriptor: GLYCEROL, Nucleoside diphosphate kinase B, [[(2R,3R,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methoxy-sulfanyl-phosphoryl] dihydrogen phosphate
Authors:Feracci, M, Chazot, A.
Deposit date:2023-07-26
Release date:2023-12-27
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.553 Å)
Cite:An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex.
Nucleic Acids Res., 52, 2024
4NZ0
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BU of 4nz0 by Molmil
The EMCV 3Dpol structure at 2.8A resolution
Descriptor: CHLORIDE ION, GLYCEROL, Genome polyprotein
Authors:Vives-adrian, L, Ferrer-orta, C, Verdaguer, N.
Deposit date:2013-12-11
Release date:2014-03-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site
J.Virol., 88, 2014
4NYZ
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BU of 4nyz by Molmil
The EMCV 3Dpol structure with altered motif A conformation at 2.15A resolution
Descriptor: GLUTAMINE, GLYCEROL, Genome polyprotein, ...
Authors:Vives-adrian, L, Lujan, C, Ferrer-orta, C, Verdaguer, N.
Deposit date:2013-12-11
Release date:2014-03-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site
J.Virol., 88, 2014
4Y2A
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BU of 4y2a by Molmil
Crystal Structure of Coxsackie Virus B3 3D polymerase in complex with GPC-N114 inhibitor
Descriptor: 2,2'-[(4-chlorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ...
Authors:Vives-Adrian, L, Ferrer-Orta, C, Verdaguer, N.
Deposit date:2015-02-09
Release date:2015-04-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
4Y34
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BU of 4y34 by Molmil
Crystal Structure of Coxsackievirus B3 3D polymerase in complex with GPC-N143
Descriptor: 2,2'-[(4-fluorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ...
Authors:Vives-Adrian, L, Ferrer-Orta, C, Cerdaguer, N.
Deposit date:2015-02-10
Release date:2015-04-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
4Y2C
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BU of 4y2c by Molmil
M300V 3D polymerase mutant of EMCV
Descriptor: GLYCEROL, Genome polyprotein
Authors:Verdaguer, N, Ferrer-Orta, C, Vives-Adrian, L.
Deposit date:2015-02-09
Release date:2015-04-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
4Y3C
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BU of 4y3c by Molmil
I304V 3D polymerase mutant of EMCV
Descriptor: 3D polymerase, CHLORIDE ION, GLYCEROL
Authors:Verdaguer, N, Ferrer-Orta, C, Vives-Adrian, L.
Deposit date:2015-02-10
Release date:2015-04-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
6SX8
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BU of 6sx8 by Molmil
Mopeia Virus Exonuclease domain complexed with Manganese
Descriptor: MANGANESE (II) ION, Nucleoprotein, ZINC ION
Authors:Nguyen, T.H.V, Ferron, F.
Deposit date:2019-09-25
Release date:2021-07-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibition of Arenaviridae nucleoprotein exonuclease by bisphosphonate
Iucrj, 2022
6SY8
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BU of 6sy8 by Molmil
Mopeia Virus Exonuclease domain fully depleted of Manganese un ALD compound
Descriptor: Nucleoprotein, ZINC ION
Authors:Nguyen, T.H.V, Ferron, F.
Deposit date:2019-09-27
Release date:2021-07-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Inhibition of Arenaviridae nucleoprotein exonuclease by bisphosphonate
Iucrj, 2022
6T2A
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BU of 6t2a by Molmil
Mopeia Virus Exonuclease domain partially complexed with Manganese
Descriptor: DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, Nucleoprotein, ...
Authors:Nguyen, T.H.V, Ferron, F.
Deposit date:2019-10-08
Release date:2021-04-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibition of Arenaviridae nucleoprotein exonuclease by bisphosphonate
Iucrj, 2022
6T6L
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BU of 6t6l by Molmil
Mopeia Virus Exonuclease domain complexed soak with Alendronate
Descriptor: MANGANESE (II) ION, Nucleoprotein, ZINC ION
Authors:Nguyen, T.H.V, Ferron, F.
Deposit date:2019-10-18
Release date:2021-07-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.757 Å)
Cite:Inhibition of Arenaviridae nucleoprotein exonuclease by bisphosphonate
Iucrj, 2022
2HCN
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BU of 2hcn by Molmil
Crystal structure of RNA dependent RNA polymerase domain from west nile virus
Descriptor: CALCIUM ION, RNA-directed RNA polymerase (NS5), ZINC ION
Authors:Egloff, M.P, Malet, H, Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2006-06-17
Release date:2007-02-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
J.Biol.Chem., 282, 2007
2HCS
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BU of 2hcs by Molmil
Crystal structure of RNA dependant RNA polymerase domain of West Nile virus
Descriptor: RNA-directed RNA polymerase (NS5), ZINC ION
Authors:Egloff, M.P, Malet, H, Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2006-06-18
Release date:2007-02-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
J.Biol.Chem., 282, 2007
2HFZ
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BU of 2hfz by Molmil
Crystal structure of RNA dependent RNA polymerase domain from West Nile virus
Descriptor: MAGNESIUM ION, RNA-directed RNA polymerase(NS5), ZINC ION
Authors:Egloff, M.P, Malet, H, Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2006-06-26
Release date:2007-02-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
J.Biol.Chem., 282, 2007
1R6A
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BU of 1r6a by Molmil
Structure of the dengue virus 2'O methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate
Descriptor: Genome polyprotein, RIBAVIRIN MONOPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Benarroch, D, Egloff, M.P, Mulard, L, Romette, J.L, Canard, B.
Deposit date:2003-10-15
Release date:2004-09-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.
J.Biol.Chem., 279, 2004
3ELD
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BU of 3eld by Molmil
Wesselsbron methyltransferase in complex with Sinefungin
Descriptor: Methyltransferase, SINEFUNGIN, SULFATE ION
Authors:Bollati, M, Milani, M, Mastrangelo, E, Ricagno, S, Bolognesi, M.
Deposit date:2008-09-22
Release date:2008-11-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELU
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BU of 3elu by Molmil
Wesselsbron virus Methyltransferase in complex with AdoMet
Descriptor: Methyltransferase, S-ADENOSYLMETHIONINE, SULFATE ION
Authors:Bollati, M, Ricagno, S, Milani, M, Mastrangelo, E, Bolognesi, M.
Deposit date:2008-09-23
Release date:2008-11-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3EMD
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BU of 3emd by Molmil
Wesselsbron virus Methyltransferase in complex with Sinefungin and 7MeGpppA
Descriptor: P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, SINEFUNGIN, SULFATE ION, ...
Authors:Bollati, M, Milani, M, Ricagno, S, Mastrangelo, E, Bolognesi, M.
Deposit date:2008-09-24
Release date:2008-11-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELY
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BU of 3ely by Molmil
Wesselsbron virus Methyltransferase in complex with AdoHcy
Descriptor: DI(HYDROXYETHYL)ETHER, Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Bollati, M, Milani, M, Ricagno, S, Mastrangelo, E, Bolognesi, M.
Deposit date:2008-09-23
Release date:2008-11-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009

 

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