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2MNR
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MECHANISM OF THE REACTION CATALYZED BY MANDELATE RACEMASE. 2. CRYSTAL STRUCTURE OF MANDELATE RACEMASE AT 2.5 ANGSTROMS RESOLUTION: IDENTIFICATION OF THE ACTIVE SITE AND POSSIBLE CATALYTIC RESIDUES
Descriptor:MANDELATE RACEMASE, MANGANESE (II) ION, SULFATE ION
Authors:Neidhart, D.J., Petsko, G.A.
Deposit date:1993-07-06
Release date:1994-01-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanism of the reaction catalyzed by mandelate racemase. 2. Crystal structure of mandelate racemase at 2.5-A resolution: identification of the active site and possible catalytic residues.
Biochemistry, 30, 1991
1SBC
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THE REFINED CRYSTAL STRUCTURE OF SUBTILISIN CARLSBERG AT 2.5 ANGSTROMS RESOLUTION
Descriptor:SUBTILISIN CARLSBERG, CALCIUM ION
Authors:Neidhart, D.J., Petsko, G.A.
Deposit date:1988-05-13
Release date:1988-07-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The refined crystal structure of subtilisin Carlsberg at 2.5 A resolution.
Protein Eng., 2, 1988
1MNS
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ON THE ROLE OF LYSINE 166 IN THE MECHANISM OF MANDELATE RACEMASE FROM PSEUDOMONAS PUTIDA: MECHANISTIC AND CRYSTALLOGRAPHIC EVIDENCE FOR STEREOSPECIFIC ALKYLATION BY (R)-ALPHA-PHENYLGLYCIDATE
Descriptor:MANDELATE RACEMASE, MAGNESIUM ION, ATROLACTIC ACID (2-PHENYL-LACTIC ACID)
Authors:Neidhart, D.J., Landro, J.A., Kozarich, J.W.
Deposit date:1993-07-06
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The role of lysine 166 in the mechanism of mandelate racemase from Pseudomonas putida: mechanistic and crystallographic evidence for stereospecific alkylation by (R)-alpha-phenylglycidate.
Biochemistry, 33, 1994
9HVP
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DESIGN, ACTIVITY AND 2.8 ANGSTROMS CRYSTAL STRUCTURE OF A C2 SYMMETRIC INHIBITOR COMPLEXED TO HIV-1 PROTEASE
Descriptor:HIV-1 PROTEASE, benzyl [(1R,4S,6S,9R)-4,6-dibenzyl-5-hydroxy-1,9-bis(1-methylethyl)-2,8,11-trioxo-13-phenyl-12-oxa-3,7,10-triazatridec-1-yl]carbamate
Authors:Neidhart, D.J., Erickson, J.
Deposit date:1990-11-06
Release date:1992-04-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease.
Science, 249, 1990
1MDR
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THE ROLE OF LYSINE 166 IN THE MECHANISM OF MANDELATE RACEMASE FROM PSEUDOMONAS PUTIDA: MECHANISTIC AND CRYSTALLOGRAPHIC EVIDENCE FOR STEREOSPECIFIC ALKYLATION BY (R)-ALPHA-PHENYLGLYCIDATE
Descriptor:MANDELATE RACEMASE, MAGNESIUM ION, ATROLACTIC ACID (2-PHENYL-LACTIC ACID)
Authors:Landro, J.A., Gerlt, J.A., Kozarich, J.W., Koo, C.W., Shah, V.J., Kenyon, G.L., Neidhart, D.J., Fujita, S., Petsko, G.A.
Deposit date:1993-11-19
Release date:1994-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The role of lysine 166 in the mechanism of mandelate racemase from Pseudomonas putida: mechanistic and crystallographic evidence for stereospecific alkylation by (R)-alpha-phenylglycidate.
Biochemistry, 33, 1994
1PSA
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STRUCTURE OF A PEPSIN(SLASH)RENIN INHIBITOR COMPLEX REVEALS A NOVEL CRYSTAL PACKING INDUCED BY MINOR CHEMICAL ALTERATIONS IN THE INHIBITOR
Descriptor:PEPSIN A, N-(ethoxycarbonyl)-L-leucyl-N-[(1R,2S,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-leucinamide
Authors:Chen, L., Abad-Zapatero, C.
Deposit date:1991-10-22
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a pepsin/renin inhibitor complex reveals a novel crystal packing induced by minor chemical alterations in the inhibitor.
Acta Crystallogr.,Sect.B, 48, 1992
1DTN
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MANDELATE RACEMASE MUTANT D270N CO-CRYSTALLIZED WITH (S)-ATROLACTATE
Descriptor:MANDELATE RACEMASE, MAGNESIUM ION, ATROLACTIC ACID (2-PHENYL-LACTIC ACID)
Authors:Clifton, J.G., Petsko, G.A.
Deposit date:1996-03-28
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mechanism of the reaction catalyzed by mandelate racemase: importance of electrophilic catalysis by glutamic acid 317.
Biochemistry, 34, 1995
1MDL
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MANDELATE RACEMASE MUTANT K166R CO-CRYSTALLIZED WITH (R)-MANDELATE
Descriptor:MANDELATE RACEMASE, MAGNESIUM ION, (R)-MANDELIC ACID, ...
Authors:Clifton, J.G., Petsko, G.A.
Deposit date:1996-03-29
Release date:1996-10-14
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mechanism of the reaction catalyzed by mandelate racemase: structure and mechanistic properties of the K166R mutant.
Biochemistry, 34, 1995
1MRA
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MANDELATE RACEMASE MUTANT D270N CO-CRYSTALLIZED WITH (S)-ATROLACTATE
Descriptor:MANDELATE RACEMASE, MAGNESIUM ION, ATROLACTIC ACID (2-PHENYL-LACTIC ACID)
Authors:Clifton, J.G., Petsko, G.A.
Deposit date:1996-03-12
Release date:1996-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mechanism of the reaction catalyzed by mandelate racemase: structure and mechanistic properties of the D270N mutant.
Biochemistry, 35, 1996
4PHV
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X-RAY CRYSTAL STRUCTURE OF THE HIV PROTEASE COMPLEX WITH L-700,417, AN INHIBITOR WITH PSEUDO C2 SYMMETRY
Descriptor:HIV-1 PROTEASE, N,N-BIS(2-HYDROXY-1-INDANYL)-2,6- DIPHENYLMETHYL-4-HYDROXY-1,7-HEPTANDIAMIDE
Authors:Bone, R.
Deposit date:1991-10-04
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-Ray Crystal Structure of the HIV Protease Complex with L-700,417, an Inhibitor with Pseudo C2 Symmetry
J.Am.Chem.Soc., 113, 1991
1BD0
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ALANINE RACEMASE COMPLEXED WITH ALANINE PHOSPHONATE
Descriptor:ALANINE RACEMASE, {1-[(3-HYDROXY-METHYL-5-PHOSPHONOOXY-METHYL-PYRIDIN-4-YLMETHYL)-AMINO]-ETHYL}-PHOSPHONIC ACID
Authors:Stamper, G.F., Morollo, A.A., Ringe, D.
Deposit date:1998-05-12
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Reaction of alanine racemase with 1-aminoethylphosphonic acid forms a stable external aldimine.
Biochemistry, 37, 1998
1SFT
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ALANINE RACEMASE
Descriptor:ALANINE RACEMASE, ACETATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Shaw, J.P., Petsko, G.A., Ringe, D.
Deposit date:1996-09-20
Release date:1997-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Determination of the structure of alanine racemase from Bacillus stearothermophilus at 1.9-A resolution.
Biochemistry, 36, 1997
2SFP
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ALANINE RACEMASE WITH BOUND PROPIONATE INHIBITOR
Descriptor:PROTEIN (ALANINE RACEMASE), PYRIDOXAL-5'-PHOSPHATE, PROPANOIC ACID
Authors:Morollo, A.A., Petsko, G.A., Ringe, D.
Deposit date:1999-02-16
Release date:1999-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a Michaelis complex analogue: propionate binds in the substrate carboxylate site of alanine racemase.
Biochemistry, 38, 1999