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2UWR
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BU of 2uwr by Molmil
High resolution structure of human CD59
Descriptor: CD59 GLYCOPROTEIN
Authors:Leath, K.J, Johnson, S, Roversi, P, Morgan, B.P, Smith, R.A.G, Lea, S.M.
Deposit date:2007-03-23
Release date:2007-08-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:High-Resolution Structures of Bacterially Expressed Soluble Human Cd59.
Acta Crystallogr.,Sect.F, 63, 2007
2XRD
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BU of 2xrd by Molmil
Structure of the N-terminal four domains of the complement regulator Rat Crry
Descriptor: COMPLEMENT REGULATORY PROTEIN CRRY
Authors:Leath, K.J, Roversi, P, Johnson, S, Morgan, B.P, Lea, S.M.
Deposit date:2010-09-14
Release date:2011-06-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structures of the Rat Complement Regulator Crry.
Acta Crystallogr.,Sect.F, 67, 2011
2XRB
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BU of 2xrb by Molmil
Structure of the N-terminal four domains of the complement regulator Rat Crry
Descriptor: 1,2-ETHANEDIOL, COMPLEMENT REGULATORY PROTEIN CRRY, SULFATE ION
Authors:Leath, K.J, Roversi, P, Johnson, S, Morgan, B.P, Lea, S.M.
Deposit date:2010-09-13
Release date:2011-06-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the Rat Complement Regulator Crry.
Acta Crystallogr.,Sect.F, 67, 2011
2J8B
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BU of 2j8b by Molmil
High resolution structure of human CD59
Descriptor: CD59 GLYCOPROTEIN
Authors:Leath, K.J, Johnson, S, Roversi, P, Morgan, B.P, Smith, R.A.G, Lea, S.M.
Deposit date:2006-10-24
Release date:2007-08-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:High-Resolution Structures of Bacterially Expressed Soluble Human Cd59.
Acta Crystallogr.,Sect.F, 63, 2007
1OK2
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BU of 1ok2 by Molmil
Decay accelerating factor (CD55): the structure of an intact human complement regulator.
Descriptor: ACETATE ION, COMPLEMENT DECAY-ACCELERATING FACTOR, GLYCEROL, ...
Authors:Lukacik, P, Roversi, P, White, J, Esser, D, Smith, G.P, Billington, J, Williams, P.A, Rudd, P.M, Wormald, M.R, Crispin, M.D.M, Radcliffe, C.M, Dwek, R.A, Evans, D.J, Morgan, B.P, Smith, R.A.G, Lea, S.M.
Deposit date:2003-07-16
Release date:2004-01-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
1OJW
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BU of 1ojw by Molmil
Decay accelerating factor (CD55): the structure of an intact human complement regulator.
Descriptor: COMPLEMENT DECAY-ACCELERATING FACTOR, GLYCEROL, SULFATE ION
Authors:Lukacik, P, Roversi, P, White, J, Esser, D, Smith, G.P, Billington, J, Williams, P.A, Rudd, P.M, Wormald, M.R, Crispin, M.D.M, Radcliffe, C.M, Dwek, C.M, Evans, D.J, Morgan, B.P, Smith, R.A.G, Lea, S.M.
Deposit date:2003-07-16
Release date:2004-01-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
1OK3
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BU of 1ok3 by Molmil
Decay accelerating factor (cd55): the structure of an intact human complement regulator.
Descriptor: ACETATE ION, COMPLEMENT DECAY-ACCELERATING FACTOR, GLYCEROL, ...
Authors:Lukacik, P, Roversi, P, White, J, Esser, D, Smith, G.P, Billington, J, Williams, P.A, Rudd, P.M, Wormald, M.R, Crispin, M.D.M, Radcliffe, C.M, Dwek, R.A, Evans, D.J, Morgan, B.P, Smith, R.A.G, Lea, S.M.
Deposit date:2003-07-16
Release date:2004-01-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
1OJY
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BU of 1ojy by Molmil
Decay accelerating factor (cd55): the structure of an intact human complement regulator.
Descriptor: ACETATE ION, COMPLEMENT DECAY-ACCELERATING FACTOR, GLYCEROL, ...
Authors:Lukacik, P, Roversi, P, White, J, Esser, D, Smith, G.P, Billington, J, Williams, P.A, Rudd, P.M, Wormald, M.R, Crispin, M.D.M, Radcliffe, C.M, Dwek, R.A, Evans, D.J, Morgan, B.P, Smith, R.A.G, Lea, S.M.
Deposit date:2003-07-16
Release date:2004-01-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
1OK9
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BU of 1ok9 by Molmil
Decay accelerating factor (CD55): The structure of an intact human complement regulator.
Descriptor: ACETATE ION, CHLORIDE ION, COMPLEMENT DECAY-ACCELERATING FACTOR, ...
Authors:Lukacik, P, Roversi, P, White, J, Esser, D, Smith, G.P, Billington, J, Williams, P.A, Rudd, P.M, Wormald, M.R, Crispin, M.D.M, Radcliffe, C.M, Dwek, R.A, Evans, D.J, Morgan, B.P, Smith, R.A.G, Lea, S.M.
Deposit date:2003-07-21
Release date:2004-01-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
1OJV
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BU of 1ojv by Molmil
Decay accelerating factor (CD55): the structure of an intact human complement regulator.
Descriptor: ACETATE ION, COMPLEMENT DECAY-ACCELERATING FACTOR, GLYCEROL, ...
Authors:Lukacik, P, Roversi, P, White, J, Esser, D, Smith, G.P, Billington, J, Williams, P.A, Rudd, P.M, Wormald, M.R, Crispin, M.D.M, Radcliffe, C.M, Dwek, C.M, Evans, D.J, Morgan, B.P, Smith, R.A.G, Lea, S.M.
Deposit date:2003-07-16
Release date:2004-01-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
1OK1
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BU of 1ok1 by Molmil
Decay accelerating factor (cd55) : the structure of an intact human complement regulator.
Descriptor: ACETATE ION, COMPLEMENT DECAY-ACCELERATING FACTOR, GLYCEROL, ...
Authors:Lukacik, P, Roversi, P, White, J, Esser, D, Smith, G.P, Billington, J, Williams, P.A, Rudd, P.M, Wormald, M.R, Crispin, M.D.M, Radcliffe, C.M, Dwek, R.A, Evans, D.J, Morgan, B.P, Smith, R.A.G, Lea, S.M.
Deposit date:2003-07-16
Release date:2004-01-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
2UX2
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BU of 2ux2 by Molmil
High resolution structure of human CD59
Descriptor: CD59 GLYCOPROTEIN
Authors:Leath, K.J, Johnson, S, Roversi, P, Morgan, B.P, Smith, R.A.G, Lea, S.M.
Deposit date:2007-03-26
Release date:2007-08-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High-Resolution Structures of Bacterially Expressed Soluble Human Cd59.
Acta Crystallogr.,Sect.F, 63, 2007
1PE5
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BU of 1pe5 by Molmil
Thermolysin with tricyclic inhibitor
Descriptor: (6-METHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL)METHYLPHOSPHINATE, 3-METHYLBUTAN-1-AMINE, CALCIUM ION, ...
Authors:Juers, D, Holland, D, Morgan, B.P, Bartlett, P.A, Matthews, B.W.
Deposit date:2003-05-21
Release date:2004-06-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Conformational Constraint and Structural Complementarity in Thermolysin Inhibitors: Structures of Enzyme Complexes and Conclusions
To be Published
2XRC
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BU of 2xrc by Molmil
Human complement factor I
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, HUMAN COMPLEMENT FACTOR I
Authors:Roversi, P, Johnson, S, Lea, S.M.
Deposit date:2010-09-13
Release date:2011-07-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Structural Basis for Complement Factor I Control and its Disease-Associated Sequence Polymorphisms.
Proc.Natl.Acad.Sci.USA, 108, 2011
7Q6C
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BU of 7q6c by Molmil
complement C6 FIM1-2 bound to CP010 antibody
Descriptor: ACETATE ION, CP010 heavy chain, CP010 light chain, ...
Authors:Olesen, H.G, Andersen, G.R.
Deposit date:2021-11-06
Release date:2022-05-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.29274 Å)
Cite:Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex.
J Innate Immun, 2022
5M05
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BU of 5m05 by Molmil
Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP form
Descriptor: 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Sirigu, S, Hartman, J, Houdusse, A.
Deposit date:2016-10-03
Release date:2016-11-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.675 Å)
Cite:Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
6H03
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BU of 6h03 by Molmil
OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ...
Authors:Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D.
Deposit date:2018-07-06
Release date:2018-12-19
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
6H04
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BU of 6h04 by Molmil
Closed conformation of the Membrane Attack Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ...
Authors:Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D.
Deposit date:2018-07-06
Release date:2018-12-19
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
3ZD2
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BU of 3zd2 by Molmil
THE STRUCTURE OF THE TWO N-TERMINAL DOMAINS OF COMPLEMENT FACTOR H RELATED PROTEIN 1 SHOWS FORMATION OF A NOVEL DIMERISATION INTERFACE
Descriptor: 1,2-ETHANEDIOL, COMPLEMENT FACTOR H-RELATED PROTEIN 1
Authors:Caesar, J.J.E, Goicoechea de Jorge, E, Pickering, M.C, Lea, S.M.
Deposit date:2012-11-23
Release date:2013-03-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Dimerization of Complement Factor H-Related Proteins Modulates Complement Activation in Vivo.
Proc.Natl.Acad.Sci.USA, 110, 2013
3ZD1
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BU of 3zd1 by Molmil
STRUCTURE OF THE TWO C-TERMINAL DOMAINS OF COMPLEMENT FACTOR H RELATED PROTEIN 2
Descriptor: 1,2-ETHANEDIOL, COMPLEMENT FACTOR H-RELATED PROTEIN 2
Authors:Caesar, J.J.E, Goicoechea de Jorge, E, Pickering, M.C, Lea, S.M.
Deposit date:2012-11-23
Release date:2013-03-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dimerization of Complement Factor H-Related Proteins Modulates Complement Activation in Vivo.
Proc.Natl.Acad.Sci.USA, 110, 2013
4A5W
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BU of 4a5w by Molmil
Crystal structure of C5b6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COMPLEMENT C5, ...
Authors:Hadders, M.A, Bubeck, D, Forneris, F, Pangburn, M, Llorca, O, Lea, S.M, Gros, P.
Deposit date:2011-10-28
Release date:2012-03-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9.
Cell Rep., 1, 2012
5T45
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BU of 5t45 by Molmil
Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP.BeFx form
Descriptor: 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Sirigu, S, Planelles-Herrero, V.J, Hartman, J, Houdusse, A.
Deposit date:2016-08-29
Release date:2016-11-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5U3I
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BU of 5u3i by Molmil
CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT compound 31
Descriptor: 2-methoxy-5-({2-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-3-yl}methoxy)pyridine-4-carbaldehyde, CARBON MONOXIDE, Hemoglobin subunit alpha, ...
Authors:Partridge, J.R, Choy, R.M, Li, Z, Metcalf, B.
Deposit date:2016-12-02
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin.
ACS Med Chem Lett, 8, 2017
5UFJ
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BU of 5ufj by Molmil
Crystal Structure of Carbonmonoxy Hemoglobin S (Liganded Sickle Cell Hemoglobin) Complexed with GBT Compound 6
Descriptor: 5-[(imidazo[1,2-a]pyridin-8-yl)methoxy]-2-methoxypyridine-4-carbaldehyde, CARBON MONOXIDE, Hemoglobin subunit alpha, ...
Authors:Partridge, J.R, Choy, R.M, Li, Z, Metcalf, B.
Deposit date:2017-01-04
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin.
ACS Med Chem Lett, 8, 2017
1PE7
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BU of 1pe7 by Molmil
Thermolysin with bicyclic inhibitor
Descriptor: 2-(4-METHYLPHENOXY)ETHYLPHOSPHINATE, 3-METHYLBUTAN-1-AMINE, CALCIUM ION, ...
Authors:Juers, D, Yusuff, N, Bartlett, P.A, Matthews, B.W.
Deposit date:2003-05-21
Release date:2004-06-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Conformational Constraint and Structural Complementarity in Thermolysin Inhibitors: Structures of Enzyme Complexes and Conclusions
To be Published

 

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