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1O0L
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BU of 1o0l by Molmil
THE STRUCTURE OF BCL-W REVEALS A ROLE FOR THE C-TERMINAL RESIDUES IN MODULATING BIOLOGICAL ACTIVITY
Descriptor: Apoptosis regulator Bcl-W
Authors:Hinds, M.G, Lackmann, M, Skea, G.L, Harrison, P.J, Huang, D.C.S, Day, C.L.
Deposit date:2003-02-22
Release date:2003-04-01
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity
Embo J., 22, 2003
2VTY
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BU of 2vty by Molmil
Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain swapped dimer
Descriptor: PROTEIN F1
Authors:Kvansakul, M, Yang, H, Fairlie, W.D, Czabotar, P.E, Fischer, S.F, Perugini, M.A, Huang, D.C.S, Colman, P.M.
Deposit date:2008-05-19
Release date:2008-06-24
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Vaccinia Virus Anti-Apoptotic F1L is a Novel Bcl-2-Like Domain-Swapped Dimer that Binds a Highly Selective Subset of Bh3-Containing Death Ligands.
Cell Death Differ., 15, 2008
2XPX
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BU of 2xpx by Molmil
Crystal structure of BHRF1:Bak BH3 complex
Descriptor: 1,2-ETHANEDIOL, APOPTOSIS REGULATOR BHRF1, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, ...
Authors:Kvansakul, M, Huang, D.C.S, Colman, P.M.
Deposit date:2010-08-31
Release date:2011-01-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus Bhrf1.
Plos Pathog., 6, 2010
2JBX
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BU of 2jbx by Molmil
Crystal Structure of the myxoma virus anti-apoptotic protein M11L
Descriptor: M11L PROTEIN
Authors:Kvansakul, M, Van Delft, M.F, Lee, E.F, Gulbis, J.M, Fairlie, W.D, Huang, D.C.S, Colman, P.M.
Deposit date:2006-12-14
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak.
Mol.Cell, 25, 2007
2JM6
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BU of 2jm6 by Molmil
Solution structure of MCL-1 complexed with NOXAB
Descriptor: Myeloid cell leukemia-1 protein Mcl-1 homolog, Noxa
Authors:Czabotar, P.E, Lee, E.F, van Delft, M.F, Day, C.L, Smith, B.J, Huang, D.C.S, Fairlie, W.D, Hinds, M.G, Colman, P.M.
Deposit date:2006-10-17
Release date:2007-03-20
Last modified:2023-12-20
Method:SOLUTION NMR
Cite:Structural insights into the degradation of Mcl-1 induced by BH3 domains
Proc.Natl.Acad.Sci.Usa, 104, 2007
5U6V
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BU of 5u6v by Molmil
X-ray crystal structure of 1,2,3-triazolobenzodiazepine in complex with BRD2(D2)
Descriptor: 1,2-ETHANEDIOL, 5-[7-(4-chlorophenyl)-1-methyl-6,7-dihydro-5H-[1,2,3]triazolo[1,5-d][1,4]benzodiazepin-9-yl]pyridin-2-amine, Bromodomain-containing protein 2
Authors:Hatfaludi, T, Sharp, P.P, Garnier, J.-M, Burns, C.J, Czabotar, P.E.
Deposit date:2016-12-09
Release date:2017-12-13
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.775 Å)
Cite:Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors.
ACS Med Chem Lett, 8, 2017
3D7V
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BU of 3d7v by Molmil
Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand
Descriptor: Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION
Authors:Lee, E.F, Czabotar, P.E, Colman, P.M, Fairlie, W.D.
Deposit date:2008-05-22
Release date:2008-06-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
J.Cell Biol., 180, 2008
2YQ7
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BU of 2yq7 by Molmil
Structure of Bcl-xL bound to BimLOCK
Descriptor: BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11, GLYCEROL
Authors:Smith, B.J, Czabotar, P.E.
Deposit date:2012-11-06
Release date:2012-11-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity.
Acs Chem.Biol., 8, 2013
2YQ6
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BU of 2yq6 by Molmil
Structure of Bcl-xL bound to BimSAHB
Descriptor: BCL-2-LIKE PROTEIN 1, BIM BETA 5, GLYCEROL
Authors:Smith, B.J, Czabotar, P.E.
Deposit date:2012-11-06
Release date:2012-11-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity.
Acs Chem.Biol., 8, 2013
2V6Q
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BU of 2v6q by Molmil
Crystal Structure of a BHRF-1 : Bim BH3 complex
Descriptor: BCL-2-LIKE PROTEIN 11, BHRF1 PROTEIN, BROMIDE ION
Authors:Kvansakul, M, Huang, D.C.S, Colman, P.M.
Deposit date:2007-07-20
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus Bhrf1.
Plos Pathog., 6, 2010
2WH6
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BU of 2wh6 by Molmil
Crystal structure of anti-apoptotic BHRF1 in complex with the Bim BH3 domain
Descriptor: BCL-2-LIKE PROTEIN 11, BROMIDE ION, EARLY ANTIGEN PROTEIN R, ...
Authors:Kvansakul, M, Huang, D.C.S, Colman, P.M.
Deposit date:2009-05-01
Release date:2010-05-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.
PLoS Pathog., 6, 2010
6UVC
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BU of 6uvc by Molmil
Crystal structure of BCL-XL bound to compound 8: (R)-3-(Benzylthio)-2-(3-(2-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonyl)-3-(4-methylbenzyl)ureido)propanoic acid
Descriptor: (R)-3-(Benzylthio)-2-(3-(2-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonyl)-3-(4-methylbenzyl)ureido)propanoic acid, 1,2-ETHANEDIOL, Bcl-2-like protein 1, ...
Authors:Roy, M.J, Birkinshaw, R, Lessene, G, Czabotar, P.E.
Deposit date:2019-11-02
Release date:2021-05-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2.
J.Med.Chem., 64, 2021
6UVE
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BU of 6uve by Molmil
Crystal structure of BCL-XL bound to compound 7: (R)-3-(Benzylthio)-2-(3-(4-chloro-[1,1':2',1'':3'',1'''-quaterphenyl]-4'''-carbonyl)-3-(4-methylbenzyl)ureido)propanoic acid
Descriptor: (R)-3-(Benzylthio)-2-(3-(4-chloro-[1,1':2',1'':3'',1'''-quaterphenyl]-4'''-carbonyl)-3-(4-methylbenzyl)ureido)propanoic acid, 1,2-ETHANEDIOL, Bcl-2-like protein 1
Authors:Roy, M.J, Lessene, G, Czabotar, P.E.
Deposit date:2019-11-02
Release date:2021-05-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2.
J.Med.Chem., 64, 2021
6UVD
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BU of 6uvd by Molmil
Crystal structure of BCL-XL bound to compound 2: (2R)-3-(Benzylsulfanyl)-2-({[(4-methylphenyl)methyl] [(4 phenylphenyl)carbonyl] carbamoyl}amino) propanoic acid
Descriptor: (2R)-3-(Benzylsulfanyl)-2-({[(4-methylphenyl)methyl] [(4 phenylphenyl)carbonyl] carbamoyl}amino) propanoic acid, 1,2-ETHANEDIOL, Bcl-2-like protein 1, ...
Authors:Roy, M.J, Birkinshaw, R, Lessene, G, Czabotar, P.E.
Deposit date:2019-11-02
Release date:2021-05-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2.
J.Med.Chem., 64, 2021
6UVH
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BU of 6uvh by Molmil
Crystal structure of BCL-XL bound to compound 15: (R)-2-(3-(2-((4'-Chloro-[1,1'-biphenyl]-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonyl)-3-(4-methylbenzyl)ureido)-3-((cyclohexylmethyl)sulfonyl)propanoic acid
Descriptor: (R)-2-(3-(2-((4'-Chloro-[1,1'-biphenyl]-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonyl)-3-(4-methylbenzyl)ureido)-3-((cyclohexylmethyl)sulfonyl)propanoic acid, 1,2-ETHANEDIOL, Bcl-2-like protein 1, ...
Authors:Roy, M.J, Lessene, G, Czabotar, P.E.
Deposit date:2019-11-02
Release date:2021-05-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2.
J.Med.Chem., 64, 2021
6UVF
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BU of 6uvf by Molmil
Crystal structure of BCL-XL bound to compound 12: (R)-2-(3-([1,1'-Biphenyl]-4-carbonyl)-3-(4-methylbenzyl)ureido)-3-((cyclohexylmethyl)sulfonyl)propanoic acid
Descriptor: (R)-2-(3-([1,1'-Biphenyl]-4-carbonyl)-3-(4-methylbenzyl)ureido)-3-((cyclohexylmethyl)sulfonyl)propanoic acid, 1,2-ETHANEDIOL, Bcl-2-like protein 1, ...
Authors:Roy, M.J, Lessene, G, Czabotar, P.E.
Deposit date:2019-11-02
Release date:2021-05-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2.
J.Med.Chem., 64, 2021
6UVG
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BU of 6uvg by Molmil
Crystal structure of BCL-XL bound to compound 13: (R)-2-(3-([1,1'-Biphenyl]-4-carbonyl)-3-(4-methylbenzyl)ureido)-3-(((3R,5R,7R)-adamantan-1-ylmethyl)sulfonyl)propanoic acid
Descriptor: (R)-2-(3-([1,1'-Biphenyl]-4-carbonyl)-3-(4-methylbenzyl)ureido)-3-(((3R,5R,7R)-adamantan-1-ylmethyl)sulfonyl)propanoic acid, 1,2-ETHANEDIOL, Bcl-2-like protein 1, ...
Authors:Roy, M.J, Lessene, G, Czabotar, P.E.
Deposit date:2019-11-02
Release date:2021-05-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2.
J.Med.Chem., 64, 2021
3ZLR
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BU of 3zlr by Molmil
Crystal structure of BCL-XL in complex with inhibitor (WEHI-539)
Descriptor: 1,2-ETHANEDIOL, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid, BCL-2-LIKE PROTEIN 1, ...
Authors:Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M.
Deposit date:2013-02-04
Release date:2013-04-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.026 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
3ZLO
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BU of 3zlo by Molmil
Crystal structure of BCL-XL in complex with inhibitor (Compound 6)
Descriptor: 2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-5-(4-phenylbutyl)-1,3-thiazole-4-carboxylic acid, BCL-2-LIKE PROTEIN 1
Authors:Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M.
Deposit date:2013-02-04
Release date:2013-04-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
3ZK6
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BU of 3zk6 by Molmil
Crystal structure of Bcl-xL in complex with inhibitor (Compound 2).
Descriptor: BCL-2-LIKE PROTEIN 1, N-(3-(5-(1-(2-(benzo[d]thiazol-2-yl)hydrazono)ethyl)furan-2-yl)phenylsulfonyl)-6-phenylhexanamide
Authors:Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M.
Deposit date:2013-01-22
Release date:2013-04-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
3ZLN
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BU of 3zln by Molmil
Crystal structure of BCL-XL in complex with inhibitor (Compound 3)
Descriptor: 1,2-ETHANEDIOL, 6-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]pyridine-2-carboxylic acid, BCL-2-LIKE PROTEIN 1, ...
Authors:Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M.
Deposit date:2013-02-04
Release date:2013-04-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.288 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
4B4S
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BU of 4b4s by Molmil
Crystal Structure of a pro-survival Bcl-2:Bim BH3 complex
Descriptor: BCL-2-LIKE PROTEIN 10, BCL-2-LIKE PROTEIN 11, TETRAETHYLENE GLYCOL
Authors:Rautureau, G.J.P, Hinds, M.G, Kvansakul, M.
Deposit date:2012-08-01
Release date:2013-01-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Restricted Binding Repertoire of Bcl-B Leaves Bim as the Universal Bh3-Only Prosurvival Bcl-2 Protein Antagonist.
Cell Death Dis., 3, 2012
4C5D
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BU of 4c5d by Molmil
Crystal structure of Bcl-xL in complex with benzoylurea compound (42)
Descriptor: (R)-3-(4-BROMOBENZYLTHIO)-2-(3-(3-((2,4-DIFLUOROPHENYL)ETHYNYL)BENZOYL)-3-PROPYLUREIDO)PROPANOIC ACID, 1,2-ETHANEDIOL, BCL-2-LIKE PROTEIN 1, ...
Authors:Roy, M.J, Brady, R.M, Lessene, G, Colman, P.M, Czabotar, P.E.
Deposit date:2013-09-11
Release date:2014-02-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:De-Novo Designed Library of Benzoylureas as Inhibitors of Bcl-Xl: Synthesis, Structural and Biochemical Characterization.
J.Med.Chem., 57, 2014
4C52
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BU of 4c52 by Molmil
Crystal structure of Bcl-xL in complex with benzoylurea compound (39b)
Descriptor: (R)-2-(3-(3-((2,4-DIFLUOROPENYL)ETHYNYL)BENZOYL)-3-PROPYLUREIDO)-3-(ISOBUTYLTHIO) PROPANOIC ACID, 1,2-ETHANEDIOL, BCL-2-LIKE PROTEIN 1, ...
Authors:Roy, M.J, Brady, R.M, Lessene, G, Colman, P.M, Czabotar, P.E.
Deposit date:2013-09-10
Release date:2014-02-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.049 Å)
Cite:De-Novo Designed Library of Benzoylureas as Inhibitors of Bcl-Xl: Synthesis, Structural and Biochemical Characterization.
J.Med.Chem., 57, 2014
2JBY
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BU of 2jby by Molmil
A viral protein unexpectedly mimics the structure and function of pro- survival Bcl-2
Descriptor: BCL-2 HOMOLOGOUS ANTAGONIST/KILLER 2, M11L PROTEIN, SODIUM ION
Authors:Kvansakul, M, Van Delft, M.F, Lee, E.F, Gulbis, J.M, Fairlie, W.D, Huang, D.C.S, Colman, P.M.
Deposit date:2006-12-14
Release date:2007-03-27
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.
Mol. Cell, 25, 2007

 

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