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2M74
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BU of 2m74 by Molmil
1H, 13C and 15N assignments of the four N-terminal domains of human fibrillin-1
Descriptor: Fibrillin-1
Authors:Yadin, D.A, Robertson, I.B, Jensen, S.A, Handford, P.A, Redfield, C.
Deposit date:2013-04-17
Release date:2013-09-25
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of the Fibrillin-1 N-Terminal Domains Suggests that Heparan Sulfate Regulates the Early Stages of Microfibril Assembly.
Structure, 21, 2013
1APJ
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BU of 1apj by Molmil
NMR STUDY OF THE TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN-LIKE DOMAIN (TB MODULE/8-CYS DOMAIN), NMR, 21 STRUCTURES
Descriptor: FIBRILLIN
Authors:Yuan, X, Downing, A.K, Knott, V, Handford, P.A.
Deposit date:1997-07-22
Release date:1998-01-28
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Solution structure of the transforming growth factor beta-binding protein-like module, a domain associated with matrix fibrils.
EMBO J., 16, 1997
2BOX
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BU of 2box by Molmil
EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with strontium.
Descriptor: CACODYLATE ION, CHLORIDE ION, EGF-LIKE MODULE CONTAINING MUCIN-LIKE HORMONE RECEPTOR-LIKE 2 PRECURSOR, ...
Authors:Abbott, R.J.M, Spendlove, I, Roversi, P, Teriete, P, Knott, V, Handford, P.A, McDonnell, J.M, Lea, S.M.
Deposit date:2005-04-14
Release date:2006-10-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Functional Characterization of a Novel T Cell Receptor Co-Regulatory Protein Complex, Cd97-Cd55.
J.Biol.Chem., 282, 2007
2BOU
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BU of 2bou by Molmil
EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with barium.
Descriptor: BARIUM ION, CACODYLATE ION, CALCIUM ION, ...
Authors:Abbott, R.J.M, Spendlove, I, Roversi, P, Teriete, P, Knott, V, Handford, P.A, McDonnell, J.M, Lea, S.M.
Deposit date:2005-04-14
Release date:2006-10-18
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Characterization of a Novel T Cell Receptor Co-Regulatory Protein Complex, Cd97-Cd55.
J.Biol.Chem., 282, 2007
2BO2
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BU of 2bo2 by Molmil
EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with calcium.
Descriptor: CACODYLATE ION, CALCIUM ION, EGF-LIKE MODULE CONTAINING MUCIN-LIKE HORMONE RECEPTOR-LIKE 2 PRECURSOR
Authors:Abbott, R.J.M, Spendlove, I, Roversi, P, Teriete, P, Knott, V, Handford, P.A, McDonnell, J.M, Lea, S.M.
Deposit date:2005-04-07
Release date:2006-08-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and Functional Characterization of a Novel T Cell Receptor Co-Regulatory Protein Complex, Cd97-Cd55.
J.Biol.Chem., 282, 2007
1TOZ
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BU of 1toz by Molmil
NMR structure of the human NOTCH-1 ligand binding region
Descriptor: Neurogenic locus notch homolog protein 1
Authors:Hambleton, S, Valeyev, N.Y, Muranyi, A, Knott, V, Werner, J.M, Mcmichael, A.J, Handford, P.A, Downing, A.K.
Deposit date:2004-06-15
Release date:2004-10-12
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Structural and functional properties of the human notch-1 ligand binding region
STRUCTURE, 12, 2004
5FMA
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BU of 5fma by Molmil
human Notch 1, EGF 4-7
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ...
Authors:Weisshuhn, P.C, Sheppard, D, Taylor, P, Whiteman, P, Lea, S.M, Handford, P.A, Redfield, C.
Deposit date:2015-11-02
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies.
Structure, 24, 2016
5FM9
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BU of 5fm9 by Molmil
human Notch 1, EGF 4-7
Descriptor: CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
Authors:Weisshuhn, P.C, Sheppard, D, Taylor, P, Whiteman, P, Lea, S.M, Handford, P.A, Redfield, C.
Deposit date:2015-11-02
Release date:2016-04-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies.
Structure, 24, 2016
5MS9
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BU of 5ms9 by Molmil
Solution structure of Human Fibrillin-1 EGF2-EGF3-Hybrid1-cbEGF1 four domain fragment
Descriptor: CALCIUM ION, Fibrillin-1
Authors:Robertson, I.B, Redfield, C, Handford, P.A.
Deposit date:2017-01-01
Release date:2017-08-09
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1.
Structure, 25, 2017
2VJ2
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BU of 2vj2 by Molmil
Human Jagged-1, domains DSL and EGFs1-3
Descriptor: D-MALATE, JAGGED-1
Authors:Johnson, S, Cordle, J, Tay, J.Z, Roversi, P, Handford, P.A, Lea, S.M.
Deposit date:2007-12-06
Release date:2008-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Conserved Face of the Jagged/Serrate Dsl Domain is Involved in Notch Trans-Activation and Cis-Inhibition.
Nat.Struct.Mol.Biol., 15, 2008
2W86
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BU of 2w86 by Molmil
Crystal structure of fibrillin-1 domains cbEGF9hyb2cbEGF10, calcium saturated form
Descriptor: CALCIUM ION, FIBRILLIN-1, IODIDE ION
Authors:Jensen, S.A, Iqbal, S, Lowe, E.D, Redfield, C, Handford, P.A.
Deposit date:2009-01-09
Release date:2009-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and Interdomain Interactions of a Hybrid Domain: A Disulphide-Rich Module of the Fibrillin/Ltbp Superfamily of Matrix Proteins.
Structure, 17, 2009
1EMN
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BU of 1emn by Molmil
NMR STUDY OF A PAIR OF FIBRILLIN CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, MINIMIZED AVERAGE STRUCTURE
Descriptor: CALCIUM ION, FIBRILLIN
Authors:Downing, A.K, Campbell, I.D, Handford, P.A.
Deposit date:1996-08-05
Release date:1996-12-23
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders.
Cell(Cambridge,Mass.), 85, 1996
1EMO
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BU of 1emo by Molmil
NMR STUDY OF A PAIR OF FIBRILLIN CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, 22 STRUCTURES
Descriptor: CALCIUM ION, FIBRILLIN
Authors:Downing, A.K, Campbell, I.D, Handford, P.A.
Deposit date:1996-08-05
Release date:1996-12-23
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders.
Cell(Cambridge,Mass.), 85, 1996
1UZK
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BU of 1uzk by Molmil
Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, Ca bound to cbEGF23 domain only
Descriptor: CALCIUM ION, FIBRILLIN-1
Authors:Lee, S.S.J, Knott, V, Harlos, K, Handford, P.A, Stuart, D.I.
Deposit date:2004-03-13
Release date:2006-05-24
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization
Structure, 12, 2004
1UZP
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BU of 1uzp by Molmil
Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, Sm bound form cbEGF23 domain only.
Descriptor: FIBRILLIN-1, SAMARIUM (III) ION
Authors:Lee, S.S.J, Knott, V, Harlos, K, Handford, P.A, Stuart, D.I.
Deposit date:2004-03-15
Release date:2004-04-08
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization
Structure, 12, 2004
1UZJ
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BU of 1uzj by Molmil
Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, holo form.
Descriptor: CALCIUM ION, FIBRILLIN-1
Authors:Lee, S.S.J, Knott, V, Harlos, K, Handford, P.A, Stuart, D.I.
Deposit date:2004-03-12
Release date:2004-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization
Structure, 12, 2004
1UZQ
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BU of 1uzq by Molmil
Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, apo form cbEGF23 domain only.
Descriptor: FIBRILLIN-1
Authors:Lee, S.S.J, Knott, V, Harlos, K, Handford, P.A, Stuart, D.I.
Deposit date:2004-03-15
Release date:2004-04-08
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization
Structure, 12, 2004
5MWF
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BU of 5mwf by Molmil
Human Jagged2 C2-EGF2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Suckling, R.J, Handford, P.A, Lea, S.M.
Deposit date:2017-01-18
Release date:2017-06-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
5MVX
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BU of 5mvx by Molmil
Human DLL4 C2-EGF3
Descriptor: Delta-like protein 4, alpha-L-fucopyranose
Authors:Suckling, R.J, Handford, P.A, Lea, S.M.
Deposit date:2017-01-17
Release date:2017-06-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
5MW7
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BU of 5mw7 by Molmil
Human Jagged2 C2-EGF3
Descriptor: Protein jagged-2, alpha-L-fucopyranose
Authors:Suckling, R.J, Handford, P.A, Lea, S.M.
Deposit date:2017-01-18
Release date:2017-06-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
5MWB
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BU of 5mwb by Molmil
Human Notch-2 EGF11-13
Descriptor: CALCIUM ION, Neurogenic locus notch homolog protein 2, alpha-L-fucopyranose, ...
Authors:Suckling, R.J, Handford, P.A, Lea, S.M.
Deposit date:2017-01-18
Release date:2017-06-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
5MW5
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BU of 5mw5 by Molmil
Human Jagged2 C2-EGF2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Protein jagged-2
Authors:Suckling, R.J, Handford, P.A, Lea, S.M.
Deposit date:2017-01-18
Release date:2017-06-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
1HJ7
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BU of 1hj7 by Molmil
NMR study of a pair of LDL receptor Ca2+ binding epidermal growth factor-like domains, 20 structures
Descriptor: CALCIUM ION, LDL RECEPTOR
Authors:Saha, S, Handford, P.A, Campbell, I.D, Downing, A.K.
Deposit date:2001-01-09
Release date:2001-07-11
Last modified:2018-02-14
Method:SOLUTION NMR
Cite:Solution Structure of the Ldl Receptor Egf-Ab Pair: A Paradigm for the Assembly of Tandem Calcium Binding Egf Domains
Structure, 9, 2001
1KSQ
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BU of 1ksq by Molmil
NMR Study of the Third TB Domain from Latent Transforming Growth Factor-beta Binding Protein-1
Descriptor: LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 1
Authors:Lack, J, O'leary, J.M, Knott, V, Yuan, X, Rifkin, D.B, Handford, P.A, Downing, A.K.
Deposit date:2002-01-14
Release date:2003-08-26
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Solution Structure of the Third TB Domain from LTBP1 Provides Insight into Assembly of the Large Latent Complex that Sequesters Latent TGF-beta.
J.Mol.Biol., 334, 2003
1LMJ
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BU of 1lmj by Molmil
NMR Study of the Fibrillin-1 cbEGF12-13 Pair of Ca2+ Binding Epidermal Growth Factor-like Domains
Descriptor: CALCIUM ION, fibrillin 1
Authors:Smallridge, R.S, Whiteman, P, Werner, J.M, Campbell, I.D, Handford, P.A, Downing, A.K.
Deposit date:2002-05-02
Release date:2003-04-29
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution Structure and Dynamics of a Calcium Binding Epidermal Growth Factor-like Domain Pair from the Neonatal Region of Human Fibrillin-1.
J.Biol.Chem., 278, 2003

 

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