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1T5I
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BU of 1t5i by Molmil
Crystal structure of the C-terminal domain of UAP56
Descriptor: C_TERMINAL DOMAIN OF A PROBABLE ATP-DEPENDENT RNA HELICASE
Authors:Zhao, R, Green, M.R, Shen, J.
Deposit date:2004-05-04
Release date:2004-08-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of UAP56, a "DEXD/H-box" protein involved in pre-mRNA splicing and mRNA export
Structure, 12, 2004
1U2F
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BU of 1u2f by Molmil
SOLUTION STRUCTURE OF THE FIRST RNA-BINDING DOMAIN OF HU2AF65
Descriptor: PROTEIN (SPLICING FACTOR U2AF 65 KD SUBUNIT)
Authors:Ito, T, Muto, Y, Green, M.R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:1999-05-26
Release date:1999-08-20
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structures of the first and second RNA-binding domains of human U2 small nuclear ribonucleoprotein particle auxiliary factor (U2AF(65)).
EMBO J., 18, 1999
2U2F
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BU of 2u2f by Molmil
SOLUTION STRUCTURE OF THE SECOND RNA-BINDING DOMAIN OF HU2AF65
Descriptor: PROTEIN (SPLICING FACTOR U2AF 65 KD SUBUNIT)
Authors:Ito, T, Muto, Y, Green, M.R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:1999-05-26
Release date:1999-08-20
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structures of the first and second RNA-binding domains of human U2 small nuclear ribonucleoprotein particle auxiliary factor (U2AF(65)).
EMBO J., 18, 1999
1JMT
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BU of 1jmt by Molmil
X-ray Structure of a Core U2AF65/U2AF35 Heterodimer
Descriptor: HEXANE-1,6-DIOL, SPLICING FACTOR U2AF 35 KDA SUBUNIT, SPLICING FACTOR U2AF 65 KDA SUBUNIT
Authors:Kielkopf, C.L, Rodionova, N.A, Green, M.R, Burley, S.K.
Deposit date:2001-07-19
Release date:2001-09-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A novel peptide recognition mode revealed by the X-ray structure of a core U2AF35/U2AF65 heterodimer.
Cell(Cambridge,Mass.), 106, 2001
1BHI
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BU of 1bhi by Molmil
STRUCTURE OF TRANSACTIVATION DOMAIN OF CRE-BP1/ATF-2, NMR, 20 STRUCTURES
Descriptor: CRE-BP1
Authors:Nagadoi, A, Nakazawa, K, Uda, H, Maekawa, T, Ishii, S, Nishimura, Y.
Deposit date:1998-06-09
Release date:1999-06-15
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Solution structure of the transactivation domain of ATF-2 comprising a zinc finger-like subdomain and a flexible subdomain.
J.Mol.Biol., 287, 1999
4OZ0
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BU of 4oz0 by Molmil
Crystal structure of human CAPERalpha U2AF homology motif (apo-state)
Descriptor: CHLORIDE ION, RNA-binding protein 39
Authors:Loerch, S, Kielkopf, C.L.
Deposit date:2014-02-13
Release date:2014-05-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cancer-relevant splicing factor CAPER alpha engages the essential splicing factor SF3b155 in a specific ternary complex.
J.Biol.Chem., 289, 2014
4OZ1
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BU of 4oz1 by Molmil
Crystal structure of human CAPERalpha UHM bound to SF3b155 ULM5
Descriptor: CHLORIDE ION, LYSINE, POTASSIUM ION, ...
Authors:Loerch, S, Kielkopf, C.L.
Deposit date:2014-02-13
Release date:2014-05-14
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Cancer-relevant splicing factor CAPER alpha engages the essential splicing factor SF3b155 in a specific ternary complex.
J.Biol.Chem., 289, 2014
4FXX
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BU of 4fxx by Molmil
Structure of SF1 coiled-coil domain
Descriptor: IMIDAZOLE, MALONATE ION, Splicing factor 1
Authors:Gupta, A, Bauer, W.J, Wang, W, Kielkopf, C.L.
Deposit date:2012-07-03
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4801 Å)
Cite:Structure of Phosphorylated SF1 Bound to U2AF(65) in an Essential Splicing Factor Complex.
Structure, 21, 2013
4FXW
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BU of 4fxw by Molmil
Structure of phosphorylated SF1 complex with U2AF65-UHM domain
Descriptor: SULFATE ION, Splicing factor 1, Splicing factor U2AF 65 kDa subunit
Authors:Wang, W, Bauer, W.J, Wedekind, J.E, Kielkopf, C.L.
Deposit date:2012-07-03
Release date:2013-01-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structure of Phosphorylated SF1 Bound to U2AF(65) in an Essential Splicing Factor Complex.
Structure, 21, 2013
5EV1
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BU of 5ev1 by Molmil
Structure I of Intact U2AF65 Recognizing a 3' Splice Site Signal
Descriptor: DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(*UP*UP*U)-D(P*UP*UP*(BRU)P*U)-R(P*UP*U)-3'), SODIUM ION, ...
Authors:Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2015-11-19
Release date:2016-02-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.037 Å)
Cite:An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
5EV2
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BU of 5ev2 by Molmil
Structure II of Intact U2AF65 Recognizing the 3' Splice Site Signal
Descriptor: 1,4-DIETHYLENE DIOXIDE, DI(HYDROXYETHYL)ETHER, DNA (5'-R(P*UP*U)-D(P*UP*U)-R(P*U)-D(P*UP*(BRU)P*U)-3'), ...
Authors:Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2015-11-19
Release date:2016-02-24
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
5EV3
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BU of 5ev3 by Molmil
Structure III of Intact U2AF65 Recognizing the 3' Splice Site Signal
Descriptor: DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU)P*UP*U)-3'), Splicing factor U2AF 65 kDa subunit
Authors:Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2015-11-19
Release date:2016-02-24
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
5EV4
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BU of 5ev4 by Molmil
Structure IV of Intact U2AF65 Recognizing the 3' Splice Site Signal
Descriptor: DNA/RNA (5'-R(P*UP*UP*UP*(UD)P*UP*U)-D(P*(BRU)P*(UD))-R(P*C)-3'), GLYCEROL, Splicing factor U2AF 65 kDa subunit
Authors:Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
Deposit date:2015-11-19
Release date:2016-02-24
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
1T6N
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BU of 1t6n by Molmil
Crystal structure of the N-terminal domain of human UAP56
Descriptor: CITRATE ANION, Probable ATP-dependent RNA helicase
Authors:Zhao, R.
Deposit date:2004-05-06
Release date:2004-08-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal Structure of UAP56, a DExD/H-Box Protein Involved in Pre-mRNA Splicing and mRNA Export
Structure, 12, 2004
3VAG
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BU of 3vag by Molmil
Structure of U2AF65 variant with BrU3C2 DNA
Descriptor: 1,4-DIETHYLENE DIOXIDE, DNA 5'-D(*U*CP*(BRU)P*UP*UP*UP*U)-3', GLYCEROL, ...
Authors:Jenkins, J.L, Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAH
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BU of 3vah by Molmil
Structure of U2AF65 variant with BrU3C4 DNA
Descriptor: 1,4-DIETHYLENE DIOXIDE, DNA 5'-D(P*UP*UP*(BRU)P*CP*UP*UP*U)-3', GLYCEROL, ...
Authors:Jenkins, J.L, Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAL
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BU of 3val by Molmil
Structure of U2AF65 variant with BrU5C1 DNA
Descriptor: 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*C*UP*UP*UP*(BRU)P*UP*U)-3'), SULFATE ION, ...
Authors:Jenkins, J.L, Frato, K.H, Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAK
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BU of 3vak by Molmil
Structure of U2AF65 variant with BrU5 DNA
Descriptor: 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*UP*U)-3'), GLYCEROL, ...
Authors:Jenkins, J.L, Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAF
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BU of 3vaf by Molmil
Structure of U2AF65 variant with BrU3 DNA
Descriptor: 1,4-DIETHYLENE DIOXIDE, DNA 5'-D(*UP*UP*(BRU)P*(BRU)P*UP*UP*U)-3', GLYCEROL, ...
Authors:Jenkins, J.L, Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAM
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BU of 3vam by Molmil
Structure of U2AF65 variant with BrU5C2 DNA
Descriptor: 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*CP*UP*UP*(BRU)P*UP*U)-3'), GLYCEROL, ...
Authors:Jenkins, J.L, Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAJ
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BU of 3vaj by Molmil
Structure of U2AF65 variant with BrU5C6 DNA
Descriptor: 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*CP*U)-3'), GLYCEROL, ...
Authors:Jenkins, J.L, Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAI
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BU of 3vai by Molmil
Structure of U2AF65 variant with BrU3C5 DNA
Descriptor: 1,4-DIETHYLENE DIOXIDE, DNA 5'-D(*UP*UP*(BRU)P*UP*CP*UP*U)-3', GLYCEROL, ...
Authors:Jenkins, J.L, Frato, K.H, Kielkopf, C.L.
Deposit date:2011-12-29
Release date:2013-02-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
2G4B
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BU of 2g4b by Molmil
Structure of U2AF65 variant with polyuridine tract
Descriptor: 1,4-DIETHYLENE DIOXIDE, 5'-R(P*UP*UP*UP*UP*UP*UP*U)-3', Splicing factor U2AF 65 kDa subunit
Authors:Sickmier, E.A, Kielkopf, C.L.
Deposit date:2006-02-21
Release date:2006-07-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of polypyrimidine tract recognition by the essential splicing factor U2AF65.
Mol.Cell, 23, 2006
2YH1
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BU of 2yh1 by Molmil
Model of human U2AF65 tandem RRM1 and RRM2 domains with eight-site uridine binding
Descriptor: 5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP)-3', SPLICING FACTOR U2AF 65 KDA SUBUNIT
Authors:Mackereth, C.D, Madl, T, Simon, B, Zanier, K, Gasch, A, Sattler, M.
Deposit date:2011-04-26
Release date:2011-07-20
Last modified:2019-09-25
Method:SOLUTION NMR
Cite:Multi-Domain Conformational Selection Underlies Pre-Mrna Splicing Regulation by U2Af
Nature, 475, 2011
2HZC
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BU of 2hzc by Molmil
Crystal structure of the N-terminal RRM of the U2AF large subunit
Descriptor: HEXAETHYLENE GLYCOL, Splicing factor U2AF 65 kDa subunit, ZINC ION
Authors:Thickman, K.R, Sickmier, E.A, Kielkopf, C.L.
Deposit date:2006-08-08
Release date:2006-08-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Alternative Conformations at the RNA-binding Surface of the N-terminal U2AF(65) RNA Recognition Motif.
J.Mol.Biol., 366, 2007

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