4XQ8
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8XMI
| Potassium transporter KtrAB from Bacillus subtilis in ATP-bound state with addition of EDTA and EGTA, C1 symmetry | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Ktr system potassium uptake protein A, Ktr system potassium uptake protein B, ... | Authors: | Chang, Y.K, Chiang, W.T, Hu, N.J, Tsai, M.D. | Deposit date: | 2023-12-27 | Release date: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Potassium transporter KtrAB from Bacillus subtilis in ATP-bound state with addition of EDTA and EGTA, C1 symmetry To Be Published
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8XMH
| Potassium transporter KtrAB from Bacillus subtilis in ATP-bound state with addition of EDTA and EGTA, vertical C2 symmetry axis | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Ktr system potassium uptake protein A, Ktr system potassium uptake protein B, ... | Authors: | Chang, Y.K, Chiang, W.T, Hu, N.J, Tsai, M.D. | Deposit date: | 2023-12-27 | Release date: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Potassium transporter KtrAB from Bacillus subtilis in ATP-bound state with addition of EDTA and EGTA, vertical C2 symmetry axis To Be Published
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1D9S
| TUMOR SUPPRESSOR P15(INK4B) STRUCTURE BY COMPARATIVE MODELING AND NMR DATA | Descriptor: | CYCLIN-DEPENDENT KINASE 4 INHIBITOR B | Authors: | Yuan, C, Ji, L, Selby, T.L, Byeon, I.J.L, Tsai, M.D. | Deposit date: | 1999-10-29 | Release date: | 2000-07-28 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C). J.Mol.Biol., 294, 1999
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2BAX
| Atomic Resolution Structure of the Double Mutant (K53,56M) of Bovine Pancreatic Phospholipase A2 | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, ... | Authors: | Sekar, K, Yogavel, M, Velmurugan, D, Dauter, Z, Dauter, M, Tsai, M.D. | Deposit date: | 2005-10-15 | Release date: | 2005-10-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Atomic resolution (0.97 A) structure of the triple mutant (K53,56,121M) of bovine pancreatic phospholipase A2. Acta Crystallogr.,Sect.F, 61, 2005
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2B96
| Third Calcium ion found in an inhibitor bound phospholipase A2 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-METHOXYBENZOIC ACID, CALCIUM ION, ... | Authors: | Sekar, K, Velmurugan, D, Yamane, T, Tsai, M.D. | Deposit date: | 2005-10-11 | Release date: | 2006-03-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Third Calcium ion found in an inhibitor bound phospholipase A2 Acta Crystallogr.,Sect.D, 62, 2006
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5CR0
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5DDM
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5CWR
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5DDY
| Binary complex of human Polymerase lambda with dCTP | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA polymerase lambda, MAGNESIUM ION, ... | Authors: | Liu, M.S, Tsai, M.D. | Deposit date: | 2015-08-25 | Release date: | 2016-02-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.36 Å) | Cite: | Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda J.Am.Chem.Soc., 138, 2016
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5DKW
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7CGY
| Human DMC1 Q244M mutant of the post-synaptic complexes | Descriptor: | CALCIUM ION, Meiotic recombination protein DMC1/LIM15 homolog, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Chi, H.Y, Ho, M.C, Tsai, M.D, Luo, S.C, Yeh, H.Y. | Deposit date: | 2020-07-03 | Release date: | 2020-11-18 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. Nat Commun, 12, 2021
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7C9C
| Human DMC1 pre-synaptic complexes | Descriptor: | CALCIUM ION, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Meiotic recombination protein DMC1/LIM15 homolog, ... | Authors: | Luo, S.C, Yeh, H.Y, Chi, P, Ho, M.C, Tsai, M.D. | Deposit date: | 2020-06-05 | Release date: | 2020-11-25 | Last modified: | 2021-01-27 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. Nat Commun, 12, 2021
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7C99
| Human DMC1 post-synaptic complexes with mismatched dsDNA | Descriptor: | CALCIUM ION, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ... | Authors: | Luo, S.C, Yeh, H.Y, Chi, P, Ho, M.C, Tsai, M.D. | Deposit date: | 2020-06-05 | Release date: | 2020-11-18 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. Nat Commun, 12, 2021
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7C9A
| Human RAD51 post-synaptic complexes mutant (V273P, D274G) | Descriptor: | CALCIUM ION, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ... | Authors: | Chi, H.Y, Ho, M.C, Tsai, M.D, Luo, S.C, Yeh, H.Y. | Deposit date: | 2020-06-05 | Release date: | 2020-11-18 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. Nat Commun, 12, 2021
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7C98
| Human DMC1 post-synaptic complexes | Descriptor: | CALCIUM ION, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ... | Authors: | Luo, S.C, Yeh, H.Y, Chi, P, Ho, M.C, Tsai, M.D. | Deposit date: | 2020-06-05 | Release date: | 2020-11-18 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. Nat Commun, 12, 2021
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1C74
| Structure of the double mutant (K53,56M) of phospholipase A2 | Descriptor: | CALCIUM ION, PHOSPHOLIPASE A2 | Authors: | Sekar, K, Tsai, M.D, Jain, M.K, Ramakumar, S. | Deposit date: | 2000-01-22 | Release date: | 2000-07-22 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis of the anionic interface preference and k*cat activation of pancreatic phospholipase A2. Biochemistry, 39, 2000
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5XZW
| Crystal structure of Rad53 1-466 | Descriptor: | Serine/threonine-protein kinase RAD53 | Authors: | Weng, J.H, Tsai, M.D. | Deposit date: | 2017-07-14 | Release date: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Phospho-Priming Confers Functionally Relevant Specificities for Rad53 Kinase Autophosphorylation Biochemistry, 56, 2017
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1GH4
| Structure of the triple mutant (K56M, K120M, K121M) of phospholipase A2 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, PHOSPHOLIPASE A2 | Authors: | Sekar, K, Velmurugan, D, Tsai, M.D. | Deposit date: | 2000-11-09 | Release date: | 2001-05-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Observation of additional calcium ion in the crystal structure of the triple mutant K56,120,121M of bovine pancreatic phospholipase A2. J.Mol.Biol., 324, 2002
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2AFF
| The solution structure of the Ki67FHA/hNIFK(226-269)3P complex | Descriptor: | Antigen KI-67, MKI67 FHA domain interacting nucleolar phosphoprotein | Authors: | Byeon, I.-J.L, Li, H, Song, H, Gronenborn, A.M, Tsai, M.D. | Deposit date: | 2005-07-25 | Release date: | 2005-10-25 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67. Nat.Struct.Mol.Biol., 12, 2005
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2X9L
| Crystal structure of deacetylase-bog complex in biosynthesis pathway of teicoplanin. | Descriptor: | N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE, ZINC ION, octyl beta-D-glucopyranoside | Authors: | Chan, H.C, Huang, Y.T, Lyu, S.Y, Huang, C.J, Li, Y.S, Liu, Y.C, Chou, C.C, Tsai, M.D, Li, T.L. | Deposit date: | 2010-03-23 | Release date: | 2011-02-09 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.732 Å) | Cite: | Regioselective Deacetylation Based on Teicoplanin-Complexed Orf2 Crystal Structures. Mol.Biosyst., 7, 2011
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2XAD
| Crystal structure of deacetylase-teicoplanin complex in biosynthesis pathway of teicoplanin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-beta-D-glucopyranose, 8-METHYLNONANOIC ACID, ... | Authors: | Chan, H.C, Huang, Y.T, Lyu, S.Y, Huang, C.J, Li, Y.S, Liu, Y.C, Chou, C.C, Tsai, M.D, Li, T.L. | Deposit date: | 2010-03-31 | Release date: | 2011-03-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Regioselective Deacetylation Based on Teicoplanin-Complexed Orf2 Crystal Structures. Mol.Biosyst., 7, 2011
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8KE3
| PylRS C-terminus domain mutant bound with D-3-trifluoromethylphenylalanine and AMPNP | Descriptor: | (2R)-2-azanyl-3-[3-(trifluoromethyl)phenyl]propanoic acid, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Weng, J.H, Tsai, M.D, Wang, Y.S. | Deposit date: | 2023-08-11 | Release date: | 2023-11-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.89980984 Å) | Cite: | Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids. Front Genet, 14, 2023
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8KE2
| PylRS C-terminus domain mutant bound with L-3-trifluoromethylphenylalanine and AMPNP | Descriptor: | (2S)-2-azanyl-3-[3-(trifluoromethyl)phenyl]propanoic acid, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Weng, J.H, Tsai, M.D, Wang, Y.S. | Deposit date: | 2023-08-11 | Release date: | 2023-11-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.19639969 Å) | Cite: | Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids. Front Genet, 14, 2023
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8KE5
| PylRS C-terminus domain mutant bound with D-3-chlorophenylalanine and AMPNP | Descriptor: | (2R)-2-azanyl-3-(3-chlorophenyl)propanoic acid, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Weng, J.H, Tsai, M.D, Wang, Y.S. | Deposit date: | 2023-08-11 | Release date: | 2023-11-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.900073 Å) | Cite: | Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids. Front Genet, 14, 2023
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