Author results

3GGQ
  • Download 3ggq
  • View 3ggq
Molmil generated image of 3ggq
DIMERIZATION OF HEPATITIS E VIRUS CAPSID PROTEIN E2S DOMAIN IS ESSENTIAL FOR VIRUS-HOST INTERACTION
Descriptor:Capsid protein, BROMIDE ION
Authors:Li, S.W., Tang, X.H., Seetharaman, J., Yang, C.Y., Gu, Y., Zhang, J., Du, H.L., Shih, J.W.K., Hew, C.L., Sivaraman, J., Xia, N.S.
Deposit date:2009-03-02
Release date:2009-08-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dimerization of hepatitis E virus capsid protein E2s domain is essential for virus-host interaction
Plos Pathog., 5, 2009
3RKC
  • Download 3rkc
  • View 3rkc
Molmil generated image of 3rkc
HEPATITIS E VIRUS CAPSID PROTEIN E2S DOMAIN (GENOTYPE IV)
Descriptor:Capsid protein
Authors:Tang, X.H., Sivaraman, J.
Deposit date:2011-04-18
Release date:2011-06-08
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural basis for the neutralization and genotype specificity of hepatitis E virus
Proc.Natl.Acad.Sci.USA, 108, 2011
3RKD
  • Download 3rkd
  • View 3rkd
Molmil generated image of 3rkd
HEPATITIS E VIRUS E2S DOMAIN (GENOTYPE I) IN COMPLEX WITH A NEUTRALIZING ANTIBODY
Descriptor:Capsid protein, Monoclonal Antibody, Light Chain, ...
Authors:Tang, X.H., Sivaraman, J.
Deposit date:2011-04-18
Release date:2011-06-08
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the neutralization and genotype specificity of hepatitis E virus
Proc.Natl.Acad.Sci.USA, 108, 2011
4FRS
  • Download 4frs
  • View 4frs
Molmil generated image of 4frs
STRUCTURE OF BACE IN COMPLEX WITH (S)-4-(3-CHLORO-5-(5-(PROP-1-YN-1-YL)PYRIDIN-3-YL)THIOPHEN-2-YL)-1,4-DIMETHYL-6-OXOTETRAHYDROPYRIMIDIN-2(1H)-IMINIUM
Descriptor:Beta-secretase 1, (2Z,6S)-6-{3-chloro-5-[5-(prop-1-yn-1-yl)pyridin-3-yl]thiophen-2-yl}-2-imino-3,6-dimethyltetrahydropyrimidin-4(1H)-one
Authors:Orth, P.
Deposit date:2012-06-26
Release date:2012-08-08
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS A(beta) Reduction
ACS Med Chem Lett, 3, 2012
4PLK
  • Download 4plk
  • View 4plk
Molmil generated image of 4plk
HEPATITIS E VIRUS E2S DOMAIN (GENOTYPE I) IN COMPLEX WITH A NEUTRALIZING ANTIBODY 8G12
Descriptor:Capsid protein, 8G12 light chain, 8G12 heavy chain
Authors:Tang, X.H., Li, S.W., Sivaraman, J.
Deposit date:2014-05-18
Release date:2015-04-08
Last modified:2015-05-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody
Cell Res., 25, 2015
4PLJ
  • Download 4plj
  • View 4plj
Molmil generated image of 4plj
HEPATITIS E VIRUS E2S DOMAIN (GENOTYPE IV) IN COMPLEX WITH A NEUTRALIZING ANTIBODY 8G12
Descriptor:Capsid protein, 8G12 light chain, 8G12 heavy chain
Authors:Tang, X.H., Li, S.W., Sivaraman, J.
Deposit date:2014-05-18
Release date:2015-04-15
Last modified:2015-05-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody
Cell Res., 25, 2015
5J6R
  • Download 5j6r
  • View 5j6r
Molmil generated image of 5j6r
CRYSTAL STRUCTURE OF HUMAN PAPILLOMAVIRUS TYPE 59 L1 PENTAMER
Descriptor:Major capsid protein L1
Authors:Li, Z.H., Yan, X.D., Yu, H., Gu, Y., Li, S.W.
Deposit date:2016-04-05
Release date:2016-05-18
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (4.011 Å)
Cite:The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction.
Structure, 24, 2016
5JB1
  • Download 5jb1
  • View 5jb1
Molmil generated image of 5jb1
PSEUDO-ATOMIC STRUCTURE OF HUMAN PAPILLOMAVIRUS TYPE 59 L1 VIRUS-LIKE PARTICLE
Descriptor:Major capsid protein L1
Authors:Li, Z.H., Yan, X.D., Yu, H., Zheng, Q.B., Gu, Y., Li, S.W.
Deposit date:2016-04-13
Release date:2016-05-18
Last modified:2017-10-18
Method:ELECTRON MICROSCOPY (6 Å)
Cite:The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction.
Structure, 24, 2016
5HTZ
  • Download 5htz
  • View 5htz
Molmil generated image of 5htz
BACE1 IN COMPLEX WITH (S)-5-(3-CHLORO-5-(5-(PROP-1-YN-1-YL)PYRIDIN-3-YL)THIOPHEN-2-YL)-2,5-DIMETHYL-1,2,4-THIADIAZINAN-3-IMINIUM 1,1-DIOXIDE
Descriptor:Beta-secretase 1, (3E,5S)-5-{3-chloro-5-[5-(prop-1-yn-1-yl)pyridin-3-yl]thiophen-2-yl}-2,5-dimethyl-1,2,4-thiadiazinan-3-imine 1,1-dioxide
Authors:Orth, P.
Deposit date:2016-01-27
Release date:2016-11-09
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.
J. Med. Chem., 59, 2016
5HU0
  • Download 5hu0
  • View 5hu0
Molmil generated image of 5hu0
BACE1 IN COMPLEX WITH 4-(3-(FURAN-2-CARBOXAMIDO)PHENYL)-1-METHYL-5-OXO-4-PHENYLIMIDAZOLIDIN-2-IMINIUM
Descriptor:Beta-secretase 1, L(+)-TARTARIC ACID, N-{3-[(2E,4R)-2-imino-1-methyl-5-oxo-4-phenylimidazolidin-4-yl]phenyl}furan-2-carboxamide
Authors:Orth, P.
Deposit date:2016-01-27
Release date:2016-11-09
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.
J. Med. Chem., 59, 2016
5HU1
  • Download 5hu1
  • View 5hu1
Molmil generated image of 5hu1
BACE1 IN COMPLEX WITH (R)-N-(3-(3-AMINO-2,5-DIMETHYL-1,1-DIOXIDO-5,6-DIHYDRO-2H-1,2,4-THIADIAZIN-5-YL)-4-FLUOROPHENYL)-5-FLUOROPICOLINAMIDE
Descriptor:Beta-secretase 1, N-{3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide
Authors:Orth, P.
Deposit date:2016-01-27
Release date:2016-11-09
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.
J. Med. Chem., 59, 2016
5U6I
  • Download 5u6i
  • View 5u6i
Molmil generated image of 5u6i
DISCOVERY OF MLI-2, AN ORALLY AVAILABLE AND SELECTIVE LRRK2 INHIBITOR THAT REDUCES BRAIN KINASE ACTIVITY
Descriptor:Mitogen-activated protein kinase 1, 3-[2-(morpholin-4-yl)pyridin-4-yl]-5-[(propan-2-yl)oxy]-1H-indazole, SULFATE ION
Authors:Scott, J.D., DeMong, D.E., Fell, M.J., Mirescu, C., Basu, K., Greshock, T.J., Morrow, J.A., Xiao, L., Hruza, A., Harris, J., Tiscia, H.E., Chang, R.K., Embrey, M.W., McCauley, J.A., Li, W., Lin, S., Liu, H., Dai, X., Baptista, M., Agnihotri, G., Columbus, J., Mei, H., Poirier, M., Zhou, X., Lin, Y., Yin, Z., Sanders, J.M., Drolet, R.E., Kern, J.T., Kennedy, M.E., Parker, E.M., Stamford, A.W., Nargund, R., Miller, M.W.
Deposit date:2016-12-08
Release date:2017-03-15
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.
J. Med. Chem., 60, 2017
5XS4
  • Download 5xs4
  • View 5xs4
Molmil generated image of 5xs4
STRUCTURE OF COXSACKIEVIRUS A6 (CVA6) VIRUS A-PARTICLE
Descriptor:Genome polyprotein
Authors:Zheng, Q.B., He, M.Z., Xu, L.F., Yu, H., Li, S.W., Cheng, T.
Deposit date:2017-06-12
Release date:2017-09-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody
Nat Commun, 8, 2017
5XS5
  • Download 5xs5
  • View 5xs5
Molmil generated image of 5xs5
STRUCTURE OF COXSACKIEVIRUS A6 (CVA6) VIRUS PROCAPSID PARTICLE
Descriptor:Genome polyprotein
Authors:Zheng, Q.B., He, M.Z., Xu, L.F., Yu, H., Cheng, T., Li, S.W.
Deposit date:2017-06-12
Release date:2017-09-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody
Nat Commun, 8, 2017
5XS7
  • Download 5xs7
  • View 5xs7
Molmil generated image of 5xs7
STRUCTURE OF COXSACKIEVIRUS A6 (CVA6) VIRUS A-PARTICLE IN COMPLEX WITH THE NEUTRALIZING ANTIBODY FRAGMENT 1D5
Descriptor:Light chain of Fab 1D5, Heavy chain of Fab 1D5, Genome polyprotein
Authors:Zheng, Q.B., He, M.Z., Xu, L.F., Yu, H., Li, S.W., Cheng, T.
Deposit date:2017-06-12
Release date:2017-09-27
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody
Nat Commun, 8, 2017
5Y9C
  • Download 5y9c
  • View 5y9c
Molmil generated image of 5y9c
CRYSTAL STRUCTURE OF HPV58 PENTAMER IN COMPLEX WITH THE FAB FRAGMENT OF ANTIBODY A12A3
Descriptor:Major capsid protein L1, heavy chain of Fab fragment of antibody A12A3, light chain of Fab fragment of antibody A12A3
Authors:Li, S.W., Li, Z.H.
Deposit date:2017-08-24
Release date:2017-10-25
Method:X-RAY DIFFRACTION (3.443 Å)
Cite:Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus.
MBio, 8, 2017
5Y9E
  • Download 5y9e
  • View 5y9e
Molmil generated image of 5y9e
CRYSTAL STRUCTURE OF HPV58 PENTAMER
Descriptor:Major capsid protein L1, GLYCEROL, MAGNESIUM ION
Authors:Li, S.W., Li, Z.H.
Deposit date:2017-08-24
Release date:2017-10-25
Method:X-RAY DIFFRACTION (2.042 Å)
Cite:Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus.
MBio, 8, 2017
5Y9F
  • Download 5y9f
  • View 5y9f
Molmil generated image of 5y9f
CRYSTAL STRUCTURE OF HPV59 PENTAMER IN COMPLEX WITH THE FAB FRAGMENT OF ANTIBODY 28F10
Descriptor:Major capsid protein L1, light chains of Fab fragment of antibody 28F10, heavy chain of Fab fragment of antibody 28F10
Authors:Li, S.W., Li, Z.H.
Deposit date:2017-08-24
Release date:2017-10-25
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus.
MBio, 8, 2017
6AJ0
  • Download 6aj0
  • View 6aj0
Molmil generated image of 6aj0
THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION
Descriptor:Viral protein 1, Virion protein 2, Capsid protein VP3, ...
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-25
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6AJ2
  • Download 6aj2
  • View 6aj2
Molmil generated image of 6aj2
THE STRUCTURE OF ICAM-5 TRIGGERED ENTEROVIRUS D68 VIRUS A-PARTICLE
Descriptor:Capsid protein VP1, Capsid protein VP2, Capsid protein VP3
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-26
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6AJ3
  • Download 6aj3
  • View 6aj3
Molmil generated image of 6aj3
THE STRUCTURE OF ENTEROVIRUS D68 PROCAPSID
Descriptor:Capsid protein VP1, Capsid protein VP2, Capsid protein VP3
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-26
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6AJ7
  • Download 6aj7
  • View 6aj7
Molmil generated image of 6aj7
THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION IN COMPLEX WITH FAB 15C5
Descriptor:VL of Fab 15C5, VH of Fab 15C5, Capsid protein VP1, ...
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-27
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6AJ9
  • Download 6aj9
  • View 6aj9
Molmil generated image of 6aj9
THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION IN COMPLEX WITH FAB 15C5 AND 11G1
Descriptor:VL of Fab 11G1, VH of Fab 11G1, VL of Fab 15C5, ...
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-27
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6ACU
  • Download 6acu
  • View 6acu
Molmil generated image of 6acu
THE STRUCTURE OF CVA10 VIRUS MATURE VIRION
Descriptor:VP1, VP2, VP3, ...
Authors:Cui, Y.X., Zheng, Q.B., Zhu, R., Xu, L.F., Li, S.W., Yan, X.D., Zhou, Z.H., Cheng, T.
Deposit date:2018-07-27
Release date:2018-11-21
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10.
Sci Adv, 4, 2018
6ACW
  • Download 6acw
  • View 6acw
Molmil generated image of 6acw
THE STRUCTURE OF CVA10 VIRUS PROCAPSID PARTICLE
Descriptor:VP1, VP0, VP3
Authors:Zhu, R., Xu, L.F., Zheng, Q.B., Cui, Y.X., Li, S.W., Yan, X.D., Zhou, Z.H., Cheng, T.
Deposit date:2018-07-27
Release date:2018-11-21
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10.
Sci Adv, 4, 2018
<12>