Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1AAL
DownloadVisualize
BU of 1aal by Molmil
STRUCTURAL EFFECTS INDUCED BY MUTAGENESIS AFFECTED BY CRYSTAL PACKING FACTORS: THE STRUCTURE OF A 30-51 DISULFIDE MUTANT OF BASIC PANCREATIC TRYPSIN INHIBITOR
Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION
Authors:Eigenbrot, C, Randal, M, Kossiakoff, A.A.
Deposit date:1992-04-09
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural effects induced by mutagenesis affected by crystal packing factors: the structure of a 30-51 disulfide mutant of basic pancreatic trypsin inhibitor.
Proteins, 14, 1992
6RLX
DownloadVisualize
BU of 6rlx by Molmil
X-RAY STRUCTURE OF HUMAN RELAXIN AT 1.5 ANGSTROMS. COMPARISON TO INSULIN AND IMPLICATIONS FOR RECEPTOR BINDING DETERMINANTS
Descriptor: RELAXIN, A-CHAIN, B-CHAIN
Authors:Eigenbrot, C, Randal, M, Kossiakoff, A.A.
Deposit date:1991-06-21
Release date:1993-10-31
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants.
J.Mol.Biol., 221, 1991
1AGQ
DownloadVisualize
BU of 1agq by Molmil
GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT
Descriptor: GLIAL CELL-DERIVED NEUROTROPHIC FACTOR
Authors:Eigenbrot, C, Gerber, N.
Deposit date:1997-03-25
Release date:1997-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding.
Nat.Struct.Biol., 4, 1997
7PTI
DownloadVisualize
BU of 7pti by Molmil
STRUCTURAL EFFECTS INDUCED BY REMOVAL OF A DISULFIDE BRIDGE. THE X-RAY STRUCTURE OF THE C30A(SLASH)C51A MUTANT OF BASIC PANCREATIC TRYPSIN INHIBITOR AT 1.6 ANGSTROMS
Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION
Authors:Eigenbrot, C, Randal, M, Kossiakoff, A.A.
Deposit date:1990-03-08
Release date:1991-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural effects induced by removal of a disulfide-bridge: the X-ray structure of the C30A/C51A mutant of basic pancreatic trypsin inhibitor at 1.6 A.
Protein Eng., 3, 1990
1JBU
DownloadVisualize
BU of 1jbu by Molmil
Coagulation Factor VII Zymogen (EGF2/Protease) in Complex with Inhibitory Exosite Peptide A-183
Descriptor: BENZAMIDINE, COAGULATION FACTOR VII, Peptide exosite inhibitor A-183, ...
Authors:Eigenbrot, C, Kirchhofer, D, Dennis, M.S, Santell, L, Lazarus, R.A, Stamos, J, Ultsch, M.H.
Deposit date:2001-06-06
Release date:2001-07-11
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:The factor VII zymogen structure reveals reregistration of beta strands during activation.
Structure, 9, 2001
3TJO
DownloadVisualize
BU of 3tjo by Molmil
HtrA1 catalytic domain, mutationally inactivated
Descriptor: GLYCEROL, SULFATE ION, Serine protease HTRA1, ...
Authors:Eigenbrot, C, Ultsch, M.
Deposit date:2011-08-24
Release date:2012-05-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structural and Functional Analysis of HtrA1 and Its Subdomains.
Structure, 20, 2012
3TJN
DownloadVisualize
BU of 3tjn by Molmil
HtrA1 catalytic domain, apo form
Descriptor: Serine protease HTRA1
Authors:Eigenbrot, C, Ultsch, M.
Deposit date:2011-08-24
Release date:2012-05-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and Functional Analysis of HtrA1 and Its Subdomains.
Structure, 20, 2012
3TJQ
DownloadVisualize
BU of 3tjq by Molmil
N-domain of HtrA1
Descriptor: CHLORIDE ION, GLYCEROL, PLATINUM (II) ION, ...
Authors:Eigenbrot, C, Ultsch, M.
Deposit date:2011-08-24
Release date:2012-05-16
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structural and Functional Analysis of HtrA1 and Its Subdomains.
Structure, 20, 2012
2FGW
DownloadVisualize
BU of 2fgw by Molmil
X-RAY STRUCTURES OF FRAGMENTS FROM BINDING AND NONBINDING VERSIONS OF A HUMANIZED ANTI-CD18 ANTIBODY: STRUCTURAL INDICATIONS OF THE KEY ROLE OF VH RESIDUES 59 TO 65
Descriptor: H52 FAB (HEAVY CHAIN), H52 FAB (LIGHT CHAIN)
Authors:Eigenbrot, C, Kessler, J.
Deposit date:1994-01-16
Release date:1994-04-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray structures of fragments from binding and nonbinding versions of a humanized anti-CD18 antibody: structural indications of the key role of VH residues 59 to 65.
Proteins, 18, 1994
1FVE
DownloadVisualize
BU of 1fve by Molmil
X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING
Descriptor: IGG1-KAPPA 4D5 FAB (HEAVY CHAIN), IGG1-KAPPA 4D5 FAB (LIGHT CHAIN)
Authors:Eigenbrot, C, Randal, M, Presta, L, Kossiakoff, A.A.
Deposit date:1992-10-20
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
J.Mol.Biol., 229, 1993
1FVC
DownloadVisualize
BU of 1fvc by Molmil
X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING
Descriptor: IGG1-KAPPA 4D5 FV (HEAVY CHAIN), IGG1-KAPPA 4D5 FV (LIGHT CHAIN)
Authors:Eigenbrot, C, Randal, M, Kossiakoff, A.A, Presta, L.
Deposit date:1992-10-20
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
J.Mol.Biol., 229, 1993
1FVD
DownloadVisualize
BU of 1fvd by Molmil
X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING
Descriptor: IGG1-KAPPA 4D5 FAB (HEAVY CHAIN), IGG1-KAPPA 4D5 FAB (LIGHT CHAIN)
Authors:Eigenbrot, C, Presta, L, Randal, M, Kossiakoff, A.A.
Deposit date:1992-10-20
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
J.Mol.Biol., 229, 1993
1ICW
DownloadVisualize
BU of 1icw by Molmil
INTERLEUKIN-8, MUTANT WITH GLU 38 REPLACED BY CYS AND CYS 50 REPLACED BY ALA
Descriptor: INTERLEUKIN-8
Authors:Eigenbrot, C, Lowman, H.B, Chee, L, Artis, D.R.
Deposit date:1996-09-18
Release date:1997-03-12
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural change and receptor binding in a chemokine mutant with a rearranged disulfide: X-ray structure of E38C/C50AIL-8 at 2 A resolution.
Proteins, 27, 1997
1PG7
DownloadVisualize
BU of 1pg7 by Molmil
Murine 6A6 Fab in complex with humanized anti-Tissue Factor D3H44 Fab
Descriptor: humanized antibody D3H44, murine antibody 6A6 Fab fragment
Authors:Eigenbrot, C, Meng, Y.G, Krishnamurthy, R, Lipari, M.T, Presta, L, Devaux, B, Wong, T, Moran, P, Bullens, S, Kirchhofer, D.
Deposit date:2003-05-27
Release date:2003-08-26
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation.
J.Mol.Biol., 331, 2003
1FGV
DownloadVisualize
BU of 1fgv by Molmil
X-RAY STRUCTURES OF FRAGMENTS FROM BINDING AND NONBINDING VERSIONS OF A HUMANIZED ANTI-CD18 ANTIBODY: STRUCTURAL INDICATIONS OF THE KEY ROLE OF VH RESIDUES 59 TO 65
Descriptor: H52 FV (HEAVY CHAIN), H52 FV (LIGHT CHAIN)
Authors:Eigenbrot, C, Kessler, J.
Deposit date:1993-11-01
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structures of fragments from binding and nonbinding versions of a humanized anti-CD18 antibody: structural indications of the key role of VH residues 59 to 65.
Proteins, 18, 1994
3MZW
DownloadVisualize
BU of 3mzw by Molmil
HER2 extracelluar region with affinity matured 3-helix affibody ZHER2:342
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin G-binding protein A, ...
Authors:Eigenbrot, C, Ultsch, M.H.
Deposit date:2010-05-13
Release date:2010-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for high-affinity HER2 receptor binding by an engineered protein.
Proc.Natl.Acad.Sci.USA, 107, 2010
5KUP
DownloadVisualize
BU of 5kup by Molmil
Bruton's tyrosine kinase (BTK) with pyridazinone compound 9
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-6-oxidanylidene-5-(pyrimidin-4-ylamino)pyridin-3-yl]pyridin-2-yl]phthalazin-1-one, GLYCEROL, ...
Authors:Eigenbrot, C, Yu, C.
Deposit date:2016-07-13
Release date:2016-09-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.389 Å)
Cite:Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations.
Acs Chem.Biol., 11, 2016
4Z5R
DownloadVisualize
BU of 4z5r by Molmil
Rontalizumab Fab bound to Interferon-a2
Descriptor: Interferon alpha-2, SULFATE ION, anti-IFN-a antibody rontalizumab heavy chain modules VH and CH1 (Fab), ...
Authors:Eigenbrot, C, Maurer, B, Bosanac, I.
Deposit date:2015-04-02
Release date:2015-07-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of the broadly neutralizing anti-interferon-alpha antibody rontalizumab.
Protein Sci., 24, 2015
2R0L
DownloadVisualize
BU of 2r0l by Molmil
Short Form HGFA with Inhibitory Fab75
Descriptor: Hepatocyte growth factor activator, antibody heavy chain, Fab portion only, ...
Authors:Eigenbrot, C, Shia, S.
Deposit date:2007-08-20
Release date:2007-12-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural insight into distinct mechanisms of protease inhibition by antibodies.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2R0K
DownloadVisualize
BU of 2r0k by Molmil
Protease domain of HGFA with inhibitor Fab58
Descriptor: Hepatocyte growth factor activator, antibody heavy chain of Fab58, Fab portion only, ...
Authors:Eigenbrot, C, Shia, S.
Deposit date:2007-08-20
Release date:2007-12-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:Structural insight into distinct mechanisms of protease inhibition by antibodies.
Proc.Natl.Acad.Sci.Usa, 104, 2007
5HCY
DownloadVisualize
BU of 5hcy by Molmil
EGFR kinase domain mutant "TMLR" with 3-carboxamide azaindole compound 13
Descriptor: 6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]-~{N}-(oxan-4-yl)-1-propan-2-yl-pyrrolo[3,2-c]pyridine-3-carboxamide, Epidermal growth factor receptor, SULFATE ION
Authors:Eigenbrot, C, Yu, C.
Deposit date:2016-01-04
Release date:2016-09-07
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.
J.Med.Chem., 59, 2016
5HIB
DownloadVisualize
BU of 5hib by Molmil
EGFR kinase domain mutant "TMLR" with a pyrazolopyrimidine inhibitor
Descriptor: Epidermal growth factor receptor, N-tert-butyl-5-{[(1-methyl-1H-pyrazol-5-yl)sulfonyl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamide
Authors:Eigenbrot, C, Yu, C.
Deposit date:2016-01-11
Release date:2016-04-06
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.
Cancer Cell, 29, 2016
5HIC
DownloadVisualize
BU of 5hic by Molmil
EGFR kinase domain mutant "TMLR" with a imidazopyridinyl-aminopyrimidine inhibitor
Descriptor: Epidermal growth factor receptor, N-{2-[1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-amine, SULFATE ION
Authors:Eigenbrot, C, Yu, C.
Deposit date:2016-01-11
Release date:2016-04-06
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.
Cancer Cell, 29, 2016
5HCX
DownloadVisualize
BU of 5hcx by Molmil
EGFR kinase domain mutant "TMLR" with azabenzimidazole compound 7
Descriptor: Epidermal growth factor receptor, SULFATE ION, ~{N}-[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]-2-methyl-1-propan-2-yl-imidazo[4,5-c]pyridin-6-amine
Authors:Eigenbrot, C, Yu, C.
Deposit date:2016-01-04
Release date:2016-09-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.
J.Med.Chem., 59, 2016
5HCZ
DownloadVisualize
BU of 5hcz by Molmil
EGFR kinase domain mutant "TMLR" with 3-azetidinyl azaindazole compound 21
Descriptor: 2-[1-[1-[(2~{S})-butan-2-yl]-6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]pyrazolo[4,3-c]pyridin-3-yl]azetidin-3-yl]propan-2-ol, Epidermal growth factor receptor, SULFATE ION
Authors:Eigenbrot, C, Yu, C.
Deposit date:2016-01-04
Release date:2016-09-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.
J.Med.Chem., 59, 2016

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon