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2BB2
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BU of 2bb2 by Molmil
X-RAY ANALYSIS OF BETA B2-CRYSTALLIN AND EVOLUTION OF OLIGOMERIC LENS PROTEINS
Descriptor: BETA B2-CRYSTALLIN, BETA-MERCAPTOETHANOL
Authors:Bax, B, Lapatto, R, Nalini, V, Driessen, H, Lindley, P.F, Mahadevan, D, Blundell, T.L, Slingsby, C.
Deposit date:1992-09-21
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray analysis of beta B2-crystallin and evolution of oligomeric lens proteins.
Nature, 347, 1990
1GNG
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BU of 1gng by Molmil
Glycogen synthase kinase-3 beta (GSK3) complex with FRATtide peptide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FRATTIDE, GLYCOGEN SYNTHASE KINASE-3 BETA, ...
Authors:Bax, B, Carter, P.S, Lewis, C, Guy, A.R, Bridges, A, Tanner, R, Pettman, G, Mannix, C, Culbert, A.A, Brown, M.J.B, Smith, D.G, Reith, A.D.
Deposit date:2001-10-04
Release date:2002-10-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Structure of Phosphorylated Gsk-3Beta Complexed with a Peptide, Frattide, that Inhibits Beta-Catenin Phosphorylation
Structure, 9, 2001
1A0R
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BU of 1a0r by Molmil
HETEROTRIMERIC COMPLEX OF PHOSDUCIN/TRANSDUCIN BETA-GAMMA
Descriptor: FARNESYL, PHOSDUCIN, TRANSDUCIN (BETA SUBUNIT), ...
Authors:Loew, A, Ho, Y.-K, Blundell, T.L, Bax, B.
Deposit date:1997-12-05
Release date:1998-12-30
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Phosducin induces a structural change in transducin beta gamma.
Structure, 6, 1998
3ZKB
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BU of 3zkb by Molmil
CRYSTAL STRUCTURE OF THE ATPASE REGION OF Mycobacterium tuberculosis GyrB WITH AMPPNP
Descriptor: DNA GYRASE SUBUNIT B, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Agrawal, A, Roue, M, Spitzfaden, C, Petrella, S, Aubry, A, Volker, C, Mossakowska, D, Hann, M, Bax, B, Mayer, C.
Deposit date:2013-01-22
Release date:2013-09-18
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Mycobacterium Tuberculosis DNA Gyrase ATPase Domain Structures Suggest a Dissociative Mechanism that Explains How ATP Hydrolysis is Coupled to Domain Motion.
Biochem.J., 456, 2013
3ZRL
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BU of 3zrl by Molmil
Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors
Descriptor: 7-BROMO-2-PYRIDIN-4-YL-5H-THIENO[3,2-C]PYRIDIN-4-ONE, GLYCEROL, GLYCOGEN SYNTHASE KINASE-3 BETA, ...
Authors:Gentile, G, Bernasconi, G, Pozzan, A, Merlo, G, Marzorati, P, Bamborough, P, Bax, B, Bridges, A, Brough, C, Carter, P, Cutler, G, Neu, M, Takada, M.
Deposit date:2011-06-17
Release date:2011-06-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Identification of 2-(4-Pyridyl)Thienopyridinones as Gsk-3Beta Inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
4BUL
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BU of 4bul by Molmil
Novel hydroxyl tricyclics (e.g. GSK966587) as potent inhibitors of bacterial type IIA topoisomerases
Descriptor: (S)-4-((4-(((2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methyl)amino)piperidin-1-yl)methyl)-3-fluoro-4-hydroxy-4H-pyrrolo[3,2,1-de][1,5]naphthyridin-7(5H)-one, 5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*AP*CP *CP*GP*CP*AP*C)-3', 5'-D(*TP*GP*TP*GP*CP*GP*GP*TP*GP*TP*AP*CP*CP*TP *AP*CP*GP*GP*CP*T)-3', ...
Authors:Miles, T.J, Hennessy, A.J, Bax, B, Brooks, G, Brown, B.S, Brown, P, Cailleau, N, Chen, D, Dabbs, S, Davies, D.T, Esken, J.M, Giordano, I, Hoover, J.L, Huang, J, Jones, G.E, Sukmar, S.K.K, Spitzfaden, C, Markwell, R.E, Minthorn, E.A, Rittenhouse, S, Gwynn, M.N, Pearson, N.D.
Deposit date:2013-06-20
Release date:2013-08-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Novel Hydroxyl Tricyclics (E.G., Gsk966587) as Potent Inhibitors of Bacterial Type Iia Topoisomerases.
Bioorg.Med.Chem.Lett., 23, 2013
1BLB
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BU of 1blb by Molmil
CLOSE PACKING OF AN OLIGOMERIC EYE LENS BETA-CRYSTALLIN INDUCES LOSS OF SYMMETRY AND ORDERING OF SEQUENCE EXTENSIONS
Descriptor: BETA B2-CRYSTALLIN
Authors:Nalini, V, Bax, B, Driessen, H, Moss, D.S, Lindley, P.F, Slingsby, C.
Deposit date:1993-12-22
Release date:1994-12-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Close packing of an oligomeric eye lens beta-crystallin induces loss of symmetry and ordering of sequence extensions.
J.Mol.Biol., 236, 1994
3ZRK
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BU of 3zrk by Molmil
Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors
Descriptor: 2-(4-PYRIDINYL)FURO[3,2-C]PYRIDIN-4(5H)-ONE, GLYCEROL, GLYCOGEN SYNTHASE KINASE-3 BETA, ...
Authors:Gentile, G, Bernasconi, G, Pozzan, A, Merlo, G, Marzorati, P, Bamborough, P, Bax, B, Bridges, A, Brough, C, Carter, P, Cutler, G, Neu, M, Takada, M.
Deposit date:2011-06-16
Release date:2011-06-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Identification of 2-(4-Pyridyl)Thienopyridinones as Gsk-3Beta Inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3ZRM
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BU of 3zrm by Molmil
Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors
Descriptor: 7-(4-HYDROXYPHENYL)-2-PYRIDIN-4-YL-5H-THIENO[3,2-C]PYRIDIN-4-ONE, GLYCEROL, GLYCOGEN SYNTHASE KINASE-3 BETA, ...
Authors:Gentile, G, Bernasconi, G, Pozzan, A, Merlo, G, Marzorati, P, Bamborough, P, Bax, B, Bridges, A, Brough, C, Carter, P, Cutler, G, Neu, M, Takada, M.
Deposit date:2011-06-17
Release date:2011-06-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Identification of 2-(4-Pyridyl)Thienopyridinones as Gsk-3Beta Inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3ZKD
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BU of 3zkd by Molmil
CRYSTAL STRUCTURE OF THE ATPASE REGION OF Mycobacterium tuberculosis GyrB WITH AMPPNP
Descriptor: DNA GYRASE SUBUNIT B, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Agrawal, A, Roue, M, Spitzfaden, C, Petrella, S, Aubry, A, Volker, C, Mossakowska, D, Hann, M, Bax, B, Mayer, C.
Deposit date:2013-01-22
Release date:2013-09-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Mycobacterium Tuberculosis DNA Gyrase ATPase Domain Structures Suggest a Dissociative Mechanism that Explains How ATP Hydrolysis is Coupled to Domain Motion.
Biochem.J., 456, 2013
3ZM7
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BU of 3zm7 by Molmil
CRYSTAL STRUCTURE OF THE ATPASE REGION OF Mycobacterium tuberculosis GyrB WITH AMPPCP
Descriptor: DNA GYRASE SUBUNIT B, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Agrawal, A, Roue, M, Spitzfaden, C, Petrella, S, Aubry, A, Volker, C, Mossakowska, D, Hann, M, Bax, B, Mayer, C.
Deposit date:2013-02-05
Release date:2013-09-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Mycobacterium Tuberculosis DNA Gyrase ATPase Domain Structures Suggest a Dissociative Mechanism that Explains How ATP Hydrolysis is Coupled to Domain Motion.
Biochem.J., 456, 2013
4AFJ
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BU of 4afj by Molmil
5-aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors
Descriptor: 5-(4-METHOXYPHENYL)-N-(PYRIDIN-4-YLMETHYL)-1,3-OXAZOLE-4-CARBOXAMIDE, GLYCEROL, GLYCOGEN SYNTHASE KINASE-3 BETA, ...
Authors:Gentile, G, Merlo, G, Pozzan, A, Bernasconi, G, Bax, B, Bamborough, P, Bridges, A, Carter, P, Neu, M, Yao, G, Brough, C, Cutler, G, Coffin, A, Belyanskaya, S.
Deposit date:2012-01-19
Release date:2012-02-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:5-Aryl-4-Carboxamide-1,3-Oxazoles: Potent and Selective Gsk-3 Inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
1G0W
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BU of 1g0w by Molmil
CRYSTAL STRUCTURE OF BOVINE RETINAL CREATINE KINASE
Descriptor: CREATINE KINASE, SULFATE ION
Authors:Tisi, D, Bax, B, Loew, A.
Deposit date:2000-10-09
Release date:2001-02-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The three-dimensional structure of cytosolic bovine retinal creatine kinase.
Acta Crystallogr.,Sect.D, 57, 2001
1VZO
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BU of 1vzo by Molmil
The structure of the N-terminal kinase domain of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein
Descriptor: BETA-MERCAPTOETHANOL, RIBOSOMAL PROTEIN S6 KINASE ALPHA 5, SULFATE ION
Authors:Smith, K.J, Carter, P.S, Bridges, A, Horrocks, P, Lewis, C, Pettman, G, Clarke, A, Brown, M, Hughes, J, Wilkinson, M, Bax, B, Reith, A.
Deposit date:2004-05-21
Release date:2004-06-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Structure of Msk1 Reveals a Novel Autoinhibitory Conformation for a Dual Kinase Protein
Structure, 12, 2004
6HPQ
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BU of 6hpq by Molmil
Crystal structure of human Pif1 helicase in complex with AMP-PNP, brominated crystal form.
Descriptor: ATP-dependent DNA helicase PIF1, BROMIDE ION, MAGNESIUM ION, ...
Authors:Ledikov, V.M, Dehghani-Tafti, S, Bax, B, Sanders, C.M, Antson, A.A.
Deposit date:2018-09-21
Release date:2019-01-23
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.
Nucleic Acids Res., 47, 2019
1RRG
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BU of 1rrg by Molmil
NON-MYRISTOYLATED RAT ADP-RIBOSYLATION FACTOR-1 COMPLEXED WITH GDP, DIMERIC CRYSTAL FORM
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAT ADP-RIBOSYLATION FACTOR-1
Authors:Greasley, S.E, Jhoti, H, Bax, B.
Deposit date:1995-12-16
Release date:1996-06-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms.
Nat.Struct.Biol., 2, 1995
1RRF
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BU of 1rrf by Molmil
NON-MYRISTOYLATED RAT ADP-RIBOSYLATION FACTOR-1 COMPLEXED WITH GDP, MONOMERIC CRYSTAL FORM
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAT ADP-RIBOSYLATION FACTOR-1
Authors:Greasley, S.E, Jhoti, H, Bax, B.
Deposit date:1995-12-16
Release date:1996-06-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms.
Nat.Struct.Biol., 2, 1995
1SGF
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BU of 1sgf by Molmil
CRYSTAL STRUCTURE OF 7S NGF: A COMPLEX OF NERVE GROWTH FACTOR WITH FOUR BINDING PROTEINS (SERINE PROTEINASES)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, NERVE GROWTH FACTOR, ...
Authors:Bax, B.D.V, Blundell, T.L, Murray-Rust, J, Mcdonald, N.Q.
Deposit date:1997-08-08
Release date:1998-05-27
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins.
Structure, 5, 1997
6HPU
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BU of 6hpu by Molmil
Crystal structure of human Pif1 helicase in complex with ADP-AlF4
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase PIF1, MAGNESIUM ION, ...
Authors:Levdikov, V.M, Dehghani-Tafti, S, Bax, B.D, Sanders, C.M, Antson, A.A.
Deposit date:2018-09-21
Release date:2019-01-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.96 Å)
Cite:Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.
Nucleic Acids Res., 47, 2019
6HPH
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BU of 6hph by Molmil
Crystal structure of human Pif1 helicase in complex with AMP-PNP
Descriptor: ATP-dependent DNA helicase PIF1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Levdikov, V.M, Dehghani-Tafti, S, Bax, B.D, Sanders, C.M, Antson, A.A.
Deposit date:2018-09-20
Release date:2019-01-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.
Nucleic Acids Res., 47, 2019
6HPT
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BU of 6hpt by Molmil
Crystal structure of human Pif1 helicase, apoform.
Descriptor: ATP-dependent DNA helicase PIF1, SULFATE ION
Authors:Levdikov, V.M, Dehghani-Tafti, S, Bax, B.D, Sanders, C.M, Antson, A.A.
Deposit date:2018-09-21
Release date:2019-01-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.
Nucleic Acids Res., 47, 2019
5IWI
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BU of 5iwi by Molmil
1.98A structure of GSK945237 with S.aureus DNA gyrase and singly nicked DNA
Descriptor: (1R)-1-[(4-{[(6,7-dihydro[1,4]dioxino[2,3-c]pyridazin-3-yl)methyl]amino}piperidin-1-yl)methyl]-9-fluoro-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one, CHLORIDE ION, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*AP*CP*CP*GP*CP*AP*CP*A)-3'), ...
Authors:Bax, B.D, Miles, T.J.
Deposit date:2016-03-22
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.
Bioorg.Med.Chem.Lett., 26, 2016
5IWM
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BU of 5iwm by Molmil
2.5A structure of GSK945237 with S.aureus DNA gyrase and DNA.
Descriptor: (1R)-1-[(4-{[(6,7-dihydro[1,4]dioxino[2,3-c]pyridazin-3-yl)methyl]amino}piperidin-1-yl)methyl]-9-fluoro-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*TP*CP*AP*CP*CP*GP*CP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*GP*CP*GP*GP*TP*GP*AP*AP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), ...
Authors:Bax, B.D, Miles, T.J.
Deposit date:2016-03-22
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.
Bioorg.Med.Chem.Lett., 26, 2016
6QTK
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BU of 6qtk by Molmil
2.31A structure of gepotidacin with S.aureus DNA gyrase and doubly nicked DNA
Descriptor: (3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*G*GP*GP*TP*AP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), DNA gyrase subunit A, ...
Authors:Bax, B.D.
Deposit date:2019-02-25
Release date:2019-03-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.
Acs Infect Dis., 5, 2019
6QTP
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BU of 6qtp by Molmil
2.37A structure of gepotidacin with S.aureus DNA gyrase and uncleaved DNA
Descriptor: (3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione, DNA (5'-D(*GP*AP*GP*CP*GP*TP*AP*CP*AP*GP*CP*TP*GP*TP*AP*CP*GP*CP*TP*T)-3'), DNA gyrase subunit A, ...
Authors:Bax, B.D.
Deposit date:2019-02-25
Release date:2019-03-13
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.
Acs Infect Dis., 5, 2019

 

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