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8FFY
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BU of 8ffy by Molmil
Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA(UGA-TL)
Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Serine--tRNA ligase, mitochondrial, ...
Authors:Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G.
Deposit date:2022-12-11
Release date:2023-08-23
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for a degenerate tRNA identity code and the evolution of bimodal specificity in human mitochondrial tRNA recognition.
Nat Commun, 14, 2023
4QBT
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BU of 4qbt by Molmil
Crystal structure of tyrosine bound human tyrosyl tRNA synthetase
Descriptor: GLYCEROL, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Mathew, S, Schimmel, P.
Deposit date:2014-05-08
Release date:2014-12-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.
Nature, 519, 2014
4Q93
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BU of 4q93 by Molmil
Crystal structure of resveratrol bound human tyrosyl tRNA synthetase
Descriptor: CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ...
Authors:Mathew, S, Schimmel, P.
Deposit date:2014-04-28
Release date:2014-12-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.
Nature, 519, 2014
7TZB
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BU of 7tzb by Molmil
Crystal structure of the human mitochondrial seryl-tRNA synthetase (mt SerRS) bound with a seryl-adenylate analogue
Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Serine--tRNA ligase, mitochondrial
Authors:Kuhle, B, Hirschi, M, Doerfel, L, Lander, G, Schimmel, P.
Deposit date:2022-02-15
Release date:2022-09-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
Nat Commun, 13, 2022
2AZX
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BU of 2azx by Molmil
Charged and uncharged tRNAs adopt distinct conformations when complexed with human tryptophanyl-tRNA synthetase
Descriptor: 72-MER, GLYCEROL, MAGNESIUM ION, ...
Authors:Yang, X.L, Otero, F.J, Ewalt, K.L, Liu, J, Swairjo, M.A, Kohrer, C, RajBhandary, U.L, Skene, R.J, McRee, D.E, Schimmel, P.
Deposit date:2005-09-12
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.
Embo J., 25, 2006
6NLY
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BU of 6nly by Molmil
Fragment of human mitochondrial Alanyl-tRNA Synthetase C-Ala domain
Descriptor: Alanine--tRNA ligase, mitochondrial
Authors:Kuhle, B, Schimmel, P.
Deposit date:2019-01-09
Release date:2020-01-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.307 Å)
Cite:Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs.
Nat Commun, 11, 2020
6NLQ
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BU of 6nlq by Molmil
Human Mitochondrial Alanyl-tRNA Synthetase C-terminal domain
Descriptor: Alanine--tRNA ligase, mitochondrial, CALCIUM ION
Authors:Kuhle, B, Schimmel, P.
Deposit date:2019-01-08
Release date:2020-01-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs.
Nat Commun, 11, 2020
6NOW
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BU of 6now by Molmil
Human Mitochondrial Alanyl-tRNA Synthetase C-Ala domain
Descriptor: Alanine--tRNA ligase, mitochondrial
Authors:Kuhle, B, Schimmel, P.
Deposit date:2019-01-16
Release date:2020-01-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (4.099 Å)
Cite:Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs.
Nat Commun, 11, 2020
3BJU
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BU of 3bju by Molmil
Crystal Structure of tetrameric form of human lysyl-tRNA synthetase
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, LYSINE, ...
Authors:Guo, M, Yang, X.L, Schimmel, P.
Deposit date:2007-12-04
Release date:2008-02-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation
Proc.Natl.Acad.Sci.Usa, 105, 2008
4G84
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BU of 4g84 by Molmil
Crystal structure of human HisRS
Descriptor: CHLORIDE ION, Histidine--tRNA ligase, cytoplasmic, ...
Authors:Wei, Z, Wu, J, Zhou, J.J, Yang, X.-L, Zhang, M, Schimmel, P.
Deposit date:2012-07-21
Release date:2012-09-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Internally Deleted Human tRNA Synthetase Suggests Evolutionary Pressure for Repurposing.
Structure, 20, 2012
4G85
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BU of 4g85 by Molmil
Crystal structure of human HisRS
Descriptor: Histidine-tRNA ligase, cytoplasmic
Authors:Wei, Z, Wu, J, Zhou, J.J, Yang, X.-L, Zhang, M, Schimmel, P.
Deposit date:2012-07-21
Release date:2012-09-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Internally Deleted Human tRNA Synthetase Suggests Evolutionary Pressure for Repurposing.
Structure, 20, 2012
4HVC
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BU of 4hvc by Molmil
Crystal structure of human prolyl-tRNA synthetase in complex with halofuginone and ATP analogue
Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, Bifunctional glutamate/proline--tRNA ligase, MAGNESIUM ION, ...
Authors:Zhou, H, Sun, L, Yang, X.L, Schimmel, P.
Deposit date:2012-11-06
Release date:2013-01-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Nature, 494, 2012
7U2A
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BU of 7u2a by Molmil
Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA (GCU)
Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, RNA (38-MER), Serine--tRNA ligase, ...
Authors:Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G.
Deposit date:2022-02-23
Release date:2022-09-14
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
Nat Commun, 13, 2022
7U2B
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BU of 7u2b by Molmil
Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA(GCU-TL)
Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, RNA (53-MER), Serine--tRNA ligase, ...
Authors:Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G.
Deposit date:2022-02-23
Release date:2022-09-14
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
Nat Commun, 13, 2022
2LW7
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BU of 2lw7 by Molmil
NMR solution structure of human HisRS splice variant
Descriptor: Histidine--tRNA ligase, cytoplasmic
Authors:Ye, F, Wei, Z, Wu, J, Schimmel, P, Zhang, M.
Deposit date:2012-07-24
Release date:2013-09-04
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:NMR solution structure of human HisRS splice variant
To be Published
3HTZ
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BU of 3htz by Molmil
Crystal Structure of the catalytic fragment of alanyl-tRNA synthetase in complex with L-serine: Re-refined
Descriptor: Alanyl-tRNA synthetase
Authors:Guo, M, Swairjo, M.A, Schimmel, P.
Deposit date:2009-06-12
Release date:2009-06-30
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Serine Paradox
To be Published
1PYB
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BU of 1pyb by Molmil
Crystal Structure of Aquifex aeolicus Trbp111: a Structure-Specific tRNA Binding Protein
Descriptor: tRNA-binding protein Trbp111
Authors:Swairjo, M.A, Morales, A.J, Wang, C.C, Ortiz, A.R, Schimmel, P.
Deposit date:2003-07-08
Release date:2003-08-05
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of trbp111: a structure-specific tRNA-binding protein.
Embo J., 19, 2000
5T5S
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BU of 5t5s by Molmil
A fragment of a human tRNA synthetase
Descriptor: Alanine--tRNA ligase, cytoplasmic
Authors:Sun, L, Schimmel, P.
Deposit date:2016-08-31
Release date:2016-11-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5T76
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BU of 5t76 by Molmil
A fragment of a human tRNA synthetase
Descriptor: Alanine--tRNA ligase, cytoplasmic
Authors:Sun, L, Schimmel, P.
Deposit date:2016-09-02
Release date:2016-11-30
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5V58
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BU of 5v58 by Molmil
Crystal structure of human prolyl-tRNA synthetase in complex with Aze-SA
Descriptor: 5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine, Bifunctional glutamate/proline--tRNA ligase, ZINC ION
Authors:Zhou, H, Song, Y, Schimmel, P.
Deposit date:2017-03-13
Release date:2018-01-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.
Nat Commun, 8, 2017
5V59
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BU of 5v59 by Molmil
Crystal structure of catalytic fragment of human AlaRS in complex with Aze-SA
Descriptor: 5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine, Alanine--tRNA ligase, cytoplasmic
Authors:Zhou, H, Song, Y, Schimmel, P.
Deposit date:2017-03-13
Release date:2018-01-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.
Nat Commun, 8, 2017
1N3L
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BU of 1n3l by Molmil
Crystal structure of a human aminoacyl-tRNA synthetase cytokine
Descriptor: GLYCEROL, SULFATE ION, tyrosyl-tRNA synthetase
Authors:Yang, X.-L, Skene, R.J, McRee, D.E, Schimmel, P.
Deposit date:2002-10-28
Release date:2002-11-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Crystal structure of a human aminoacyl-tRNA synthetase cytokine
Proc.Natl.Acad.Sci.USA, 99, 2002
1NTG
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BU of 1ntg by Molmil
Crystal Structure of the EMAP II-like Cytokine Released from human tyrosyl-tRNA Synthetase
Descriptor: Tyrosyl-tRNA synthetase
Authors:Yang, X.-L, Skene, R.J, Mcree, D.E, Schimmel, P.
Deposit date:2003-01-29
Release date:2003-05-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Crystal Structure of an EMAP-II-like Cytokine Released from a human tRNA Synthetase
Helv.Chim.Acta, 86, 2003
1ILE
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BU of 1ile by Molmil
ISOLEUCYL-TRNA SYNTHETASE
Descriptor: ISOLEUCYL-TRNA SYNTHETASE, ZINC ION
Authors:Nureki, O, Vassylyev, D.G, Tateno, M, Shimada, A, Nakama, T, Fukai, S, Konno, M, Schimmel, P, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:1998-02-24
Release date:1999-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Enzyme structure with two catalytic sites for double-sieve selection of substrate.
Science, 280, 1998
1Q11
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BU of 1q11 by Molmil
Crystal structure of an active fragment of human tyrosyl-tRNA synthetase with tyrosinol
Descriptor: 4-[(2S)-2-amino-3-hydroxypropyl]phenol, GLYCEROL, PHOSPHATE ION, ...
Authors:Yang, X.-L, Schimmel, P, Ribas de Pouplana, L.
Deposit date:2003-07-18
Release date:2004-01-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains
Proc.Natl.Acad.Sci.USA, 100, 2003

 

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