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5D2N
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BU of 5d2n by Molmil
Crystal structure of C25-NLV-HLA-A2 complex
Descriptor: ASN-LEU-VAL-PRO-MET-VAL-ALA-THR-VAL, Beta-2-microglobulin, C25 alpha, ...
Authors:Mariuzza, R.A, Yang, X.
Deposit date:2015-08-05
Release date:2015-10-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus Epitope.
J.Biol.Chem., 290, 2015
1NBY
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BU of 1nby by Molmil
Crystal Structure of HyHEL-63 complexed with HEL mutant K96A
Descriptor: Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain
Authors:Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J.
Deposit date:2002-12-04
Release date:2003-04-01
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen
Biochemistry, 42, 2003
1NDG
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BU of 1ndg by Molmil
Crystal structure of Fab fragment of antibody HyHEL-8 complexed with its antigen lysozyme
Descriptor: ACETIC ACID, Lysozyme C, antibody kappa light chain, ...
Authors:Mariuzza, R.A, Li, Y, Li, H, Yang, F, Smith-Gill, S.J.
Deposit date:2002-12-09
Release date:2003-06-03
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray snapshots of the maturation of an antibody response to a protein antigen
Nat.Struct.Biol., 10, 2003
1NDM
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BU of 1ndm by Molmil
Crystal structure of Fab fragment of antibody HyHEL-26 complexed with lysozyme
Descriptor: Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain
Authors:Mariuzza, R.A, Li, Y, Li, H.
Deposit date:2002-12-09
Release date:2003-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray snapshots of the maturation of an antibody response to a protein antigen
Nat.Struct.Biol., 10, 2003
1NBZ
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BU of 1nbz by Molmil
Crystal Structure of HyHEL-63 complexed with HEL mutant K97A
Descriptor: Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain
Authors:Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J.
Deposit date:2002-12-04
Release date:2003-04-01
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen
Biochemistry, 42, 2003
1BEC
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BU of 1bec by Molmil
BETA CHAIN OF A T CELL ANTIGEN RECEPTOR
Descriptor: 14.3.D T CELL ANTIGEN RECEPTOR
Authors:Bentley, G.A, Boulot, G, Karjalainen, K, Mariuzza, R.A.
Deposit date:1995-02-28
Release date:1995-10-25
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the beta chain of a T cell antigen receptor.
Science, 267, 1995
7JTY
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BU of 7jty by Molmil
Co-crystal structure of alpha glucosidase with compound 1
Descriptor: (1S,2S,3R,4S,5S)-5-(butylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol, 1,2-ETHANEDIOL, Alpha glucosidase 2 alpha neutral subunit, ...
Authors:Karade, S.S, Mariuzza, R.A.
Deposit date:2020-08-18
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum alpha-Glucosidases I and II with Antiviral Activity.
J.Med.Chem., 64, 2021
8SO3
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BU of 8so3 by Molmil
CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Lymphocyte activation gene 3 protein, favezelimab Fab heavy chain, ...
Authors:Mishra, A.K, Shahid, S, Karade, S.S, Mariuzza, R.A.
Deposit date:2023-04-28
Release date:2023-09-06
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (3.61 Å)
Cite:CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker.
Structure, 31, 2023
8SR0
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BU of 8sr0 by Molmil
CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 local refined
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Lymphocyte activation gene 3 protein, favezelimab Fab heavy chain, ...
Authors:Mishra, A.K, Shahid, S, Karade, S.S, Mariuzza, R.A.
Deposit date:2023-05-05
Release date:2023-09-06
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker.
Structure, 31, 2023
1AC6
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BU of 1ac6 by Molmil
CRYSTAL STRUCTURE OF A VARIABLE DOMAIN MUTANT OF A T-CELL RECEPTOR ALPHA CHAIN
Descriptor: T-CELL RECEPTOR ALPHA
Authors:Li, H.-M, Mariuzza, R.A.
Deposit date:1997-02-13
Release date:1998-02-25
Last modified:2013-03-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dual conformations of a T cell receptor V alpha homodimer: implications for variability in V alpha V beta domain association.
J.Mol.Biol., 269, 1997
1A2Y
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BU of 1a2y by Molmil
HEN EGG WHITE LYSOZYME, D18A MUTANT, IN COMPLEX WITH MOUSE MONOCLONAL ANTIBODY D1.3
Descriptor: IGG1-KAPPA D1.3 FV (HEAVY CHAIN), IGG1-KAPPA D1.3 FV (LIGHT CHAIN), LYSOZYME, ...
Authors:Tsuchiya, D, Mariuzza, R.A.
Deposit date:1998-01-13
Release date:1998-04-29
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A mutational analysis of binding interactions in an antigen-antibody protein-protein complex.
Biochemistry, 37, 1998
4E41
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BU of 4e41 by Molmil
Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Descriptor: HLA class II histocompatibility antigen, DR alpha chain, DRB1-1 beta chain, ...
Authors:Deng, L, Langley, R.J, Wang, Q, Topalian, S.L, Mariuzza, R.A.
Deposit date:2012-03-11
Release date:2012-08-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Proc.Natl.Acad.Sci.USA, 2012
5TEZ
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BU of 5tez by Molmil
TCR F50 recgonizing M1-HLA-A2
Descriptor: Beta-2-microglobulin, GLY-ILE-LEU-GLY-PHE-VAL-PHE-THR-LEU, HLA class I histocompatibility antigen, ...
Authors:Yang, X, Mariuzza, R.A.
Deposit date:2016-09-23
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope.
J. Biol. Chem., 292, 2017
4K5U
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BU of 4k5u by Molmil
Recognition of the BG-H Antigen by a Lamprey Variable Lymphocyte Receptor
Descriptor: Variable lymphocyte receptor, beta-D-galactopyranose
Authors:Luo, M, Velikovsky, C.A, Yang, X.B, Mariuzza, R.A.
Deposit date:2013-04-15
Release date:2013-06-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Recognition of the thomsen-friedenreich pancarcinoma carbohydrate antigen by a lamprey variable lymphocyte receptor.
J.Biol.Chem., 288, 2013
3T0E
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BU of 3t0e by Molmil
Crystal structure of a complete ternary complex of T cell receptor, peptide-MHC and CD4
Descriptor: HLA class II histocompatibility antigen, DR alpha chain, DRB1-4 beta chain, ...
Authors:Yin, Y, Mariuzza, R.A.
Deposit date:2011-07-20
Release date:2012-03-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4.
Proc.Natl.Acad.Sci.USA, 109, 2012
4E42
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BU of 4e42 by Molmil
Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Descriptor: CHLORIDE ION, NITRATE ION, SODIUM ION, ...
Authors:Deng, L, Langley, R.J, Wang, Q, Topalian, S.L, Mariuzza, R.A.
Deposit date:2012-03-11
Release date:2012-08-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Proc.Natl.Acad.Sci.USA, 2012
4K79
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BU of 4k79 by Molmil
Recognition of the Thomsen-Friedenreich Antigen by a Lamprey Variable Lymphocyte Receptor
Descriptor: Variable lymphocyte receptor, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-galactopyranose
Authors:Luo, M, Velikovsky, C.A, Yang, X.B, Mariuzza, R.A.
Deposit date:2013-04-16
Release date:2013-06-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Recognition of the thomsen-friedenreich pancarcinoma carbohydrate antigen by a lamprey variable lymphocyte receptor.
J.Biol.Chem., 288, 2013
1JCK
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BU of 1jck by Molmil
T-CELL RECEPTOR BETA CHAIN COMPLEXED WITH SEC3 SUPERANTIGEN
Descriptor: 14.3.D T CELL ANTIGEN RECEPTOR, STAPHYLOCOCCAL ENTEROTOXIN C3
Authors:Fields, B.A, Mariuzza, R.A.
Deposit date:1996-10-22
Release date:1997-11-12
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of a T-cell receptor beta-chain complexed with a superantigen.
Nature, 384, 1996
2PTT
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BU of 2ptt by Molmil
Structure of NK cell receptor 2B4 (CD244) bound to its ligand CD48
Descriptor: CD48 antigen, Natural killer cell receptor 2B4, SULFATE ION
Authors:Deng, L, Velikovsky, C.A, Mariuzza, R.A.
Deposit date:2007-05-08
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family.
Immunity, 27, 2007
2PTU
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BU of 2ptu by Molmil
Structure of NK cell receptor 2B4 (CD244)
Descriptor: Natural killer cell receptor 2B4
Authors:Deng, L, Velikovsky, C.A, Mariuzza, R.A.
Deposit date:2007-05-08
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family.
Immunity, 27, 2007
2PTV
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BU of 2ptv by Molmil
Structure of NK cell receptor ligand CD48
Descriptor: CD48 antigen
Authors:Deng, L, Velikovsky, C.A, Mariuzza, R.A.
Deposit date:2007-05-08
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family.
Immunity, 27, 2007
4XVJ
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BU of 4xvj by Molmil
STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC 2 REGION 412-423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY HC33.1
Descriptor: HCV E2 antigen, antibody heavy chain variable domain, antibody light chain variable domain
Authors:Li, Y, Mariuzza, R.A.
Deposit date:2015-01-27
Release date:2015-03-11
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for penetration of the glycan shield of hepatitis C virus e2 glycoprotein by a broadly neutralizing human antibody.
J.Biol.Chem., 290, 2015
4Z0X
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BU of 4z0x by Molmil
Structure of Hepatitis C Virus Envelope glycoprotein E2 antigenic region 434-446 bound to the broadly neutralizing antibody HC26AM
Descriptor: Antibody HC26AM heavy chain variable domain, Antibody HC26AM light chain variable domain, HCV E2 Antigen (residues 432-446)
Authors:Rangarajan, S, Shahid, S, Mariuzza, R.A.
Deposit date:2015-03-26
Release date:2016-07-20
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice.
Hepatology, 64, 2016
4ZSO
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BU of 4zso by Molmil
Crystal structure of a complex between B7-H6, a tumor cell ligand for natural cytotoxicity receptor NKp30, and an inhibitory antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, ...
Authors:Xu, X, Li, Y, Mariuzza, R.A.
Deposit date:2015-05-13
Release date:2016-05-18
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a complex between B7-H6, a tumor cell ligand for natural cytotoxicity receptor NKp30, and an inhibitory antibody
to be published
6VR1
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BU of 6vr1 by Molmil
Complex of HLA-A2, a class I MHC, with a p53 peptide
Descriptor: Beta-2-microglobulin, Cellular tumor antigen p53 peptide, MHC class I antigen
Authors:Wu, D, Pierce, B.G, Gallagher, D.T, Mariuzza, R.A.
Deposit date:2020-02-06
Release date:2020-06-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen.
Nat Commun, 11, 2020

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PDB entries from 2024-03-27

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