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1VHH
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A POTENTIAL CATALYTIC SITE WITHIN THE AMINO-TERMINAL SIGNALLING DOMAIN OF SONIC HEDGEHOG
Descriptor:SONIC HEDGEHOG, ZINC ION, SULFATE ION
Authors:Hall, T.M.T., Porter, J.A., Beachy, P.A., Leahy, D.J.
Deposit date:1995-10-03
Release date:1996-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog.
Nature, 378, 1995
2WFX
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN HEDGEHOG-INTERACTING PROTEIN HIP AND SONIC HEDGEHOG IN THE PRESENCE OF CALCIUM
Descriptor:SONIC HEDGEHOG PROTEIN N-PRODUCT, HEDGEHOG-INTERACTING PROTEIN, ZINC ION, ...
Authors:Bishop, B., Aricescu, A.R., Harlos, K., O'Callaghan, C.A., Jones, E.Y., Siebold, C.
Deposit date:2009-04-15
Release date:2009-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip
Nat.Struct.Mol.Biol., 16, 2009
2WG4
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN HEDGEHOG-INTERACTING PROTEIN HIP AND SONIC HEDGEHOG WITHOUT CALCIUM
Descriptor:SONIC HEDGEHOG PROTEIN N-PRODUCT, HEDGEHOG-INTERACTING PROTEIN, ZINC ION, ...
Authors:Bishop, B., Aricescu, A.R., Harlos, K., O'Callaghan, C.A., Jones, E.Y., Siebold, C.
Deposit date:2009-04-15
Release date:2009-06-30
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip
Nat.Struct.Mol.Biol., 16, 2009
3D1M
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CRYSTAL STRUCTURE OF SONIC HEDGEHOG BOUND TO THE THIRD FNIII DOMAIN OF CDO
Descriptor:Sonic hedgehog protein, Cell adhesion molecule, ZINC ION, ...
Authors:McLellan, J.S., Leahy, D.J.
Deposit date:2008-05-06
Release date:2008-09-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla.
Nature, 455, 2008
3M1N
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CRYSTAL STRUCTURE OF HUMAN SONIC HEDGEHOG N-TERMINAL DOMAIN
Descriptor:Sonic hedgehog protein, ZINC ION, SULFATE ION
Authors:Boriack-Sjodin, P.A., Pepinsky, R.B., Garber, E.A., Silvian, L.F.
Deposit date:2010-03-05
Release date:2010-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mapping sonic hedgehog-receptor interactions by steric interference.
J.Biol.Chem., 275, 2000
3MXW
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CRYSTAL STRUCTURE SONIC HEDGEHOG BOUND TO THE 5E1 FAB FRAGMENT
Descriptor:Sonic hedgehog protein, 5E1 light chain, 5E1 heavy chain, ...
Authors:Hymowitz, S.G., Maun, H.R.
Deposit date:2010-05-07
Release date:2010-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.
J.Biol.Chem., 285, 2010
3N1R
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CRYSTAL STRUCTURE OF SHHN
Descriptor:Sonic hedgehog protein, ZINC ION, CALCIUM ION
Authors:Kavran, J.M., Leahy, D.J.
Deposit date:2010-05-16
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Crystal Structure of ShhN
TO BE PUBLISHED
4C4M
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CRYSTAL STRUCTURE OF THE SONIC HEDGEHOG-CHONDROITIN-4-SULPHATE COMPLEX
Descriptor:SONIC HEDGEHOG PROTEIN, ZINC ION, CALCIUM ION, ...
Authors:Whalen, D.M., Malinauskas, T., Gilbert, R.J.C., Siebold, C.
Deposit date:2013-09-05
Release date:2013-10-02
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural Insights Into Proteoglycan-Shaped Hedgehog Signaling.
Proc.Natl.Acad.Sci.USA, 110, 2013
4C4N
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CRYSTAL STRUCTURE OF THE SONIC HEDGEHOG-HEPARIN COMPLEX
Descriptor:SONIC HEDGEHOG PROTEIN, ZINC ION, CALCIUM ION, ...
Authors:Whalen, D.M., Malinauskas, T., Gilbert, R.J.C., Siebold, C.
Deposit date:2013-09-05
Release date:2013-10-02
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structural Insights Into Proteoglycan-Shaped Hedgehog Signaling.
Proc.Natl.Acad.Sci.USA, 110, 2013
3HO5
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CRYSTAL STRUCTURE OF HEDGEHOG-INTERACTING PROTEIN (HHIP) AND SONIC HEDGEHOG (SHH) COMPLEX
Descriptor:Hedgehog-interacting protein, Sonic hedgehog protein, ZINC ION, ...
Authors:Hymowitz, S.G., Bosanac, I.
Deposit date:2009-06-01
Release date:2009-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Nat.Struct.Mol.Biol., 16, 2009
6D4J
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STRUCTURE OF HUMAN PATCHED1 IN COMPLEX WITH NATIVE SONIC HEDGEHOG
Descriptor:Protein patched homolog 1, Sonic hedgehog protein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Qi, X., Li, X.
Deposit date:2018-04-18
Release date:2018-07-11
Last modified:2018-08-15
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Nature, 560, 2018
6DMY
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CRYO-EM STRUCTURE OF HUMAN PTCH1 AND SHHN COMPLEX
Descriptor:Protein patched homolog 1, Sonic hedgehog protein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Yan, N., Gong, X., Qian, H.W.
Deposit date:2018-06-05
Release date:2018-07-11
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Science, 361, 2018
6E1H
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STRUCTURE OF 2:1 HUMAN PTCH1-SHH-N COMPLEX
Descriptor:Protein patched homolog 1, Sonic hedgehog protein N-product, ZINC ION, ...
Authors:Qi, X., Li, X.
Deposit date:2018-07-09
Release date:2018-08-29
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
Science, 362, 2018
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