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1L3E
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NMR STRUCTURES OF THE HIF-1ALPHA CTAD/P300 CH1 COMPLEX
Descriptor:hypoxia inducible factor-1 alpha subunit, p300 protein, ZINC ION
Authors:Freedman, S.J., Sun, Z.J., Poy, F., Kung, A.L., Livingston, D.M., Wagner, G., Eck, M.J.
Deposit date:2002-02-26
Release date:2002-04-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.
Proc.Natl.Acad.Sci.USA, 99, 2002
4H6J
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IDENTIFICATION OF CYS 255 IN HIF-1 AS A NOVEL SITE FOR DEVELOPMENT OF COVALENT INHIBITORS OF HIF-1 /ARNT PASB DOMAIN PROTEIN-PROTEIN INTERACTION.
Descriptor:HYPOXIA INDUCIBLE FACTOR 1-ALPHA, ARYL HYDROCARBON NUCLEAR TRANSLOCATOR
Authors:Cardoso, R., Love, R.A., Nilsson, C., Bergqvist, S., Nowlin, D., Yan, J., Liu, K., Zhu, J., Chen, P., Deng, Y.-L., Dyson, H.J., Greig, M.J., Brooun, A.
Deposit date:2012-09-19
Release date:2012-12-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Identification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction.
Protein Sci., 21, 2012
4ZPR
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-1A:ARNT COMPLEX WITH HRE DNA
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 1-alpha, DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ...
Authors:Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.
Deposit date:2015-05-08
Release date:2015-08-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.902 Å)
Cite:Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
1H2K
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH HIF-1 ALPHA FRAGMENT PEPTIDE
Descriptor:FACTOR INHIBITING HIF1, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, FE (II) ION, ...
Authors:Elkins, J.M., Hewitson, K.S., McNeill, L.A., Schlemminger, I., Seibel, J.F., Schofield, C.J.
Deposit date:2002-08-12
Release date:2002-11-28
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278, 2003
1H2L
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH HIF-1 ALPHA FRAGMENT PEPTIDE
Descriptor:FACTOR INHIBITING HIF1, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, FE (II) ION, ...
Authors:Elkins, J.M., Hewitson, K.S., McNeill, L.A., Schlemminger, I., Seibel, J.F., Schofield, C.J.
Deposit date:2002-08-12
Release date:2002-11-28
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278, 2003
1H2M
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH HIF-1 ALPHA FRAGMENT PEPTIDE
Descriptor:FACTOR INHIBITING HIF1, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, ZINC ION, ...
Authors:Elkins, J.M., Hewitson, K.S., McNeill, L.A., Schlemminger, I., Seibel, J.F., Schofield, C.J.
Deposit date:2002-08-12
Release date:2002-11-28
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278, 2003
1L8C
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STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR HYPOXIC RESPONSE
Descriptor:CREB-binding protein, Hypoxia-inducible factor 1 alpha, ZINC ION
Authors:Dames, S.A., Martinez-Yamout, M., De Guzman, R.N., Dyson, H.J., Wright, P.E.
Deposit date:2002-03-19
Release date:2002-04-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response.
Proc.Natl.Acad.Sci.USA, 99, 2002
1LM8
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STRUCTURE OF A HIF-1A-PVHL-ELONGINB-ELONGINC COMPLEX
Descriptor:ELONGIN B, ELONGIN C, Von Hippel-Lindau disease tumor suppressor, ...
Authors:Min, J.-H., Yang, H., Ivan, M., Gertler, F., Kaelin JR., W.G., Pavletich, N.P.
Deposit date:2002-04-30
Release date:2002-06-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
Science, 296, 2002
1LQB
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CRYSTAL STRUCTURE OF A HYDROXYLATED HIF-1 ALPHA PEPTIDE BOUND TO THE PVHL/ELONGIN-C/ELONGIN-B COMPLEX
Descriptor:Elongin B, Elongin C, von hippel-lindau disease tumor supressor, ...
Authors:Hon, W.C., Wilson, M.I., Harlos, K., Claridge, T.D., Schofield, C.J., Pugh, C.W., Maxwell, P.H., Ratcliffe, P.J., Stuart, D.I., Jones, E.Y.
Deposit date:2002-05-09
Release date:2002-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Nature, 417, 2002
2ILM
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FACTOR INHIBITING HIF-1 ALPHA D201A MUTANT IN COMPLEX WITH FE(II), ALPHA-KETOGLUTARATE AND HIF-1 ALPHA 35MER
Descriptor:Hypoxia-inducible factor 1 alpha inhibitor, Hypoxia-inducible factor 1 alpha, FE (II) ION, ...
Authors:Mcdonough, M.A., Schofield, C.J.
Deposit date:2006-10-03
Release date:2007-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
J.Biol.Chem., 283, 2008
3HQR
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PHD2:MN:NOG:HIF1-ALPHA SUBSTRATE COMPLEX
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1 alpha, MANGANESE (II) ION, ...
Authors:Chowdhury, R., McDonough, M.A., Schofield, C.J.
Deposit date:2009-06-08
Release date:2009-07-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
Structure, 17, 2009
3HQU
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PHD2:FE:UN9:PARTIAL HIF1-ALPHA SUBSTRATE COMPLEX
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1 alpha, FE (II) ION, ...
Authors:Chowdhury, R., McDonough, M.A., Schofield, C.J.
Deposit date:2009-06-08
Release date:2009-07-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
Structure, 17, 2009
4AJY
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VON HIPPEL-LINDAU PROTEIN-ELONGINB-ELONGINC COMPLEX, BOUND TO HIF1- ALPHA PEPTIDE
Descriptor:TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, HYPOXIA-INDUCIBLE FACTOR 1-ALPHA, ...
Authors:Van Molle, I., Thomann, A., Buckley, D.L., So, E.C., Lang, S., Crews, C.M., Ciulli, A.
Deposit date:2012-02-21
Release date:2012-11-14
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Dissecting Fragment-Based Lead Discovery at the Von Hippel-Lindau Protein:Hypoxia Inducible Factor 1Alpha Protein-Protein Interface.
Chem.Biol., 19, 2012
5JWP
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CRYSTAL STRUCTURE OF HUMAN FIH D201E VARIANT IN COMPLEX WITH ZN, ALPHA-KETOGLUTARATE, AND HIF1 ALPHA PEPTIDE.
Descriptor:Hypoxia-inducible factor 1-alpha inhibitor, Hypoxia-inducible factor 1-alpha, 2-OXOGLUTARIC ACID, ...
Authors:Taabazuing, C.Y., Garman, S.C., Eron, S., Knapp, M.J.
Deposit date:2016-05-12
Release date:2016-11-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The facial triad in the alpha-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation.
J.Inorg.Biochem., 166, 2016
5L9B
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HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-10
Release date:2016-08-31
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5L9V
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HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/P317C) CROSS-LINKED TO HIF-1ALPHA NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-1)
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-11
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.829 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LA9
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HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/V314C) CROSS-LINKED TO HIF-1ALPHA NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-2)
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-14
Release date:2016-08-31
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (2.813 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
5LAS
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HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/P317C/R396T) CROSS-LINKED TO HIF-1ALPHA NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-3)
Descriptor:Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2016-06-14
Release date:2016-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Nat Commun, 7, 2016
6GFX
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PVHL:ELOB:ELOC IN COMPLEX WITH MODIFIED HIF-1A CODD PEPTIDE CONTAINING (3R,4S)-3-FLUORO-4-HYDROXYPROLINE (LIGAND 13A)
Descriptor:Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ...
Authors:Castro, G.V., Testa, A., Ciulli, A.
Deposit date:2018-05-02
Release date:2018-07-11
Last modified:2018-08-01
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation.
J. Am. Chem. Soc., 140, 2018
6GMR
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PVHL:ELOB:ELOC IN COMPLEX WITH (4-(1H-PYRROL-1-YL)PHENYL)METHANOL
Descriptor:Elongin-B, Elongin-C, Hypoxia inducible factor 1alpha, ...
Authors:Van Molle, I., Lucas, X., Ciulli, A.
Deposit date:2018-05-28
Release date:2018-08-08
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
J. Med. Chem., 61, 2018
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