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1NPU
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1
Descriptor:Programmed cell death protein 1
Authors:Zhang, X., Schwartz, J.-C.D., Guo, X., Cao, E., Chen, L., Zhang, Z.-Y., Nathenson, S.G., Almo, S.C., Burley, S.K., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2003-01-20
Release date:2004-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional analysis of the costimulatory receptor programmed death-1.
Immunity, 20, 2004
3BP5
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CRYSTAL STRUCTURE OF THE MOUSE PD-1 AND PD-L2 COMPLEX
Descriptor:Programmed cell death protein 1, Programmed cell death 1 ligand 2, GLYCEROL
Authors:Yan, Q., Lazar-Molnar, E., Cao, E., Ramagopal, U.A., Toro, R., Nathenson, S.G., Almo, S.C.
Deposit date:2007-12-18
Release date:2008-07-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3BP6
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CRYSTAL STRUCTURE OF THE MOUSE PD-1 MUTANT AND PD-L2 COMPLEX
Descriptor:Programmed cell death protein 1, Programmed cell death 1 ligand 2, GLYCEROL
Authors:Yan, Q., Lazar-Molnar, E., Cao, E., Ramagopal, U.A., Toro, R., Nathenson, S.G., Almo, S.C.
Deposit date:2007-12-18
Release date:2009-02-24
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the mouse PD-1 A99L and PD-L2 complex
To be published
3RNK
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MOUSE PD-1 MUTANT AND PD-L2 IGV DOMAIN
Descriptor:Programmed cell death protein 1, Programmed cell death 1 ligand 2
Authors:Lazar-Molnar, E., Ramagopal, U.A., Cao, E., Nathenson, S.G., Almo, S.C.
Deposit date:2011-04-22
Release date:2011-06-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of the complex between mouse PD-1 mutant and PD-L2 IgV domain
To be Published
3SBW
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE EXTRACELLULAR DOMAINS OF MOUSE PD-1 MUTANT AND HUMAN PD-L1
Descriptor:Programmed cell death protein 1, Programmed cell death 1 ligand 1
Authors:Lazar-Molnar, E., Ramagopal, U.A., Cao, E., Nathenson, S.G., Almo, S.C.
Deposit date:2011-06-06
Release date:2011-07-13
Last modified:2016-08-03
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and human PD-L1
To be published
2M2D
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HUMAN PROGRAMMED CELL DEATH 1 RECEPTOR
Descriptor:Programmed cell death protein 1
Authors:Veverka, V., Cheng, X., Waters, L.C., Muskett, F.W., Morgan, S., Lesley, A., Griffiths, M., Stubberfield, C., Griffin, R., Henry, A.J., Robinson, M.K., Jansson, A., Ladbury, J.E., Ikemizu, S., Davis, S.J., Carr, M.D.
Deposit date:2012-12-18
Release date:2013-02-27
Last modified:2013-05-15
Method:SOLUTION NMR
Cite:Structure and interactions of the human programmed cell death 1 receptor.
J.Biol.Chem., 288, 2013
3RRQ
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN PD-1
Descriptor:Programmed cell death protein 1
Authors:Lazar-Molnar, E., Ramagopal, U.A., Nathenson, S.G., Almo, S.C.
Deposit date:2011-04-29
Release date:2012-05-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the extracellular domain of human PD-1
To be Published
5B8C
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HIGH RESOLUTION STRUCTURE OF THE HUMAN PD-1 IN COMPLEX WITH PEMBROLIZUMAB FV
Descriptor:Pembrolizumab light chain variable region (PemVL), Pembrolizumab heavy chain variable region (PemVH), Programmed cell death protein 1
Authors:Horita, S., Shimamura, T., Iwata, S., Nomura, N.
Deposit date:2016-06-14
Release date:2016-10-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.146 Å)
Cite:High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1
Sci Rep, 6, 2016
5GGR
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PD-1 IN COMPLEX WITH NIVOLUMAB FAB
Descriptor:heavy chain, light chain, Programmed cell death protein 1
Authors:Heo, Y.S.
Deposit date:2016-06-16
Release date:2016-11-09
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy
Nat Commun, 7, 2016
5GGS
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PD-1 IN COMPLEX WITH PEMBROLIZUMAB FAB
Descriptor:heavy chain, light chain, Programmed cell death protein 1
Authors:Heo, Y.S.
Deposit date:2016-06-16
Release date:2016-11-09
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy
Nat Commun, 7, 2016
5IUS
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CRYSTAL STRUCTURE OF HUMAN PD-L1 IN COMPLEX WITH HIGH AFFINITY PD-1 MUTANT
Descriptor:Programmed cell death protein 1, Programmed cell death 1 ligand 1, CHLORIDE ION
Authors:Pascolutti, R., Sun, X., Kao, J., Maute, R., Ring, A.M., Bowman, G.R., Kruse, A.C.
Deposit date:2016-03-18
Release date:2016-09-28
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.889 Å)
Cite:Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant.
Structure, 24, 2016
5JXE
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HUMAN PD-1 ECTODOMAIN COMPLEXED WITH PEMBROLIZUMAB FAB
Descriptor:Programmed cell death protein 1, Pembrolizumab Fab light chain, Pembrolizumab Fab heavy chain
Authors:Na, Z., Bharath, S.R., Song, H.
Deposit date:2016-05-13
Release date:2016-08-10
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab.
Cell Res., 27, 2017
5WT9
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COMPLEX STRUCTURE OF PD-1 AND NIVOLUMAB-FAB
Descriptor:Heavy Chain of Nivolumab, Light Chain of Nivolumab, Programmed cell death protein 1, ...
Authors:Tan, S., Zhang, H., Chai, Y., Song, H., Tong, Z., Wang, Q., Qi, J., Wong, G., Zhu, X., Liu, W.J., Gao, S., Wang, Z., Shi, Y., Yang, F., Gao, G.F., Yan, J.
Deposit date:2016-12-10
Release date:2017-02-15
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:An unexpected N-terminal loop in PD-1 dominates binding by nivolumab.
Nat Commun, 8, 2017
3BIK
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CRYSTAL STRUCTURE OF THE PD-1/PD-L1 COMPLEX
Descriptor:Programmed cell death 1 ligand 1, Programmed cell death protein 1, GLYCEROL
Authors:Lin, D.Y., Tanaka, Y., Iwasaki, M., Gittis, A.G., Su, H.P., Mikami, B., Okazaki, T., Honjo, T., Minato, N., Garboczi, D.N.
Deposit date:2007-11-30
Release date:2008-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3RNQ
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE EXTRACELLULAR DOMAINS OF MOUSE PD-1 MUTANT AND PD-L2
Descriptor:Programmed cell death 1 ligand 2, Programmed cell death protein 1
Authors:Lazar-Molnar, E., Ramagopal, U.A., Nathenson, S.G., Almo, S.C.
Deposit date:2011-04-22
Release date:2011-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and PD-L2
To be Published
4ZQK
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STRUCTURE OF THE COMPLEX OF HUMAN PROGRAMMED DEATH-1 (PD-1) AND ITS LIGAND PD-L1.
Descriptor:Programmed cell death 1 ligand 1, Programmed cell death protein 1, SODIUM ION
Authors:Zak, K.M., Dubin, G., Holak, T.A.
Deposit date:2015-05-10
Release date:2015-11-04
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1.
Structure, 23, 2015
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