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1MH1
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SMALL G-PROTEIN
Descriptor:RAC1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Hirshberg, M., Stockley, R.W., Dodson, G., Webb, M.R.
Deposit date:1997-01-21
Release date:1998-01-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue.
Nat.Struct.Biol., 4, 1997
1RYF
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ALTERNATIVE SPLICING OF RAC1 GENERATES RAC1B, A SELF-ACTIVATING GTPASE
Descriptor:ras-related C3 botulinum toxin substrate 1 isoform Rac1b, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Ahmadian, M.R., Fiegen, D.
Deposit date:2003-12-22
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase
J.Biol.Chem., 279, 2004
1RYH
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ALTERNATIVE SPLICING OF RAC1 GENERATES RAC1B, A SELF-ACTIVATING GTPASE
Descriptor:ras-related C3 botulinum toxin substrate 1 isoform Rac1b, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Ahmadian, M.R., Fiegen, D.
Deposit date:2003-12-22
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase
J.Biol.Chem., 279, 2004
2FJU
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ACTIVATED RAC1 BOUND TO ITS EFFECTOR PHOSPHOLIPASE C BETA 2
Descriptor:Ras-related C3 botulinum toxin substrate 1, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2, MAGNESIUM ION, ...
Authors:Jezyk, M.R., Snyder, J.T., Harden, T.K., Sondek, J.
Deposit date:2006-01-03
Release date:2006-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Rac1 bound to its effector phospholipase C-beta2.
Nat.Struct.Mol.Biol., 13, 2006
2H7V
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CO-CRYSTAL STRUCTURE OF YPKA-RAC1
Descriptor:Migration-inducing protein 5, Protein kinase ypkA, MAGNESIUM ION, ...
Authors:Prehna, G., Ivanov, M., Bliska, J.B., Stebbins, C.E.
Deposit date:2006-06-04
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Yersinia virulence depends on mimicry of host rho-family nucleotide dissociation inhibitors.
Cell(Cambridge,Mass.), 126, 2006
2NZ8
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N-TERMINAL DHPH CASSETTE OF TRIO IN COMPLEX WITH NUCLEOTIDE-FREE RAC1
Descriptor:ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein
Authors:Chhatriwala, M.K., Betts, L., Worthylake, D.K., Sondek, J.
Deposit date:2006-11-22
Release date:2007-04-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
J.Mol.Biol., 368, 2007
2P2L
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RAC1-GDP-ZINC COMPLEX
Descriptor:Ras-related C3 botulinum toxin substrate 1, ZINC ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Prehna, G., Stebbins, C.E.
Deposit date:2007-03-07
Release date:2007-05-01
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A Rac1-GDP trimer complex binds zinc with tetrahedral and octahedral coordination, displacing magnesium.
Acta Crystallogr.,Sect.D, 63, 2007
2RMK
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RAC1/PRK1 COMPLEX
Descriptor:Ras-related C3 botulinum toxin substrate 1, Serine/threonine-protein kinase N1, MAGNESIUM ION, ...
Authors:Modha, R., Campbell, L.J., Nietlispach, D., Buhecha, H.R., Owen, D., Mott, H.R.
Deposit date:2007-10-25
Release date:2007-11-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Rac1 Polybasic Region Is Required for Interaction with Its Effector PRK1
J.Biol.Chem., 283, 2008
2VRW
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CRITICAL STRUCTURAL ROLE FOR THE PH AND C1 DOMAINS OF THE VAV1 EXCHANGE FACTOR
Descriptor:RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, PROTO-ONCOGENE VAV, ZINC ION
Authors:Rapley, J., Tybulewicz, V., Rittinger, K.
Deposit date:2008-04-16
Release date:2008-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crucial Structural Role for the Ph and C1 Domains of the Vav1 Exchange Factor.
Embo Rep., 9, 2008
3SBD
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CRYSTAL STRUCTURE OF RAC1 P29S MUTANT
Descriptor:Ras-related C3 botulinum toxin substrate 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION
Authors:Ha, B.H., Boggon, T.J.
Deposit date:2011-06-03
Release date:2012-07-18
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
3SBE
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CRYSTAL STRUCTURE OF RAC1 P29S MUTANT
Descriptor:Ras-related C3 botulinum toxin substrate 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION
Authors:Ha, B.H., Boggon, T.J.
Deposit date:2011-06-03
Release date:2012-07-18
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
3SU8
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CRYSTAL STRUCTURE OF A TRUNCATED INTRACELLULAR DOMAIN OF PLEXIN-B1 IN COMPLEX WITH RAC1
Descriptor:Ras-related C3 botulinum toxin substrate 1, Plexin-B1, MAGNESIUM ION, ...
Authors:Bell, C.H., Aricescu, A.R., Jones, E.Y., Siebold, C.
Deposit date:2011-07-11
Release date:2011-09-28
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A Dual Binding Mode for RhoGTPases in Plexin Signalling.
Plos Biol., 9, 2011
3SUA
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CRYSTAL STRUCTURE OF THE INTRACELLULAR DOMAIN OF PLEXIN-B1 IN COMPLEX WITH RAC1
Descriptor:Ras-related C3 botulinum toxin substrate 1, Plexin-B1, MAGNESIUM ION, ...
Authors:Bell, C.H., Aricescu, A.R., Jones, E.Y., Siebold, C.
Deposit date:2011-07-11
Release date:2011-09-07
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (4.39 Å)
Cite:A Dual Binding Mode for RhoGTPases in Plexin Signalling.
Plos Biol., 9, 2011
3TH5
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CRYSTAL STRUCTURE OF WILD-TYPE RAC1
Descriptor:Ras-related C3 botulinum toxin substrate 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION
Authors:Ha, B.H., Boggon, T.J.
Deposit date:2011-08-18
Release date:2012-07-18
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
4GZL
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CRYSTAL STRUCTURE OF RAC1 Q61L MUTANT
Descriptor:Ras-related C3 botulinum toxin substrate 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ...
Authors:Ha, B.H., Boggon, T.J.
Deposit date:2012-09-06
Release date:2012-12-12
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:RAC1P29S is a spontaneously activating cancer-associated GTPase.
Proc.Natl.Acad.Sci.USA, 110, 2013
4GZM
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CRYSTAL STRUCTURE OF RAC1 F28L MUTANT
Descriptor:Ras-related C3 botulinum toxin substrate 1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION
Authors:Ha, B.H., Boggon, T.J.
Deposit date:2012-09-06
Release date:2012-12-12
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:RAC1P29S is a spontaneously activating cancer-associated GTPase.
Proc.Natl.Acad.Sci.USA, 110, 2013
5HZH
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CRYSTAL STRUCTURE OF PHOTOINHIBITABLE RAC1 CONTAINING C450A MUTANT LOV2 DOMAIN
Descriptor:Ras-related C3 botulinum toxin substrate 1,NPH1-1,Ras-related C3 botulinum toxin substrate 1, GUANOSINE-5'-TRIPHOSPHATE, FLAVIN MONONUCLEOTIDE, ...
Authors:Tarnawski, M., Dagliyan, O., Chu, P.H., Shirvanyants, D., Dokholyan, N.V., Hahn, K.M., Schlichting, I.
Deposit date:2016-02-02
Release date:2016-12-21
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Engineering extrinsic disorder to control protein activity in living cells.
Science, 354, 2016
5N6O
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WILD TYPE GDP FORM RAC1
Descriptor:Ras-related C3 botulinum toxin substrate 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Cherfils, J., Ferrandez, Y.
Deposit date:2017-02-15
Release date:2017-12-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule.
Sci Rep, 7, 2017
5O33
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A STRUCTURE OF THE GEF KALIRIN DH1 DOMAIN IN COMPLEX WITH THE SMALL GTPASE RAC1
Descriptor:Ras-related C3 botulinum toxin substrate 1, Kalirin, 1,2-ETHANEDIOL, ...
Authors:Gray, J., Krojer, T., Talon, R., Fairhead, M., Bountra, C., Arrowsmith, C.H., Edwards, A., Brennan, P., von Delft, F.
Deposit date:2017-05-23
Release date:2017-05-31
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1
To Be Published
6BC1
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A COMPLEX BETWEEN PH DOMAIN OF P190RHOGEF AND ACTIVATED RAC1 BOUND TO A GTP ANALOG
Descriptor:Ras-related C3 botulinum toxin substrate 1, Rho guanine nucleotide exchange factor 28, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ...
Authors:Chen, Z., Sternweis, P.C.
Deposit date:2017-10-20
Release date:2017-12-13
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Direct regulation of p190RhoGEF by activated Rho and Rac GTPases.
J. Struct. Biol., 202, 2018
1E96
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STRUCTURE OF THE RAC/P67PHOX COMPLEX
Descriptor:RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, NEUTROPHIL CYTOSOL FACTOR 2 (NCF-2) TPR DOMAIN, RESIDUES 1-203, ...
Authors:Lapouge, K., Smith, S.J.M., Walker, P.A., Gamblin, S.J., Smerdon, S.J., Rittinger, K.
Deposit date:2000-10-10
Release date:2000-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the Tpr Domain of P67Phox in Complex with Rac.GTP
Mol.Cell, 6, 2000
1FOE
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CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1
Descriptor:T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE, SULFATE ION
Authors:Worthylake, D.K., Rossman, K.L., Sondek, J.
Deposit date:2000-08-27
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.
Nature, 408, 2000
1G4U
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CRYSTAL STRUCTURE OF THE SALMONELLA TYROSINE PHOSPHATASE AND GTPASE ACTIVATING PROTEIN SPTP BOUND TO RAC1
Descriptor:PROTEIN TYROSINE PHOSPHATASE SPTP, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, MAGNESIUM ION, ...
Authors:Stebbins, C.E., Galan, J.E.
Deposit date:2000-10-28
Release date:2001-01-24
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Modulation of host signaling by a bacterial mimic: structure of the Salmonella effector SptP bound to Rac1.
Mol.Cell, 6, 2000
1HE1
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE GAP DOMAIN OF THE PSEUDOMONAS AERUGINOSA EXOS TOXIN AND HUMAN RAC
Descriptor:EXOENZYME S, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, NICKEL (II) ION, ...
Authors:Wurtele, M., Wolf, E., Pederson, K.J., Buchwald, G., Ahmadian, M.R., Barbieri, J.T., Wittinghofer, A.
Deposit date:2000-11-18
Release date:2001-01-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:How the Pseudomonas Aeruginosa Exos Toxin Downregulates Rac
Nat.Struct.Biol., 8, 2001
1HH4
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RAC1-RHOGDI COMPLEX INVOLVED IN NADPH OXIDASE ACTIVATION
Descriptor:RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, RHO GDP-DISSOCIATION INHIBITOR 1, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Grizot, S., Faure, J., Fieschi, F., Vignais, P.V., Dagher, M.-C., Pebay-Peyroula, E.
Deposit date:2000-12-20
Release date:2001-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of the Rac1-Rhogdi Complex Involved in Nadph Oxidase Activation
Biochemistry, 40, 2001
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