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1JM7
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SOLUTION STRUCTURE OF THE BRCA1/BARD1 RING-DOMAIN HETERODIMER
Descriptor:BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN, BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1, ZINC ION
Authors:Brzovic, P.S., Rajagopal, P., Hoyt, D.W., King, M.-C., Klevit, R.E.
Deposit date:2001-07-17
Release date:2001-10-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.
Nat.Struct.Biol., 8, 2001
1JNX
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CRYSTAL STRUCTURE OF THE BRCT REPEAT REGION FROM THE BREAST CANCER ASSOCIATED PROTEIN, BRCA1
Descriptor:BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN, NICKEL (II) ION
Authors:Williams, R.S., Green, R., Glover, J.N.M.
Deposit date:2001-07-26
Release date:2001-09-21
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.
Nat.Struct.Biol., 8, 2001
1N5O
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STRUCTURAL CONSEQUENCES OF A CANCER-CAUSING BRCA1-BRCT MISSENSE MUTATION
Descriptor:Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION
Authors:Williams, R.S., Glover, J.N.M.
Deposit date:2002-11-06
Release date:2002-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural consequences of a cancer-causing BRCA1-BRCT missense mutation
J.Biol.Chem., 278, 2003
1OQA
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SOLUTION STRUCTURE OF THE BRCT-C DOMAIN FROM HUMAN BRCA1
Descriptor:Breast cancer type 1 susceptibility protein
Authors:Gaiser, O.J., Ball, L.J., Schmieder, P., Leitner, D., Strauss, H., Wahl, M., Kuhne, R., Oschkinat, H., Heinemann, U.
Deposit date:2003-03-07
Release date:2004-06-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1.
Biochemistry, 43, 2004
1T15
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CRYSTAL STRUCTURE OF THE BRCA1 BRCT DOMAINS IN COMPLEX WITH THE PHOSPHORYLATED INTERACTING REGION FROM BACH1 HELICASE
Descriptor:Breast cancer type 1 susceptibility protein, BRCA1 interacting protein C-terminal helicase 1
Authors:Clapperton, J.A., Manke, I.A., Lowery, D.M., Ho, T., Haire, L.F., Yaffe, M.B., Smerdon, S.J.
Deposit date:2004-04-15
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer
Nat.Struct.Mol.Biol., 11, 2004
1T29
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CRYSTAL STRUCTURE OF THE BRCA1 BRCT REPEATS BOUND TO A PHOSPHORYLATED BACH1 PEPTIDE
Descriptor:Breast cancer type 1 susceptibility protein, BACH1 phosphorylated peptide
Authors:Shiozaki, E.N., Gu, L., Yan, N., Shi, Y.
Deposit date:2004-04-20
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.
Mol.Cell, 14, 2004
1T2U
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STRUCTURAL BASIS OF PHOSPHOPEPTIDE RECOGNITION BY THE BRCT DOMAIN OF BRCA1: STRUCTURE OF BRCA1 MISSENSE VARIANT V1809F
Descriptor:Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION
Authors:Williams, R.S., Lee, M.S., Duong, D.D., Glover, J.N.M.
Deposit date:2004-04-22
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis of Phosphopeptide recognition by the BRCT domain of BRCA1
Nat.Struct.Mol.Biol., 11, 2004
1T2V
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STRUCTURAL BASIS OF PHOSPHO-PEPTIDE RECOGNITION BY THE BRCT DOMAIN OF BRCA1, STRUCTURE WITH PHOSPHOPEPTIDE
Descriptor:Breast cancer type 1 susceptibility protein, BRCTide-7PS
Authors:Williams, R.S., Lee, M.S., Hau, D.D., Glover, J.N.M.
Deposit date:2004-04-22
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
Nat.Struct.Mol.Biol., 11, 2004
1Y98
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STRUCTURE OF THE BRCT REPEATS OF BRCA1 BOUND TO A CTIP PHOSPHOPEPTIDE.
Descriptor:Breast cancer type 1 susceptibility protein, CtIP PHOSPHORYLATED PEPTIDE, COBALT (II) ION, ...
Authors:Varma, A.K., Brown, R.S., Birrane, G., Ladias, J.A.A.
Deposit date:2004-12-14
Release date:2005-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Cell Cycle Checkpoint Control by the BRCA1-CtIP Complex.
Biochemistry, 44, 2005
2ING
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X-RAY STRUCTURE OF THE BRCA1 BRCT MUTANT M1775K
Descriptor:Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION
Authors:Birrane, G., Soni, A., Ladias, J.A.A.
Deposit date:2006-10-07
Release date:2007-09-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach.
Eur.J.Hum.Genet., 16, 2008
3COJ
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CRYSTAL STRUCTURE OF THE BRCT DOMAINS OF HUMAN BRCA1 IN COMPLEX WITH A PHOSPHORYLATED PEPTIDE FROM HUMAN ACETYL-COA CARBOXYLASE 1
Descriptor:Breast cancer type 1 susceptibility protein, Acetyl-CoA carboxylase 1
Authors:Shen, Y., Tong, L.
Deposit date:2008-03-28
Release date:2008-05-27
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1
Biochemistry, 47, 2008
3K0H
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THE CRYSTAL STRUCTURE OF BRCA1 BRCT IN COMPLEX WITH A MINIMAL RECOGNITION TETRAPEPTIDE WITH AN AMIDATED C-TERMINUS
Descriptor:Breast cancer type 1 susceptibility protein, phospho peptide, NICKEL (II) ION, ...
Authors:Campbell, S.J., Edwards, R.A., Glover, J.N.
Deposit date:2009-09-24
Release date:2010-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1
Structure, 18, 2010
3K0K
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CRYSTAL STRUCTURE OF BRCA1 BRCT IN COMPLEX WITH A MINIMAL RECOGNITION TETRAPEPTIDE WITH A FREE CARBOXY C-TERMINUS.
Descriptor:Breast cancer type 1 susceptibility protein, phospho peptide pSPTF-COOH, NICKEL (II) ION, ...
Authors:Campbell, S.J., Edwards, R.A., Glover, J.N.
Deposit date:2009-09-24
Release date:2010-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1
Structure, 18, 2010
3K15
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CRYSTAL STRUCTURE OF BRCA1 BRCT D1840T IN COMPLEX WITH A MINIMAL RECOGNITION TETRAPEPTIDE WITH AN AMIDATED C-TERMINUS
Descriptor:Breast cancer type 1 susceptibility protein, phospho peptide, NICKEL (II) ION, ...
Authors:Campbell, S.J., Edwards, R.A., Glover, J.N.
Deposit date:2009-09-25
Release date:2010-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1
Structure, 18, 2010
3K16
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CRYSTAL STRUCTURE OF BRCA1 BRCT D1840T IN COMPLEX WITH A MINIMAL RECOGNITION TETRAPEPTIDE WITH A FREE CARBOXY C-TERMINUS
Descriptor:Breast cancer type 1 susceptibility protein, phospho peptide, NICKEL (II) ION, ...
Authors:Campbell, S.J., Edwards, R.A., Glover, J.N.
Deposit date:2009-09-25
Release date:2010-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1
Structure, 18, 2010
3PXA
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IMPACT OF BRCA1 BRCT DOMAIN MISSENSE SUBSTITUTIONS ON PHOSPHO-PEPTIDE RECOGNITION: G1656D
Descriptor:Breast cancer type 1 susceptibility protein, NICKEL (II) ION, SULFATE ION
Authors:Coquelle, N., Green, R., Glover, J.N.M.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
3PXB
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IMPACT OF BRCA1 BRCT DOMAIN MISSENSE SUBSTITUTIONS ON PHOSPHO-PEPTIDE RECOGNITION: T1700A
Descriptor:Breast cancer type 1 susceptibility protein, SULFATE ION, NICKEL (II) ION
Authors:Coquelle, N., Green, R., Glover, J.N.M.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
3PXC
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IMPACT OF BRCA1 BRCT DOMAIN MISSENSE SUBSTITUTIONS ON PHOSPHO-PEPTIDE RECOGNITION: R1699Q
Descriptor:Breast cancer type 1 susceptibility protein, SULFATE ION, NICKEL (II) ION
Authors:Coquelle, N., Green, R., Glover, J.N.M.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
3PXD
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IMPACT OF BRCA1 BRCT DOMAIN MISSENSE SUBSTITUTIONS ON PHOSPHO-PEPTIDE RECOGNITION: R1835P
Descriptor:Breast cancer type 1 susceptibility protein, SULFATE ION, NICKEL (II) ION
Authors:Coquelle, N., Green, R., Glover, J.N.M.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
3PXE
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IMPACT OF BRCA1 BRCT DOMAIN MISSENSE SUBSTITUTIONS ON PHOSPHO-PEPTIDE RECOGNITION: E1836K
Descriptor:Breast cancer type 1 susceptibility protein, phospho peptide
Authors:Coquelle, N., Green, R., Glover, J.N.M.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
4IFI
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STRUCTURE OF HUMAN BRCA1 BRCT IN COMPLEX WITH BAAT PEPTIDE
Descriptor:Breast cancer type 1 susceptibility protein, BAAT peptide, ACETATE ION
Authors:Liu, X., Ladias, J.A.A.
Deposit date:2012-12-14
Release date:2013-10-30
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1.
Biochemistry, 52, 2013
4IGK
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STRUCTURE OF HUMAN BRCA1 BRCT IN COMPLEX WITH ATRIP PEPTIDE
Descriptor:Breast cancer type 1 susceptibility protein, ATRIP peptide, GLYCEROL
Authors:Liu, X., Ladias, J.A.A.
Deposit date:2012-12-17
Release date:2013-10-30
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1.
Biochemistry, 52, 2013
4JLU
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CRYSTAL STRUCTURE OF BRCA1 BRCT WITH DOUBLY PHOSPHORYLATED ABRAXAS
Descriptor:Breast cancer type 1 susceptibility protein, BRCA1-A complex subunit Abraxas
Authors:Badgujar, D., Varma, A.K.
Deposit date:2013-03-13
Release date:2014-09-10
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of BRCA1 BRCT with doubly phosphorylated Abraxas
To be Published
4OFB
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CRYSTAL STRUCTURE OF HUMAN BRCA1 BRCT IN COMPLEX WITH NONPHOSPHOPEPTIDE INHIBITOR
Descriptor:Breast cancer type 1 susceptibility protein, nonphosphopeptide inhibitor
Authors:Sun, L., Edwards, R.A., Glover, J.N.M.
Deposit date:2014-01-14
Release date:2015-04-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain.
Acs Chem.Biol., 10, 2015
4U4A
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COMPLEX STRUCTURE OF BRCA1 BRCT WITH SINGLY PHOSPHO ABRAXAS
Descriptor:Breast cancer type 1 susceptibility protein, BRCA1-A complex subunit Abraxas
Authors:Badgujar, D., Hosur, M.V., Varma, A.K.
Deposit date:2014-07-23
Release date:2015-08-26
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:Complex Structure of BRCA1 BRCT with singly phospho Abraxas
To Be Published
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