Mine: Advanced search results

Advanced query:
Other DB:UniProt: P37238 | P37231 | E7EUD1
Add keyword:
Search
Go to Advanced search
4XLD
  • Download 4xld
  • View 4xld
Molmil generated image of 4xld
CRYSTAL STRUCTURE OF THE HUMAN PPARG-LBD/ROSIGLITAZONE COMPLEX OBTAINED BY DRY CO-CRYSTALLIZATION AND IN SITU DIFFRACTION
Descriptor:Peroxisome proliferator-activated receptor gamma, FORMIC ACID, 2,4-THIAZOLIDIINEDIONE, ...
Authors:Delfosse, V., Guichou, J.-F.
Deposit date:2015-01-13
Release date:2015-08-12
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.
Acta Crystallogr.,Sect.D, 71, 2015
5F9B
  • Download 5f9b
  • View 5f9b
Molmil generated image of 5f9b
X-RAY CRYSTAL STRUCTURE OF PPARGAMMA IN THE COMPLEX WITH CAULOPHYLLOGENIN
Descriptor:Peroxisome proliferator-activated receptor gamma, Caulophyllogenin
Authors:Pochetti, G., Montanari, R., Capelli, D.
Deposit date:2015-12-09
Release date:2016-06-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Screening of saponins and sapogenins from Medicago species as potential PPAR gamma agonists and X-ray structure of the complex PPAR gamma /caulophyllogenin.
Sci Rep, 6, 2016
6AN1
  • Download 6an1
  • View 6an1
Molmil generated image of 6an1
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN PPARGAMMA LBD AND THE LIGAND AM-879
Descriptor:Peroxisome proliferator-activated receptor gamma, 4-({2-[(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)methyl]phenoxy}methyl)benzoic acid
Authors:Veras, H., Figueira, A.C., le Maire, A.
Deposit date:2017-08-11
Release date:2018-02-14
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.687 Å)
Cite:Screening for PPAR Non-Agonist Ligands Followed by Characterization of a Hit, AM-879, with Additional No-Adipogenic and cdk5-Mediated Phosphorylation Inhibition Properties.
Front Endocrinol (Lausanne), 9, 2018
6FZG
  • Download 6fzg
  • View 6fzg
Molmil generated image of 6fzg
PPAR GAMMA MUTANT COMPLEX
Descriptor:Peroxisome proliferator-activated receptor gamma, (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid, CHLORIDE ION
Authors:Rochel, N.
Deposit date:2018-03-14
Release date:2019-02-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Recurrent activating mutations of PPAR gamma associated with luminal bladder tumors.
Nat Commun, 10, 2019
1I7I
  • Download 1i7i
  • View 1i7i
Molmil generated image of 1i7i
CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST AZ 242
Descriptor:PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA, (2S)-2-ETHOXY-3-[4-(2-{4-[(METHYLSULFONYL)OXY]PHENYL}ETHOXY)PHENYL]PROPANOIC ACID
Authors:Petersen, J.F.W., Cronet, P., Folmer, R., Blomberg, N., Sjoblom, K., Karlsson, U., Lindstedt, E.-L., Bamberg, K.
Deposit date:2001-03-09
Release date:2002-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family.
Structure, 9, 2001
1KNU
  • Download 1knu
  • View 1knu
Molmil generated image of 1knu
LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA IN COMPLEX WITH A SYNTHETIC AGONIST
Descriptor:PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA, (S)-3-(4-(2-CARBAZOL-9-YL-ETHOXY)-PHENYL)-2-ETHOXY-PROPIONIC ACID
Authors:Svensson, L.A., Mortensen, S.B., Fleckner, J., Woeldike, H.F.
Deposit date:2001-12-19
Release date:2002-12-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity
J.MED.CHEM., 45, 2002
1NYX
  • Download 1nyx
  • View 1nyx
Molmil generated image of 1nyx
LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA IN COMPLEX WITH AN AGONIST
Descriptor:peroxisome proliferator activated receptor gamma, (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID
Authors:Ebdrup, S., Pettersson, I., Rasmussen, H.B., Deussen, H.-J., Frost Jensen, A., Mortensen, S.B., Fleckner, J., Pridal, L., Nygaard, L., Sauerberg, P.
Deposit date:2003-02-14
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar
J.MED.CHEM., 46, 2003
1PRG
  • Download 1prg
  • View 1prg
Molmil generated image of 1prg
LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
Descriptor:PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA)
Authors:Nolte, R.T., Wisely, G.B., Milburn, M.V.
Deposit date:1998-07-02
Release date:2001-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.
Nature, 395, 1998
1ZEO
  • Download 1zeo
  • View 1zeo
Molmil generated image of 1zeo
CRYSTAL STRUCTURE OF HUMAN PPAR-GAMMA LIGAND BINDING DOMAIN COMPLEXED WITH AN ALPHA-ARYLOXYPHENYLACETIC ACID AGONIST
Descriptor:Peroxisome proliferator activated receptor gamma, (2S)-(4-ISOPROPYLPHENYL)[(2-METHYL-3-OXO-5,7-DIPROPYL-2,3-DIHYDRO-1,2-BENZISOXAZOL-6-YL)OXY]ACETATE
Authors:Shi, G.Q., Dropinski, J.F., McKeever, B.M., Adams, A.D., MacNaul, K.L., Elbrecht, A., Berger, J.P., Zhou, G., Doebber, T.W.
Deposit date:2005-04-19
Release date:2006-04-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design and Synthesis of alpha-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPAR alpha/gamma Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity
J.Med.Chem., 48, 2005
1ZGY
  • Download 1zgy
  • View 1zgy
Molmil generated image of 1zgy
STRUCTURAL AND BIOCHEMICAL BASIS FOR SELECTIVE REPRESSION OF THE ORPHAN NUCLEAR RECEPTOR LRH-1 BY SHP
Descriptor:Peroxisome proliferator activated receptor gamma, Nuclear receptor subfamily 0, group B, ...
Authors:Li, Y., Choi, M., Suino, K., Kovach, A., Daugherty, J., Kliewer, S.A., Xu, H.E.
Deposit date:2005-04-22
Release date:2005-07-26
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner.
Proc.Natl.Acad.Sci.Usa, 102, 2005
2ATH
  • Download 2ath
  • View 2ath
Molmil generated image of 2ath
CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IM COMPLEX WITH AN AGONIST
Descriptor:Peroxisome proliferator activated receptor gamma, 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
Authors:Mahindroo, N., Huang, C.-F., Wu, S.-Y., Hsieh, H.-P.
Deposit date:2005-08-25
Release date:2006-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities
J.Med.Chem., 48, 2005
2F4B
  • Download 2f4b
  • View 2f4b
Molmil generated image of 2f4b
CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH AN AGONIST
Descriptor:Peroxisome proliferator-activated receptor gamma, (5-{3-[(6-BENZOYL-1-PROPYL-2-NAPHTHYL)OXY]PROPOXY}-1H-INDOL-1-YL)ACETIC ACID
Authors:Lu, I.L., Peng, Y.H., Mahindroo, N., Hsieh, H.P., Wu, S.Y.
Deposit date:2005-11-23
Release date:2006-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Indol-1-yl Acetic Acids as Peroxisome Proliferator-Activated Receptor Agonists: Design, Synthesis, Structural Biology, and Molecular Docking Studies
J.Med.Chem., 49, 2006
2FVJ
  • Download 2fvj
  • View 2fvj
Molmil generated image of 2fvj
A NOVEL ANTI-ADIPOGENIC PARTIAL AGONIST OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA (PPARG) RECRUITS PPARG-COACTIVATOR-1 ALPHA (PGC1A) BUT POTENTIATES INSULIN SIGNALING IN VITRO
Descriptor:Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-4-{[4-(2-METHOXYPHENYL)PIPERIDIN-1-YL]METHYL}ISOQUINOLINE, ...
Authors:Benz, J., Burgermeister, E., Flament, A., Schnoebelen, A., Stihle, M., Gsell, B., Rufer, A., Ruf, A., Kuhn, B., Maerki, H.P., Mizrahi, J., Sebokova, E., Niesor, E., Meyer, M.
Deposit date:2006-01-31
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro
Mol.Endocrinol., 20, 2006
2G0G
  • Download 2g0g
  • View 2g0g
Molmil generated image of 2g0g
STRUCTURE-BASED DRUG DESIGN OF A NOVEL FAMILY OF PPAR PARTIAL AGONISTS: VIRTUAL SCREENING, X-RAY CRYSTALLOGRAPHY AND IN VITRO/IN VIVO BIOLOGICAL ACTIVITIES
Descriptor:Peroxisome proliferator-activated receptor gamma, 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE
Authors:Lu, I.L., Peng, Y.H., Huang, C.F., Lin, Y.T., Hsu, J.T.A., Wu, S.Y.
Deposit date:2006-02-13
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structure-Based Drug Design of a Novel Family of PPARgamma Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities
J.Med.Chem., 49, 2006
2GTK
  • Download 2gtk
  • View 2gtk
Molmil generated image of 2gtk
STRUCTURE-BASED DESIGN OF INDOLE PROPIONIC ACIDS AS NOVEL PPARAG CO-AGONISTS
Descriptor:Peroxisome proliferator-activated receptor gamma, Decamer from Nuclear receptor coactivator 1, (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID
Authors:Kuhn, B., Hilpert, H., Benz, J., Binggeli, A., Grether, U., Humm, R., Maerki, H.-P., Meyer, M., Mohr, P.
Deposit date:2006-04-28
Release date:2006-09-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists
Bioorg.Med.Chem.Lett., 16, 2006
2HWQ
  • Download 2hwq
  • View 2hwq
Molmil generated image of 2hwq
STRUCTURAL BASIS FOR THE STRUCTURE-ACTIVITY RELATIONSHIPS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR AGONISTS
Descriptor:Peroxisome proliferator-activated receptor gamma, [(1-{3-[(6-BENZOYL-1-PROPYL-2-NAPHTHYL)OXY]PROPYL}-1H-INDOL-5-YL)OXY]ACETIC ACID
Authors:Peng, Y.H., Lu, I.L., Mahindroo, N., Lin, C.H., Hsieh, H.P., Wu, S.Y.
Deposit date:2006-08-01
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists
J.Med.Chem., 49, 2006
2HWR
  • Download 2hwr
  • View 2hwr
Molmil generated image of 2hwr
STRUCTURAL BASIS FOR THE STRUCTURE-ACTIVITY RELATIONSHIPS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR AGONISTS
Descriptor:Peroxisome proliferator-activated receptor gamma, 2-[(1-{3-[(6-BENZOYL-1-PROPYL-2-NAPHTHYL)OXY]PROPYL}-1H-INDOL-4-YL)OXY]-2-METHYLPROPANOIC ACID
Authors:Peng, Y.H., Lu, I.L., Mahindroo, N., Lin, C.H., Hsieh, H.P., Wu, S.Y.
Deposit date:2006-08-01
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists
J.Med.Chem., 49, 2006
2I4J
  • Download 2i4j
  • View 2i4j
Molmil generated image of 2i4j
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN PPARGAMMA AND THE AGONIST LT160 (UREIDOFIBRATE DERIVATIVE)
Descriptor:Peroxisome proliferator-activated receptor gamma, (2R)-2-(4-{2-[1,3-BENZOXAZOL-2-YL(HEPTYL)AMINO]ETHYL}PHENOXY)-2-METHYLBUTANOIC ACID
Authors:Pochetti, G., Mazza, F.
Deposit date:2006-08-22
Release date:2007-04-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands
J.Biol.Chem., 282, 2007
2I4P
  • Download 2i4p
  • View 2i4p
Molmil generated image of 2i4p
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN PPARGAMMA AND THE PARTIAL AGONIST LT127 (UREIDOFIBRATE DERIVATIVE). STRUCTURE OBTAINED FROM CRYSTALS OF THE APO-FORM SOAKED FOR 30 DAYS.
Descriptor:Peroxisome proliferator-activated receptor gamma, (2S)-2-(4-{2-[1,3-BENZOXAZOL-2-YL(HEPTYL)AMINO]ETHYL}PHENOXY)-2-METHYLBUTANOIC ACID
Authors:Pochetti, G., Mazza, F.
Deposit date:2006-08-22
Release date:2007-04-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands.
J.Biol.Chem., 282, 2007
2I4Z
  • Download 2i4z
  • View 2i4z
Molmil generated image of 2i4z
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN PPARGAMMA AND THE PARTIAL AGONIST LT127 (UREIDOFIBRATE DERIVATIVE). THIS STRUCTURE HAS BEEN OBTAINED FROM CRYSTALS SOAKED FOR 6 HOURS.
Descriptor:Peroxisome proliferator-activated receptor gamma, (2S)-2-(4-{2-[1,3-BENZOXAZOL-2-YL(HEPTYL)AMINO]ETHYL}PHENOXY)-2-METHYLBUTANOIC ACID
Authors:Pochetti, G., Mazza, F.
Deposit date:2006-08-23
Release date:2007-04-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands
J.Biol.Chem., 282, 2007
2OM9
  • Download 2om9
  • View 2om9
Molmil generated image of 2om9
AJULEMIC ACID, A SYNTHETIC CANNABINOID BOUND TO PPAR GAMMA
Descriptor:Peroxisome proliferator-activated receptor gamma, (6AR,10AR)-3-(1,1-DIMETHYLHEPTYL)-1-HYDROXY-6,6-DIMETHYL-6A,7,10,10A-TETRAHYDRO-6H-BENZO[C]CHROMENE-9-CARBOXYLIC ACID
Authors:Ambrosio, A.L.B., Garratt, R.C.
Deposit date:2007-01-21
Release date:2007-04-24
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Ajulemic Acid, a Synthetic Nonpsychoactive Cannabinoid Acid, Bound to the Ligand Binding Domain of the Human Peroxisome Proliferator-activated Receptor gamma
J.Biol.Chem., 282, 2007
2P4Y
  • Download 2p4y
  • View 2p4y
Molmil generated image of 2p4y
CRYSTAL STRUCTURE OF HUMAN PPAR-GAMMA-LIGAND BINDING DOMAIN COMPLEXED WITH AN INDOLE-BASED MODULATOR
Descriptor:Peroxisome proliferator-activated receptor gamma, (2R)-2-(4-CHLORO-3-{[3-(6-METHOXY-1,2-BENZISOXAZOL-3-YL)-2-METHYL-6-(TRIFLUOROMETHOXY)-1H-INDOL-1-YL]METHYL}PHENOXY)PROPANOIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:McKeever, B.M.
Deposit date:2007-03-13
Release date:2008-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities.
Mol.Pharmacol., 73, 2008
2POB
  • Download 2pob
  • View 2pob
Molmil generated image of 2pob
PPARGAMMA LIGAND BINDING DOMAIN COMPLEXED WITH A FARGLITAZAR ANALOGUE GW4709
Descriptor:Peroxisome proliferator-activated receptor gamma, N-[(2S)-2-[(2-BENZOYLPHENYL)AMINO]-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL]ACETAMIDE, GLYCEROL
Authors:Nolte, R.T.
Deposit date:2007-04-26
Release date:2008-03-18
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cocrystal structure guided array synthesis of PPARgamma inverse agonists
BIOORG.MED.CHEM.LETT., 17, 2007
2PRG
  • Download 2prg
  • View 2prg
Molmil generated image of 2prg
LIGAND-BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
Descriptor:PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA, NUCLEAR RECEPTOR COACTIVATOR SRC-1, 2,4-THIAZOLIDIINEDIONE, ...
Authors:Nolte, R.T., Wisely, G.B., Milburn, M.V.
Deposit date:1998-08-14
Release date:1999-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.
Nature, 395, 1998
2Q59
  • Download 2q59
  • View 2q59
Molmil generated image of 2q59
CRYSTAL STRUCTURE OF PPARGAMMA LBD BOUND TO FULL AGONIST MRL20
Descriptor:Peroxisome Proliferator-Activated Receptor gamma, (2S)-2-(2-{[1-(4-METHOXYBENZOYL)-2-METHYL-5-(TRIFLUOROMETHOXY)-1H-INDOL-3-YL]METHYL}PHENOXY)PROPANOIC ACID
Authors:Bruning, J.B., Nettles, K.W.
Deposit date:2007-05-31
Release date:2007-10-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism
Structure, 15, 2007
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan