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1P8J
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CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN
Descriptor:Furin precursor, DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE INHIBITOR, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Henrich, S., Cameron, A., Bourenkov, G.P., Kiefersauer, R., Huber, R., Lindberg, I., Bode, W., Than, M.E.
Deposit date:2003-05-07
Release date:2003-07-08
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Crystal Structure of the Proprotein Processing Proteinase Furin Explains its Stringent Specificity
Nat.Struct.Biol., 10, 2003
4OMC
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X-RAY STRUCTURE OF HUMAN FURIN IN COMPLEX WITH THE COMPETITIVE INHIBITOR META-GUANIDINOMETHYL-PHAC-RVR-AMBA
Descriptor:Furin, meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine, FORMIC ACID, ...
Authors:Dahms, S.O., Than, M.E.
Deposit date:2014-01-27
Release date:2014-04-09
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
Acs Chem.Biol., 9, 2014
4OMD
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X-RAY STRUCTURE OF HUMAN FURIN IN COMPLEX WITH THE COMPETITIVE INHIBITOR PHAC-RVR-AMBA
Descriptor:Furin, phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine, FORMIC ACID, ...
Authors:Dahms, S.O., Than, M.E.
Deposit date:2014-01-27
Release date:2014-04-09
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
Acs Chem.Biol., 9, 2014
4RYD
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X-RAY STRUCTURE OF HUMAN FURIN IN COMPLEX WITH THE COMPETITIVE INHIBITOR PARA-GUANIDINOMETHYL-PHAC-R-TLE-R-AMBA
Descriptor:Furin, para-guanidinomethyl-phenylacetyl-Arg-(3-methylvaline)-Arg-(amidomethyl)benzamidine, FORMIC ACID, ...
Authors:Dahms, S.O., Than, M.E.
Deposit date:2014-12-15
Release date:2015-05-27
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Novel Furin Inhibitors with Potent Anti-infectious Activity.
Chemmedchem, 10, 2015
4Z2A
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CRYSTAL STRUCTURE OF UNGLYCOSYLATED APO HUMAN FURIN @1.89A
Descriptor:Furin, CALCIUM ION, PHOSPHATE ION, ...
Authors:Gampe, R.T., Pearce, K., Reid, R.
Deposit date:2015-03-29
Release date:2016-05-04
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:A BacMam Method for Producing High Levels of Active Human Furin Protein for Biochemical Studies and Crystallography
To Be Published
5JMO
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X-RAY STRUCTURE OF FURIN IN COMPLEX WITH THE INHIBITORY ANTIBODY NB14
Descriptor:Furin, camelid VHH fragment, CMK-inhibitor, ...
Authors:Dahms, S.O., Than, M.E.
Deposit date:2016-04-29
Release date:2016-12-07
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
Sci Rep, 6, 2016
5JXG
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STRUCTURE OF THE UNLIGANDED FORM OF THE PROPROTEIN CONVERTASE FURIN.
Descriptor:Furin, CALCIUM ION, SODIUM ION, ...
Authors:Dahms, S.O., Arciniega, M., Steinmetzer, T., Huber, R., Than, M.E.
Deposit date:2016-05-13
Release date:2016-10-05
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JXH
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STRUCTURE THE PROPROTEIN CONVERTASE FURIN IN COMPLEX WITH META-GUANIDINOMETHYL-PHAC-RVR-AMBA AT 2.0 ANGSTROM RESOLUTION.
Descriptor:Furin, 2UC-ARG-VAL-ARG-00S, CALCIUM ION, ...
Authors:Dahms, S.O., Arciniega, M., Steinmetzer, T., Huber, R., Than, M.E.
Deposit date:2016-05-13
Release date:2016-10-05
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JXI
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STRUCTURE OF THE UNLIGANDED FORM OF THE PROPROTEIN CONVERTASE FURIN IN PRESENCE OF EDTA.
Descriptor:Furin, CALCIUM ION, SODIUM ION, ...
Authors:Dahms, S.O., Arciniega, M., Steinmetzer, T., Huber, R., Than, M.E.
Deposit date:2016-05-13
Release date:2016-10-05
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JXJ
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STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN COMPLEXED TO META-GUANIDINOMETHYL-PHAC-RVR-AMBA IN PRESENCE OF EDTA
Descriptor:Furin, 2UC-ARG-VAL-ARG-00S, CALCIUM ION, ...
Authors:Dahms, S.O., Arciniega, M., Steinmetzer, T., Huber, R., Than, M.E.
Deposit date:2016-05-13
Release date:2016-10-05
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5MIM
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XRAY STRUCTURE OF HUMAN FURIN BOUND WITH THE 2,5-DIDEOXYSTREPTAMINE DERIVED SMALL MOLECULE INHIBITOR 1N
Descriptor:Furin, CALCIUM ION, SODIUM ION, ...
Authors:Dahms, S.O., Guan-Sheng, J., Than, M.E.
Deposit date:2016-11-28
Release date:2017-05-10
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.
ACS Chem. Biol., 12, 2017
6EQV
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X-RAY STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN BOUND WITH THE COMPETITIVE INHIBITOR PHAC-CIT-VAL-ARG-AMBA
Descriptor:Furin, HY1-LLI-VAL-ARG-00S, CALCIUM ION, ...
Authors:Dahms, S.O., Than, M.E.
Deposit date:2017-10-16
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.895 Å)
Cite:X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Biochemistry, 57, 2018
6EQW
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X-RAY STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN BOUND WITH THE COMPETITIVE INHIBITOR 4-AMINOMETHYL-PHENYLACETYL-ARG-VAL-ARG-AMBA
Descriptor:Furin, AMA-ARG-TBG-ARG-00S, CALCIUM ION, ...
Authors:Dahms, S.O., Than, M.E.
Deposit date:2017-10-16
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Biochemistry, 57, 2018
6EQX
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X-RAY STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN BOUND WITH THE COMPETITIVE INHIBITOR ARG-ARG-ARG-VAL-ARG-AMBA
Descriptor:Furin, Arg-Arg-Arg-Val-Arg-00S, CALCIUM ION, ...
Authors:Dahms, S.O., Than, M.E.
Deposit date:2017-10-16
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Biochemistry, 57, 2018
6HLB
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X-RAY STRUCTURE OF FURIN IN COMPLEX WITH THE CYCLIC PEPTIDE C[SUCCINYL-PHE-2-NAL-(ARG)4-LYS]-ARG-4-AMBA
Descriptor:Furin, PHE-(ALN)-ARG-ARG-ARG-ARG-SLL-ARG-00S, CALCIUM ION, ...
Authors:Dahms, S.O.
Deposit date:2018-09-11
Release date:2019-02-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design, synthesis and characterization of new macrocyclic inhibitors of the proprotein convertase furin.
ChemMedChem, 2019
6HLD
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X-RAY STRUCTURE OF FURIN IN COMPLEX WITH THE CYCLIC PEPTIDE C[SUCCINYL-PHE-2-NAL-(ARG)3-LYS]-LYS-4-AMBA
Descriptor:Furin, ALN-ARG-ARG-ARG-SLL-LYS-00S, CALCIUM ION, ...
Authors:Dahms, S.O.
Deposit date:2018-09-11
Release date:2019-02-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design, synthesis and characterization of new macrocyclic inhibitors of the proprotein convertase furin.
ChemMedChem, 2019
6HLE
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X-RAY STRUCTURE OF FURIN IN COMPLEX WITH THE P6-P2-CYCLIZED PEPTIDE H-LYS-ARG-ARG-TLE-LYS-4-AMBA
Descriptor:Furin, LYS-ARG-ARG-TBG-LYS-00S, CALCIUM ION, ...
Authors:Dahms, S.O.
Deposit date:2018-09-11
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:Design, synthesis and characterization of new macrocyclic inhibitors of the proprotein convertase furin.
ChemMedChem, 2019
6HZA
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X-RAY STRUCTURE OF FURIN IN COMPLEX WITH THE CYCLIC PEPTIDE C[GLUTARYL-ARG-ARG-LYS]-ARG-4-AMBA
Descriptor:Furin, ARG-ARG-LYS-ARG-00S, CALCIUM ION, ...
Authors:Dahms, S.O.
Deposit date:2018-10-23
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design, synthesis and characterization of new macrocyclic inhibitors of the proprotein convertase furin.
ChemMedChem, 2019
6HZB
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X-RAY STRUCTURE OF FURIN IN COMPLEX WITH THE CYCLIC INHIBITOR C[GLUTARYL-ARG-ARG-LYS]-LYS-4-AMBA
Descriptor:Furin, ARG-ARG-LYS-LYS-00S, CALCIUM ION, ...
Authors:Dahms, S.O.
Deposit date:2018-10-23
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design, synthesis and characterization of new macrocyclic inhibitors of the proprotein convertase furin.
ChemMedChem, 2019
6HZC
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X-RAY STRUCTURE OF FURIN IN COMPLEX WITH THE CYCLIC INHIBITOR C[GLUTARYL-BVK-LYS-ARG-ARG-TLE-LYS]-4-AMBA
Descriptor:Furin, LYS-ARG-ARG-TBG-LYS-00S, CALCIUM ION, ...
Authors:Dahms, S.O.
Deposit date:2018-10-23
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design, synthesis and characterization of new macrocyclic inhibitors of the proprotein convertase furin.
ChemMedChem, 2019
6HZD
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X-RAY STRUCTURE OF FURIN IN COMPLEX WITH THE CYCLIC INHIBITOR C[GLUTARYL-ARG-ARG-ARG-LYS]-ARG-4-AMBA
Descriptor:Furin, ARG-ARG-ARG-LYS-ARG-00S, CALCIUM ION, ...
Authors:Dahms, S.O.
Deposit date:2018-10-23
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design, synthesis and characterization of new macrocyclic inhibitors of the proprotein convertase furin.
ChemMedChem, 2019
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