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1HRK
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CRYSTAL STRUCTURE OF HUMAN FERROCHELATASE
Descriptor:FERROCHELATASE, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER
Authors:Wu, C.K., Dailey, H.A., Rose, J.P., Burden, A., Sellers, V.M., Wang, B.-C.
Deposit date:2000-12-21
Release date:2001-06-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis.
Nat.Struct.Biol., 8, 2001
2HRC
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1.7 ANGSTROM STRUCTURE OF HUMAN FERROCHELATASE VARIANT R115L
Descriptor:Ferrochelatase, CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Medlock, A., Swartz, L., Dailey, T.A., Dailey, H.A., Lanzilotta, W.N.
Deposit date:2006-07-20
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Substrate interactions with human ferrochelatase
Proc.Natl.Acad.Sci.Usa, 104, 2007
2HRE
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STRUCTURE OF HUMAN FERROCHELATASE VARIANT E343K WITH PROTOPORPHYRIN IX BOUND
Descriptor:Ferrochelatase, PROTOPORPHYRIN IX, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Medlock, A., Swartz, L., Dailey, T.A., Dailey, H.A., Lanzilotta, W.N.
Deposit date:2006-07-20
Release date:2007-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Substrate interactions with human ferrochelatase
Proc.Natl.Acad.Sci.Usa, 104, 2007
2PNJ
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CRYSTAL STRUCTURE OF HUMAN FERROCHELATASE MUTANT WITH PHE 337 REPLACED BY ALA
Descriptor:Ferrochelatase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Dailey, H.A., Wu, C.-K., Horanyi, P., Medlock, A.E., Najahi-Missaoui, W., Burden, A.E., Dailey, T.A., Rose, J.P.
Deposit date:2007-04-24
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis
Biochemistry, 46, 2007
2PO5
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CRYSTAL STRUCTURE OF HUMAN FERROCHELATASE MUTANT WITH HIS 263 REPLACED BY CYS
Descriptor:Ferrochelatase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Dailey, H.A., Wu, C.-K., Horanyi, P., Medlock, A.E., Najahi-Missaoui, A.E.W., Burden, A., Dailey, T.A., Rose, J.P.
Deposit date:2007-04-25
Release date:2007-10-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis
Biochemistry, 46, 2007
2PO7
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CRYSTAL STRUCTURE OF HUMAN FERROCHELATASE MUTANT WITH HIS 341 REPLACED BY CYS
Descriptor:Ferrochelatase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Dailey, H.A., Wu, C.-K., Horanyi, P., Medlock, A.E., Najahi-Missaoui, W., Burden, A., Dailey, T.A., Rose, J.P.
Deposit date:2007-04-25
Release date:2007-10-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis.
Biochemistry, 46, 2007
2QD1
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2.2 ANGSTROM STRUCTURE OF THE HUMAN FERROCHELATASE VARIANT E343K WITH SUBSTRATE BOUND
Descriptor:Ferrochelatase, FE2/S2 (INORGANIC) CLUSTER, PROTOPORPHYRIN IX, ...
Authors:Medlock, A.E., Dailey, T.A., Ross, T.A., Dailey, H.A., Lanzilotta, W.N.
Deposit date:2007-06-20
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
J.Mol.Biol., 373, 2007
2QD3
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WILD TYPE HUMAN FERROCHELATASE CRYSTALLIZED WITH AMMONIUM SULFATE
Descriptor:Ferrochelatase, FE2/S2 (INORGANIC) CLUSTER, CHOLIC ACID, ...
Authors:Medlock, A.E., Dailey, T.A., Ross, T.A., Dailey, H.A., Lanzilotta, W.N.
Deposit date:2007-06-20
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
J.Mol.Biol., 373, 2007
2QD4
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WILD TYPE HUMAN FERROCHELATASE CRYSTALLIZED WITH MNCL2
Descriptor:Ferrochelatase, CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Medlock, A.E., Dailey, T.A., Ross, T.A., Dailey, H.A., Lanzilotta, W.N.
Deposit date:2007-06-20
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
J.Mol.Biol., 373, 2007
2QD5
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STRUCTURE OF WILD TYPE HUMAN FERROCHELATASE IN COMPLEX WITH A LEAD-PORPHYRIN COMPOUND
Descriptor:Ferrochelatase, LEAD (II) ION, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Meldock, A.E., Dailey, T.A., Ross, T.A., Dailey, H.A., Lanzilotta, W.N.
Deposit date:2007-06-20
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
J.Mol.Biol., 373, 2007
3AQI
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H240A VARIANT OF HUMAN FERROCHELATASE
Descriptor:Ferrochelatase, FE2/S2 (INORGANIC) CLUSTER, CHOLIC ACID, ...
Authors:Lanzilotta, W.N., Medlock, A.E., Dailey, T.A., Dailey, H.A.
Deposit date:2010-11-03
Release date:2012-01-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:H240A variant of human ferrochelatase
To be published
3HCN
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HG AND PROTOPORPHYRIN BOUND HUMAN FERROCHELATASE
Descriptor:Ferrochelatase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Medlock, A.E., Dailey, H.A., Lanzilotta, W.N.
Deposit date:2009-05-06
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Product release rather than chelation determines metal specificity for ferrochelatase.
J.Mol.Biol., 393, 2009
3HCO
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HUMAN FERROCHELATASE WITH CD AND PROTOPORPHYRIN IX BOUND
Descriptor:Ferrochelatase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Medlock, A.E., Dailey, H.A., Lanzilotta, W.N.
Deposit date:2009-05-06
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Product release rather than chelation determines metal specificity for ferrochelatase.
J.Mol.Biol., 393, 2009
3HCP
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HUMAN FERROCHELATASE WITH MN AND DEUTEROPORPHYRIN BOUND
Descriptor:Ferrochelatase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Medlock, A.E., Dailey, H.A., Lanzilotta, W.N.
Deposit date:2009-05-06
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Product release rather than chelation determines metal specificity for ferrochelatase.
J.Mol.Biol., 393, 2009
3HCR
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HUMAN FERROCHELATASE WITH DEUTEROPORPHYRIN AND NI BOUND
Descriptor:Ferrochelatase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Medlock, A.E., Dailey, H.A., Lanzilotta, W.N.
Deposit date:2009-05-06
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Product release rather than chelation determines metal specificity for ferrochelatase.
J.Mol.Biol., 393, 2009
3W1W
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PROTEIN-DRUG COMPLEX
Descriptor:Ferrochelatase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Ishii, R., Gupta, V., Yamaguchi, Y., Handa, H., Nureki, O.
Deposit date:2012-11-21
Release date:2013-10-09
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.006 Å)
Cite:Salicylic Acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity
Mol.Pharmacol., 84, 2013
4F4D
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F337R VARIANT OF HUMAN FERROCHELATASE
Descriptor:Ferrochelatase, mitochondrial, CHLORIDE ION, ...
Authors:Lanzilotta, W.N., Medlock, A.E., Dailey, T.E., Dailey, H.A.
Deposit date:2012-05-10
Release date:2012-09-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:F337R Variant of Human Ferrochelatase
TO BE PUBLISHED
4KLA
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E343D VARIANT OF HUMAN FERROCHELATASE
Descriptor:Ferrochelatase, mitochondrial, CHOLIC ACID, ...
Authors:Lanzilotta, W.N., Medlock, A.E.
Deposit date:2013-05-07
Release date:2014-05-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:E343D variant of human ferrochelatase
To be Published
4KLC
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E343D/F110A DOUBLE MUTANT OF HUMAN FERROCHELATASE
Descriptor:Ferrochelatase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Lanzilotta, W.N., Medlock, A.E.
Deposit date:2013-05-07
Release date:2014-06-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:E343D/F110A Double mutant of human ferrochelatase
To be Published
4KLR
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E343Q VARIANT OF HUMAN FERROCHELATASE
Descriptor:Ferrochelatase, mitochondrial, IMIDAZOLE, ...
Authors:Lanzilotta, W.N., Medlock, A.E.
Deposit date:2013-05-07
Release date:2014-06-18
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:E343Q variant of human ferrochelatase
To be Published
4KMM
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M76H VARIANT OF HUMAN FERROCHELATASE
Descriptor:Ferrochelatase, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Lanzilotta, W.N., Medlock, A.E.
Deposit date:2013-05-08
Release date:2014-05-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:M76H variant of human ferrochelatase
To be Published
4MK4
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S197C VARIANT OF HUMAN FERROCHELATASE.
Descriptor:Ferrochelatase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Lanzilotta, W.N., Medlock, A.E., Dailey, T.E., Dailey, H.A.
Deposit date:2013-09-04
Release date:2013-09-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:S197C variant of human ferrochelatase.
To be Published
2QD2
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F110A VARIANT OF HUMAN FERROCHELATASE WITH PROTOHEME BOUND
Descriptor:Ferrochelatase, BICARBONATE ION, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Medlock, A.E., Dailey, T.A., Ross, T.A., Dailey, H.A., Lanzilota, W.N.
Deposit date:2007-06-20
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
J.Mol.Biol., 373, 2007
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