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2QPY
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AR LBD WITH SMALL MOLECULE
Descriptor:Androgen receptor, Coactivator peptide, 5-ALPHA-DIHYDROTESTOSTERONE, ...
Authors:Estebanez-Perpina, E., Fletterick, R.
Deposit date:2007-07-25
Release date:2007-09-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A surface on the androgen receptor that allosterically regulates coactivator binding.
Proc.Natl.Acad.Sci.Usa, 104, 2007
5T8E
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS). PART II: OPTIMIZATION OF 4-(PYRROLIDIN-1-YL)BENZONITRILE DERIVATIVES
Descriptor:Androgen receptor, GLYCEROL, 2-chloro-4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]-3-methylbenzonitrile
Authors:Wilson, K.P.
Deposit date:2016-09-07
Release date:2017-04-26
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives.
Bioorg. Med. Chem. Lett., 27, 2017
5T8J
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS). PART II: OPTIMIZATION OF 4-(PYRROLIDIN-1-YL)BENZONITRILE DERIVATIVES
Descriptor:Androgen receptor, GLYCEROL, 2-fluoro-4-[(2S,3S)-3-hydroxy-2,3-dimethylpyrrolidin-1-yl]-3-methylbenzonitrile
Authors:Wilson, K.P.
Deposit date:2016-09-07
Release date:2017-04-26
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives.
Bioorg. Med. Chem. Lett., 27, 2017
5V8Q
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS): PART III
Descriptor:Androgen receptor, GLYCEROL, 4-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
Authors:Wilson, K.P.
Deposit date:2017-03-22
Release date:2017-05-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate.
Bioorg. Med. Chem., 25, 2017
1E3G
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HUMAN ANDROGEN RECEPTOR LIGAND BINDING IN COMPLEX WITH THE LIGAND METRIBOLONE (R1881)
Descriptor:ANDROGEN RECEPTOR, (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE
Authors:Matias, P.M., Donner, P., Coelho, R., Thomaz, M., Peixoto, C., Macedo, S., Otto, N., Joschko, S., Scholz, P., Wegg, A., Basler, S., Schafer, M., Ruff, M., Egner, U., Carrondo, M.A.
Deposit date:2000-06-14
Release date:2001-06-14
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations.
J. Biol. Chem., 275, 2000
1GS4
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STRUCTURAL BASIS FOR THE GLUCOCORTICOID RESPONSE IN A MUTANT HUMAN ANDROGEN RECEPTOR (ARCCR) DERIVED FROM AN ANDROGEN-INDEPENDENT PROSTATE CANCER
Descriptor:ANDROGEN RECEPTOR, 9ALPHA-FLUOROCORTISOL, PHOSPHATE ION
Authors:Matias, P.M., Carrondo, M.A., Coelho, R., Thomaz, M., Zhao, X.-Y., Wegg, A., Crusius, K., Egner, U., Donner, P.
Deposit date:2001-12-27
Release date:2003-01-16
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Basis for the Glucocorticoid Response in a Mutant Human Androgen Receptor (Ar(Ccr)) Derived from an Androgen-Independent Prostate Cancer
J.Med.Chem., 45, 2002
1T5Z
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CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING DOMAIN (LBD) WITH DHT AND A PEPTIDE DERIVED FROM ITS PHYSIOLOGICAL COACTIVATOR ARA70
Descriptor:Androgen receptor, Nuclear receptor coactivator 4, 5-ALPHA-DIHYDROTESTOSTERONE
Authors:Estebanez-Perpina, E., Moore, J.M.R., Mar, E., Nguyen, P., Delgado-Rodrigues, E., Baxter, J.D., Webb, P., Fletterick, R.J., Guy, R.K.
Deposit date:2004-05-05
Release date:2005-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor.
J.Biol.Chem., 280, 2005
1T63
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CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING DOMAIN WITH DHT AND A PEPTIDE DERIVED FROM ITS PHYSIOLOGICAL COACTIVATOR GRIP1 NR BOX3
Descriptor:Androgen receptor, Nuclear receptor coactivator 2, 5-ALPHA-DIHYDROTESTOSTERONE
Authors:Estebanez-Perpina, E., Moore, J.M.R., Mar, E., Nguyen, P., Delgado-Rodrigues, E., Baxter, J.D., Webb, P., Fletterick, R.J., Guy, R.K.
Deposit date:2004-05-05
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor.
J.Biol.Chem., 280, 2005
1T65
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CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING DOMAIN WITH DHT AND A PEPTIDE DERIVED FORM ITS PHYSIOLOGICAL COACTIVATOR GRIP1 NR BOX 2 BOUND IN A NON-HELICAL CONFORMATION
Descriptor:Androgen receptor, Nuclear receptor coactivator 2, 5-ALPHA-DIHYDROTESTOSTERONE
Authors:Estebanez-Perpina, E., Moore, J.M.R., Mar, E., Nguyen, P., Delgado-Rodrigues, E., Baxter, J.D., Webb, P., Fletterick, R.J., Guy, R.K.
Deposit date:2004-05-05
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor.
J.Biol.Chem., 280, 2005
1XJ7
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COMPLEX ANDROGEN RECEPTOR LBD AND RAC3 PEPTIDE
Descriptor:Androgen receptor, RAC3 derived peptide, 5-ALPHA-DIHYDROTESTOSTERONE
Authors:Estebanez-Perpina, E., Moore, J.M.R., Mar, E., Nguyen, P., Delgado-Rodrigues, E., Baxter, J.D., Buehrer, B.M., Webb, P., Fletterick, R.J., Guy, R.K.
Deposit date:2004-09-22
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor
J.Biol.Chem., 280, 2005
1XOW
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CRYSTAL STRUCTURE OF THE HUMAN ANDROGEN RECEPTOR LIGAND BINDING DOMAIN BOUND WITH AN ANDROGEN RECEPTOR NH2-TERMINAL PEPTIDE, AR20-30, AND R1881
Descriptor:androgen receptor, decamer fragment of androgen receptor, (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE
Authors:He, B., Gampe Jr., R.T., Kole, A.J., Hnat, A.T., Stanley, T.B., An, G., Stewart, E.L., Kalman, R.I., Minges, J.T., Wilson, E.M.
Deposit date:2004-10-07
Release date:2004-11-16
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance
Mol.Cell, 16, 2004
1XQ3
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CRYSTAL STRUCTURE OF THE HUMAN ANDROGEN RECEPTOR LIGAND BINDING DOMAIN BOUND WITH R1881
Descriptor:androgen receptor, (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE
Authors:He, B., Gampe Jr., R.T., Kole, A.J., Hnat, A.T., Stanley, T.B., An, G., Stewart, E.L., Kalman, R.I., Minges, J.T., Wilson, E.M.
Deposit date:2004-10-11
Release date:2004-11-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance
Mol.Cell, 16, 2004
1Z95
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CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND-BINDING DOMAIN W741L MUTANT COMPLEX WITH R-BICALUTAMIDE
Descriptor:Androgen Receptor, SULFATE ION, R-BICALUTAMIDE
Authors:Bohl, C.E., Gao, W., Miller, D.D., Bell, C.E., Dalton, J.T.
Deposit date:2005-03-31
Release date:2005-04-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for antagonism and resistance of bicalutamide in prostate cancer.
Proc.Natl.Acad.Sci.Usa, 102, 2005
2AM9
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CRYSTAL STRUCTURE OF HUMAN ANDROGEN RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH TESTOSTERONE
Descriptor:Androgen receptor, SULFATE ION, TESTOSTERONE, ...
Authors:Pereira de Jesus-Tran, K., Cote, P.-L., Cantin, L., Blanchet, J., Labrie, F., Breton, R.
Deposit date:2005-08-09
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein Sci., 15, 2006
2AMA
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CRYSTAL STRUCTURE OF HUMAN ANDROGEN RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH DIHYDROTESTOSTERONE
Descriptor:Androgen receptor, SULFATE ION, 5-ALPHA-DIHYDROTESTOSTERONE
Authors:Pereira de Jesus-Tran, K., Cote, P.-L., Cantin, L., Blanchet, J., Labrie, F., Breton, R.
Deposit date:2005-08-09
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein Sci., 15, 2006
2AMB
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CRYSTAL STRUCTURE OF HUMAN ANDROGEN RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH TETRAHYDROGESTRINONE
Descriptor:Androgen receptor, SULFATE ION, 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE, ...
Authors:Pereira de Jesus-Tran, K., Cote, P.-L., Cantin, L., Blanchet, J., Labrie, F., Breton, R.
Deposit date:2005-08-09
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein Sci., 15, 2006
2AO6
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CRYSTAL STRUCTURE OF THE HUMAN ANDROGEN RECEPTOR LIGAND BINDING DOMAIN BOUND WITH TIF2(III) 740-753 PEPTIDE AND R1881
Descriptor:androgen receptor, 14-mer fragment of Nuclear receptor coactivator 2, (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE
Authors:He, B., Gampe Jr., R.T., Kole, A.J., Hnat, A.T., Stanley, T.B., An, G., Stewart, E.L., Kalman, R.I., Minges, J.T., Wilson, E.M.
Deposit date:2005-08-12
Release date:2005-08-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance
Mol.Cell, 16, 2004
2AX6
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CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING DOMAIN T877A MUTANT IN COMPLEX WITH HYDROXYFLUTAMIDE
Descriptor:Androgen receptor, HYDROXYFLUTAMIDE
Authors:Bohl, C.E., Miller, D.D., Chen, J., Bell, C.E., Dalton, J.T.
Deposit date:2005-09-03
Release date:2005-09-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor
J.Biol.Chem., 280, 2005
2AX7
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CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING DOMAIN T877A MUTANT IN COMPLEX WITH S-1
Descriptor:Androgen receptor, S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
Authors:Bohl, C.E., Miller, D.D., Chen, J., Bell, C.E., Dalton, J.T.
Deposit date:2005-09-03
Release date:2005-09-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor
J.Biol.Chem., 280, 2005
2AX8
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CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING DOMAIN W741L MUTANT IN COMPLEX WITH S-1
Descriptor:Androgen receptor, S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
Authors:Bohl, C.E., Miller, D.D., Chen, J., Bell, C.E., Dalton, J.T.
Deposit date:2005-09-03
Release date:2005-09-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor
J.Biol.Chem., 280, 2005
2AX9
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CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH R-3
Descriptor:Androgen receptor, (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
Authors:Bohl, C.E., Miller, D.D., Chen, J., Bell, C.E., Dalton, J.T.
Deposit date:2005-09-03
Release date:2005-09-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor
J.Biol.Chem., 280, 2005
2AXA
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CRYSTAL STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH S-1
Descriptor:Androgen receptor, S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
Authors:Bohl, C.E., Miller, D.D., Chen, J., Bell, C.E., Dalton, J.T.
Deposit date:2005-09-03
Release date:2005-09-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor
J.Biol.Chem., 280, 2005
2HVC
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THE CRYSTAL STRUCTURE OF LIGAND-BINDING DOMAIN (LBD) OF HUMAN ANDROGEN RECEPTOR IN COMPLEX WITH A SELECTIVE MODULATOR LGD2226
Descriptor:Androgen receptor, 6-[BIS(2,2,2-TRIFLUOROETHYL)AMINO]-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE
Authors:Wang, F., Liu, X.-Q., Li, H., Liang, K.-N., Miner, J.N., Hong, M., Kallel, E.A., van Oeveren, A., Zhi, L., Jiang, T.
Deposit date:2006-07-28
Release date:2007-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the ligand-binding domain (LBD) of human androgen receptor in complex with a selective modulator LGD2226
ACTA CRYSTALLOGR.,SECT.F, 62, 2006
2OZ7
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CRYSTAL STRUCTURE OF THE HUMAN ANDROGEN RECEPTOR T877A MUTANT LIGAND-BINDING DOMAIN WITH CYPROTERONE ACETATE
Descriptor:Androgen receptor, CYPROTERONE ACETATE
Authors:Bohl, C.E., Wu, Z., Miller, D.D., Bell, C.E., Dalton, J.T.
Deposit date:2007-02-25
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design.
J.Biol.Chem., 282, 2007
2PIO
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ANDROGEN RECEPTOR LBD WITH SMALL MOLECULE
Descriptor:Androgen receptor, SULFATE ION, 5-ALPHA-DIHYDROTESTOSTERONE, ...
Authors:Estebanez-Perpina, E., Arnold, A.A., Baxter, J.D., Webb, P., Guy, R.K., Fletterick, K.R.
Deposit date:2007-04-13
Release date:2007-09-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:A surface on the androgen receptor that allosterically regulates coactivator binding.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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