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2F9Q
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CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 2D6
Descriptor:Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Rowland, P.
Deposit date:2005-12-06
Release date:2005-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.002 Å)
Cite:Crystal Structure of Human Cytochrome P450 2D6
J.Biol.Chem., 281, 2006
3QM4
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HUMAN CYTOCHROME P450 (CYP) 2D6 - PRINOMASTAT COMPLEX
Descriptor:Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, Prinomastat, ...
Authors:Wang, A., Stout, C.D., Johnson, E.F.
Deposit date:2011-02-03
Release date:2012-02-15
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat Bound.
J.Biol.Chem., 287, 2012
3TBG
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HUMAN CYTOCHROME P450 2D6 WITH TWO THIORIDAZINES BOUND IN ACTIVE SITE
Descriptor:Cytochrome P450 2D6, 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, ZINC ION, ...
Authors:Wang, A., Stout, C.D., Johnson, E.F.
Deposit date:2011-08-05
Release date:2012-08-08
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding.
J.Biol.Chem., 290, 2015
3TDA
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COMPETITIVE REPLACEMENT OF THIORIDAZINE BY PRINOMASTAT IN CRYSTALS OF CYTOCHROME P450 2D6
Descriptor:Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, Prinomastat, ...
Authors:Wang, A., Stout, C.D., Johnson, E.F.
Deposit date:2011-08-10
Release date:2012-08-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding.
J.Biol.Chem., 290, 2015
4WNT
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HUMAN CYTOCHROME P450 2D6 AJMALICINE COMPLEX
Descriptor:Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, Ajmalicine, ...
Authors:Wang, A., Stout, C.D., Johnson, E.F.
Deposit date:2014-10-14
Release date:2015-01-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding.
J.Biol.Chem., 290, 2015
4WNU
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HUMAN CYTOCHROME P450 2D6 QUINIDINE COMPLEX
Descriptor:Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, Quinidine, ...
Authors:Wang, A., Stout, C.D., Johnson, E.F.
Deposit date:2014-10-14
Release date:2015-01-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding.
J.Biol.Chem., 290, 2015
4WNV
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HUMAN CYTOCHROME P450 2D6 QUININE COMPLEX
Descriptor:Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, Quinine, ...
Authors:Wang, A., Stout, C.D., Johnson, E.F.
Deposit date:2014-10-14
Release date:2015-01-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding.
J.Biol.Chem., 290, 2015
4WNW
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HUMAN CYTOCHROME P450 2D6 THIORIDAZINE COMPLEX
Descriptor:Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, ...
Authors:Wang, A., Stout, C.D., Johnson, E.F.
Deposit date:2014-10-14
Release date:2015-01-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.299 Å)
Cite:Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding.
J.Biol.Chem., 290, 2015
4XRY
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HUMAN CYTOCHROME P450 2D6 BACE1 INHIBITOR 5 COMPLEX
Descriptor:Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, (4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1-methyl-1H-pyrazol-4-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine, ...
Authors:Johnson, E.F., Fan, Y.
Deposit date:2015-01-21
Release date:2015-05-20
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors.
J.Med.Chem., 58, 2015
4XRZ
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HUMAN CYTOCHROME P450 2D6 BACE1 INHIBITOR 6 COMPLEX
Descriptor:Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, (4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1H-pyrazol-4-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine, ...
Authors:Johnson, E.F., Fan, Y.
Deposit date:2015-01-21
Release date:2015-05-20
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors.
J.Med.Chem., 58, 2015
5TFT
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STRUCTURE OF CYTOCHROME P450 2D6 (CYP2D6) BACE1 INHIBITOR COMPLEX
Descriptor:Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ZINC ION, ...
Authors:Hsu, M.H., Johnson, E.F.
Deposit date:2016-09-26
Release date:2017-01-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
J. Med. Chem., 60, 2017
5TFU
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STRUCTURE OF CYTOCHROME P450 2D6 (CYP2D6) BACE1 INHIBITOR COMPLEX
Descriptor:Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ZINC ION, ...
Authors:Hsu, M.H., Johnson, E.F.
Deposit date:2016-09-26
Release date:2017-01-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
J. Med. Chem., 60, 2017
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