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1A07
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C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-MALONYL TYR-GLU-(N,N-DIPENTYL AMINE)
Descriptor:C-SRC TYROSINE KINASE, ACE-MALONYL TYR-GLU-(N,N-DIPENTYL AMINE)
Authors:Shewchuk, L., Jordan, S.
Deposit date:1997-12-09
Release date:1998-04-08
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A08
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C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-DIFLUORO PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Descriptor:C-SRC TYROSINE KINASE, ACE-DIFLUORO PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Authors:Shewchuk, L., Jordan, S.
Deposit date:1997-12-09
Release date:1998-04-08
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A09
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C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Descriptor:C-SRC TYROSINE KINASE, ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Authors:Shewchuk, L., Jordan, S.
Deposit date:1997-12-10
Release date:1998-04-08
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A1A
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C-SRC (SH2 DOMAIN WITH C188A MUTATION) COMPLEXED WITH ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Descriptor:C-SRC TYROSINE KINASE, ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Authors:Shewchuk, L., Jordan, S.
Deposit date:1997-12-10
Release date:1998-04-08
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A1B
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C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Descriptor:C-SRC TYROSINE KINASE, ACE-PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE)
Authors:Shewchuk, L., Jordan, S.
Deposit date:1997-12-10
Release date:1998-04-08
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A1C
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C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(N-ME(-(CH2)3-CYCLOPENTYL))
Descriptor:C-SRC TYROSINE KINASE, ACE-PHOSPHOTYR-GLU-(N-ME(-(CH2)3-CYCLOPENTYL))
Authors:Shewchuk, L., Jordan, S.
Deposit date:1997-12-10
Release date:1998-04-08
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1A1E
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C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(3-BUTYLPIPERIDINE)
Descriptor:C-SRC TYROSINE KINASE, ACE-PHOSPHOTYR-GLU-(3-BUTYLPIPERIDINE)
Authors:Shewchuk, L., Jordan, S.
Deposit date:1997-12-10
Release date:1998-04-08
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Biochemistry, 36, 1997
1FMK
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CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC
Descriptor:TYROSINE-PROTEIN KINASE SRC
Authors:Xu, W., Harrison, S.C., Eck, M.J.
Deposit date:1997-01-24
Release date:1997-08-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Three-dimensional structure of the tyrosine kinase c-Src.
Nature, 385, 1997
1HCS
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NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX
Descriptor:ACETYL-PYEEIE-OH, HUMAN SRC
Authors:Gampe Junior, R.T., Xu, R.X.
Deposit date:1994-09-02
Release date:1995-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.
Biochemistry, 34, 1995
1HCT
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NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX
Descriptor:ACETYL-PYEEIE-OH, HUMAN SRC
Authors:Gampe Junior, R.T., Xu, R.X.
Deposit date:1994-09-02
Release date:1995-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.
Biochemistry, 34, 1995
1KSW
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STRUCTURE OF HUMAN C-SRC TYROSINE KINASE (THR338GLY MUTANT) IN COMPLEX WITH N6-BENZYL ADP
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, N6-BENZYL ADENOSINE-5'-DIPHOSPHATE
Authors:Witucki, L.A., Huang, X., Shah, K., Liu, Y., Kyin, S., Eck, M.J., Shokat, K.M.
Deposit date:2002-01-14
Release date:2002-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme.
Chem.Biol., 9, 2002
1O41
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78300.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 2-FORMYL-6-METHOXYPHENYL DIHYDROGEN PHOSPHATE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O42
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU81843.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-O-PHOSPHONOTYROSINAMIDE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O43
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82129.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, [4-((1Z)-2-(ACETYLAMINO)-3-{[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]AMINO}-3-OXOPROP-1-ENYL)-2-FORMYLPHENYL]ACETIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O44
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85052
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXY-PHENYL}-MALONIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O45
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU84687.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-3-FORMYL-O-PHOSPHONOTYROSINAMIDE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O46
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU90395.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-METHOXYCARBONYL-PHENYL}-2-FLUORO-MALONIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O47
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82209.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-4-[DIFLUORO(PHOSPHONO)METHYL]PHENYLALANINAMIDE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O48
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85053.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 5-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXYMETHYL-BENZOIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O49
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85493.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, {4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-PHOSPHONO-PHENOXY}-ACETIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4A
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82197.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-FORMYL-BENZOIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4B
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU83876.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-3,4-DIPHOSPHONOPHENYLALANINAMIDE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4C
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHOSPHATE.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, PHOSPHATE ION
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4D
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78262.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 2-FORMYLPHENYL DIHYDROGEN PHOSPHATE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4E
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78299.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 2,6-DIFORMYL-4-METHYLPHENYL DIHYDROGEN PHOSPHATE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
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