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1A7F
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INSULIN MUTANT B16 GLU, B24 GLY, DES-B30, NMR, 20 STRUCTURES
Descriptor:INSULIN
Authors:Ludvigsen, S., Kaarsholm, N.C.
Deposit date:1998-03-12
Release date:1998-07-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A structural switch in a mutant insulin exposes key residues for receptor binding.
J.Mol.Biol., 279, 1998
1AI0
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R6 HUMAN INSULIN HEXAMER (NON-SYMMETRIC), NMR, 10 STRUCTURES
Descriptor:R6 INSULIN HEXAMER, ZINC ION, PHENOL
Authors:Chang, X., Jorgensen, A.M.M., Bardrum, P., Led, J.J.
Deposit date:1997-04-30
Release date:1997-11-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structures of the R6 human insulin hexamer.
Biochemistry, 36, 1997
1AIY
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R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 10 STRUCTURES
Descriptor:R6 INSULIN HEXAMER, ZINC ION, PHENOL
Authors:Chang, X., Jorgensen, A.M.M., Bardrum, P., Led, J.J.
Deposit date:1997-04-30
Release date:1997-11-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structures of the R6 human insulin hexamer.
Biochemistry, 36, 1997
1B9E
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HUMAN INSULIN MUTANT SERB9GLU
Descriptor:PROTEIN (INSULIN)
Authors:Wang, D.C., Zeng, Z.H., Yao, Z.P., Li, H.M.
Deposit date:1998-11-12
Release date:1999-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of an insulin dimer in an orthorhombic crystal: the structure analysis of a human insulin mutant (B9 Ser-->Glu).
Acta Crystallogr.,Sect.D, 55, 1999
1BEN
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INSULIN COMPLEXED WITH 4-HYDROXYBENZAMIDE
Descriptor:HUMAN INSULIN, ZINC ION, 4-HYDROXYBENZAMIDE, ...
Authors:Smith, G.D., Ciszak, E., Pangborn, W.
Deposit date:1996-02-15
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A novel complex of a phenolic derivative with insulin: structural features related to the T-->R transition.
Protein Sci., 5, 1996
1EFE
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AN ACTIVE MINI-PROINSULIN, M2PI
Descriptor:MINI-PROINSULIN
Authors:Cho, Y., Chang, S.G., Choi, K.D., Shin, H., Ahn, B., Kim, K.S.
Deposit date:2000-02-08
Release date:2000-03-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of an Active Mini-Proinsulin, M2PI: Inter-chain Flexibility is Crucial for Insulin Activity
J.Biochem.Mol.Biol., 33, 2000
1EV3
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STRUCTURE OF THE RHOMBOHEDRAL FORM OF THE M-CRESOL/INSULIN R6 HEXAMER
Descriptor:INSULIN, M-CRESOL, ZINC ION, ...
Authors:Smith, G.D., Ciszak, E., Magrum, L.A., Pangborn, W.A., Blessing, R.H.
Deposit date:2000-04-19
Release date:2000-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:R6 hexameric insulin complexed with m-cresol or resorcinol.
Acta Crystallogr.,Sect.D, 56, 2000
1EV6
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STRUCTURE OF THE MONOCLINIC FORM OF THE M-CRESOL/INSULIN R6 HEXAMER
Descriptor:INSULIN, M-CRESOL, ZINC ION, ...
Authors:Smith, G.D., Ciszak, E., Magrum, L.A., Pangborn, W.A., Blessing, R.H.
Deposit date:2000-04-19
Release date:2000-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:R6 Hexameric Insulin Complexed with m-Cresol or Resorcinol
Biochem.Biophys.Res.Commun., 56, 2000
1EVR
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THE STRUCTURE OF THE RESORCINOL/INSULIN R6 HEXAMER
Descriptor:INSULIN, RESORCINOL, ZINC ION, ...
Authors:Smith, G.D., Ciszak, E., Magrum, L.A., Pangborn, W.A., Blessing, R.H.
Deposit date:2000-04-20
Release date:2000-12-04
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:R6 hexameric insulin complexed with m-cresol or resorcinol.
Acta Crystallogr.,Sect.D, 56, 2000
1FU2
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FIRST PROTEIN STRUCTURE DETERMINED FROM X-RAY POWDER DIFFRACTION DATA
Descriptor:INSULIN, A CHAIN, B CHAIN, ...
Authors:Von Dreele, R.B., Stephens, P.W., Blessing, R.H., Smith, G.D.
Deposit date:2000-09-13
Release date:2000-10-16
Last modified:2018-10-03
Method:POWDER DIFFRACTION
Cite:The first protein crystal structure determined from high-resolution X-ray powder diffraction data: a variant of T3R3 human insulin-zinc complex produced by grinding.
Acta Crystallogr.,Sect.D, 56, 2000
1FUB
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FIRST PROTEIN STRUCTURE DETERMINED FROM X-RAY POWDER DIFFRACTION DATA
Descriptor:INSULIN, A CHAIN, B CHAIN, ...
Authors:Von Dreele, R.B., Stephens, P.W., Blessing, R.H., Smith, G.D.
Deposit date:2000-09-14
Release date:2000-10-16
Last modified:2018-10-03
Method:POWDER DIFFRACTION
Cite:The first protein crystal structure determined from high-resolution X-ray powder diffraction data: a variant of T3R3 human insulin-zinc complex produced by grinding.
Acta Crystallogr.,Sect.D, 56, 2000
1G7A
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1.2 A STRUCTURE OF T3R3 HUMAN INSULIN AT 100 K
Descriptor:INSULIN A-CHAIN, INSULIN B-CHAIN, ZINC ION, ...
Authors:Smith, G.D., Pangborn, W.A., Blessing, R.H.
Deposit date:2000-11-09
Release date:2001-08-03
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Phase changes in T(3)R(3)(f) human insulin: temperature or pressure induced?
Acta Crystallogr.,Sect.D, 57, 2001
1G7B
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1.3 A STRUCTURE OF T3R3 HUMAN INSULIN AT 100 K
Descriptor:INSULIN A-CHAIN, INSULIN B-CHAIN, ZINC ION, ...
Authors:Smith, G.D., Pangborn, W.A., Blessing, R.H.
Deposit date:2000-11-09
Release date:2001-08-03
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Phase changes in T(3)R(3)(f) human insulin: temperature or pressure induced?
Acta Crystallogr.,Sect.D, 57, 2001
1GUJ
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INSULIN AT PH 2: STRUCTURAL ANALYSIS OF THE CONDITIONS PROMOTING INSULIN FIBRE FORMATION.
Descriptor:INSULIN, SULFATE ION
Authors:Whittingham, J.L., Scott, D.J., Chance, K., Wilson, A., Finch, J., Brange, J., Dodson, G.G.
Deposit date:2002-01-28
Release date:2002-03-08
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Insulin at Ph2: Structural Analysis of the Conditions Promoting Insulin Fibre Formation
J.Mol.Biol., 318, 2002
1HIQ
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PARADOXICAL STRUCTURE AND FUNCTION IN A MUTANT HUMAN INSULIN ASSOCIATED WITH DIABETES MELLITUS
Descriptor:INSULIN
Authors:Hua, Q.X., Shoelson, S.E., Inouye, K., Weiss, M.A.
Deposit date:1993-03-05
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.
Proc.Natl.Acad.Sci.USA, 90, 1993
1HIS
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STRUCTURE AND DYNAMICS OF DES-PENTAPEPTIDE-INSULIN IN SOLUTION: THE MOLTEN-GLOBULE HYPOTHESIS.
Descriptor:INSULIN
Authors:Hua, Q.X., Kochoyan, M., Weiss, M.A.
Deposit date:1992-02-28
Release date:1994-01-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and dynamics of des-pentapeptide-insulin in solution: the molten-globule hypothesis.
Proc.Natl.Acad.Sci.USA, 89, 1992
1HIT
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RECEPTOR BINDING REDEFINED BY A STRUCTURAL SWITCH IN A MUTANT HUMAN INSULIN
Descriptor:INSULIN
Authors:Hua, Q.X., Kochoyan, M., Weiss, M.A.
Deposit date:1992-02-28
Release date:1994-01-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Receptor binding redefined by a structural switch in a mutant human insulin.
Nature, 354, 1991
1HLS
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NMR STRUCTURE OF THE HUMAN INSULIN-HIS(B16)
Descriptor:INSULIN
Authors:Ludvigsen, S., Kaarsholm, N.C.
Deposit date:1995-06-28
Release date:1995-09-15
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:High-resolution structure of an engineered biologically potent insulin monomer, B16 Tyr-->His, as determined by nuclear magnetic resonance spectroscopy.
Biochemistry, 33, 1994
1HTV
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CRYSTAL STRUCTURE OF DESTRIPEPTIDE (B28-B30) INSULIN
Descriptor:INSULIN, ZINC ION
Authors:Ye, J., Chang, W., Liang, D.
Deposit date:2001-01-01
Release date:2001-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of destripeptide (B28-B30) insulin: implications for insulin dissociation.
Biochim.Biophys.Acta, 1547, 2001
1HUI
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INSULIN MUTANT (B1, B10, B16, B27)GLU, DES-B30, NMR, 25 STRUCTURES
Descriptor:INSULIN
Authors:Olsen, H.B., Ludvigsen, S., Kaarsholm, N.C.
Deposit date:1996-03-29
Release date:1997-03-12
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of an engineered insulin monomer at neutral pH.
Biochemistry, 35, 1996
1IOG
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INSULIN MUTANT A3 GLY,(B1, B10, B16, B27)GLU, DES-B30, NMR, 19 STRUCTURES
Descriptor:PROTEIN (INSULIN PRECURSOR)
Authors:Olsen, H.B., Ludvigsen, S., Kaarsholm, N.C.
Deposit date:1998-08-13
Release date:1999-01-13
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:The relationship between insulin bioactivity and structure in the NH2-terminal A-chain helix.
J.Mol.Biol., 284, 1998
1IOH
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INSULIN MUTANT A8 HIS,(B1, B10, B16, B27)GLU, DES-B30, NMR, 26 STRUCTURES
Descriptor:PROTEIN (INSULIN PRECURSOR)
Authors:Olsen, H.B., Ludvigsen, S., Kaarsholm, N.C.
Deposit date:1998-08-13
Release date:1999-01-13
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:The relationship between insulin bioactivity and structure in the NH2-terminal A-chain helix.
J.Mol.Biol., 284, 1998
1J73
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CRYSTAL STRUCTURE OF AN UNSTABLE INSULIN ANALOG WITH NATIVE ACTIVITY.
Descriptor:insulin a, insulin b, ZINC ION
Authors:Wan, Z., Zhao, M., Nakagawa, S., Jia, W., Weiss, M.A.
Deposit date:2001-05-15
Release date:2001-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
1JCA
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NON-STANDARD DESIGN OF UNSTABLE INSULIN ANALOGUES WITH ENHANCED ACTIVITY
Descriptor:insulin a, insulin b, ZINC ION
Authors:Weiss, M.A., Wan, Z., Zhao, M., Chu, Y.-C., Nakagawa, S.H., Burke, G.T., Jia, W., Hellmich, R., Katsoyannis, P.G.
Deposit date:2001-06-08
Release date:2001-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
1JCO
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SOLUTION STRUCTURE OF THE MONOMERIC [THR(B27)->PRO,PRO(B28)->THR] INSULIN MUTANT (PT INSULIN)
Descriptor:Insulin A chain, Insulin B chain
Authors:Keller, D., Clausen, R., Josefsen, K., Led, J.J.
Deposit date:2001-06-11
Release date:2001-10-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Flexibility and bioactivity of insulin: an NMR investigation of the solution structure and folding of an unusually flexible human insulin mutant with increased biological activity.
Biochemistry, 40, 2001