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2J24
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THE FUNCTIONAL ROLE OF THE CONSERVED ACTIVE SITE PROLINE OF TRIOSEPHOSPHATE ISOMERASE
Descriptor:TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL
Authors:Casteleijn, M.G., Alahuhta, M., Groebel, K., El-Sayed, I., Augustyns, K., Lambeir, A.M., Neubauer, P., Wierenga, R.K.
Deposit date:2006-08-16
Release date:2007-01-02
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Functional Role of the Conserved Active Site Proline of Triosephosphate Isomerase.
Biochemistry, 45, 2006
2J27
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THE FUNCTIONAL ROLE OF THE CONSERVED ACTIVE SITE PROLINE OF TRIOSEPHOSPHATE ISOMERASE
Descriptor:TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL, 2-PHOSPHOGLYCOLIC ACID, SULFATE ION
Authors:Casteleijn, M.G., Alahuhta, M., Groebel, K., El-Sayed, I., Augustyns, K., Lambeir, A.M., Neubauer, P., Wierenga, R.K.
Deposit date:2006-08-16
Release date:2007-01-02
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Functional Role of the Conserved Active Site Proline of Triosephosphate Isomerase.
Biochemistry, 45, 2006
2V0T
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THE A178L MUTATION IN THE C-TERMINAL HINGE OF THE FLEXIBLE LOOP-6 OF TRIOSEPHOSPHATE ISOMERASE (TIM) INDUCES A MORE CLOSED CONFORMATION OF THIS HINGE REGION IN DIMERIC AND MONOMERIC TIM
Descriptor:TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL, SULFATE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Alahuhta, M., Casteleijn, M.G., Neubauer, P., Wierenga, R.K.
Deposit date:2007-05-18
Release date:2008-02-19
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM.
Acta Crystallogr. D Biol. Crystallogr., 64, 2008
2V2C
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THE A178L MUTATION IN THE C-TERMINAL HINGE OF THE FLEXIBLE LOOP-6 OF TRIOSEPHOSPHATE ISOMERASE (TIM) INDUCES A MORE CLOSED CONFORMATION OF THIS HINGE REGION IN DIMERIC AND MONOMERIC TIM
Descriptor:TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL, SULFATE ION, 2-PHOSPHOGLYCOLIC ACID
Authors:Alahuhta, M., Casteleijn, M.G., Neubauer, P., Wierenga, R.K.
Deposit date:2007-06-05
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural Studies Show that the A178L Mutation in the C-Terminal Hinge of the Catalytic Loop-6 of Triosephosphate Isomerase (Tim) Induces a Closed-Like Conformation in Dimeric and Monomeric Tim.
Acta Crystallogr.,Sect.D, 64, 2008
2V2D
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THE A178L MUTATION IN THE C-TERMINAL HINGE OF THE FLEXIBLE LOOP-6 OF TRIOSEPHOSPHATE ISOMERASE (TIM) INDUCES A MORE CLOSED CONFORMATION OF THIS HINGE REGION IN DIMERIC AND MONOMERIC TIM
Descriptor:TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL, PHOSPHATE ION
Authors:Alahuhta, M., Casteleijn, M.G., Neubauer, P., Wierenga, R.K.
Deposit date:2007-06-05
Release date:2008-02-19
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Studies Show that the A178L Mutation in the C-Terminal Hinge of the Catalytic Loop-6 of Triosephosphate Isomerase (Tim) Induces a Closed- Like Conformation in Dimeric and Monomeric Tim.
Acta Crystallogr.,Sect.D, 64, 2008
2V2H
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THE A178L MUTATION IN THE C-TERMINAL HINGE OF THE FLEXIBLE LOOP-6 OF TRIOSEPHOSPHATE ISOMERASE (TIM) INDUCES A MORE CLOSED CONFORMATION OF THIS HINGE REGION IN DIMERIC AND MONOMERIC TIM
Descriptor:TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL, 2-PHOSPHOGLYCOLIC ACID, CHLORIDE ION
Authors:Alahuhta, M., Casteleijn, M.G., Neubauer, P., Wierenga, R.K.
Deposit date:2007-06-06
Release date:2008-02-19
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Structural Studies Show that the A178L Mutation in the C-Terminal Hinge of the Catalytic Loop-6 of Triosephosphate Isomerase (Tim) Induces a Closed-Like Conformation in Dimeric and Monomeric Tim.
Acta Crystallogr.,Sect.D, 64, 2008
2V5L
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STRUCTURES OF THE OPEN AND CLOSED STATE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE: AS OBSERVED IN A NEW CRYSTAL FORM: IMPLICATIONS FOR THE REACTION MECHANISM
Descriptor:TRIOSEPHOSPHATE ISOMERASE, SULFATE ION
Authors:Noble, M.E.M., Zeelen, J.P., Wierenga, R.K.
Deposit date:2007-07-06
Release date:2007-07-31
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the Open and Closed State of Trypanosomal Triosephosphate Isomerase: As Observed in a New Crystal Form: Implications for the Reaction Mechanism
Proteins: Struct.,Funct., Genet., 16, 1993
2VEI
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STRUCTURE-BASED ENZYME ENGINEERING EFFORTS WITH AN INACTIVE MONOMERIC TIM VARIANT: THE IMPORTANCE OF A SINGLE POINT MUTATION FOR GENERATING AN ACTIVE SITE WITH SUITABLE BINDING PROPERTIES
Descriptor:GLYCOSOMAL TRIOSEPHOSPHATE ISOMERASE, SULFATE ION
Authors:Alahuhta, M., Salin, M., Casteleijn, M.G., Kemmer, C., El-Sayed, I., Augustyns, K., Neubauer, P., Wierenga, R.K.
Deposit date:2007-10-24
Release date:2008-02-19
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure-Based Protein Engineering Efforts with a Monomeric Tim Variant: The Importance of a Single Point Mutation for Generating an Active Site with Suitable Binding Properties.
Protein Eng.Des.Sel., 21, 2008
2VEK
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STRUCTURE-BASED ENZYME ENGINEERING EFFORTS WITH AN INACTIVE MONOMERIC TIM VARIANT: THE IMPORTANCE OF A SINGLE POINT MUTATION FOR GENERATING AN ACTIVE SITE WITH SUITABLE BINDING PROPERTIES
Descriptor:TRIOSEPHOSPHATE ISOMERASE, CITRIC ACID, TERTIARY-BUTYL ALCOHOL, ...
Authors:Alahuhta, M., Salin, M., Casteleijn, M.G., Kemmer, C., El-Sayed, I., Augustyns, K., Neubauer, P., Wierenga, R.K.
Deposit date:2007-10-24
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Based Protein Engineering Efforts with a Monomeric Tim Variant: The Importance of a Single Point Mutation for Generating an Active Site with Suitable Binding Properties.
Protein Eng.Des.Sel., 21, 2008
2VEL
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STRUCTURE-BASED ENZYME ENGINEERING EFFORTS WITH AN INACTIVE MONOMERIC TIM VARIANT: THE IMPORTANCE OF A SINGLE POINT MUTATION FOR GENERATING AN ACTIVE SITE WITH SUITABLE BINDING PROPERTIES
Descriptor:GLYCOSOMAL TRIOSEPHOSPHATE ISOMERASE, CHLORIDE ION, 2-PHOSPHOGLYCOLIC ACID
Authors:Alahuhta, M., Salin, M., Casteleijn, M.G., Kemmer, C., El-Sayed, I., Augustyns, K., Neubauer, P., Wierenga, R.K.
Deposit date:2007-10-24
Release date:2008-02-19
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Based Protein Engineering Efforts with a Monomeric Tim Variant: The Importance of a Single Point Mutation for Generating an Active Site with Suitable Binding Properties.
Protein Eng.Des.Sel., 21, 2008
2VEM
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STRUCTURE-BASED ENZYME ENGINEERING EFFORTS WITH AN INACTIVE MONOMERIC TIM VARIANT: THE IMPORTANCE OF A SINGLE POINT MUTATION FOR GENERATING AN ACTIVE SITE WITH SUITABLE BINDING PROPERTIES
Descriptor:GLYCOSOMAL TRIOSEPHOSPHATE ISOMERASE, (3-bromo-2-oxo-propoxy)phosphonic acid, TERTIARY-BUTYL ALCOHOL
Authors:Alahuhta, M., Salin, M., Casteleijn, M.G., Kemmer, C., El-Sayed, I., Augustyns, K., Neubauer, P., Wierenga, R.K.
Deposit date:2007-10-25
Release date:2008-02-19
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Based Protein Engineering Efforts with a Monomeric Tim Variant: The Importance of a Single Point Mutation for Generating an Active Site with Suitable Binding Properties.
Protein Eng.Des.Sel., 21, 2008
2VEN
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STRUCTURE-BASED ENZYME ENGINEERING EFFORTS WITH AN INACTIVE MONOMERIC TIM VARIANT: THE IMPORTANCE OF A SINGLE POINT MUTATION FOR GENERATING AN ACTIVE SITE WITH SUITABLE BINDING PROPERTIES
Descriptor:GLYCOSOMAL TRIOSEPHOSPHATE ISOMERASE, CITRIC ACID
Authors:Alahuhta, M., Salin, M., Casteleijn, M.G., Kemmer, C., El-Sayed, I., Augustyns, K., Neubauer, P., Wierenga, R.K.
Deposit date:2007-10-25
Release date:2008-02-19
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Protein Engineering Efforts with a Monomeric Tim Variant: The Importance of a Single Point Mutation for Generating an Active Site with Suitable Binding Properties.
Protein Eng.Des.Sel., 21, 2008
2X1T
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CRYSTALLOGRAPHIC BINDING STUDIES WITH AN ENGINEERED MONOMERIC VARIANT OF TRIOSEPHOSPHATE ISOMERASE
Descriptor:TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL, 4-PHOSPHO-D-ERYTHRONOHYDROXAMIC ACID
Authors:Salin, M., Kapetaniou, E.G., Vaismaa, M., Lajunen, M., Casteleijn, M.G., Neubauer, P., Salmon, L., Wierenga, R.
Deposit date:2010-01-04
Release date:2010-01-26
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystallographic Binding Studies with an Engineered Monomeric Variant of Triosephosphate Isomerase
Acta Crystallogr.,Sect.D, 66, 2010
2Y6Z
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CRYSTALLOGRAPHIC STRUCTURE OF GM23 AN EXAMPLE OF CATALYTIC MIGRATION FROM TIM TO THIAMIN PHOSPHATE SYNTHASE.
Descriptor:TRIOSE-PHOSPHATE ISOMERASE, THIAMIN PHOSPHATE, PYROPHOSPHATE 2-
Authors:Saab-Rincon, G., Olvera, L., Olvera, M., Rudino-Pinera, E., Soberon, X., Morett, E.
Deposit date:2011-01-27
Release date:2011-12-07
Last modified:2012-02-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Evolutionary Walk between (Beta/Alpha)(8) Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase.
J.Mol.Biol., 416, 2012
2Y70
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CRYSTALLOGRAPHIC STRUCTURE OF GM23, MUTANT G89D, AN EXAMPLE OF CATALYTIC MIGRATION FROM TIM TO THIAMIN PHOSPHATE SYNTHASE.
Descriptor:TRIOSE-PHOSPHATE ISOMERASE, SULFATE ION, ACETATE ION
Authors:Saab-Rincon, G., Olvera, L., Olvera, M., Rudino-Pinera, E., Soberon, X., Morett, E.
Deposit date:2011-01-27
Release date:2011-12-07
Last modified:2012-02-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evolutionary Walk between (Beta/Alpha)(8) Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase.
J.Mol.Biol., 416, 2012
1QDS
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SUPERSTABLE E65Q MUTANT OF LEISHMANIA MEXICANA TRIOSEPHOSPHATE ISOMERASE (TIM)
Descriptor:TRIOSEPHOSPHATE ISOMERASE, 2-PHOSPHOGLYCOLIC ACID
Authors:Lambeir, A.M., Backmann, J., Ruiz-Sanz, J., Filimonov, V., Nielsen, J.E., Vriend, G., Kursula, I., Norledge, B.V., Wierenga, R.K.
Deposit date:1999-07-10
Release date:2000-12-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:The ionization of a buried glutamic acid is thermodynamically linked to the stability of Leishmania mexicana triose phosphate isomerase.
Eur.J.Biochem., 267, 2000
2BTM
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DOES THE HIS12-LYS13 PAIR PLAY A ROLE IN THE ADAPTATION OF THERMOPHILIC TIMS TO HIGH TEMPERATURES?
Descriptor:PROTEIN (TRIOSEPHOSPHATE ISOMERASE), 2-PHOSPHOGLYCOLIC ACID
Authors:Delboni, L.F., Mande, S.C., Hol, W.G.J.
Deposit date:1999-01-04
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Lys13 plays a crucial role in the functional adaptation of the thermophilic triose-phosphate isomerase from Bacillus stearothermophilus to high temperatures.
J.Biol.Chem., 274, 1999
2X16
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CRYSTALLOGRAPHIC BINDING STUDIES WITH AN ENGINEERED MONOMERIC VARIANT OF TRIOSEPHOSPHATE ISOMERASE
Descriptor:TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL
Authors:Salin, M., Kapetaniou, E.G., Vaismaa, M., Lajunen, M., Casteleijn, M.G., Neubauer, P., Salmon, L., Wierenga, R.
Deposit date:2009-12-21
Release date:2009-12-29
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Crystallographic Binding Studies with an Engineered Monomeric Variant of Triosephosphate Isomerase
Acta Crystallogr.,Sect.D, 66, 2010
1AG1
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MONOHYDROGEN PHOSPHATE BINDING TO TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE
Descriptor:TRIOSEPHOSPHATE ISOMERASE, PHOSPHATE ION
Authors:Verlinde, C.L.M.J., Hol, W.G.J.
Deposit date:1997-03-28
Release date:1997-06-16
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Anion binding at the active site of trypanosomal triosephosphate isomerase. Monohydrogen phosphate does not mimic sulphate.
Eur.J.Biochem., 198, 1991
1AMK
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LEISHMANIA MEXICANA TRIOSE PHOSPHATE ISOMERASE
Descriptor:TRIOSE PHOSPHATE ISOMERASE, 2-PHOSPHOGLYCOLIC ACID
Authors:Williams, J.C., Wierenga, R.
Deposit date:1997-06-17
Release date:1997-12-17
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural and mutagenesis studies of leishmania triosephosphate isomerase: a point mutation can convert a mesophilic enzyme into a superstable enzyme without losing catalytic power.
Protein Eng., 12, 1999
1AW1
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TRIOSEPHOSPHATE ISOMERASE OF VIBRIO MARINUS COMPLEXED WITH 2-PHOSPHOGLYCOLATE
Descriptor:TRIOSEPHOSPHATE ISOMERASE, 2-PHOSPHOGLYCOLIC ACID
Authors:Maes, D., Zeelen, J.P., Wierenga, R.K.
Deposit date:1997-10-09
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Triose-phosphate isomerase (TIM) of the psychrophilic bacterium Vibrio marinus. Kinetic and structural properties.
J.Biol.Chem., 273, 1998
1AW2
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TRIOSEPHOSPHATE ISOMERASE OF VIBRIO MARINUS
Descriptor:TRIOSEPHOSPHATE ISOMERASE, SULFATE ION
Authors:Maes, D., Zeelen, J.P., Wierenga, R.K.
Deposit date:1997-10-09
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Triose-phosphate isomerase (TIM) of the psychrophilic bacterium Vibrio marinus. Kinetic and structural properties.
J.Biol.Chem., 273, 1998
1B9B
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TRIOSEPHOSPHATE ISOMERASE OF THERMOTOGA MARITIMA
Descriptor:PROTEIN (TRIOSEPHOSPHATE ISOMERASE), SULFATE ION
Authors:Maes, D., Wierenga, R.K.
Deposit date:1999-02-09
Release date:2000-01-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The crystal structure of triosephosphate isomerase (TIM) from Thermotoga maritima: a comparative thermostability structural analysis of ten different TIM structures.
Proteins, 37, 1999
1BTM
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TRIOSEPHOSPHATE ISOMERASE (TIM) COMPLEXED WITH 2-PHOSPHOGLYCOLIC ACID
Descriptor:TRIOSEPHOSPHATE ISOMERASE, 2-PHOSPHOGLYCOLIC ACID
Authors:Delboni, L.F., Mande, S.C., Hol, W.G.J.
Deposit date:1995-11-11
Release date:1996-04-03
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of recombinant triosephosphate isomerase from Bacillus stearothermophilus. An analysis of potential thermostability factors in six isomerases with known three-dimensional structures points to the importance of hydrophobic interactions.
Protein Sci., 4, 1995
1CI1
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CRYSTAL STRUCTURE OF TRIOSEPHOSPHATE ISOMERASE FROM TRYPANOSOMA CRUZI IN HEXANE
Descriptor:PROTEIN (TRIOSEPHOSPHATE ISOMERASE), HEXANE
Authors:Gao, X.-G., Maldondo, E., Perez-Montfort, R., De Gomez-Puyou, M.T., Gomez-Puyou, A., Rodriguez-Romero, A.
Deposit date:1999-04-06
Release date:1999-09-01
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of triosephosphate isomerase from Trypanosoma cruzi in hexane.
Proc.Natl.Acad.Sci.USA, 96, 1999