Mine: Advanced search results

Advanced query:
Other DB:EC Number: 1.1.1.21
Add keyword:
Search
Go to Advanced search
1ABN
  • Download 1abn
  • View 1abn
Molmil generated image of 1abn
THE CRYSTAL STRUCTURE OF THE ALDOSE REDUCTASE NADPH BINARY COMPLEX
Descriptor:ALDOSE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Borhani, D.W., Harter, T.M., Petrash, J.M.
Deposit date:1992-09-03
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of the aldose reductase.NADPH binary complex.
J.Biol.Chem., 267, 1992
1ADS
  • Download 1ads
  • View 1ads
Molmil generated image of 1ads
AN UNLIKELY SUGAR SUBSTRATE SITE IN THE 1.65 ANGSTROMS STRUCTURE OF THE HUMAN ALDOSE REDUCTASE HOLOENZYME IMPLICATED IN DIABETIC COMPLICATIONS
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Wilson, D.K., Quiocho, F.A.
Deposit date:1992-07-08
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications.
Science, 257, 1992
1AH0
  • Download 1ah0
  • View 1ah0
Molmil generated image of 1ah0
PIG ALDOSE REDUCTASE COMPLEXED WITH SORBINIL
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SORBINIL
Authors:Moras, D., Podjarny, A.D.
Deposit date:1997-04-11
Release date:1998-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil.
Structure, 5, 1997
1AH3
  • Download 1ah3
  • View 1ah3
Molmil generated image of 1ah3
ALDOSE REDUCTASE COMPLEXED WITH TOLRESTAT INHIBITOR
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TOLRESTAT
Authors:Moras, D., Podjarny, A.
Deposit date:1997-04-12
Release date:1998-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil.
Structure, 5, 1997
1AH4
  • Download 1ah4
  • View 1ah4
Molmil generated image of 1ah4
PIG ALDOSE REDUCTASE, HOLO FORM
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Moras, D., Podjarny, A.
Deposit date:1997-04-12
Release date:1998-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil.
Structure, 5, 1997
1AZ1
  • Download 1az1
  • View 1az1
Molmil generated image of 1az1
ALRESTATIN BOUND TO C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ALRESTATIN
Authors:Harrison, D.H.T., Bohren, K.M., Petsko, G.A., Ringe, D., Gabbay, K.H.
Deposit date:1997-11-24
Release date:1998-03-18
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.
Biochemistry, 36, 1997
1AZ2
  • Download 1az2
  • View 1az2
Molmil generated image of 1az2
CITRATE BOUND, C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID
Authors:Harrison, D.H., Bohren, K.M., Ringe, D., Petsko, G.A., Gabbay, K.H.
Deposit date:1997-11-24
Release date:1998-03-18
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.
Biochemistry, 36, 1997
1DLA
  • Download 1dla
  • View 1dla
Molmil generated image of 1dla
NOVEL NADPH-BINDING DOMAIN REVEALED BY THE CRYSTAL STRUCTURE OF ALDOSE REDUCTASE
Descriptor:ALDOSE REDUCTASE
Authors:Rondeau, J.-M., Tete-Favier, F., Podjarny, A., Reymann, J.-M., Barth, P., Biellmann, J.-F., Moras, D.
Deposit date:1993-02-08
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Novel NADPH-binding domain revealed by the crystal structure of aldose reductase.
Nature, 355, 1992
1EF3
  • Download 1ef3
  • View 1ef3
Molmil generated image of 1ef3
FIDARESTAT BOUND TO HUMAN ALDOSE REDUCTASE
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE
Authors:Oka, M., Matsumoto, Y., Sugiyama, S., Tsuruta, N., Matsushima, M.
Deposit date:2000-02-06
Release date:2001-02-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography.
J.Med.Chem., 43, 2000
1EKO
  • Download 1eko
  • View 1eko
Molmil generated image of 1eko
PIG ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [2,6-DIMETHYL-4-(2-O-TOLYL-ACETYLAMINO)-BENZENESULFONYL]-GLYCINE
Authors:Podjarny, A.
Deposit date:2000-03-09
Release date:2000-05-10
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of human aldose reductase bound to the inhibitor IDD384.
Acta Crystallogr.,Sect.D, 56, 2000
1EL3
  • Download 1el3
  • View 1el3
Molmil generated image of 1el3
HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [2,6-DIMETHYL-4-(2-O-TOLYL-ACETYLAMINO)-BENZENESULFONYL]-GLYCINE
Authors:Podjarny, A.
Deposit date:2000-03-13
Release date:2000-05-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structure of human aldose reductase bound to the inhibitor IDD384.
Acta Crystallogr.,Sect.D, 56, 2000
1IEI
  • Download 1iei
  • View 1iei
Molmil generated image of 1iei
CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE INHIBITOR ZENARESTAT.
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [3-(4-BROMO-2-FLUORO-BENZYL)-7-CHLORO-2,4-DIOXO-3,4-DIHYDRO-2H-QUINAZOLIN-1-YL]-ACETIC ACID
Authors:Kinoshita, T., Miyake, H., Fujii, T., Takakura, S., Goto, T.
Deposit date:2001-04-09
Release date:2002-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure of human recombinant aldose reductase complexed with the potent inhibitor zenarestat.
Acta Crystallogr.,Sect.D, 58, 2002
1JEZ
  • Download 1jez
  • View 1jez
Molmil generated image of 1jez
THE STRUCTURE OF XYLOSE REDUCTASE, A DIMERIC ALDO-KETO REDUCTASE FROM CANDIDA TENUIS
Descriptor:XYLOSE REDUCTASE
Authors:Kavanagh, K.L., Klimacek, M., Nidetzky, B., Wilson, D.K.
Deposit date:2001-06-19
Release date:2002-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of apo and holo forms of xylose reductase, a dimeric aldo-keto reductase from Candida tenuis.
Biochemistry, 41, 2002
1K8C
  • Download 1k8c
  • View 1k8c
Molmil generated image of 1k8c
CRYSTAL STRUCTURE OF DIMERIC XYLOSE REDUCTASE IN COMPLEX WITH NADP(H)
Descriptor:xylose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Kavanagh, K.L., Klimacek, M., Nidetzky, B., Wilson, D.K.
Deposit date:2001-10-23
Release date:2002-07-05
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of apo and holo forms of xylose reductase, a dimeric aldo-keto reductase from Candida tenuis.
Biochemistry, 41, 2002
1MAR
  • Download 1mar
  • View 1mar
Molmil generated image of 1mar
REFINED 1.8 ANGSTROMS STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE POTENT INHIBITOR ZOPOLRESTAT
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID
Authors:Wilson, D.K., Quiocho, F.A.
Deposit date:1993-07-20
Release date:1995-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat.
Proc.Natl.Acad.Sci.USA, 90, 1993
1MI3
  • Download 1mi3
  • View 1mi3
Molmil generated image of 1mi3
1.8 ANGSTROM STRUCTURE OF XYLOSE REDUCTASE FROM CANDIDA TENUIS IN COMPLEX WITH NAD
Descriptor:xylose reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kavanagh, K.L., Klimacek, M., Nidetzky, B., Wilson, D.K.
Deposit date:2002-08-21
Release date:2003-08-05
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of xylose reductase bound to NAD+ and the basis for single and dual co-substrate specificity in family 2 aldo-keto reductases
Biochem.J., 373, 2003
1PWL
  • Download 1pwl
  • View 1pwl
Molmil generated image of 1pwl
CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH NADP AND MINALRESTAT
Descriptor:aldose reductase, 2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:El-Kabbani, O., Darmanin, C., Schneider, T.R., Hazemann, I., Ruiz, F., Oka, M., Joachimiak, A., Schulze-Briese, C., Tomizaki, T., Mitschler, A., Podjarny, A.
Deposit date:2003-07-02
Release date:2004-02-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors
PROTEINS, 55, 2004
1PWM
  • Download 1pwm
  • View 1pwm
Molmil generated image of 1pwm
CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH NADP AND FIDARESTAT
Descriptor:aldose reductase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:El-Kabbani, O., Darmanin, C., Schneider, T.R., Hazemann, I., Ruiz, F., Oka, M., Joachimiak, A., Schulze-Briese, C., Tomizaki, T., Mitschler, A., Podjarny, A.
Deposit date:2003-07-02
Release date:2004-02-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (0.92 Å)
Cite:Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors
PROTEINS, 55, 2004
1R38
  • Download 1r38
  • View 1r38
Molmil generated image of 1r38
CRYSTAL STRUCTURE OF H114A MUTANT OF CANDIDA TENUIS XYLOSE REDUCTASE
Descriptor:xylose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Kratzer, R., Kavanagh, K.L., Wilson, D.K., Nidetzky, B.
Deposit date:2003-09-30
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Studies of the enzymic mechanism of Candida tenuis xylose reductase (AKR 2B5): X-ray structure and catalytic reaction profile for the H113A mutant
Biochemistry, 43, 2004
1SM9
  • Download 1sm9
  • View 1sm9
Molmil generated image of 1sm9
CRYSTAL STRUCTURE OF AN ENGINEERED K274RN276D DOUBLE MUTANT OF XYLOSE REDUCTASE FROM CANDIDA TENUIS OPTIMIZED TO UTILIZE NAD
Descriptor:xylose reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Petschacher, B., Leitgeb, S., Kavanagh, K.L., Wilson, D.K., Nidetzky, B.
Deposit date:2004-03-08
Release date:2004-12-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The coenzyme specificity of Candida tenuis xylose reductase (AKR2B5) explored by site-directed mutagenesis and X-ray crystallography.
Biochem.J., 385, 2005
1T40
  • Download 1t40
  • View 1t40
Molmil generated image of 1t40
CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH NADP AND IDD552 AT PH 5
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [5-FLUORO-2-({[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]AMINO}CARBONYL)PHENOXY]ACETIC ACID
Authors:Ruiz, F., Hazemann, I., Mitschler, A., Chevrier, B., Schneider, T., Joachimiak, A., Karplus, M., Podjarny, A.
Deposit date:2004-04-28
Release date:2004-08-03
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48.
Acta Crystallogr.,Sect.D, 60, 2004
1T41
  • Download 1t41
  • View 1t41
Molmil generated image of 1t41
CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH NADP AND IDD552
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [5-FLUORO-2-({[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]AMINO}CARBONYL)PHENOXY]ACETIC ACID
Authors:Ruiz, F., Hazemann, I., Mitschler, A., Chevrier, B., Schneider, T., Joachimiak, A., Karplus, M., Podjarny, A.
Deposit date:2004-04-28
Release date:2004-08-03
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48.
Acta Crystallogr.,Sect.D, 60, 2004
1US0
  • Download 1us0
  • View 1us0
Molmil generated image of 1us0
HUMAN ALDOSE REDUCTASE IN COMPLEX WITH NADP+ AND THE INHIBITOR IDD594 AT 0.66 ANGSTROM
Descriptor:ALDOSE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, IDD594, ...
Authors:Howard, E.I., Sanishvili, R., Cachau, R.E., Mitschler, A., Chevrier, B., Barth, P., Lamour, V., Van Zandt, M., Sibley, E., Bon, C., Moras, D., Schneider, T.R., Joachimiak, A., Podjarny, A.
Deposit date:2003-11-16
Release date:2004-05-07
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (0.66 Å)
Cite:Ultrahigh Resolution Drug Design I: Details of Interactions in Human Aldose Reductase-Inhibitor Complex at 0.66 A.
Proteins, 55, 2004
1X96
  • Download 1x96
  • View 1x96
Molmil generated image of 1x96
CRYSTAL STRUCTURE OF ALDOSE REDUCTASE WITH CITRATES BOUND IN THE ACTIVE SITE
Descriptor:aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID
Authors:El-Kabbani, O., Darmanin, C., Oka, M., Schulze-Briese, C., Tomizaki, T., Hazemann, I., Mitschler, A., Podjarny, A.
Deposit date:2004-08-19
Release date:2004-09-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor
J.Med.Chem., 47, 2004
1X97
  • Download 1x97
  • View 1x97
Molmil generated image of 1x97
CRYSTAL STRUCTURE OF ALDOSE REDUCTASE COMPLEXED WITH 2R4S (STEREOISOMER OF FIDARESTAT, 2S4S)
Descriptor:Aldose Reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2R,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE
Authors:El-Kabbani, O., Darmanin, C., Oka, M., Schulze-Briese, C., Tomizaki, T., Hazemann, I., Mitschler, A., Podjarny, A.
Deposit date:2004-08-19
Release date:2004-09-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor
J.Med.Chem., 47, 2004