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1AWX
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SH3 DOMAIN FROM BRUTON'S TYROSINE KINASE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:BRUTON'S TYROSINE KINASE
Authors:Hansson, H., Mattsson, P.T., Allard, P., Haapaniemi, P., Vihinen, M., Smith, C.I.E., Hard, T.
Deposit date:1997-10-06
Release date:1998-04-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the SH3 domain from Bruton's tyrosine kinase.
Biochemistry, 37, 1998
1B55
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PH DOMAIN FROM BRUTON'S TYROSINE KINASE IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE
Descriptor:TYROSINE-PROTEIN KINASE BTK, ZINC ION, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
Authors:Djinovic Carugo, K., Baraldi, E., Hyvoenen, M., Lo Surdo, P., Riley, A.M., Potter, B.V.L., O'Brien, R., Ladbury, J.E., Saraste, M.
Deposit date:1999-01-12
Release date:1999-06-15
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate.
Structure Fold.Des., 7, 1999
1BTK
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PH DOMAIN AND BTK MOTIF FROM BRUTON'S TYROSINE KINASE MUTANT R28C
Descriptor:BRUTON'S TYROSINE KINASE, ZINC ION, SODIUM ION
Authors:Hyvonen, M., Saraste, M.
Deposit date:1997-07-01
Release date:1997-09-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia.
EMBO J., 16, 1997
1BWN
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PH DOMAIN AND BTK MOTIF FROM BRUTON'S TYROSINE KINASE MUTANT E41K IN COMPLEX WITH INS(1,3,4,5)P4
Descriptor:BRUTON'S TYROSINE KINASE, ZINC ION, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
Authors:Djinovic Carugo, K., Baraldi, E., Hyvoenen, M., Lo Surdo, P., Riley, A., Potter, B., Saraste, M.
Deposit date:1998-09-25
Release date:1999-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate.
Structure Fold.Des., 7, 1999
1K2P
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CRYSTAL STRUCTURE OF BRUTON'S TYROSINE KINASE DOMAIN
Descriptor:Tyrosine-protein kinase BTK
Authors:Mao, C., Zhou, M., Uckun, F.M.
Deposit date:2001-09-28
Release date:2002-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia.
J.Biol.Chem., 276, 2001
1QLY
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NMR STUDY OF THE SH3 DOMAIN FROM BRUTON'S TYROSINE KINASE, 20 STRUCTURES
Descriptor:TYROSINE-PROTEIN KINASE BTK
Authors:Tzeng, S.R., Lou, Y.C., Pai, M.T., Chen, C., Chen, S.H., Cheng, J.Y.
Deposit date:1999-09-20
Release date:1999-12-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the Human Btk SH3 Domain Complexed with a Proline-Rich Peptide from P120Cbl
J.Biomol.NMR, 16, 2000
2GE9
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SOLUTION STRUCTURES OF THE SH2 DOMAIN OF BRUTON'S TYROSINE KINASE
Descriptor:Tyrosine-protein kinase BTK
Authors:Cheng, J.-W., Huang, K.-C.
Deposit date:2006-03-18
Release date:2006-10-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase
J.Biomol.Nmr, 36, 2006
2Z0P
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CRYSTAL STRUCTURE OF PH DOMAIN OF BRUTON'S TYROSINE KINASE
Descriptor:Tyrosine-protein kinase BTK, ZINC ION, (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXYBUTOXY)PROPYL BUTYRATE
Authors:Murayama, K., Kato-Murayama, M., Mishima, C., Shirouzu, M., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-05-07
Release date:2008-05-13
Last modified:2015-07-08
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Crystal structure of the Bruton's tyrosine kinase PH domain with phosphatidylinositol
Biochem.Biophys.Res.Commun., 377, 2008
3GEN
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THE 1.6 A CRYSTAL STRUCTURE OF HUMAN BRUTON'S TYROSINE KINASE BOUND TO A PYRROLOPYRIMIDINE-CONTAINING COMPOUND
Descriptor:Tyrosine-protein kinase BTK, 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane
Authors:Marcotte, D.J., Liu, Y.T., Arduini, R.M., Hession, C.A., Miatkowski, K., Wildes, C.P., Cullen, P.F., Hopkins, B., Mertsching, E., Jenkins, T.J., Romanowski, M.J., Baker, D.P., Silvian, L.F.
Deposit date:2009-02-25
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.
Protein Sci., 19, 2010
3K54
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STRUCTURES OF HUMAN BRUTON'S TYROSINE KINASE IN ACTIVE AND INACTIVE CONFORMATIONS SUGGESTS A MECHANISM OF ACTIVATION FOR TEC FAMILY KINASES.
Descriptor:Tyrosine-protein kinase BTK, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE
Authors:Marcotte, D.J., Liu, Y.-T., Arduini, R.M., Hession, C.A., Miatkowski, K., Wildes, C.P., Cullen, P.F., Hopkins, B.T., Mertsching, E., Jenkins, T.J., Romanowski, M.J., Baker, D.P., Silvian, L.F.
Deposit date:2009-10-06
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.
Protein Sci., 19, 2010
3OCS
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CRYSTAL STRUCTURE OF BRUTON'S TYROSINE KINASE IN COMPLEX WITH INHIBITOR CGI1746
Descriptor:Tyrosine-protein kinase BTK, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Davies, D.R., Gallion, S.L., Staker, B.L.
Deposit date:2010-08-10
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A novel, specific Btk inhibitor antagonizes BCR and Fc[gamma]R signaling and suppresses inflammatory arthritis
To be Published
3OCT
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CRYSTAL STRUCTURE OF BRUTON'S TYROSINE KINASE MUTANT V555R IN COMPLEX WITH DASATINIB
Descriptor:Tyrosine-protein kinase BTK, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE
Authors:Davies, D.R., Staker, B.L.
Deposit date:2010-08-10
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A novel, specific Btk inhibitor antagonizes BCR and Fc[gamma]R signaling and suppresses inflammatory arthritis
To be Published
3P08
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CRYSTAL STRUCTURE OF THE HUMAN BTK KINASE DOMAIN
Descriptor:Tyrosine-protein kinase BTK
Authors:Yu, C.L., Hymowitz, S.G.
Deposit date:2010-09-27
Release date:2010-11-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A novel, specific BTK inhibitor antagonizes BCR and FcgR signaling and suppresses inflammatory arthritis
To be Published
3PIX
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 2-ISOPROPYL-7-(4-METHYL-PIPERAZIN-1-YL)-4-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-2H-PHTHALAZIN-1-ONE
Descriptor:Tyrosine-protein kinase BTK, 7-(4-methylpiperazin-1-yl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-(propan-2-yl)phthalazin-1(2H)-one
Authors:Kuglstatter, A., Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
3PIY
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH R406
Descriptor:Tyrosine-protein kinase BTK, 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Authors:Kuglstatter, A., Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
3PIZ
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH (5-AMINO-1-O-TOLYL-1H-PYRAZOL-4-YL)-[3-(1-METHANESULFONYL-PIPERIDIN-4-YL)-PHENYL]-METHANONE
Descriptor:Tyrosine-protein kinase BTK, [5-amino-1-(2-methylphenyl)-1H-pyrazol-4-yl]{3-[1-(methylsulfonyl)piperidin-4-yl]phenyl}methanone
Authors:Kuglstatter, A., Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
3PJ1
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 3-(2,6-DICHLORO-PHENYL)-7-[4-(2-DIETHYLAMINO-ETHOXY)-PHENYLAMINO]-1-METHYL-3,4-DIHYDRO-1H-PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE
Descriptor:Tyrosine-protein kinase BTK, 3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
Authors:Kuglstatter, A., Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
3PJ2
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 2-[4-(2-DIETHYLAMINO-ETHOXY)-PHENYLAMINO]-6-(4-FLUORO-PHENOXY)-8-METHYL-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE
Descriptor:Tyrosine-protein kinase BTK, 2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-6-(4-fluorophenoxy)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Authors:Kuglstatter, A., Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
3PJ3
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 2-METHYL-5-[(E)-(3-PHENYL-ACRYLOYL)AMINO]-N-(2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-BENZAMIDE
Descriptor:Tyrosine-protein kinase BTK, 2-methyl-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-5-{[(2E)-3-phenylprop-2-enoyl]amino}benzamide
Authors:Kuglstatter, A., Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
4NWM
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CRYSTAL STRUCTURE OF BRUTON AGAMMAGLOBULINEMIA TYROSINE KINASE COMPLEXED WITH BMS-809959 AKA 4-TERT-BUTYL-N-[2-ME THYL-3-(6-{[4-(MORPHOLINE-4-CARBONYL)PHENYL]AMINO}-9H- PURIN-2-YL)PHENYL]BENZAMIDE
Descriptor:Tyrosine-protein kinase BTK, 4-tert-butyl-N-[2-methyl-3-(6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-7H-purin-2-yl)phenyl]benzamide
Authors:Muckelbauer, J.K.
Deposit date:2013-12-06
Release date:2014-04-02
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.
Bioorg.Med.Chem.Lett., 24, 2014
4OT5
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 4-TERT-BUTYL-N-(3-{8-[4-(4-METHYL-PIPERAZINE-1-CARBONYL)-PHENYLAMINO]-IMIDAZO[1,2-A]PYRAZIN-6-YL}-PHENYL)-BENZAMIDE
Descriptor:Tyrosine-protein kinase BTK, 4-tert-butyl-N-{3-[8-({4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}amino)imidazo[1,2-a]pyrazin-6-yl]phenyl}benzamide, DIMETHYL SULFOXIDE
Authors:Kuglstatter, A., Wong, A.
Deposit date:2014-02-13
Release date:2014-05-14
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure-Based Drug Design of RN486, a Potent and Selective Bruton's Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis.
J.Med.Chem., 58, 2015
4OT6
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 4-METHANESULFONYL-N-(3-{8-[4-(MORPHOLINE-4-CARBONYL)-PHENYLAMINO]-IMIDAZO[1,2-A]PYRAZIN-6-YL}-PHENYL)-BENZAMIDE
Descriptor:Tyrosine-protein kinase BTK, 4-(methylsulfonyl)-N-[3-(8-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}imidazo[1,2-a]pyrazin-6-yl)phenyl]benzamide
Authors:Kuglstatter, A., Wong, A.
Deposit date:2014-02-13
Release date:2014-05-14
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure-Based Drug Design of RN486, a Potent and Selective Bruton's Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis.
J.Med.Chem., 58, 2015
4OTF
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CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF BRUTON'S TYROSINE KINASE WITH GDC0834
Descriptor:Tyrosine-protein kinase BTK, SULFATE ION, N-{3-[6-({4-[(2R)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl}-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide
Authors:Hymowitz, S.G., Maurer, B.
Deposit date:2014-02-13
Release date:2015-01-28
Last modified:2015-04-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Potent and selective Bruton's tyrosine kinase inhibitors: Discovery of GDC-0834.
Bioorg.Med.Chem.Lett., 25, 2015
4OTQ
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 1-[5-[3-(7-TERT-BUTYL-4-OXO-QUINAZOLIN-3-YL)-2-METHYL-PHENYL]-1-METHYL-2-OXO-3-PYRIDYL]-3-METHYL-UREA
Descriptor:Tyrosine-protein kinase BTK, 1-{5-[3-(7-tert-butyl-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl]-1-methyl-2-oxo-1,2-dihydropyridin-3-yl}-3-methylurea, DIMETHYL SULFOXIDE
Authors:Kuglstatter, A., Wong, A.
Deposit date:2014-02-14
Release date:2014-05-14
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure-Based Drug Design of RN486, a Potent and Selective Bruton's Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis.
J.Med.Chem., 58, 2015
4OTR
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CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 6-CYCLOPROPYL-2-[3-[5-[[5-(4-ETHYLPIPERAZIN-1-YL)-2-PYRIDYL]AMINO]-1-METHYL-6-OXO-3-PYRIDYL]-2-(HYDROXYMETHYL)PHENYL]-8-FLUORO-ISOQUINOLIN-1-ONE
Descriptor:Tyrosine-protein kinase BTK, 6-cyclopropyl-2-[3-(5-{[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl]-8-fluoroisoquinolin-1(2H)-one, DIMETHYL SULFOXIDE
Authors:Kuglstatter, A., Wong, A.
Deposit date:2014-02-14
Release date:2014-05-14
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-Based Drug Design of RN486, a Potent and Selective Bruton's Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis.
J.Med.Chem., 58, 2015
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