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6QPD
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ENGINEERED BETA-LACTOGLOBULIN: VARIANT I56F
Descriptor:Beta-lactoglobulin, SULFATE ION, GLYCEROL
Authors:Loch, J.I., Kaczor, K., Leiwnski, K.
Deposit date:2019-02-13
Release date:2019-02-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Engineered beta-lactoglobulin: variant I56F
To Be Published
6QPC
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CRYO-EM STRUCTURE OF CALCIUM-BOUND MTMEM16F LIPID SCRAMBLASE IN NANODISC
Descriptor:Anoctamin-6, CALCIUM ION, 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Authors:Alvadia, C., Lim, N.K., Clerico Mosina, V., Oostergetel, G.T., Dutzler, R., Paulino, C.
Deposit date:2019-02-13
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F.
Elife, 8, 2019
6QPB
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CRYO-EM STRUCTURE OF CALCIUM-FREE MTMEM16F LIPID SCRAMBLASE IN DIGITONIN
Descriptor:Anoctamin-6, 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Authors:Alvadia, C., Lim, N.K., Clerico Mosina, V., Oostergetel, G.T., Dutzler, R., Paulino, C.
Deposit date:2019-02-13
Release date:2019-03-06
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F.
Elife, 8, 2019
6QP6
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CRYO-EM STRUCTURE OF CALCIUM-BOUND MTMEM16F LIPID SCRAMBLASE IN DIGITONIN
Descriptor:Anoctamin-6, CALCIUM ION, 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Authors:Alvadia, C., Lim, N.K., Clerico Mosina, V., Oostergetel, G.T., Dutzler, R., Paulino, C.
Deposit date:2019-02-13
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F.
Elife, 8, 2019
6QP0
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CRYSTAL STRUCTURE OF CHAETOMIUM THERMOPHILUM KTI12 IN COMPLEX WITH ADP-ALF3
Descriptor:Putative chromatin binding protein, ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, ...
Authors:Krutyholowa, R., Glatt, S.
Deposit date:2019-02-13
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.409 Å)
Cite:Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator
To Be Published
6QNV
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FIBRINOGEN-LIKE GLOBE DOMAIN OF HUMAN TENASCIN-C
Descriptor:Tenascin
Authors:Coker, J.A., Bezerra, G.A., Bradshaw, W.J., Zhang, M., Yosaatmadja, Y., Fernandez-Cid, A., Shrestha, L., Burgess-Brown, N., Gileadi, O., Arrowsmith, C.H., Bountra, C., Midwood, K.S., Yue, W.W., Marsden, B.D., Structural Genomics Consortium (SGC)
Deposit date:2019-02-12
Release date:2019-02-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Fibrinogen-like globe domain of Human Tenascin-C
To Be Published
6QMB
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CRYO-EM STRUCTURE OF CALCIUM-BOUND NHTMEM16 LIPID SCRAMBLASE IN NANODISC (CLOSED STATE)
Descriptor:Predicted protein, CALCIUM ION
Authors:Kalienkova, V., Clerico Mosina, V., Bryner, L., Oostergetel, G.T., Dutzler, R., Paulino, C.
Deposit date:2019-02-01
Release date:2019-03-06
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM.
Elife, 8, 2019
6QMA
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CRYO-EM STRUCTURE OF CALCIUM-BOUND NHTMEM16 LIPID SCRAMBLASE IN NANODISC (INTERMEDIATE STATE)
Descriptor:Predicted protein, CALCIUM ION
Authors:Kalienkova, V., Clerico Mosina, V., Bryner, L., Oostergetel, G.T., Dutzler, R., Paulino, C.
Deposit date:2019-02-01
Release date:2019-03-06
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM.
Elife, 8, 2019
6QM9
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CRYO-EM STRUCTURE OF CALCIUM-BOUND NHTMEM16 LIPID SCRAMBLASE IN NANODISC (OPEN STATE)
Descriptor:Predicted protein, CALCIUM ION
Authors:Kalienkova, V., Clerico Mosina, V., Bryner, L., Oostergetel, G.T., Dutzler, R., Paulino, C.
Deposit date:2019-02-01
Release date:2019-03-06
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM.
Elife, 8, 2019
6QM6
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CRYO-EM STRUCTURE OF CALCIUM-FREE NHTMEM16 LIPID SCRAMBLASE IN DDM
Descriptor:Predicted protein
Authors:Kalienkova, V., Clerico Mosina, V., Bryner, L., Oostergetel, G.T., Dutzler, R., Paulino, C.
Deposit date:2019-02-01
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM.
Elife, 8, 2019
6QM5
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CRYO-EM STRUCTURE OF CALCIUM-BOUND NHTMEM16 LIPID SCRAMBLASE IN DDM
Descriptor:Predicted protein, CALCIUM ION
Authors:Kalienkova, V., Clerico Mosina, V., Bryner, L., Oostergetel, G.T., Dutzler, R., Paulino, C.
Deposit date:2019-02-01
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM.
Elife, 8, 2019
6QM4
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CRYO-EM STRUCTURE OF CALCIUM-FREE NHTMEM16 LIPID SCRAMBLASE IN NANODISC
Descriptor:Predicted protein
Authors:Kalienkova, V., Clerico Mosina, V., Bryner, L., Oostergetel, G.T., Dutzler, R., Paulino, C.
Deposit date:2019-02-01
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM.
Elife, 8, 2019
6QKL
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MECHANISM OF EIF6 RELEASE FROM THE NASCENT 60S RIBOSOMAL SUBUNIT
Descriptor:26S RIBOSOMAL RNA, 60S ribosomal protein L3, 60S ribosomal protein L9, ...
Authors:Kargas, V., Warren, A.J.
Deposit date:2019-01-29
Release date:2019-03-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanism of eIF6 release from the nascent 60S ribosomal subunit.
Nat.Struct.Mol.Biol., 22, 2015
6QKF
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STRUCTURE INVESTIGATIONS OF PROTEGRIN-4 BY HIGH RESOLUTION NMR SPECTROSCOPY
Descriptor:Protegrin-4
Authors:Usachev, K.S., Kolosova, O.A., Klochkova, E.A., Klochkov, V.V.
Deposit date:2019-01-29
Release date:2019-03-20
Method:SOLUTION NMR
Cite:Structure investigations of Protegrin-4 by High resolution NMR spectroscopy
Molecular Biology of the Cell, 29(26), 2018
6QJQ
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CRYO-EM STRUCTURE OF HEPARIN-INDUCED 2N3R TAU FILAMENTS
Descriptor:Microtubule-associated protein tau
Authors:Zhang, W., Falcon, B., Murzin, A.G., Fan, J., Crowther, R.A., Goedert, M., Scheres, S.H.W.
Deposit date:2019-01-24
Release date:2019-02-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.
Elife, 8, 2019
6QJP
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CRYO-EM STRUCTURE OF HEPARIN-INDUCED 2N4R TAU JAGGED FILAMENTS
Descriptor:Microtubule-associated protein tau
Authors:Zhang, W., Falcon, B., Murzin, A.G., Fan, J., Crowther, R.A., Goedert, M., Scheres, S.H.W.
Deposit date:2019-01-24
Release date:2019-02-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.
Elife, 8, 2019
6QJM
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CRYO-EM STRUCTURE OF HEPARIN-INDUCED 2N4R TAU TWISTER FILAMENTS
Descriptor:Microtubule-associated protein tau
Authors:Zhang, W., Falcon, B., Murzin, A.G., Fan, J., Crowther, R.A., Goedert, M., Scheres, S.H.W.
Deposit date:2019-01-24
Release date:2019-02-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.
Elife, 8, 2019
6QJH
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CRYO-EM STRUCTURE OF HEPARIN-INDUCED 2N4R TAU SNAKE FILAMENTS
Descriptor:Microtubule-associated protein tau
Authors:Zhang, W., Falcon, B., Murzin, A.G., Fan, J., Crowther, R.A., Goedert, M., Scheres, S.H.W.
Deposit date:2019-01-24
Release date:2019-02-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.
Elife, 8, 2019
6QJE
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STRUCTURE OF HUMAN GALACTOKINASE 1 BOUND WITH 4-{[2-(METHYLSULFONYL)-1H-IMIDAZOL-1-YL]METHYL}-1,3-THIAZOLE
Descriptor:Galactokinase, BETA-D-GALACTOSE, 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, ...
Authors:Mackinnon, S.R., Bezerra, G.A., Zhang, M., Foster, W., Krojer, T., Brandao-Neto, J., Douangamath, A., Arrowsmith, C., Edwards, A., Bountra, C., Brennan, P., Lai, K., Yue, W.W.
Deposit date:2019-01-24
Release date:2019-02-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of human galactokinase 1 bound with 4-{[2-(Methylsulfonyl)-1H-imidazol-1-yl]methyl}-1,3-thiazole
To Be Published
6QIE
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CRYSTAL STRUCTURE OF DEAH-BOX ATPASE PRP43-S387G
Descriptor:Prp43, (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Hamann, F., Ficner, R., Enders, M.
Deposit date:2019-01-18
Release date:2019-03-06
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for RNA translocation by DEAH-box ATPases.
Nucleic Acids Res., 2019
6QID
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CRYSTAL STRUCTURE OF DEAH-BOX ATPASE PRP43-S387A
Descriptor:Prp43, (4S)-2-METHYL-2,4-PENTANEDIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Hamann, F., Ficner, R., Enders, M.
Deposit date:2019-01-18
Release date:2019-03-06
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Structural basis for RNA translocation by DEAH-box ATPases.
Nucleic Acids Res., 2019
6QIC
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CRYSTAL STRUCTURE OF DEAH-BOX ATPASE PRP22-S837A WITH BOUND SSRNA
Descriptor:Putative pre-mRNA splicing factor, RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3')
Authors:Hamann, F., Ficner, R., Enders, M.
Deposit date:2019-01-18
Release date:2019-03-06
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for RNA translocation by DEAH-box ATPases.
Nucleic Acids Res., 2019
6QI7
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ENGINEERED BETA-LACTOGLOBULIN: VARIANT L39Y IN COMPLEX WITH ENDOGENOUS LIGAND
Descriptor:Beta-lactoglobulin, PALMITIC ACID, 1,2-ETHANEDIOL
Authors:Loch, J.I., Siuda, M.K., Lewinski, K.
Deposit date:2019-01-17
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Engineered beta-lactoglobulin: variant L39Y in complex with endogenous ligand
To Be Published
6QI6
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TRIGONAL FORM OF WT RECOMBINANT BOVINE BETA-LACTOGLOBULIN
Descriptor:Beta-lactoglobulin, 1,2-ETHANEDIOL, ETHANOL
Authors:Loch, J.I., Krawczyk, A., Lewinski, K.
Deposit date:2019-01-17
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Trigonal form of WT recombinant bovine beta-lactoglobulin
To Be Published
6QHC
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CRYSTAL STRUCTURE OF HUMAN KALLIKREIN 6 IN COMPLEX WITH GSK358180B
Descriptor:Kallikrein-6, GLYCEROL, N-(4-CARBAMIMIDOYL-PHENYL)-2-HYDROXY-BENZAMIDE, ...
Authors:Thorpe, J.H.
Deposit date:2019-01-16
Release date:2019-02-06
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.
Bioorg. Med. Chem. Lett., 29, 2019