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6ZWV
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CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE PROTEINS ON INTACT VIRIONS: 3 CLOSED RBDS
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Ke, Z., Qu, K., Nakane, T., Xiong, X., Cortese, M., Zila, V., Scheres, S.H.W., Briggs, J.A.G.
Deposit date:2020-07-28
Release date:2020-08-05
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures and distributions of SARS-CoV-2 spike proteins on intact virions
To Be Published
7JJL
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CRYSTAL STRUCTURE OF IMPORTIN ALPHA 3 IN COMPLEX WITH HUMAN LSD1 NLS
Descriptor:Importin subunit alpha-3, Lysine-specific histone demethylase 1A
Authors:Tu, W.J., McCuaig, R., Tan, H.Y.A., Hardy, K., Seddiki, N., Ali, S., Dahlstrom, J.E., Bean, E.G., Dunn, J., Forwood, J.K., Tsimbalyuk, S., Smith, K., Yip, D., Malik, L., Prasana, T., Milburn, P., Rao, S.
Deposit date:2020-07-27
Release date:2020-08-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
7JJM
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CRYSTAL STRUCTURE OF IMPORTIN ALPHA 2 IN COMPLEX WITH LSD1 NLS
Descriptor:Lysine-specific histone demethylase 1A, Importin subunit alpha-1, CHLORIDE ION
Authors:Tu, W.J., McGuaig, R., Tan, H.Y.A., Hardy, C., Seddiki, N., Ali, S., Dahlstrom, J.E., Bean, E.G., Dunn, J., Forwood, J.K., Tsimbalyuk, S., Smith, K.M., Yip, D., Malik, L., Prasana, T., Milburn, P., Rao, S.
Deposit date:2020-07-27
Release date:2020-08-05
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
7JK7
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CRYSTAL STRUCTURE OF IMPORTIN ALPHA 2 IN COMPLEX WITH LSD1 NLS S111E MUTANT
Descriptor:Lysine-specific histone demethylase 1A, Importin subunit alpha-1, GLYCEROL
Authors:Tu, W.J., McCuaig, R., Tan, A.H.Y., Hardy, K., Seddiki, N., Ali, S., Dahlstron, J.E., Bean, E.G., Dunn, J., Forwood, J.K., Tsimbalyuk, S., Smith, K.M., Yip, D., Malik, L., Prasana, T., Milburn, P., Rao, S.
Deposit date:2020-07-27
Release date:2020-08-05
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
7CM2
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THE CRYSTAL STRUCTURE OF HUMAN USP7 USP DOMAIN FROM WUXI BIORTUS.
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, GLYCEROL
Authors:Wang, F., Cheng, W., Lv, Z., Lin, D., Zhu, B., Miao, Q., Bao, X., Shang, H.
Deposit date:2020-07-24
Release date:2020-08-05
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The Crystal Structure of human USP7 USP domain from Wuxi Biortus.
To Be Published
7JIR
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2 , C111S MUTANT, IN COMPLEX WITH PLP_SNYDER457
Descriptor:Papain-like protease, 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, ZINC ION, ...
Authors:Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-07-23
Release date:2020-08-05
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant, in complex with PLP_Snyder457
to be published
7JIT
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2 , C111S MUTANT, IN COMPLEX WITH PLP_SNYDER495
Descriptor:Papain-like protease, 5-[(carbamoylcarbamoyl)amino]-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ZINC ION, ...
Authors:Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-07-23
Release date:2020-08-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant, in complex with PLP_Snyder495
to be published
7JIV
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2 , C111S MUTANT, IN COMPLEX WITH PLP_SNYDER530
Descriptor:Papain-like protease, 5-(acryloylamino)-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ZINC ION, ...
Authors:Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-07-23
Release date:2020-08-05
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant, in complex with PLP_Snyder530
to be published
7JIW
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2 IN COMPLEX WITH PLP_SNYDER530
Descriptor:Papain-Like Protease, 5-(acryloylamino)-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ZINC ION, ...
Authors:Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-07-23
Release date:2020-08-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of Papain-Like Protease of SARS CoV-2 in complex with PLP_Snyder530
to be published
6ZU8
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CRYSTAL STRUCTURE OF HUMAN BRACHYURY G177D VARIANT IN COMPLEX WITH AFATINIB
Descriptor:Brachyury protein, ZINC ION, N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide
Authors:Newman, J.A., Gavard, A.E., Shrestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2020-07-21
Release date:2020-08-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human Brachyury G177D variant in complex with Afatinib
To Be Published
7JHP
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CRYSTAL STRUCTURE OF HRAS IN COMPLEX WITH THE RAS-BINDING AND CYSTEINE-RICH DOMAINS OF CRAF-KINASE
Descriptor:GTPase HRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Cookis, T., Mattos, C.
Deposit date:2020-07-21
Release date:2020-08-05
Method:X-RAY DIFFRACTION (2.766 Å)
Cite:Crystal structure reveals the full Ras:Raf interface and advances mechanistic understanding of Raf activation
Biorxiv, 2020
7CKJ
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CRYSTAL STRUCTURE OF CMP KINASE IN COMPLEX WITH CMP FROM THERMUS THERMOPHILUS HB8
Descriptor:Cytidylate kinase, CYTIDINE-5'-MONOPHOSPHATE
Authors:Mega, R., Nakagawa, N., Kuramitsu, S., Masui, R., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2020-07-17
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The crystal structures of Thermus thermophilus CMP kinase complexed with a phosphoryl group acceptor and donor.
PLoS ONE, 15, 2020
7JFN
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CRYSTAL STRUCTURE OF LEUCINE-, ISOLEUCINE-, VALINE-, THREONINE-, AND ALANINE-BINDING PROTEIN FROM BRUCELLA OVIS, CLOSED CONFORMATION
Descriptor:Putative branched chain amino acid ABC transporter, periplasmic amino acid-binding protein, NITRATE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-07-17
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein from Brucella ovis, closed conformation
to be published
7JFQ
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THE CRYSTAL STRUCTURE OF 3CL MAINPRO OF SARS-COV-2 WITH DE-OXIDIZED C145
Descriptor:3C-like proteinase, 1,2-ETHANEDIOL, FORMIC ACID
Authors:Tan, K., Maltseva, N.I., Welk, L.F., Jedrzejczak, R.P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-07-17
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The crystal structure of 3CL MainPro of SARS-CoV-2 with de-oxidized C145
To Be Published
6XT2
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EQADH-NADH-HEPTAFLUOROBUTANOL, P21
Descriptor:Alcohol dehydrogenase E chain, ZINC ION, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ...
Authors:Plapp, B.V., Ramaswamy, S.
Deposit date:2020-07-16
Release date:2020-08-05
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Alternative binding modes in abortive NADH and alcohol complexes of horse liver alcohol dehydrogenase
To Be Published
6XS6
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SARS-COV-2 SPIKE D614G VARIANT, MINUS RBD
Descriptor:Spike glycoprotein
Authors:Wang, X., Egri, S.B., Dudkina, N., Luban, J., Shen, K.
Deposit date:2020-07-15
Release date:2020-07-22
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
Biorxiv, 2020
6ZSL
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CRYSTAL STRUCTURE OF THE SARS-COV-2 HELICASE AT 1.94 ANGSTROM RESOLUTION
Descriptor:SARS-CoV-2 helicase NSP13, ZINC ION, PHOSPHATE ION
Authors:Newman, J.A., Yosaatmadja, Y., Douangamath, A., Arrowsmith, C.H., von Delft, F., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2020-07-15
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structure of the SARS-CoV-2 helicase at 1.94 Angstrom resolution
To Be Published
7CJU
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CRYSTAL STRUCTURE OF INACTIVE FORM OF CHITOSANASE CRYSTALLIZED BY AMMONIUM SULFATE
Descriptor:Glucanase
Authors:Guo, Y., Qu, L., Nishida, N., Hoshino, T.
Deposit date:2020-07-14
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Electrostatic potential around the proteins crystallized by ammonium sulfate
To be published
6XR8
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DISTINCT CONFORMATIONAL STATES OF SARS-COV-2 SPIKE PROTEIN
Descriptor:Spike glycoprotein, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, J., Cai, Y.F., Xiao, T.S., Peng, H.Q., Sterling, S.M., Walsh Jr, R.M., Rawson, S., Volloch, S.R., Chen, B.
Deposit date:2020-07-11
Release date:2020-07-22
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Distinct conformational states of SARS-CoV-2 spike protein
Science, 2020
6XRA
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DISTINCT CONFORMATIONAL STATES OF SARS-COV-2 SPIKE PROTEIN
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, J., Cai, Y.F., Xiao, T.S., Peng, H.Q., Sterling, S.M., Walsh Jr, R.M., Rawson, S., Rits-Volloch, S., Chen, B.
Deposit date:2020-07-11
Release date:2020-07-22
Last modified:2020-08-05
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Distinct conformational states of SARS-CoV-2 spike protein.
Science, 2020
6XQS
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EXTREME MALLEABILITY OF THE SARS-COV-2 3CL MPRO ACTIVE SITE CAVITY FACILITATES BINDING OF CLINICAL ANTIVIRALS: PROSPECTS FOR REPURPOSING EXISTING DRUGS AND RAMIFICATIONS FOR INHIBITOR DESIGN
Descriptor:3C-like proteinase, (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide
Authors:Kneller, D.W., Kovalevsky, A., Coates, L.
Deposit date:2020-07-10
Release date:2020-07-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Extreme malleability of the SARS-CoV-2 3CL Mpro active site cavity facilitates binding of clinical antivirals: Prospects for repurposing existing drugs and ramifications for inhibitor design
To Be Published
6XQT
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EXTREME MALLEABILITY OF THE SARS-COV-2 3CL MPRO ACTIVE SITE CAVITY FACILITATES BINDING OF CLINICAL ANTIVIRALS: PROSPECTS FOR REPURPOSING EXISTING DRUGS AND RAMIFICATIONS FOR INHIBITOR DESIGN
Descriptor:3C-like proteinase, (1R,2S,5S)-3-[N-({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-{(1S)-1-[(1R)-2-(cyclopropyla mino)-1-hydroxy-2-oxoethyl]pentyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
Authors:Kneller, D.W., Kovalevsky, A., Coates, L.
Deposit date:2020-07-10
Release date:2020-07-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Extreme malleability of the SARS-CoV-2 3CL Mpro active site cavity facilitates binding of clinical antivirals: Prospects for repurposing existing drugs and ramifications for inhibitor design
To Be Published
6XQU
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EXTREME MALLEABILITY OF THE SARS-COV-2 3CL MPRO ACTIVE SITE CAVITY FACILITATES BINDING OF CLINICAL ANTIVIRALS: PROSPECTS FOR REPURPOSING EXISTING DRUGS AND RAMIFICATIONS FOR INHIBITOR DESIGN
Descriptor:3C-like proteinase, boceprevir (bound form)
Authors:Kneller, D.W., Kovalevsky, A., Coates, L.
Deposit date:2020-07-10
Release date:2020-07-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Extreme malleability of the SARS-CoV-2 3CL Mpro active site cavity facilitates binding of clinical antivirals: Prospects for repurposing existing drugs and ramifications for inhibitor design
To Be Published
6XQB
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SARS-COV-2 RDRP/RNA COMPLEX
Descriptor:RNA-directed RNA polymerase, Non-structural protein 8, Non-structural protein 7, ...
Authors:Liu, B., Shi, W., Yang, Y.
Deposit date:2020-07-09
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of SARS-CoV-2 RdRp/RNA complex at 3.4 Angstroms resolution
To Be Published
6XQD
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH SARECYCLINE, UUC-MRNA, AND DEACYLATED P-SITE TRNA AT 2.80A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Batool, Z., Lomakin, I.B., Bunick, C.G., Polikanov, Y.S.
Deposit date:2020-07-09
Release date:2020-08-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome
Proc.Natl.Acad.Sci.USA, 2020
167327
PDB entries from 2020-08-05